Item 13. (b)
CERTIFICATION
UNDER SECTION 906 OF SARBANES-OXLEY ACT OF 2002
Name of Issuer: T. Rowe Price GNMA Fund
In connection with the Report on Form N-CSR for the above named Issuer, the undersigned hereby certifies, to the best of his knowledge, that:
| 1. | The Report fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934; |
| 2. | The
information contained in the Report fairly presents, in all material respects, the financial
condition and results of operations of the Issuer. |
| Date: January 18, 2022 | /s/ David Oestreicher |
| David Oestreicher | |
| Principal Executive Officer |
| Date: January 18, 2022 | /s/ Alan S. Dupski |
| Alan S. Dupski | |
| Principal Financial Officer |