NAME:

JURISDICTION OF INCORPORATION:

Horizon Medicines LLC

Delaware

Horizon Therapeutics U.S. Holding LLC

Delaware

Horizon Properties Holding LLC

Delaware

Horizon Therapeutics Brasil Ltda

Brazil

Horizon Therapeutics Capital Limited

Ireland

Horizon Therapeutics Finance Limited

Ireland

Horizon Therapeutics Finance S.à.r.l

Luxembourg

Horizon Therapeutics France SAS

France

Horizon Therapeutics GmbH

Germany

Horizon Therapeutics Holdings Limited

Ireland

Horizon Therapeutics Ireland DAC

Ireland

Horizon Therapeutics Italy S.r.l.

Italy

Horizon Therapeutics Japan G.K.

Japan

Horizon Therapeutics Services LLC

Delaware

Horizon Therapeutics Spain, S.L.

Spain

Horizon Therapeutics Switzerland GmbH

Switzerland

Horizon Therapeutics Treasury DAC

Ireland

Horizon Therapeutics USA, Inc.

Delaware

HZNP Canada Limited

Canada

HZNP Finance Limited

Bermuda

HZNP Limited

Ireland

Viela Bio, Inc.

Delaware

Horizon Therapeutics Netherlands B.V.

Netherlands

Viela Bio GmbH

Switzerland

Horizon Therapeutics Austria GmbH

Austria

Horizon Therapeutics Belgium S.r.l.

Belgium

Horizon Therapeutics Colombia S.A.S.

Colombia

Horizon Therapeutics Denmark ApS

Denmark

Horizon Therapeutics Finland Oy

Finland

Horizon Therapeutics Norway AS

Norway

HZNP Portugal Unipessoal Lda

Portugal

Horizon Therapeutics Sweden AB

Sweden

Horizon Therapeutics UK Limited

United Kingdom