UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F COVER PAGE
OMB APPROVAL
OMB Number:3235-0006
Expires:July 31, 2015
Estimated average burden
hours per response:23.8
Report for the Calendar Year or Quarter Ended:
12-31-2021
Check here if Amendment: ☐ Amendment Number:
This Amendment (Check only one.):☐ is a restatement.
☐ adds new holdings entries.

Institutional Investment Manager Filing this Report:

Name:
FRAZIER MANAGEMENT LLC
Address:
601 UNION ST
SUITE 2110
SEATTLE, WA 98101
Form 13F File Number:
028-17176

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.


Person Signing this Report on Behalf of Reporting Manager:
Name:
STEVE R. BAILEY
Title:
CHIEF FINANCIAL OFFICER AND CHIEF COMPLIANCE OFFICER
Phone:
206.621.7200


Signature, Place, and Date of Signing:

STEVE R. BAILEY, CHIEF FINANCIAL OFFICER AND CHIEF COMPLIANCE OFFICER
                         [Signature]
SEATTLE, WASHINGTON
                 [City, State]
02-08-2022
                           [Date]
                          

Report Type (Check only one.):

☒ 13F HOLDINGS REPORT. (Check here if all holdings of this reporting manager are reported in this report.) 

☐ 13F NOTICE. (Check here if no holdings reported are in this report, and all holdings are reported by other reporting manager(s).) 

☐ 13F COMBINATION REPORT. (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)


Form 13F Summary Page

Report Summary:

Number of Other Included Managers:
0
Form 13F Information table Entry Total:
43
Form 13F Information table Value Total:
1298925
          (thousands)

List of Other Included Managers:

Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report.
[If there are no entries in this list, state "NONE" and omit the column headings and list entries.]

  
NONE


UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number:3235-0006
Expires:July 31, 2015
Estimated average burden
hours per response:23.8
COLUMN 1COLUMN 2COLUMN 3COLUMN 4COLUMN 5COLUMN 6COLUMN 7COLUMN 8
VALUESHRS ORSH/PUT/INVESTMENTOTHERVOTING AUTHORITY
NAME OF ISSUERTITLE OF CLASSCUSIP(x$1000)PRN AMTPRNCALLDISCRETIONMANAGERSOLESHAREDNONE
ACLARIS THERAPEUTICS INCCOM00461U1055,937408,329SHSOLE408,329 0 0
ALLENA PHARMACEUTICALSCOM0181191079781,651,357SHSOLE1,651,357 0 0
ALPINE IMMUNE SCIENCES INCCOM02083G10024,7211,784,913SHSOLE1,784,913 0 0
ANAPTYSBIO INCCOM03272410631,265899,700SHSOLE899,700 0 0
APTINYX INCCOM03836N1035,0281,883,244SHSOLE1,883,244 0 0
ARCUTIS BIOTHERAPEUTICS INCCOM03969K108174,9268,434,232SHSOLE8,434,232 0 0
ARVINAS INCCOM04335A10513,451163,763SHSOLE163,763 0 0
AUTOLUS THERAPEUTICS PLCSPON ADS05280R10019,4463,746,857SHSOLE3,746,857 0 0
AVADEL PHARMACEUTICALS PLCSPONSORED ADR05337M1047,691951,814SHSOLE951,814 0 0
BICYCLE THERAPEUTICS PLCSPONSORED ADS08878610833,797555,240SHSOLE555,240 0 0
CHINOOK THERAPEUTICS INCCOM16961L10638,6862,371,918SHSOLE2,371,918 0 0
COGENT BIOSCIENCES INCCOM19240Q20115,2291,774,891SHSOLE1,774,891 0 0
CRINETICS PHARMACEUTICALS INCOM22663K10739,3281,384,293SHSOLE1,384,293 0 0
EPIZYME INCCOM29428V1041,848739,369SHSOLE739,369 0 0
ESSA PHARMA INCCOM NEW29668H7087,717543,470SHSOLE543,470 0 0
FRAZIER LIFESCIENCES ACQU COUNIT 12/09/2025G3710A12114,8901,501,000SHSOLE1,501,000 0 0
GRACELL BIOTECHNOLOGIES INCSPONSORED ADS38406L1039,9961,654,938SHSOLE1,654,938 0 0
GRITSTONE BIO INCCOM39868T10560,0214,667,242SHSOLE4,667,242 0 0
IMAGO BIOSCIENCES INCCOM45250K10770,4492,971,274SHSOLE2,971,274 0 0
IMMUNOVANT INCCOM45258J1024,991585,759SHSOLE585,759 0 0
IOVANCE BIOTHERAPEUTICS INCCOM46226010033,3621,747,622SHSOLE1,747,622 0 0
IVERIC BIO INCCOM46583P10230,7381,838,402SHSOLE1,838,402 0 0
KALVISTA PHARMACEUTICALS INCCOM48349710317,2661,305,087SHSOLE1,305,087 0 0
KRYSTAL BIOTECH INCCOM50114710253,949771,250SHSOLE771,250 0 0
MERUS N VCOMN5749R10017,782559,179SHSOLE559,179 0 0
MIRUM PHARMACEUTICALS INCCOM60474910156,8923,566,912SHSOLE3,566,912 0 0
MOLECULAR TEMPLATES INCCOM6085501095,3861,374,047SHSOLE1,374,047 0 0
NABRIVA THERAPEUTICS PLCSHSG63637113255425,650SHSOLE425,650 0 0
PARDES BIOSCIENCES INCCOM69945Q10540,2292,457,507SHSOLE2,457,507 0 0
PASSAGE BIO INCCOM70271210031,8095,009,219SHSOLE5,009,219 0 0
PHATHOM PHARMACEUTICALS INCCOM71722W107114,6255,827,415SHSOLE5,827,415 0 0
REGENXBIO INCCOM75901B1077,711235,809SHSOLE235,809 0 0
REPLIMUNE GROUP INCCOM76029N10617,638650,862SHSOLE650,862 0 0
SCHOLAR ROCK HLDG CORPCOM80706P1033,875156,000SHSOLE156,000 0 0
SIERRA ONCOLOGY INCCOM NEW82640U40427,4981,264,861SHSOLE1,264,861 0 0
SILENCE THERAPEUTICS PLCADS82686Q10121,171886,173SHSOLE886,173 0 0
SUTRO BIOPHARMA INCCOM86936710226,4341,776,479SHSOLE1,776,479 0 0
SYNDAX PHARMACEUTICALS INCCOM87164F10560,6802,772,062SHSOLE2,772,062 0 0
TARSUS PHARMACEUTICALS INCCOM87650L10331,8861,417,157SHSOLE1,417,157 0 0
TRICIDA INCCOM89610F10117,0541,783,893SHSOLE1,783,893 0 0
TYRA BIOSCIENCES INCCOM90240B10617,5881,250,000SHSOLE1,250,000 0 0
VAXCYTE INCCOM92243G10854,9442,309,554SHSOLE2,309,554 0 0
VIRIDIAN THERAPEUTICS INCCOM92790C10429,7581,505,200SHSOLE1,505,200 0 0