UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F COVER PAGE
OMB APPROVAL
OMB Number:3235-0006
Expires:July 31, 2015
Estimated average burden
hours per response:23.8
Report for the Calendar Year or Quarter Ended:
09-30-2019
Check here if Amendment: ☐ Amendment Number:
This Amendment (Check only one.):☐ is a restatement.
☐ adds new holdings entries.

Institutional Investment Manager Filing this Report:

Name:
INTERNATIONAL BIOTECHNOLOGY TRUST PLC
Address:
10 HAREWOOD AVENUE
LONDON, X0 NW1 6AA
Form 13F File Number:
028-18673

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.


Person Signing this Report on Behalf of Reporting Manager:
Name:
James Costine
Title:
Authorized Signatory
Phone:
0044 2074217081


Signature, Place, and Date of Signing:

James Costine
                         [Signature]
London, UNITED KINGDOM
                 [City, State]
11-14-2019
                           [Date]
                          

Report Type (Check only one.):

☒ 13F HOLDINGS REPORT. (Check here if all holdings of this reporting manager are reported in this report.) 

☐ 13F NOTICE. (Check here if no holdings reported are in this report, and all holdings are reported by other reporting manager(s).) 

☐ 13F COMBINATION REPORT. (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)


Form 13F Summary Page

Report Summary:

Number of Other Included Managers:
0
Form 13F Information table Entry Total:
58
Form 13F Information table Value Total:
216398
          (thousands)

List of Other Included Managers:

Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report.
[If there are no entries in this list, state "NONE" and omit the column headings and list entries.]

  
NONE


UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number:3235-0006
Expires:July 31, 2015
Estimated average burden
hours per response:23.8
COLUMN 1COLUMN 2COLUMN 3COLUMN 4COLUMN 5COLUMN 6COLUMN 7COLUMN 8
VALUESHRS ORSH/PUT/INVESTMENTOTHERVOTING AUTHORITY
NAME OF ISSUERTITLE OF CLASSCUSIP(x$1000)PRN AMTPRNCALLDISCRETIONMANAGERSOLESHAREDNONE
Ascendis Pharma ASSponsored ADR04351P1011,32913,800SHSOLE13,800 0 0
UNIQURE NVSHSN900641011,08227,500SHSOLE27,500 0 0
GW Pharmaceuticals PlcADS36197T1032,27619,800SHSOLE19,800 0 0
Amarin Corp PlcSPONS ADR NEW0231112063,926259,000SHSOLE259,000 0 0
Dermira IncCOM24983L10419130,000SHSOLE30,000 0 0
G1 Therapeutics IncCOM3621LQ10925511,200SHSOLE11,200 0 0
Arqule INCCOM04269E10729441,000SHSOLE41,000 0 0
ANAPTYSBIO INCCOM03272410635010,000SHSOLE10,000 0 0
Radius Health IncCOM75046920743717,000SHSOLE17,000 0 0
Amicus Therapeutics IncCOM03152W10947058,600SHSOLE58,600 0 0
AKCEA THERAPEUTICS INCCOM00972L10748831,723SHSOLE31,723 0 0
Supernus Pharmaceuticals IncCOM86845910854819,953SHSOLE19,953 0 0
Zogenix IncCOM98978L20457714,400SHSOLE14,400 0 0
DECIPHERA PHARMACEUTICALS INCCOM24344T10157717,000SHSOLE17,000 0 0
Myriad Genetics incCOM62855J10471625,000SHSOLE25,000 0 0
FibroGen IncCOM31572Q80872819,700SHSOLE19,700 0 0
Arena Pharmaceuticals IncCOM04004760775516,500SHSOLE16,500 0 0
Halozyme Therapeutics IncCOM40637H10981652,633SHSOLE52,633 0 0
MIRATI THERAPEUTICS INCCOM60468T10584910,900SHSOLE10,900 0 0
Global Blood TherapeuticsCOM37890U10889718,500SHSOLE18,500 0 0
Exact Sciences CorpCOM30063P10596710,700SHSOLE10,700 0 0
MOMENTA PHARMACEUTICALS INCCOM60877T1001,03680,000SHSOLE80,000 0 0
NEKTAR THERAPEUTICSCOM6402681081,09360,000SHSOLE60,000 0 0
Tricida IncCOM89610F1011,14137,000SHSOLE37,000 0 0
Agios Pharmaceuticals IncCOM00847X1041,18036,500SHSOLE36,500 0 0
ACCELERON PHARMA INCCOM00434H1081,18430,000SHSOLE30,000 0 0
Globus Med IncCOM3795772081,23724,200SHSOLE24,200 0 0
Blueprint Medicines CorpCOM09627Y1091,25017,000SHSOLE17,000 0 0
SUTRO BIOPHARMA INCCOM8693671021,264139,331SHSOLE139,331 0 0
Millendo Therapeutics IncCOM60040X1031,264177,825SHSOLE177,825 0 0
Bluebird Bio IncCOM09609G1001,56117,000SHSOLE17,000 0 0
Myokardia INCCOM62857M1051,56430,000SHSOLE30,000 0 0
Exelixis IncCOM30161Q1041,830103,534SHSOLE103,534 0 0
REPLIGEN CORPCOM7599161091,84124,000SHSOLE24,000 0 0
Sarepta Therapeutics IncCOM8036071001,96626,100SHSOLE26,100 0 0
Kalvista Pharmaceuticals IncCOM4834971032,058177,433SHSOLE177,433 0 0
Abiomed IncCOM0036541002,08111,700SHSOLE11,700 0 0
Sage Therapeutics IncCOM78667J1082,24516,000SHSOLE16,000 0 0
ACADIA PHARMACEUTICALS INCCOM0042251082,44668,000SHSOLE68,000 0 0
Alnylam Pharmaceuticals IncCOM02043Q1072,71533,800SHSOLE33,800 0 0
Ionis Pharmaceuticals IncCOM4622221002,76746,181SHSOLE46,181 0 0
Sangamo Therapeutics IncCOM8006771063,168350,000SHSOLE350,000 0 0
Seattle Genetics IncCOM8125781025,66766,400SHSOLE66,400 0 0
Biomarin Pharmaceutical IncCOM09061G1015,88387,284SHSOLE87,284 0 0
HORIZON THERAPEUTICS PUB LTDSHSG461881015,938218,000SHSOLE218,000 0 0
INSMED INCCOM4576693076,287356,600SHSOLE356,600 0 0
Incyte CorpCOM45337C1027,16196,500SHSOLE96,500 0 0
Biogen IncCOM09062X1037,38131,700SHSOLE31,700 0 0
ILLUMINA INCCOM4523271097,63625,100SHSOLE25,100 0 0
PTC Therapuetics COMCOM69366J2007,982236,000SHSOLE236,000 0 0
Stemline Therapeutics IncCOM85858C1078,695835,245SHSOLE835,245 0 0
Alexion Pharmaceuticals IncCOM01535110910,002102,141SHSOLE102,141 0 0
Regeneron PharmaceuticalsCOM75886F10711,05039,830SHSOLE39,830 0 0
Amgen IncCOM03116210012,77266,000SHSOLE66,000 0 0
Neurocrine Biosciences IncCOM64125C10913,266147,300SHSOLE147,300 0 0
Vertex Pharmaceuticals IncCOM92532F10014,23284,022SHSOLE84,022 0 0
Celgene CorpCOM15102010416,981171,022SHSOLE171,022 0 0
Gilead Sciences IncCOM37555810320,046316,284SHSOLE316,284 0 0