FORM 4
☐

Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person *
Walbert Timothy P
 2. Issuer Name and Ticker or Trading Symbol
Horizon Therapeutics Public Ltd Co [HZNP] 		5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
__X__ Director _____ 10% Owner
__X__ Officer (give title below) _____ Other (specify below)
Chairman, President and CEO
(Last)
(First)
(Middle)

C/O HORIZON THERAPEUTICS PLC,, 70 ST. STEPHEN?S GREEN		 3. Date of Earliest Transaction (Month/Day/Year)
01/04/2023
(Street)

DUBLIN, L2 D02 E2X4
(City)
(State)
(Zip)
4. If Amendment, Date Original Filed(Month/Day/Year)
6. Individual or Joint/Group Filing
(Check applicable line)

__X__ Form Filed by One Reporting Person
_____ Form Filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned

1.Title of Security (Instr. 3)

2. Transaction Date (Month/Day/Year)

2A. Deemed Execution Date, if any (Month/Day/Year)

3. Transaction Code (Instr. 8)

4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)

5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)

6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)

7. Nature of Indirect Beneficial Ownership (Instr. 4)

Code

V

Amount

(A) or (D)

Price

Ordinary Shares

01/05/2023 M 219,995A (1) 713,954D 

Ordinary Shares

01/05/2023 F 97,461D $113.24616,493D 

Ordinary Shares

       107,739I

See Footnote (2)

Ordinary Shares

       100,300I

See Footnote (3)

Ordinary Shares

       49,656I

By Spouse



Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security
(Instr. 3)

2. Conversion or Exercise Price of Derivative Security

3. Transaction Date (Month/Day/Year)

3A. Deemed Execution Date, if any (Month/Day/Year)

4. Transaction Code
(Instr. 8)

5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5)

6. Date Exercisable and Expiration Date (Month/Day/Year)

7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)

8. Price of Derivative Security (Instr. 5)

9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)

10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)

11. Nature of Indirect Beneficial Ownership (Instr. 4)

Code

V

(A)

(D)

Date Exercisable

Expiration Date

Title

Amount or Number of Shares

Restricted Stock Units (RSUs)

 (1) 01/04/2023 A 71,290   (4)   (4)

Ordinary Shares

71,290 $ 0 71,290D 

Restricted Stock Units (RSUs)

 (1) 01/04/2023 A 20,697   (4)   (4)

Ordinary Shares

20,697 $ 0 20,697I

By Spouse

Restricted Stock Units (RSUs)

 (1) 01/05/2023 M  58,055  (5)   (5)

Ordinary Shares

58,055 $ 0 0 D 

Restricted Stock Units (RSUs)

 (1) 01/05/2023 M  34,928  (6)   (6)

Ordinary Shares

34,928 $ 0 34,929D 

Restricted Stock Units (RSUs)

 (1) 01/05/2023 M  24,598  (7)   (7)

Ordinary Shares

24,598 $ 0 49,198D 

Performance Restricted Stock Units (PSUs)

 (1) 01/05/2023 M  34,835  (8)   (8)

Ordinary Shares

34,835 $ 0 0 D 

Performance Restricted Stock Units (PSUs)

 (1) 01/05/2023 M  9,435  (8)   (8)

Ordinary Shares

9,435 $ 0 0 D 

Performance Restricted Stock Units (PSUs)

 (1) 01/05/2023 M  23,200  (8)   (8)

Ordinary Shares

23,200 $ 0 0 D 

Performance Restricted Stock Units (PSUs)

 (1) 01/05/2023 M  39,944  (6)   (6)

Ordinary Shares

39,944 $ 0 17,448D 

Explanation of Responses:
1.

Each PSU/RSU represents a contingent right to receive one ordinary share of the Issuer.

2.

The shares are held by the Timothy P. Walbert 2021 Gift Trust, of which the Reporting Person's spouse is the Trustee and beneficiary.

3.

The shares are held by the Keli B. Walbert 2021 Gift Trust, of which the Reporting Person is the Trustee. The beneficiaries of the Trust include the Reporting Person and his descendants.

4.

The RSUs vest 1/3rd annually on each anniversary of January 5, 2023.

5.

The final tranche of ordinary shares subject to the RSU vested on January 5, 2023.

6.

The remaining ordinary shares subject to the PSU/RSU vest on January 5, 2024.

7.

The remaining ordinary shares subject to the RSU vest ratably on January 5, 2024 and January 5, 2025.

8.

The ordinary shares subject to the PSU vested on January 5, 2023.



Signatures

/s/ Adriana Hernandez-Capone, Attorney-in-Fact

01/06/2023
** Signature of Reporting PersonDate
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
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