UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, D.C. 20549

FORM 8-K

CURRENT REPORT

Pursuant to Section 13 or 15(d) of the

Securities Exchange Act of 1934

Date of report (date of earliest event reported): February 29, 2008

DOCUMENT SCIENCES CORPORATION

(Exact Name of Registrant as Specified in its Charter)

Registrant’s telephone number, including area code: (760) 602-1400

Not Applicable

(Former Name or Former Address, if Changed Since Last Report)

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2. below):

On December 26, 2007, Document Sciences Corporation (“Document Sciences” or the “Company”), EMC Corporation and Esteem Merger Corporation entered into an Agreement and Plan of Merger (the “Merger Agreement”) whereby the Company will, subject to the satisfaction of certain conditions, become a wholly-owned subsidiary of EMC (the “Merger”). In connection with the Merger, the Board of Directors of the Company authorized amendments to the following agreements and plans.

On March 3, 2008, the Company entered into the First Amendment (the “Rights Agreement Amendment”), dated as of March 3, 2008, by and between the Company and Computershare Trust Company, N.A., as successor rights agent, to the Rights Agreement (the “Rights Agreement”), dated as of May 11, 2001, by and between the Company and U.S. Stock Transfer Corporation. The Rights Agreement Amendment provides that the Rights Agreement shall not apply to the Merger Agreement, the Merger and any other transactions contemplated by the Merger Agreement, and any compliance with the terms of the Merger Agreement, such that (i) the execution, delivery and performance of, and compliance with, the Merger Agreement and the consummation of the Merger and any of the transactions contemplated by the Merger Agreement shall not be deemed a Section 13(a) Event (as defined in the Rights Agreement), (ii) a 20% Ownership Date (as defined in the Rights Agreement) shall not occur, and the rights issued under the Rights Agreement shall not become exercisable due to the execution, delivery and performance of, or compliance with, the Merger Agreement or the consummation of the Merger or any other transactions contemplated by the Merger Agreement, and (iii) the expiration date of the Rights Agreement shall occur immediately prior to the effective time of the Merger. Notwithstanding the foregoing, if the Merger Agreement is terminated, the Rights Agreement will continue to remain in effect and shall apply to EMC, Esteem Merger Corporation and any of their affiliates with the same effect as though the Rights Agreement Amendment had not occurred.

The foregoing description of the Rights Agreement Amendment is qualified in its entirety by reference to the full text of the Rights Agreement Amendment, which is attached hereto as Exhibit 4.1 and incorporated herein by reference.

On March 3, 2008, the Company entered into Amendment No. 1 (the “1995 Plan Amendment”) to the Document Sciences Corporation 1995 Stock Incentive Plan, as amended and restated on March 26, 1999 (the “1995 Plan”). The 1995 Plan Amendment provides that as of the effective time of the Merger, each outstanding Stock Option (as defined in the 1995 Plan), whether or not vested, shall be deemed fully vested and shall be cancelled and terminated, and each Optionee (as defined in the 1995 Plan) shall be entitled to receive in exchange therefor a cash payment (at the time and in the manner specified in the Merger Agreement), equal to the product of (i) the number of shares of stock for which such Stock Option is exercisable, and (ii) the excess (if any) of the Per Share Merger Consideration (as defined in the Merger Agreement) over the per share Exercise Price (as defined in the 1995 Plan) of such Stock Option, less applicable tax withholdings.

On March 3, 2008, the Company entered into Amendment No. 1 (the “2004 Plan Amendment”) to the Document Sciences Corporation Amended and Restated 2004 Stock Incentive Plan (the “2004 Plan”). The 2004 Plan Amendment provides that as of the effective time of the Merger, each outstanding Stock Option (as defined in the 2004 Plan), whether or not vested, shall be deemed fully vested and shall be cancelled and terminated, and each Holder (as defined in the 2004 Plan) shall be entitled to receive in exchange therefor a cash payment (at the time and in the manner specified in the Merger Agreement), equal to the product of (i) the number of shares of stock for which such Stock Option is exercisable, and (ii) the excess (if any) of the Per Share Merger Consideration (as defined in the Merger Agreement) over the per share Exercise Price (as defined in the 2004 Plan) of such Stock Option, less applicable tax withholdings.

On March 3, 2008, the Company entered into Amendment No. 1 (the “Calnan Plan Amendment”) to the Stock Option and Restricted Stock Plan and Agreement with Edward Calnan (the “Calnan Plan”), dated as of September 16, 2006, by and between Edward Calnan (“Calnan”) and the Company. The Calnan Plan Amendment

provides that as of the effective time of the Merger, each outstanding Option (as defined in the Calnan Plan), whether or not vested, shall be deemed fully vested and shall be cancelled and terminated, and Calnan shall be entitled to receive in exchange therefor a cash payment (at the time and in the manner specified in the Merger Agreement), equal to the product of (i) the number of shares of stock for which such Option is exercisable, and (ii) the excess (if any) of the Per Share Merger Consideration over the per share Exercise Price (as defined in the Calnan Plan) of such Option, less applicable tax withholdings.

The foregoing descriptions of the 1995 Plan Amendment, the 2004 Plan Amendment and the Calnan Plan Amendment are qualified in their entirety by reference to the full text of such amendments, which are attached hereto as Exhibits 10.1, 10.2 and 10.3, respectively, and are incorporated herein by reference.

(d) Exhibits

SIGNATURE

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

EXHIBIT INDEX

Exhibit 4.1

FIRST AMENDMENT TO RIGHTS AGREEMENT

This First Amendment (the “Amendment”), dated as of March 3, 2008, by and between Document Sciences Corporation, a Delaware corporation (the “Company”), and Computershare Trust Company, N.A., as successor rights agent (the “Rights Agent”), amends that certain Rights Agreement, dated as of May 11, 2001, by and between the Company and U.S. Stock Transfer Corporation (the “Rights Agreement”).

WHEREAS, the Company is a party to the Agreement and Plan of Merger, dated as of December 26, 2007, by and among EMC Corporation, Esteem Merger Corporation and the Company (the “Merger Agreement”);

WHEREAS, for the avoidance of doubt, the Board of Directors of the Company has determined that it is in the best interests of the Company and its stockholders to amend the Rights Agreement to exempt the Merger Agreement and the transactions contemplated thereby from the application of the Rights Agreement as provided for herein;

WHEREAS, U.S. Stock Transfer Corporation served as the rights agent under the Rights Agreement until it was succeeded as rights agent by Computershare Trust Company, N.A., which undertook the duties and obligations of rights agent under the terms and conditions of the Rights Agreement; and

WHEREAS, pursuant to its authority under Section 27 of the Rights Agreement, the Board of Directors of the Company has authorized and approved this Amendment as of the date hereof.

NOW, THEREFORE, in consideration of the premises and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the parties hereto do hereby agree as follows:

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[Signature Page Follows]

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IN WITNESS WHEREOF, the parties hereto have caused this Amendment to be duly executed and delivered as of the date first above written.

Exhibit 10.1

AMENDMENT NO. 1 TO

DOCUMENT SCIENCES CORPORATION

1995 STOCK INCENTIVE PLAN

(As Amended & Restated on March 26, 1999)

This Amendment No. 1 to Document Sciences Corporation 1995 Stock Incentive Plan (this “Amendment No. 1”) is made on March 3, 2008, by Document Sciences Corporation, a Delaware corporation (the “Company”), effective as of the date hereof. Capitalized terms not defined herein shall be construed and interpreted in the manner described in the Document Sciences Corporation 1995 Stock Incentive Plan, as amended and restated (the “Plan”).

RECITALS

WHEREAS, the Company has entered into an Agreement and Plan of Merger by and among EMC Corporation, Esteem Merger Corporation and the Company, dated as of December 26, 2007 (the “Merger Agreement”);

WHEREAS, pursuant to Section 2.9 of the Merger Agreement, as of the Effective Time (as such term is defined in the Merger Agreement), all Company stock options shall be fully vested, cancelled and cashed-out, and each holder of such options shall automatically receive, for each option held by such holder that is then-outstanding, a cash payment (less withholdings) equal to the excess (if any) of the Per Share Merger Consideration (as such term is defined in the Merger Agreement) over the per share exercise price applicable to such option;

WHEREAS, pursuant to Section 5.7 of the Merger Agreement, each Company option plan (including the Plan) must be amended prior to the Effective Time to the extent necessary to effectuate the transactions contemplated by Section 2.9 of the Merger Agreement;

WHEREAS, pursuant to Section 9 of the Plan, the Board of Directors of the Company (the “Board”) may amend the Plan at any time, as long as such amendment does not impair the rights of a Plan Participant, and no shareholder approval is needed unless otherwise required by law or any stock exchange or market system listing standard;

WHEREAS, pursuant to its powers in Article 3 of the Plan, the Plan Administrator has determined that the amendments hereunder will not impair the rights of any Plan Participant and that no shareholder approval is required for such amendments; and

WHEREAS, the Board has approved this Amendment No. 1.

AMENDMENT

NOW, THEREFORE, the Plan is hereby amended as follows:

1. A new Section 8.1(g) is hereby added to read as follows:

“(g) EMC Merger Cash-Out. Notwithstanding anything to the contrary herein, but subject to the consummation of the merger contemplated by the Agreement and Plan of Merger by and among EMC Corporation, Esteem Merger Corporation and the Company, dated as of December 26, 2007 (the “Merger Agreement”), as of the Effective Time (as such term is defined in the Merger Agreement), each outstanding Stock Option (whether or not vested) shall be deemed fully vested and shall be cancelled and terminated, and each Optionee shall be entitled to receive in exchange therefor a cash payment (at the time and in the manner specified in the Merger Agreement), equal to the product of (i) the number of shares of Stock for which such Stock Option is exercisable, and (ii) the excess (if any) of the Per Share Merger Consideration (as such term is defined in the Merger Agreement) over the per share Exercise Price of such Stock Option, less applicable tax withholdings.”

2. This Amendment No. 1 shall be deemed a contract made under the laws of the State of Delaware and for all purposes shall be governed by and construed in accordance with the laws such state applicable to contracts made and performed entirely within such state.

3. Except as expressly herein amended, the terms and conditions of the Plan shall remain in full force and effect.

4. The invalidity or unenforceability of any provision of this Amendment No. 1 shall not affect the validity or enforceability of any other provision of this Amendment No. 1 or the Plan, each of which shall remain in full force and effect, and in lieu of such invalid or unenforceable provision there shall be automatically added as part of this Amendment No. 1 a valid and enforceable provision as similar in terms to the invalid or unenforceable provision as possible, provided that this Amendment No. 1, as so amended, (a) reflects the intent of the parties hereto, and (b) does not change the bargained for consideration or benefits to be received by each party hereto.

5. This Amendment No. 1 may be executed in counterparts, each of which shall for all purposes be deemed to be an original, and both such counterparts shall together constitute but one and the same instrument.

[Signature page follows.]

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IN WITNESS WHEREOF, the Company has caused this Amendment No. 1 to be executed by a duly authorized officer as of the day and year first written above.

SIGNATURE PAGE TO

AMENDMENT NO. 1 TO

DOCUMENT SCIENCES CORPORATION 1995 STOCK INCENTIVE PLAN

Exhibit 10.2

AMENDMENT NO. 1 TO

DOCUMENT SCIENCES CORPORATION

AMENDED AND RESTATED 2004 STOCK INCENTIVE PLAN

This Amendment No. 1 to Document Sciences Corporation Amended and Restated 2004 Stock Incentive Plan (this “Amendment No. 1”) is made on March 3, 2008, by Document Sciences Corporation, a Delaware corporation (the “Company”), effective as of the date hereof. Capitalized terms not defined herein shall be construed and interpreted in the manner described in the Document Sciences Corporation Amended and Restated 2004 Stock Incentive Plan (the “Plan”).

RECITALS

WHEREAS, the Company has entered into an Agreement and Plan of Merger by and among EMC Corporation, Esteem Merger Corporation, and the Company, dated as of December 26, 2007 (the “Merger Agreement”);

WHEREAS, pursuant to Section 2.9 of the Merger Agreement, as of the Effective Time (as such term is defined in the Merger Agreement), all Company stock options shall be fully vested, cancelled and cashed-out, and each holder of such options shall automatically receive, for each option held by such holder that is then-outstanding, a cash payment (less withholdings) equal to the excess (if any) of the Per Share Merger Consideration (as such term is defined in the Merger Agreement) over the per share option exercise price applicable to such option;

WHEREAS, pursuant to Section 5.7 of the Merger Agreement, each Company option plan (including the Plan) must be amended prior to the Effective Time to the extent necessary to effectuate the transactions contemplated by Section 2.9 of the Merger Agreement;

WHEREAS, pursuant to Section 11 of the Plan, the Board of Directors of the Company (the “Board”) may amend the Plan at any time, as long as such amendment does not impair the rights of a Plan Participant, and no shareholder approval is needed unless otherwise required by law or any stock exchange or market system listing standard;

WHEREAS, pursuant to its powers in Article 3 of the Plan, the Plan Administrator has determined that the amendments hereunder will not impair the rights of any Plan Participant and that no shareholder approval is required for such amendments; and

WHEREAS, the Board has approved this Amendment No. 1.

AMENDMENT

NOW, THEREFORE, the Plan is hereby amended as follows:

1. A new Section 10.1(g) is hereby added to read as follows:

“(g) EMC Merger Cash-Out. Notwithstanding anything to the contrary herein, but subject to the consummation of the merger contemplated by the Agreement and Plan of Merger by and among EMC Corporation, Esteem Merger Corporation, and the Company, dated as of December 26, 2007 (the “Merger Agreement”), as of the Effective Time (as such term is defined in the Merger Agreement), each outstanding Stock Option (whether or not vested) shall be deemed fully vested and shall be cancelled and terminated, and each Holder shall be entitled to receive in exchange therefor a cash payment (at the time and in the manner specified in the Merger Agreement), equal to the product of (i) the number of shares of Stock for which such Stock Option is exercisable, and (ii) the excess (if any) of the Per Share Merger Consideration (as such term is defined in the Merger Agreement) over the per share Exercise Price of such Stock Option, less applicable tax withholdings.”

2. This Amendment No. 1 shall be deemed a contract made under the laws of the State of Delaware and for all purposes shall be governed by and construed in accordance with the laws such state applicable to contracts made and performed entirely within such state.

3. Except as expressly herein amended, the terms and conditions of the Plan shall remain in full force and effect.

4. The invalidity or unenforceability of any provision of this Amendment No. 1 shall not affect the validity or enforceability of any other provision of this Amendment No. 1 or the Plan, each of which shall remain in full force and effect, and in lieu of such invalid or unenforceable provision there shall be automatically added as part of this Amendment No. 1 a valid and enforceable provision as similar in terms to the invalid or unenforceable provision as possible, provided that this Amendment No. 1, as so amended, (a) reflects the intent of the parties hereto, and (b) does not change the bargained for consideration or benefits to be received by each party hereto.

5. This Amendment No. 1 may be executed in counterparts, each of which shall for all purposes be deemed to be an original, and both such counterparts shall together constitute but one and the same instrument.

[Signature page follows.]

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IN WITNESS WHEREOF, the Company has caused this Amendment No. 1 to be executed by a duly authorized officer as of the day and year first written above.

SIGNATURE PAGE TO

AMENDMENT NO. 1 TO

DOCUMENT SCIENCES CORPORATION AMENDED AND RESTATED 2004 STOCK INCENTIVE PLAN

Exhibit 10.3

AMENDMENT NO. 1 TO

STOCK OPTION AND RESTRICTED STOCK PLAN AND AGREEMENT

WITH EDWARD CALNAN

This Amendment No. 1 (this “Amendment No. 1”) to that certain Stock Option and Restricted Stock Plan and Agreement with Edward Calnan, dated as of September 16, 2006 (the “Agreement”), by and between Edward Calnan (“Grantee”) and Document Sciences Corporation, a Delaware corporation (the “Company”), is made on March 3, 2008, by and between Grantee and the Company, effective as of the date hereof. Capitalized terms not defined herein shall be construed and interpreted in the manner described in the Agreement.

RECITALS

WHEREAS, the Company has entered into an Agreement and Plan of Merger by and among EMC Corporation, Esteem Merger Corporation and the Company, dated as of December 26, 2007 (the “Merger Agreement”);

WHEREAS, pursuant to Section 2.9 of the Merger Agreement, as of the Effective Time (as such term is defined in the Merger Agreement), all Company stock options shall be fully vested, cancelled and cashed-out, and each holder of such options shall automatically receive, for each option held by such holder that is then-outstanding, a cash payment (less withholdings) equal to the excess (if any) of the Per Share Merger Consideration (as such term is defined in the Merger Agreement) over the per share option exercise price applicable to such option;

WHEREAS, pursuant to Section 5.7 of the Merger Agreement, each Company option plan (including the Agreement) must be amended prior to the Effective Time to the extent necessary to effectuate the transactions contemplated by Section 2.9 of the Merger Agreement;

WHEREAS, Grantee and the Company desire to amend the Agreement in accordance with the Company’s obligations of Section 2.9 of the Merger Agreement; and

WHEREAS, the Board of Directors of the Company has approved this Amendment No. 1.

AMENDMENT

NOW, THEREFORE, the Plan is hereby amended as follows:

1. A new Section 12(a)(7) is hereby added to read as follows:

“(7) EMC Merger Cash-Out. Notwithstanding anything to the contrary herein, including anything contained in Sections 12(a)(1) through 12(a)(6), but subject to the consummation of the merger contemplated by the Agreement and Plan of Merger by and among EMC Corporation, Esteem Merger Corporation, and the Company, dated as of December 26, 2007 (the “Merger Agreement”), as

of the Effective Time (as such term is defined in the Merger Agreement), each outstanding Option (whether or not vested) shall be deemed fully vested and shall be cancelled and terminated, and Grantee shall be entitled to receive in exchange therefor a cash payment (at the time and in the manner specified in the Merger Agreement), equal to the product of (i) the number of shares of Common Stock for which such Option is exercisable, and (ii) the excess (if any) of the Per Share Merger Consideration (as such term is defined in the Merger Agreement) over the per share Exercise Price of such Option, less applicable tax withholdings.”

2. This Amendment No. 1 shall be deemed a contract made under the laws of the State of Delaware and for all purposes shall be governed by and construed in accordance with the laws such state applicable to contracts made and performed entirely within such state.

3. Except as expressly herein amended, the terms and conditions of the Agreement shall remain in full force and effect.

4. The invalidity or unenforceability of any provision of this Amendment No. 1 shall not affect the validity or enforceability of any other provision of this Amendment No. 1 or the Agreement, each of which shall remain in full force and effect, and in lieu of such invalid or unenforceable provision there shall be automatically added as part of this Amendment No. 1 a valid and enforceable provision as similar in terms to the invalid or unenforceable provision as possible, provided that this Amendment No. 1, as so amended, (a) reflects the intent of the parties hereto, and (b) does not change the bargained for consideration or benefits to be received by each party hereto.

5. This Amendment No. 1 may be executed in counterparts, each of which shall for all purposes be deemed to be an original, and both such counterparts shall together constitute but one and the same instrument.

[Signature page follows.]

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IN WITNESS WHEREOF, the Company has caused this Amendment No. 1 to be executed by a duly authorized officer as of the day and year first written above.

SIGNATURE PAGE TO

AMENDMENT NO. 1 TO

STOCK OPTION AND RESTRICTED STOCK PLAN AND AGREEMENT

WITH EDWARD CALNAN