UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F COVER PAGE
OMB APPROVAL
OMB Number:3235-0006
Expires:July 31, 2015
Estimated average burden
hours per response:23.8
Report for the Calendar Year or Quarter Ended:
09-30-2018
Check here if Amendment: ☒ Amendment Number:
1
This Amendment (Check only one.):☒ is a restatement.
☐ adds new holdings entries.

Institutional Investment Manager Filing this Report:

Name:
INTERNATIONAL BIOTECHNOLOGY TRUST PLC
Address:
10 HAREWOOD AVENUE
LONDON, X0 NW1 6AA
Form 13F File Number:
028-18673

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.


Person Signing this Report on Behalf of Reporting Manager:
Name:
James Costine
Title:
Authorized Signatory
Phone:
0207 421 7081


Signature, Place, and Date of Signing:

James Costine
                         [Signature]
London, UNITED KINGDOM
                 [City, State]
08-14-2018
                           [Date]
                          

Report Type (Check only one.):

☒ 13F HOLDINGS REPORT. (Check here if all holdings of this reporting manager are reported in this report.) 

☐ 13F NOTICE. (Check here if no holdings reported are in this report, and all holdings are reported by other reporting manager(s).) 

☐ 13F COMBINATION REPORT. (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)


Form 13F Summary Page

Report Summary:

Number of Other Included Managers:
0
Form 13F Information table Entry Total:
51
Form 13F Information table Value Total:
210403
          (thousands)

List of Other Included Managers:

Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report.
[If there are no entries in this list, state "NONE" and omit the column headings and list entries.]

  
NONE


UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number:3235-0006
Expires:July 31, 2015
Estimated average burden
hours per response:23.8
COLUMN 1COLUMN 2COLUMN 3COLUMN 4COLUMN 5COLUMN 6COLUMN 7COLUMN 8
VALUESHRS ORSH/PUT/INVESTMENTOTHERVOTING AUTHORITY
NAME OF ISSUERTITLE OF CLASSCUSIP(x$1000)PRN AMTPRNCALLDISCRETIONMANAGERSOLESHAREDNONE
Abiomed IncCOM0036541004,55313,200SHSOLE13,200 0 0
ACADIA PHARMACEUTICALS INCCOM0042251081,03565,000SHSOLE65,000 0 0
Adamas Pharmaceuticals IncCOM00548A1065,672370,000SHSOLE370,000 0 0
Aerie Pharmaceuticals IncCOM00771V1085,908125,179SHSOLE125,179 0 0
Agios Pharmaceuticals IncCOM00847X1042,15936,500SHSOLE36,500 0 0
Alexion Pharmaceuticals IncCOM0153511098,70081,641SHSOLE81,641 0 0
Alnylam Pharmaceuticals IncCOM02043Q1073,54352,800SHSOLE52,800 0 0
Amicus Therapeutics IncCOM03152W10954358,600SHSOLE58,600 0 0
Array Biopharma IncCOM04269X1059,844844,500SHSOLE844,500 0 0
Biomarin Pharmaceutical IncCOM09061G1017,23497,284SHSOLE97,284 0 0
Bluebird Bio IncCOM09609G1001,90317,000SHSOLE17,000 0 0
Celgene CorpCOM15102010417,398253,522SHSOLE253,522 0 0
Corvus Pharmaceuticals IncCOM221015100710108,000SHSOLE108,000 0 0
Cymabay Therapeutics IncCOM23257D1031,231145,000SHSOLE145,000 0 0
Deciphera Pharmaceuticals IncCOM24344T1012,28677,000SHSOLE77,000 0 0
Exelixis IncCOM30161Q1049,574704,534SHSOLE704,534 0 0
FibroGen IncCOM31572Q8081,46431,400SHSOLE31,400 0 0
G1 Therapeutics IncCOM3621LQ1092,88472,000SHSOLE72,000 0 0
Gilead Sciences IncCOM3755581035,34690,284SHSOLE90,284 0 0
Globus Med IncCOM3795772081,26229,000SHSOLE29,000 0 0
GW Pharmaceuticals PlcADS36197T1031,2729,600SHSOLE9,600 0 0
Halozyme Therapeutics IncCOM40637H1095,969428,633SHSOLE428,633 0 0
Horizon Pharma PlcSHSG4617B1051,03669,000SHSOLE69,000 0 0
ILLUMINA INCCOM45232710914,52251,600SHSOLE51,600 0 0
Incyte CorpCOM45337C10210,593200,000SHSOLE200,000 0 0
Intersect Ent IncCOM46071F1032,469112,000SHSOLE112,000 0 0
Ionis Pharmaceuticals IncCOM4622221002,03751,500SHSOLE51,500 0 0
Jazz Pharmaceuticals PLCSHS USDG508711052,78521,600SHSOLE21,600 0 0
Kalvista Pharmaceuticals IncCOM4834971035,467322,436SHSOLE322,436 0 0
Ligand Pharmaceuticals IncCOM53220K5047,36335,000SHSOLE35,000 0 0
Madrigal Pharmaceuticals IncCOM5588681051,64110,000SHSOLE10,000 0 0
Merus N VCOMN5749R1001,13675,060SHSOLE75,060 0 0
Neurocrine Biosciences IncCOM64125C1093,34835,500SHSOLE35,500 0 0
Paratek Pharmaceuticals IncCOM699374302766103,500SHSOLE103,500 0 0
Puma Biotechnology IncCOM74587V1075,074144,300SHSOLE144,300 0 0
Radius Health IncCOM75046920725718,799SHSOLE18,799 0 0
Regeneron PharmaceuticalsCOM75886F1079,70731,330SHSOLE31,330 0 0
ReShape Lifesciences IncCOM761123108252,546SHSOLE52,546 0 0
Sage Therapeutics IncCOM78667J1081,73215,996SHSOLE15,996 0 0
Sangamo Therapeutics IncCOM8006771061,464113,000SHSOLE113,000 0 0
Sarepta Therapeutics IncCOM8036071003,34427,000SHSOLE27,000 0 0
Seattle Genetics IncCOM8125781022,51342,500SHSOLE42,500 0 0
Shire plcSPONSORED ADR82481R1063,47525,000SHSOLE25,000 0 0
Spark Therapeutics IncCOM84652J10350212,000SHSOLE12,000 0 0
Spectrum Pharmaceuticals IncCOM84763A1083,863300,000SHSOLE300,000 0 0
Spring Bk Pharmaceuticals IncCOM84943110167373,000SHSOLE73,000 0 0
Stemline Therapeutics IncCOM85858C1077,459585,930SHSOLE585,930 0 0
Supernus Pharmaceuticals IncCOM86845910880920,953SHSOLE20,953 0 0
SUTRO BIOPHARMA INCCOM8693671021,686146,653SHSOLE146,653 0 0
Vertex Pharmaceuticals IncCOM92532F10010,00967,722SHSOLE67,722 0 0
Zogenix IncCOM98978L2044,184110,000SHSOLE110,000 0 0