UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F COVER PAGE
OMB APPROVAL
OMB Number:3235-0006
Expires:July 31, 2015
Estimated average burden
hours per response:23.8
Report for the Calendar Year or Quarter Ended:
03-31-2023
Check here if Amendment: ☐ Amendment Number:
This Amendment (Check only one.):☐ is a restatement.
☐ adds new holdings entries.

Institutional Investment Manager Filing this Report:

Name:
INTERNATIONAL BIOTECHNOLOGY TRUST PLC
Address:
6TH FLOOR, 65 GRESHAM STREET
London, X0 EC2V 7NQ
Form 13F File Number:
028-18673

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.


Person Signing this Report on Behalf of Reporting Manager:
Name:
James Costine
Title:
Authorised Signatory
Phone:
0044 2074217081


Signature, Place, and Date of Signing:

James Costine
                         [Signature]
London, UNITED KINGDOM
                 [City, State]
05-10-2023
                           [Date]
                          

Report Type (Check only one.):

☒ 13F HOLDINGS REPORT. (Check here if all holdings of this reporting manager are reported in this report.) 

☐ 13F NOTICE. (Check here if no holdings reported are in this report, and all holdings are reported by other reporting manager(s).) 

☐ 13F COMBINATION REPORT. (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)


Form 13F Summary Page

Report Summary:

Number of Other Included Managers:
0
Form 13F Information table Entry Total:
64
Form 13F Information table Value Total:
358401018
          (thousands)

List of Other Included Managers:

Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report.
[If there are no entries in this list, state "NONE" and omit the column headings and list entries.]

  
NONE


UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number:3235-0006
Expires:July 31, 2015
Estimated average burden
hours per response:23.8
COLUMN 1COLUMN 2COLUMN 3COLUMN 4COLUMN 5COLUMN 6COLUMN 7COLUMN 8
VALUESHRS ORSH/PUT/INVESTMENTOTHERVOTING AUTHORITY
NAME OF ISSUERTITLE OF CLASSCUSIP(x$1000)PRN AMTPRNCALLDISCRETIONMANAGERSOLESHAREDNONE
ACADIA PHARMACEUTICALS INCOM0042251084,060,800216,000SHSOLE216,000 0 0
ADICET BIO INCCOM007002108889,571154,708SHSOLE154,708 0 0
ALKERMES PLCSHSG0176710516,716,670593,000SHSOLE593,000 0 0
ALNYLAM PHARMS.COM02043Q1079,333,04846,600SHSOLE46,600 0 0
AMGEN INC COMCOM03116210022,053,24691,246SHSOLE91,246 0 0
APELLIS PHARMS.COM03753U1062,089,34731,700SHSOLE31,700 0 0
ARVINAS INCCOM04335A105463,93017,000SHSOLE17,000 0 0
ASCENDIS PHARMA ADRSponsored ADR04351P1013,151,09229,400SHSOLE29,400 0 0
ASTRAZENECA PLC SPONSOREDSPONSORED ADR0463531084,511,65065,000SHSOLE65,000 0 0
AURINIA PHARMACEUTICALS INCCOM05156V1026,280,154573,530SHSOLE573,530 0 0
BEAM THERAPEUTICS INCCOM07373V105717,92523,500SHSOLE23,500 0 0
BEIGENE ADRSponsored ADR07725L1024,892,75822,700SHSOLE22,700 0 0
BIOCRYST PHARMS.COM09058V103475,38057,000SHSOLE57,000 0 0
BIOGEN INCCOM09062X1035,949,62821,400SHSOLE21,400 0 0
BIOMARIN PHARM.COM09061G1015,704,88358,656SHSOLE58,656 0 0
BLACK DIAMOND THERAPEUTICCOM0920E310582,28044,000SHSOLE44,000 0 0
CARIBOU BIOSCIENCES INCCOM1420381082,426,828457,892SHSOLE457,892 0 0
CHINOOK THERAPEUTICSCOM16961L1067,407,745319,989SHSOLE319,989 0 0
CRISPR THERAPEUTICS AGNAMEN AKTH171821081,546,52434,200SHSOLE34,200 0 0
DENALI THERAPEUTICSCOM24823R1051,994,68886,575SHSOLE86,575 0 0
DYNE THERAPEUTICSCOM26818M1084,988,137433,751SHSOLE433,751 0 0
ERASCA INCCOM29479A1084,278,0001,426,000SHSOLE1,426,000 0 0
EXELIXIS INCCOM30161Q10410,545,060543,000SHSOLE543,000 0 0
GENMAB A/S SPONSORED ADS3723032063,322,88088,000SHSOLE88,000 0 0
GILEAD SCIENCESCOM3755581034,777,16957,584SHSOLE57,584 0 0
GUARDANT HEALTHCOM40131M1091,746,28074,500SHSOLE74,500 0 0
HALOZYME THERAPEUTICS INCCOM40637H1091,736,73545,500SHSOLE45,500 0 0
HARMONY BIOSCIENCES HLDGSCOM41319710418,621,120570,500SHSOLE570,500 0 0
HUTCHMED CHINA LTDSPONSORED ADS44842L103885,36068,000SHSOLE68,000 0 0
IDEAYA BIOSCIENCESCOM45166A102260,87019,000SHSOLE19,000 0 0
ILLUMINA INCCOM4523271096,162,31026,500SHSOLE26,500 0 0
I-MAB-SPONSORED ADRSPONSORED ADS44975P1031,074,327310,499SHSOLE310,499 0 0
INCYTE CORPCOM45337C10220,163,330279,000SHSOLE279,000 0 0
INSMED INCCOM457669307682,10140,100SHSOLE40,100 0 0
INTELLIA THERAPEUTICSCOM45826J105894,00024,000SHSOLE24,000 0 0
INTRA-CELLULAR THERAPIESCOM46116X10113,957,745257,856SHSOLE257,856 0 0
IONIS PHARMS.COM4622221001,537,25043,000SHSOLE43,000 0 0
IOVANCE BIOTHERAPEUTICSCOM462260100341,60056,000SHSOLE56,000 0 0
IRONWOOD PHARMACEUTICALS INCCOM46333X108631,20060,000SHSOLE60,000 0 0
JAZZ PHARMS.SHS USDG508711052,514,98417,200SHSOLE17,200 0 0
KARUNA THERAPEUTICS INCCOM48576A1001,997,16011,000SHSOLE11,000 0 0
KRYSTAL BIOTECHCOM5011471024,883,66061,000SHSOLE61,000 0 0
LEGEND BIOTECHSPONSORED ADS52490G1021,833,88038,000SHSOLE38,000 0 0
MIRATI THERAPEUTICS INCCOM60468T1059,071,920244,000SHSOLE244,000 0 0
MIRUM PHARMACEUTICALS INCCOM6047491011,616,62567,500SHSOLE67,500 0 0
NOVAVAX INCCOM670002401924,850132,500SHSOLE132,500 0 0
NOVOCURE LTDORD SHSG6674U1081,924,48032,000SHSOLE32,000 0 0
PTC THERAPEUTICSCOM69366J2004,504,92093,000SHSOLE93,000 0 0
REGENERON PHARMS.COM75886F1079,197,55211,200SHSOLE11,200 0 0
RELMADA THERAPEUTICSCOM75955J40222,50010,000SHSOLE10,000 0 0
REVANCE THERAPEUTICS INCCOM7613301095,888,940183,000SHSOLE183,000 0 0
ROCKET PHARMS.COM77313F1061,079,19063,000SHSOLE63,000 0 0
SANOFISPONSORED ADR80105N1057,809,270143,500SHSOLE143,500 0 0
SEAGEN INCCOM81181C10440,510,470200,200SHSOLE200,200 0 0
SUPERNUS PHARMS.COM86845910815,326,465423,500SHSOLE423,500 0 0
TRAVERE THERAPEUTICS INCCOM89422G1073,170,107141,019SHSOLE141,019 0 0
ULTRAGENYX PHARM.COM90400D10810,580,564264,052SHSOLE264,052 0 0
UNIQURE NVSHSN900641019,636,990478,500SHSOLE478,500 0 0
UNITED THERAPEUTICS CORP DELCOM91307C1026,380,01028,500SHSOLE28,500 0 0
VENTYX BIOSCIENCES INCCOM92332V107501,45015,000SHSOLE15,000 0 0
VERA THERAPEUTICSCL A92337R1017,747,4471,002,257SHSOLE1,002,257 0 0
VERTEX PHARMACEUTICALS INCCOM92532F10010,385,43033,000SHSOLE33,000 0 0
XENON PHARMACEUTICALS INCCOM98420N105912,39025,500SHSOLE25,500 0 0
Zai Lab Ltd ADR (V1 Ord)ADR98887Q1042,626,14378,958SHSOLE78,958 0 0