UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F COVER PAGE
OMB APPROVAL
OMB Number:3235-0006
Expires:July 31, 2015
Estimated average burden
hours per response:23.8
Report for the Calendar Year or Quarter Ended:
03-31-2022
Check here if Amendment: ☐ Amendment Number:
This Amendment (Check only one.):☐ is a restatement.
☐ adds new holdings entries.

Institutional Investment Manager Filing this Report:

Name:
INTERNATIONAL BIOTECHNOLOGY TRUST PLC
Address:
6th Floor, 65 Gresham Street
London, X0 EC2V 7NQ
Form 13F File Number:
028-18673

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.


Person Signing this Report on Behalf of Reporting Manager:
Name:
James Costine
Title:
Authorised Signatory
Phone:
0044 2074217081


Signature, Place, and Date of Signing:

James Costine
                         [Signature]
London, UNITED KINGDOM
                 [City, State]
05-20-2022
                           [Date]
                          

Report Type (Check only one.):

☒ 13F HOLDINGS REPORT. (Check here if all holdings of this reporting manager are reported in this report.) 

☐ 13F NOTICE. (Check here if no holdings reported are in this report, and all holdings are reported by other reporting manager(s).) 

☐ 13F COMBINATION REPORT. (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)


Form 13F Summary Page

Report Summary:

Number of Other Included Managers:
0
Form 13F Information table Entry Total:
70
Form 13F Information table Value Total:
330275
          (thousands)

List of Other Included Managers:

Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report.
[If there are no entries in this list, state "NONE" and omit the column headings and list entries.]

  
NONE


UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number:3235-0006
Expires:July 31, 2015
Estimated average burden
hours per response:23.8
COLUMN 1COLUMN 2COLUMN 3COLUMN 4COLUMN 5COLUMN 6COLUMN 7COLUMN 8
VALUESHRS ORSH/PUT/INVESTMENTOTHERVOTING AUTHORITY
NAME OF ISSUERTITLE OF CLASSCUSIP(x$1000)PRN AMTPRNCALLDISCRETIONMANAGERSOLESHAREDNONE
2SEVENTY BIO INC-W/ICOMMON STOCK901384107943,666SHSOLE3,666 0 0
AGIOS PHARMS.COM00847X10470721,500SHSOLE21,500 0 0
ALLOGENE THERAPEUTICSCOM01977010674750,000SHSOLE50,000 0 0
ALNYLAM PHARMS.COM02043Q10721,70638,000SHSOLE38,000 0 0
AMGEN INC COMCOM03116210032,56566,746SHSOLE66,746 0 0
AMICUS THERAPEUTICSCOM03152W1091,09494,600SHSOLE94,600 0 0
ANAPTYSBIOCOM03272410634810,000SHSOLE10,000 0 0
APELLIS PHARMS.COM03753U1061,53632,500SHSOLE32,500 0 0
ASCENDIS PHARMA ADRSponsored ADR04351P1011,95129,400SHSOLE29,400 0 0
Aurinia Pharmaceuticals Inc Com NPVCOM05156V1023,955435,000SHSOLE435,000 0 0
AVADEL PHARMS.sponsored ADR05337M1047,64750,000SHSOLE50,000 0 0
AXSOME THERAPEUTICSCOM05464T1045,40214,000SHSOLE14,000 0 0
BEIGENE ADRSponsored ADR07725L10211,39815,700SHSOLE15,700 0 0
BIOCRYST PHARMS.COM09058V10319,28257,000SHSOLE57,000 0 0
BIOHAVEN PHARM. HLDG.COMG111961059,291130,900SHSOLE130,900 0 0
BIOMARIN PHARM.COM09061G10123579,656SHSOLE79,656 0 0
BLACK DIAMOND THERAPEUTICCOM0920E31052,08944,000SHSOLE44,000 0 0
BLUEPRINT MEDICINESCOM09627Y10988119,500SHSOLE19,500 0 0
CHEMOCENTRYXCOM16383L1061,31436,100SHSOLE36,100 0 0
CHINOOK THERAPEUTICSCOM16961L1064,714340,389SHSOLE340,389 0 0
DENALI THERAPEUTICSCOM24823R1058,19238,000SHSOLE38,000 0 0
DYNE THERAPEUTICSCOM26818M1081,158476,000SHSOLE476,000 0 0
FATE THERAPEUTICSCOM31189P1025,64128,000SHSOLE28,000 0 0
FULCRUM THERAPEUTICS INCCOM35961610983382,741SHSOLE82,741 0 0
Gamida Cell Ltd COM USD0.01SHSM473641009,985107,000SHSOLE107,000 0 0
GBL. BLOOD THERAPEUTICSCOM37890U1081,638151,800SHSOLE151,800 0 0
GILEAD SCIENCESCOM3755581031,08088,784SHSOLE88,784 0 0
GUARDANT HEALTHCOM40131M10927174,500SHSOLE74,500 0 0
HARMONY BIOSCIENCES HLDGSCOM41319710420,533205,474SHSOLE205,474 0 0
HARPOON THERAPEUTICSCOM41358P1062,771151,445SHSOLE151,445 0 0
HORIZON THERAPEUTICSSHSG4617B1057,451183,473SHSOLE183,473 0 0
Hutchmed China Ltd ADR(V0.5 Ord)SPONSORED ADS44842L10310,06368,000SHSOLE68,000 0 0
IDEAYA BIOSCIENCESCOM45166A1021,623109,000SHSOLE109,000 0 0
ILLUMINACOM45232710910,76248,000SHSOLE48,000 0 0
I-MAB-SPONSORED ADRSPONSORED ADS44975P1032,37718,000SHSOLE18,000 0 0
IMMUNOVANTCOM45258J10285160,000SHSOLE60,000 0 0
INCYTECOM45337C1022,577238,000SHSOLE238,000 0 0
INSMEDCOM45766930714,26640,100SHSOLE40,100 0 0
INTELLIA THERAPEUTICSCOM45826J10551124,000SHSOLE24,000 0 0
INTRA-CELLULAR THERAPIESCOM46116X10120,93050,956SHSOLE50,956 0 0
IONIS PHARMS.COM4622221003,299154,088SHSOLE154,088 0 0
IOVANCE BIOTHERAPEUTICSCOM4622601002,83658,000SHSOLE58,000 0 0
JAZZ PHARMS.SHS USDG508711055,92417,200SHSOLE17,200 0 0
KALVISTA PHARMS.COM48349710310,805383,233SHSOLE383,233 0 0
KRYSTAL BIOTECHCOM5011471021,10645,000SHSOLE45,000 0 0
LEGEND BIOTECHSPONSORED ADS52490G1025,6324,500SHSOLE4,500 0 0
MADRIGAL PHARMS.COM5588681055,0665,350SHSOLE5,350 0 0
MIRATI THERAPEUTICS INCCOM60468T1051,373188,500SHSOLE188,500 0 0
NEUROCRINE BIOSCIENCESCOM64125C1093,148203,000SHSOLE203,000 0 0
NKARTACOM65487U10820910,034SHSOLE10,034 0 0
NOVAVAXCOM NEW67000240118,549132,500SHSOLE132,500 0 0
ORIC PHARMS.COM68622P109905176,217SHSOLE176,217 0 0
Prothena Corp PLC USD0.01SHSG7280010823,84815,000SHSOLE15,000 0 0
PTC THERAPEUTICSCOM69366J200617411,000SHSOLE411,000 0 0
REGENERON PHARMS.COM75886F1072,24912,100SHSOLE12,100 0 0
RELMADA THERAPEUTICSCOM75955J40274110,000SHSOLE10,000 0 0
ROCKET PHARMS.COM77313F10617,88463,000SHSOLE63,000 0 0
SANOFISPONSORED ADR80105N1057,64131,500SHSOLE31,500 0 0
SEAGENCOM81181C10422576,200SHSOLE76,200 0 0
SPRINGWORKS THERAPEUTICSCOM85205L1071,37516,300SHSOLE16,300 0 0
SUPERNUS PHARMS.COM86845910817,478297,500SHSOLE297,500 0 0
TRAVERE THERAPEUTICS INCCOM89422G1071,550380,000SHSOLE380,000 0 0
TURNING POINT THERAPEUTICCOM90041T1088,67514,093SHSOLE14,093 0 0
ULTRAGENYX PHARM.COM90400D1082,073233,100SHSOLE233,100 0 0
Uniqure B V EUR0.05SHSN9006410111,803155,500SHSOLE155,500 0 0
UTD. THERAPEUTICSCOM91307C1022,94520,000SHSOLE20,000 0 0
VERA THERAPEUTICSCL A92337R10111,613190,749SHSOLE190,749 0 0
VERTEX PHARMS.COM92532F1003,22525,122SHSOLE25,122 0 0
Xenon Pharmaceuticals Inc NPVCOM98420N1053,19825,500SHSOLE25,500 0 0
Zai Lab Ltd ADR (V1 Ord)ADR98887Q10416,95878,958SHSOLE78,958 0 0