Radius Health, Inc. Form 10-Q Quarterly Report Filed 2022-08-09

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UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 10-Q

☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the quarterly period ended June 30, 2022

☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the transition period from to .

Commission File Number 001-35726

Radius Health, Inc.

(Exact name of registrant as specified in its charter)


Delaware						80-0145732
(State or other jurisdiction of						(I.R.S. Employer
incorporation or organization)						Identification No.)

22 Boston Wharf Road, 7th Floor

Boston, Massachusetts 02210

(Address of Principal Executive Offices and Zip Code)

(617) 551-4000

(Registrant’s telephone number, including area code)

Securities registered pursuant to Section 12(b) of the Act:


Title of each class	Trading Symbol(s)	Name of each exchange on which registered
Common Stock, $0.0001 par value per share	RDUS	The Nasdaq Global Market

Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days. Yes ☒ No ☐

Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S-T during the preceding 12 months (or for such shorter period that the registrant was required to submit such files). Yes ☒ No ☐

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging growth company” in Rule 12b-2 of the Exchange Act.

Large accelerated filer

☒

Accelerated filer

☐

Non-accelerated filer

☐

Smaller reporting company

☐

Emerging growth company

☐

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If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act). Yes ☐ No ☒

Number of shares of the registrant’s Common Stock, $0.0001 par value per share, outstanding as of August 4, 2022 : 47,620,498 shares

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RADIUS HEALTH, INC.

FORM 10-Q

FOR THE QUARTER ENDED JUNE 30, 2022

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PART I FINANCIAL INFORMATION

Item 1.	Condensed Consolidated Financial Statements (Unaudited)	4
	Condensed Consolidated Balance Sheets as of J u ne 30 , 2022 and December 31, 2021	4
	Condensed Consolidated Statements of Operations and Comprehensive Loss for the three and six months ended June 30 , 2022 and 2021	5
	Condensed Consolidated Statements of Stockholders’ Deficit for the three and six months ended June 30 , 2022 and 2021	6
	Condensed Consolidated Statements of Cash Flows for the six months ended June 30 , 2022 and 2021	8
	Notes to Condensed Consolidated Financial Statements	9
Item 2.	Management’s Discussion and Analysis of Financial Condition and Results of Operations	21
Item 3.	Quantitative and Qualitative Disclosures About Market Risk	31
Item 4.	Controls and Procedures	32

PART II OTHER INFORMATION		33

Item 1.	Legal Proceedings	33
Item 1A.	Risk Factors	33
Item 2.	Unregistered Sales of Equity Securities and Use of Proceeds	36
Item 3.	Defaults Upon Senior Securities	36
Item 4.	Mine Safety Disclosures	36
Item 5.	Other Information	36
Item 6.	Exhibits	36

SIGNATURES		37

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PART I— FINANCIAL INFORMATION

Item 1. Condensed Consolidated Financial Statements

Radius Health, Inc.

Condensed Consolidated Balance Sheets

(Unaudited, in thousands, except share amounts)


	June 30, 2022		December 31, 2021
	(unaudited)
ASSETS
Current assets:
Cash and cash equivalents	$	72,491	$	111,533
Restricted cash	567		567

Accounts receivable, net	26,260		23,355
Inventory	12,491		11,373
Prepaid expenses	16,674		10,050
License receivables	5,750		—
Other current assets	12,178		16,201
Total current assets	146,411		173,079

Property and equipment, net	912		647
Intangible assets	4,587		4,986
Right of use assets - operating leases	829		835
Other assets	1,701		1,995
Total assets	$	154,440	$	181,542

LIABILITIES AND STOCKHOLDERS’ DEFICIT
Current liabilities:
Accounts payable	$	14,485	$	17,625
Accrued expenses and other current liabilities	72,956		76,549

Operating lease liability, current	418		613
Total current liabilities	87,859		94,787
Convertible notes payable	190,892		190,479
Term loan	148,681		148,265
Operating lease liability, long term	411		315
Total liabilities	427,843		433,846

Stockholders’ deficit:
Common stock, 0.0001 par value; 200,000,000 shares authorized, 47,607,604 shares and 47,359,573 shares issued and outstanding at June 30, 2022 and December 31, 2021, respectively	5		5
Additional paid-in-capital	1,125,532		1,115,672
Accumulated other comprehensive income	50		—
Accumulated deficit	(1,398,990)		(1,367,981)
Total stockholders’ deficit	(273,403)		(252,304)
Total liabilities and stockholders’ deficit	$	154,440	$	181,542

See accompanying notes to unaudited condensed consolidated financial statements.

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Radius Health, Inc.

Condensed Consolidated Statements of Operations and Comprehensive Loss

(Unaudited, in thousands, except share and per share amounts)


	Three Months Ended June 30,				Six Months Ended June 30,
	2022		2021		2022		2021
REVENUES:
Product revenue, net	$	52,535	$	51,797	$	95,493	$	97,057
License revenue	5,750		—		5,950		11,000
Total revenue	58,285		51,797		101,443		108,057
OPERATING EXPENSES:
Cost of sales - product	5,377		4,394		9,437		8,319
Cost of sales - intangible amortization	199		200		399		399
Research and development, net of amounts reimbursable (a)	26,312		26,950		49,009		58,391
Selling, general and administrative	34,248		32,143		64,296		66,240

Loss from operations	(7,851)		(11,890)		(21,698)		(25,292)
OTHER INCOME (EXPENSE):
Other (expense) income	(109)		(79)		269		(80)
Interest expense	(4,861)		(4,847)		(9,683)		(9,211)
Interest income	88		6		102		64
Gain on extinguishment of debt	—		—		—		1,960
NET LOSS	$	(12,733)	$	(16,810)	$	(31,010)	$	(32,559)
OTHER COMPREHENSIVE LOSS:
Foreign currency	44		—		50		—
Unrealized loss from available-for-sale debt securities	—		—		—		(21)
COMPREHENSIVE LOSS	$	(12,689)	$	(16,810)	$	(30,960)	$	(32,580)
LOSS ATTRIBUTABLE TO COMMON STOCKHOLDERS - BASIC AND DILUTED (Note 7)	$	(12,733)	$	(16,810)	$	(31,010)	$	(32,559)
LOSS PER SHARE:
Basic and diluted	$	(0.27)	$	(0.35)	$	(0.65)	$	(0.69)

WEIGHTED AVERAGE SHARES:
Basic and diluted	47,588,158		47,391,530		47,515,394		47,114,947

(a) Amounts reimbursable for the three and six months ended June 30, 2022 were $9.6 million and $18.7 million, respectively, and $18.5 million and $32.8 million, respectively, for the three and six months ended June 30, 2021.

See accompanying notes to unaudited condensed consolidated financial statements.

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Radius Health, Inc.

Condensed Consolidated Statements of Stockholders’ Deficit

(Unaudited, in thousands, except share amounts)


	Stockholders’ Deficit
	Common Stock					Additional Paid-In Capital			Accumulated Other Comprehensive Income (Loss)			Accumulated Deficit		Total Stockholders’ Deficit
	Shares		Amount			Amount			Amount			Amount		Amount
Balance at December 31, 2021	47,359,573		$	5		$	1,115,672		$	—		$	(1,367,981)	$	(252,304)
Net loss	—		—			—			—			(18,276)		(18,276)


Foreign currency translation adjustment	—		—			—			6			—		6
Vesting of restricted shares	139,056		—			—			—			—		—


Share-based compensation expense related to share-based awards for employee stock purchase plan	—		—			113			—			—		113
Issuance of common stock upon purchase by employee stock purchase plan	66,135		—			482			—			—		482

Share-based compensation expense	—		—			4,032			—			—		4,032


Balance at March 31, 2022	47,564,764	0	$	5	0	$	1,120,299	0	$	6	0	$	(1,386,257)	$	(265,947)
Net Loss	—		—			—			—			(12,733)		(12,733)
Foreign currency translation adjustment	—		—			—			44			—		44
Vesting of restricted shares	40,901		—			—			—			—		—
Share-based compensation expense related to share-based awards for employee stock purchase plan	—		—			125			—			—		125
Issuance of common stock upon purchase by employee stock purchase plan	1,939		—			—			—			—		—
Share-based compensation expense	—		—			5,108			—			—		5,108
Balance at June 30, 2022	47,607,604		$	5		$	1,125,532		$	50		$	(1,398,990)	$	(273,403)

See accompanying notes to unaudited condensed consolidated financial statements.

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Radius Health, Inc.

Condensed Consolidated Statements of Stockholders’ Deficit

(Unaudited, in thousands, except share amounts)


	Stockholders’ Deficit
	Common Stock				Additional Paid-In Capital		Accumulated Other Comprehensive Income (Loss)		Accumulated Deficit		Total Stockholders’ Deficit
	Shares		Amount		Amount		Amount		Amount		Amount
Balance at December 31, 2020	46,779,479		$	5	$	1,222,137	$	21	$	(1,345,822)	$	(123,659)
Net loss	—		—		—		—		(15,749)		(15,749)
Adjustment due to adoption of ASU 2020-06	—		—		(134,450)		—		48,017		(86,433)
Unrealized gain from available-for-sale securities	—		—		—		(21)		—		(21)
Vesting of restricted shares	202,018		—		—		—		—		—
Exercise of options	193,300		—		3,764		—		—		3,764


Issuance of common stock upon purchase by employee stock purchase plan	66,301		—		678		—		—		678
Share-based compensation expense	—		—		5,410		—		—		5,410


Balance at March 31, 2021	47,241,098		$	5	$	1,097,539	$	—	$	(1,313,554)	$	(216,010)

Net loss	—		—		—		—		(16,810)		(16,810)

Vesting of restricted shares	11,621		—		—		—		—		—
Exercise of options	2,375		—		40		—		—		40



Share-based compensation expense			—		5,703		—		—		5,703
Balance at June 30, 2021	$	47,255,094	$	5	$	1,103,282	$	—	$	(1,330,364)	$	(227,077)

See accompanying notes to unaudited condensed consolidated financial statements.

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Radius Health, Inc.

Condensed Consolidated Statements of Cash Flows

(Unaudited, in thousands)


	Six Months Ended June 30,
	2022		2021
CASH FLOWS USED IN OPERATING ACTIVITIES:
Net loss	$	(31,010)	$	(32,559)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	777		494
Amortization of premium/discount on marketable securities, net	—		19
Amortization of debt discount and debt issuance costs	829		771


Share-based compensation	9,378		11,113

Gain on extinguishment of debt	—		(1,960)
Gain on the lease termination	—		(901)
Changes in operating assets and liabilities:
Inventory	(1,118)		(2,136)
Accounts receivable, net	(2,905)		(3,328)
Prepaid expenses	(6,624)		1,877
License receivables	(5,750)		—
Other current assets	4,023		(15,959)
Operating lease right of use assets	302		667
Other long-term assets	—		(967)
Accounts payable	(3,090)		4,637
Deferred revenue	—		(1,000)
Accrued expenses and other current liabilities	(3,592)		6,327
Lease liability, operating leases	(395)		(1,199)

Net cash used in operating activities	(39,175)		(34,104)
CASH FLOWS PROVIDED BY INVESTING ACTIVITIES:
Purchases of property and equipment	(349)		—


Sales and maturities of marketable securities	—		23,240
Net cash (used in) provided by investing activities	(349)		23,240
CASH FLOWS PROVIDED BY FINANCING ACTIVITIES:
Proceeds from exercise of stock options	—		3,804
Proceeds from issuance of term loan, net of issuance costs	—		122,687


Repurchase of convertible notes	—		(108,568)
Proceeds from issuance of shares under employee stock purchase plan	482		678
Net cash provided by financing activities	482		18,601
NET (DECREASE) INCREASE IN CASH, CASH EQUIVALENTS, AND RESTRICTED CASH	(39,042)		7,737
CASH, CASH EQUIVALENTS, AND RESTRICTED CASH AT BEGINNING OF PERIOD	112,100		92,003
CASH, CASH EQUIVALENTS, AND RESTRICTED CASH AT END OF PERIOD	$	73,058	$	99,740
SUPPLEMENTAL DISCLOSURES:
Cash paid for interest	$	8,704	$	7,622

Cash paid for amounts included in the measurement of operating lease liabilities	$	412	$	1,340
Right of use assets obtained in exchange for operating lease liability	$	488	$	332

See accompanying notes to unaudited condensed consolidated financial statements.

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Radius Health, Inc.

Notes to Condensed Consolidated Financial Statements

(Unaudited)

1. Organization

Radius Health, Inc. (“Radius,” the “Company,” “us,” “our” or “we”) is a global biopharmaceutical company focused on addressing unmet medical needs in the areas of bone health, neuroscience, and oncology. In April 2017, the Company’s first commercial product, TYMLOS (abaloparatide) injection, was approved by the U.S. Food and Drug Administration (“FDA”) for the treatment of postmenopausal women with osteoporosis at high risk for fracture defined as history of osteoporotic fracture, multiple risk factors for fracture, or patients who have failed or are intolerant to other available osteoporosis therapy. We are also developing certain assets we acquired related to formulations of cannabidiol related to the oral administration of a solution of CBD for therapeutic use in humans or animals (“RAD011”), for which the Company intends to seek FDA approval for a Phase 2/3 trial for treatment of hyperphagia behavior and weight loss in patients with Prader Willi syndrome (“PWS”). In June 2022, with support from the Company, our licensee, Berlin-Chemie AG, a company of the Menarini Group (“Berlin-Chemie”), submitted a New Drug Application (“NDA”) to the FDA for elacestrant in patients with ER+/HER2- advanced or metastatic breast cancer. The NDA submission was based on positive top-line results from the EMERALD Phase 3 study of our investigational product candidate elacestrant that was previously announced in October 2021. Berlin-Chemie holds an exclusive, worldwide license to develop and commercialize products containing elacestrant.

The Company is subject to risks common to companies in its industry including, but not limited to, the dependence on revenues from a single commercialized product, competition, uncertainty about clinical trial outcomes and regulatory approvals, uncertainties relating to pharmaceutical pricing reimbursement, uncertain protection of proprietary technology and potential product liability. As of June 30, 2022, the Company had an accumulated deficit of $1,399.0 million, and total cash and cash equivalents of $72.5 million.

Based upon its cash and cash equivalents balance and the $25.0 million secured revolving credit facility available to the Company under its Revolving Credit Agreement with MidCap Funding IV Trust as discussed in Note 6, “Term Loan and Credit Facilities” as of June 30, 2022, the Company believes that, prior to the consideration of revenue from the potential future sales of any of its investigational products that may receive regulatory approval or proceeds from partnering and/or collaboration activities, it has sufficient capital to fund its commercial operations, development plans, and other operational activities for at least one year from the date of this filing. The Company expects to finance its ongoing and future operations with its product revenue, existing cash and cash equivalents, or through strategic financing opportunities that could include, but are not limited to collaboration agreements or the incurrence of debt. However, there is no guarantee that any strategic or financing opportunities will be executed or executed on favorable terms, and some could be dilutive to existing stockholders.

Pending Transaction

On June 23, 2022, the Company entered into an Agreement and Plan of Merger (the “Merger Agreement”) with Ginger Acquisition, Inc., (“Parent”), a subsidiary jointly owned by affiliates of Gurnet Point Capital, LLC and Patient Square Capital, LP, and Ginger Merger Sub, Inc., a wholly owned subsidiary of Parent (“Purchaser”). Pursuant to the Merger Agreement, and upon the terms and subject to the conditions thereof, Purchaser has commenced a tender offer (the “Offer”) to purchase each issued and outstanding share (the “Shares”) of common stock of the Company (the “Common Stock”) in exchange for an amount in cash equal to $10.00 and one contractual contingent value right (a “CVR”) that will represent the right to receive a contingent payment of $1.00 in cash, without interest but subject to applicable withholding upon the achievement of the sum of (A) cumulative net sales of TYMLOS in the United States and (B) either (i) royalty payments based on sales of TYMLOS in Japan or (ii) if and at such time that no such royalty payments are owed, supply payments based on the supply of TYMLOS for sale in Japan that together exceed $300 million during any consecutive 12-month period beginning on the date of the CVR Agreement (defined below) and ending on or prior to December 31, 2025, pursuant to a Contingent Value Rights Agreement (the “CVR Agreement”) to be entered into between Parent and a rights agent. The Offer is currently scheduled to expire at one minute after 11:59 p.m. Eastern Time on August 10, 2022, the twentieth business day following the commencement of the Offer, but may be extended in accordance with the terms of the Merger Agreement. Subject to the terms and conditions of the Merger Agreement, if certain conditions are satisfied and the Offer closes, Parent, no later than the second day following the satisfaction of such conditions, would acquire any remaining shares by virtue of a merger of Purchaser with and into the Company (the “Merger”), with the Company being the surviving corporation and a wholly-owned subsidiary of Parent. If the Merger is consummated, the Company will cease to be a publicly-traded company. The consummation of the transaction is subject to customary closing conditions, including the Company’s stockholders tendering a minimum number of Shares in the Offer and receipt of regulatory approvals.

2. Basis of Presentation and Significant Accounting Policies

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Basis of Presentation

The accompanying unaudited condensed consolidated financial statements and the related disclosures of the Company have been prepared in accordance with accounting principles generally accepted in the United States (“U.S. GAAP”) for interim financial reporting and as required by Regulation S-X, Rule 10-01. Accordingly, they do not include all the information and footnotes required by U.S. GAAP for complete financial statements. In the opinion of management, all adjustments (including those which are normal and recurring) considered necessary for a fair presentation of the interim financial information have been included.

When preparing financial statements in conformity with U.S. GAAP, the Company must make estimates and assumptions that affect the reported amounts of assets, liabilities, revenue, expenses and related disclosures at the date of the financial statements. Actual results could differ from those estimates. Additionally, operating results for the three and six months ended June 30, 2022 are not necessarily indicative of the results that may be expected for any other interim period or for the fiscal year ending December 31, 2022.

Subsequent events have been evaluated up to the date of issuance of these financial statements. These interim condensed consolidated financial statements should be read in conjunction with the audited consolidated financial statements and notes, which are contained in the Company’s Annual Report on Form 10-K for the year ended December 31, 2021, filed with the Securities and Exchange Commission (“SEC”) on February 24, 2022.

Significant Accounting Policies

The significant accounting policies identified in the Company’s Annual Report on Form 10-K for the year ended December 31, 2021 that require the Company to make estimates and assumptions include: revenue recognition, inventory obsolescence, long-lived assets and intangible assets, accounting for share-based compensation, contingencies, tax valuation reserves, fair value measures, and accrued expenses. There were no changes to significant accounting policies during the six months ended June 30, 2022.

Recent Accounting Standards Not Yet Adopted

There are no applicable material accounting pronouncements recently issued that have not yet been adopted by the Company.

3. Fair Value Measurements

The Company determines the fair value of its financial instruments based upon the fair value hierarchy, which requires an entity to maximize the use of observable inputs and minimize the use of unobservable inputs when measuring fair value. Below are the three levels of inputs that may be used to measure fair value:

•Level 1—Quoted prices in active markets for identical assets or liabilities that the Company has the ability to access at the measurement date.

•Level 2—Observable inputs other than Level 1 prices, such as quoted prices for similar assets or liabilities; quoted prices in markets that are not active; or other inputs that are observable or can be corroborated by observable market data for substantially the full term of the assets or liabilities.

•Level 3—Unobservable inputs that are supported by little or no market activity and that are significant to the fair value of the assets or liabilities.

Transfers into or out of any hierarchy level are recognized at the end of the reporting period in which the transfers occurred. There were no material transfers between any levels during the six months ended June 30, 2022 or 2021.

The following table summarizes the financial instruments measured at fair value on a recurring basis as of June 30, 2022 and December 31, 2021 (in thousands):


	As of June 30, 2022
	Level 1		Level 2		Level 3		Total
Assets
Cash and cash equivalents:
Cash	$	22,156	$	—	$	—	$	22,156
Money market funds (1)	50,335		—		—		50,335
Total	$	72,491	$	—	$	—	$	72,491

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	As of December 31, 2021
	Level 1		Level 2		Level 3		Total
Assets
Cash and cash equivalents:
Cash	$	41,285	$	—	$	—	$	41,285
Money market funds (1)	70,248		—		—		70,248
Total	$	111,533	$	—	$	—	$	111,533

(1) Fair value is based upon quoted market prices.

The Company considers only those investments that are highly liquid, readily convertible to cash, and that mature within three months from the date of purchase to be cash equivalents. From time to time, the Company may have balances in financial institutions in excess of insurance limits. The Company has not experienced any losses related to these balances.

The Company’s Convertible Notes are classified within Level 2 in the fair value hierarchy. The fair values of the Convertible Notes are based on data from readily available pricing sources which utilize market observable inputs and other characteristics for similar types of instruments. The fair value of the Convertible Notes, which differs from their carrying value, is influenced by interest rates, the Company’s stock price and stock price volatility. The estimated fair value of the Convertible Notes as of June 30, 2022 was approximately $189.1 million.

The Company’s Term Loan falls into the Level 2 category within the fair value level hierarchy and the fair value was determined using quoted prices for similar liabilities in active markets, as well as inputs that are observable for the liability (other than quoted prices), such as interest rates that are observable at commonly quoted intervals. The estimated fair value of the Term Facility as of June 30, 2022 was approximately $147.2 million.

As of June 30, 2022, the carrying amounts of the cash and cash equivalents, restricted cash, accounts receivable, prepaid expenses, license receivables, other current assets, accounts payable, accrued expenses, and operating lease liabilities approximated their estimated fair values.

4. Inventory

Inventory consisted of the following as of June 30, 2022 and December 31, 2021 (in thousands):


	June 30, 2022		December 31, 2021
Raw materials	$	7,716	$	7,159
Work in process	1,377		1,335
Finished goods	3,398		2,879
Total inventories	$	12,491	$	11,373

Finished goods manufactured by the Company have a 36-month shelf life from date of manufacture.

5. Convertible Notes Payable

On August 14, 2017, in a registered underwritten public offering, the Company issued $300.0 million aggregate principal amount of 3% Convertible Senior Notes due September 1, 2024 (the “Convertible Notes”). In addition, on September 12, 2017, the Company issued an additional $5.0 million principal amount of Convertible Notes pursuant to the exercise of an over-allotment option granted to the underwriters in the offering. In connection with the issuance of the Convertible Notes, the Company incurred approximately $9.4 million of debt issuance costs, which primarily consisted of underwriting, legal and other professional fees.

The Convertible Notes are senior unsecured obligations of the Company and bear interest at a rate of 3.00% per annum, payable semi-annually in arrears on March 1 and September 1. Upon conversion, the Convertible Notes will be convertible into cash, shares of the Company’s common stock or a combination of cash and shares of the Company’s common stock, at the Company’s election. The Convertible Notes may be redeemed at the Company’s option, in whole or in part, if the conditions described below are satisfied. The redemption of the Convertible Notes may also be subject to certain restrictions in the Credit Agreements. The Convertible Notes will mature on September 1, 2024, unless earlier converted, redeemed or repurchased in accordance with their terms. Subject to satisfaction of certain conditions and during the periods described below, the Convertible Notes may be converted at an initial conversion rate of 20.4891 shares of common stock per $1,000 principal amount of the Convertible Notes (equivalent to an initial conversion price of approximately $48.81 per share of common stock).

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Holders of the Convertible Notes may convert all or any portion of their notes, in multiples of $1,000 principal amount, at their option at any time prior to the close of business on the business day immediately preceding June 1, 2024 only under the following circumstances:

(1)if the last reported sale price of the Company’s common stock for at least 20 trading days (whether consecutive or not) during a period of 30 consecutive trading days ending on the last trading day of the immediately preceding calendar quarter is greater than or equal to 130% of the conversion price on each applicable trading day;

(2)during the five-business day period after any five-consecutive trading day period (the “measurement period”) in which the “trading price” per $1,000 principal amount of the Convertible Notes for each trading day of the measurement period was less than 98% of the product of the last reported sale price of the Company’s common stock and the conversion rate on each such trading day;

(3)if the Company calls the Convertible Notes for redemption, until the close of business on the business day immediately preceding the redemption date; or

(4)upon the occurrence of specified corporate events.

As of June 30, 2022, none of the above circumstances had occurred and, as such, the Convertible Notes were not convertible.

The Company expects that a fundamental change, a make-whole fundamental change and a share exchange event will occur upon the consummation of the Offer and the Merger. Upon a fundamental change, holders of Convertible Notes are permitted to require the Company to repurchase for cash all or any portion of their Convertible Notes at a fundamental change repurchase price equal to 100% of the principal amount of the Convertible Notes to be repurchased, plus accrued and unpaid interest to, but excluding, the fundamental change repurchase date. Upon a make-whole fundamental change, under certain circumstances, the conversion rate for notes converted in connection with such make-whole fundamental change will increase. However, if the price per share of our common stock paid (or deemed paid) in the transaction is less than $36.835 per share, the conversion rate will not be increased. As a result, the Company does not expect the make-whole fundamental change will trigger an adjustment to the conversion rate. On or after the occurrence of a share exchange event, the right to convert the Convertible Notes will be substituted with the right to receive an amount in cash equal to the per share amount of cash received by holders of the Company’s common stock

The Company may redeem for cash all or part of the Convertible Notes if the last reported sale price of the Company’s common stock equals or exceeds 130% of the conversion price then in effect for at least 20 trading days (whether or not consecutive) during any 30-consecutive trading day period ending within five trading days prior to the date on which the Company provides notice of the redemption. The redemption price will be the principal amount of the Convertible Notes to be redeemed, plus accrued and unpaid interest to, but excluding, the redemption date. In addition, calling any Convertible Note for redemption will constitute a make-whole fundamental change with respect to that Convertible Note, in which case the conversion rate applicable to the conversion of that Convertible Note, if it is converted in connection with the redemption, will be increased in certain circumstances.

In March 2021, the Company entered into separate, privately negotiated transactions with certain holders of the Convertible Notes to repurchase $112.2 million face amount of the Convertible Notes for a cash purchase of $108.6 million. As the Company only extinguished a portion of the debt, the difference between the reacquisition price and the net carrying amount of the extinguished portion resulted in a gain on extinguishment of $2.0 million. Third party costs associated with the extinguishment of $0.3 million were included in selling, general and administrative expense for the six months ended June 30, 2021.

The outstanding balances of the Convertible Notes as of June 30, 2022 consisted of the following (in thousands):


	2024 Convertible Notes
Liability
Principal	$	192,753
Less: debt discount and issuance costs	(1,861)
Net carrying amount	$	190,892

The debt issuance costs on the Convertible Notes will be amortized over the remaining period.

The Company determined the expected life of the Convertible Notes was equal to their seven-year term. The effective interest rate on the Convertible Notes is 3.43%.

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As of June 30, 2022, the “if-converted value” did not exceed the remaining principal amount of the Convertible Notes.

The following table sets forth total interest expense recognized related to the Convertible Notes during the three months and six ended June 30, 2022 and 2021 (in thousands):


	Three Months Ended June 30,				Six Months Ended June 30,
	2022		2021		2022		2021
Contractual interest expense	1,446		1,446		2,892		3,602
Amortization of debt discount	195		196		391		489
Amortization of debt issuance costs	11		11		22		26
Total interest expense	$	1,652	$	1,653	$	3,305	$	4,117

Future minimum payments on the Company’s Convertible Notes as of June 30, 2022 are as follows (in thousands):


Years ended December 31,	Future Minimum Payments

2022 (excluding the 6 months ended June 30, 2022)	2,891
2023	5,783
2024	198,535
Total minimum payments	$	207,209
Less: interest	(14,456)
Less: unamortized discount	(1,861)

Convertible notes payable	$	190,892

6. Term Loan and Credit Facilities

On March 3, 2021, the Company and two of its wholly-owned subsidiaries, Radius Pharmaceuticals, Inc. and Radius Health Ventures, Inc. (collectively with the Company, the “Borrowers”), entered into an (i) Amended and Restated Credit and Security Agreement (Term Loan) (the “Term Credit Agreement”), with MidCap Funding IV Trust, in its capacity as administrative agent, and the financial institutions or other entities from time to time parties thereto as lenders (the “Term Lenders”) and (ii) Amended and Restated Credit and Security Agreement (Revolving Loan) (the “Revolving Credit Agreement,” together with the Term Credit Agreement, the “Credit Agreements”), with MidCap Funding IV Trust, in its capacity as administrative agent, and the financial institutions or other entities from time to time parties thereto as lenders.

The Term Credit Agreement provides for a secured term loan facility (the “Term Facility”) in an aggregate principal amount of $150.0 million (the “Initial Term Loan”), an increase of $125.0 million from the arrangement entered into in January 2020.

The Revolving Credit Agreement provides for a secured revolving credit facility (the “Revolving Facility”, together with the Term Facility, the “Facilities”) under which the Borrowers may borrow up to $25.0 million, the availability of which is determined based on a borrowing base as follows: (i) up to 85% of the net collectable value of the Borrowers’ domestic accounts receivable due from eligible direct and third-party payors, plus (ii) up to 40% of the Borrowers’ domestic eligible inventory, minus certain reserves; provided that the availability from eligible inventory may not exceed 20% of the borrowing base at any time. As of June 30, 2022 and up to the date of issuance of these condensed consolidated financial statements, the Company was eligible to borrow $25.0 million of the Revolving Facility.

The Facilities have a maturity date of June 1, 2024. The obligations under the Credit Agreements are guaranteed by the Borrowers and are guaranteed by certain future subsidiaries of the Borrowers, subject to certain exceptions. The obligations under the Facilities are secured by substantially all of the assets of the Borrowers, and are secured by substantially all assets of the future subsidiaries of the Borrowers that become borrowers or guarantors under the Facilities, subject to certain exceptions.

Borrowings under the Term Facility bear interest through maturity at a variable rate based upon the LIBOR rate plus 5.75%, subject to a LIBOR floor of 2.00%. Borrowings under the Revolving Facility bear interest through maturity at a variable rate based upon the LIBOR rate plus 3.50%, subject to a LIBOR floor of 2.00%. The Borrowers are required to pay a monthly commitment fee on the unused commitments under the Revolving Facility of 0.50% per annum.

The Company’s obligations under the Credit Agreement are secured by substantially all of the assets of the Borrowers and their wholly-owned subsidiaries. The security interest granted over these assets could limit the Company’s ability to obtain additional debt financing. In addition, the Credit Agreements contain affirmative and negative covenants customarily applicable to senior secured credit facilities, including covenants that, among other things, will limit or restrict the Company’s ability,

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subject to negotiated exceptions, to incur additional indebtedness and additional liens on its assets, engage in mergers or acquisitions or dispose of assets, pay dividends or make other distributions, voluntarily prepay other indebtedness, enter into transactions with affiliated persons, make investments, and change the nature of its businesses. In addition, the Company is required to maintain an amount of unrestricted cash of at least $50.0 million and to achieve net revenue for each preceding twelve-month period of at least certain specified amounts. Failure to comply with the covenants in the Credit Agreements, including the minimum cash and minimum net revenue covenants, could result in the acceleration of its obligations under the Credit Agreements. The Company expects the Credit Agreements to be repaid in full and terminated in connection with the consummation of the Offer and the Merger.

On March 11, 2021, the Company received proceeds of $122.6 million under the Term Loan, net of fees and expenses of $2.4 million. With the issuance of a new term loan, the Company performed an assessment comparing the discounted cash flows of the original debt and the new debt as of the modification date, and concluded that the change is considered a modification. As of the modification date, the Company established a new effective interest rate based on the carrying value of the debt and the revised cash flows. Fees paid to the lender of $2.4 million were capitalized as debt discount and will be amortized to interest expense using the effective interest method over the term of the loan. Third party costs associated with the modification of $2.8 million were included in selling, general and administrative expense for the six months ended June 30, 2021. The outstanding balance of the Term Loan as of June 30, 2022 consisted of the following (in thousands):


	Term loan

Principal	$	150,000
Less: debt issuance costs	(1,319)
Net carrying amount	$	148,681

The following table sets forth total interest expense recognized related to the Term Facility during the three and six months ended June 30, 2022 and 2021 (in thousands):


	Three Months Ended June 30,				Six Months Ended June 30,
	2022		2021		2022		2021
Contractual interest expense	$	2,968	$	2,939	$	5,929	$	3,976
Amortization of debt discount	208		208		416		256
Total interest expense	$	3,176	$	3,147	$	6,345	$	4,232

Future minimum payments on the Term Facility as of June 30, 2022 are as follows (in thousands):


Years ended December 31,	Future Minimum Payments

2022 (excluding the 6 months ended June 30, 2022)	5,813
2023	61,302
2024	102,260
Total minimum payments	$	169,375
Less: interest	(19,375)
Less: unamortized issuance costs	(1,319)

Term loan	$	148,681

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7. Net Loss Per Share

Basic and diluted net loss per share for the periods set forth below is calculated as follows (in thousands, except share and per share amounts):


	Three Months Ended June 30,				Six Months Ended June 30,
	2022		2021		2022		2021
Numerator:
Net loss	$	(12,733)	$	(16,810)	$	(31,010)	$	(32,559)

Denominator:
Weighted-average number of common shares used in loss per share - basic and diluted	47,588,158		47,391,530		47,515,394		47,114,947
Loss per share - basic and diluted	$	(0.27)	$	(0.35)	$	(0.65)	$	(0.69)

The following potentially dilutive securities, prior to the use of the treasury stock method, have been excluded from the computation of diluted weighted-average shares outstanding, as they would be anti-dilutive. For the three and six months ended June 30, 2022 and 2021, respectively, all of the Company’s options to purchase common stock, restricted stock units outstanding, and performance options were assumed to be anti-dilutive as earnings attributable to common stockholders was in a loss position.


	Three and Six Months Ended June 30,
	2022	2021
Options to purchase common stock	5,757,747	6,287,436

Restricted stock units	1,686,052	438,134
Performance units	960,000	—
Performance options	1,035,000	1,035,000

The Company has the option to settle the conversion obligation for the Convertible Notes in cash, shares or any combination of the two. As the Convertible Notes are not convertible as of June 30, 2022, they are not participating securities and they will not have an impact on the calculation of basic earnings or loss per share. Based on the Company’s net loss position, there is no impact on the calculation of dilutive loss per share during the three and six month periods ended June 30, 2022 and 2021, respectively. The Company uses the if-converted method for the Convertible Notes.

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8. Product Revenue Reserves and Allowances

To date, the Company’s only source of product revenue has been from the U.S. sales of TYMLOS, which it began shipping to customers in May 2017. The following table summarizes activity in each of the product revenue allowance and reserve categories for the six months ended June 30, 2022 and 2021 (in thousands):


	Chargebacks, Discounts, and Fees		Government and other rebates		Returns		Total
Ending balance at December 31, 2021	$	2,061	$	24,604	$	224	$	26,889
Provision related to sales in the current year	10,447		63,772		262		74,481
Adjustments related to prior period sales	—		(435)		—		(435)
Credits and payments made	(10,656)		(58,624)		(278)		(69,558)
Ending balance at June 30, 2022	$	1,852	$	29,317	$	208	$	31,377

Ending balance at December 31, 2020	$	1,891	$	14,644	$	2,572	$	19,107
Provision related to sales in the current year	9,313		52,886		187		62,386
Adjustments related to prior period sales	(54)		(989)		(2,249)		(3,292)
Credits and payments made	(9,677)		(42,859)		(189)		(52,725)
Ending balance at June 30, 2021	$	1,473	$	23,682	$	321	$	25,476

Chargebacks, discounts, fees, and returns are recorded as reductions of accounts receivables, net on the condensed consolidated balance sheets. Government and other rebates are recorded as a component of accrued expenses and other current liabilities on the condensed consolidated balance sheets.

9. License Revenue and Reimbursable Expenses

General

The Company has generated revenue from contracts with customers, which include upfront payments for licenses.

Teijin

In July 2017, the Company entered into a License and Development Agreement (the “Teijin Agreement”) with Teijin Limited (“Teijin”) for abaloparatide for subcutaneous injection (“abaloparatide-SC”) in Japan.

Pursuant to the Teijin Agreement, the Company granted Teijin: (i) an exclusive payment-bearing license under certain of the Company’s intellectual property to develop and commercialize abaloparatide-SC in Japan, (ii) a non-exclusive payment-bearing license under certain of the Company’s intellectual property to manufacture abaloparatide-SC for commercial supply in Japan, (iii) a right of reference to certain of the Company’s regulatory data related to abaloparatide-SC for purposes of developing, manufacturing and commercializing abaloparatide-SC in Japan, (iv) a manufacture transfer package, upon Teijin’s request, consisting of information and the Company’s know-how that is necessary for the manufacture of active pharmaceutical ingredient and abaloparatide-SC, (v) a right, at Teijin’s request, to have the Company manufacture (or arrange for a third party to manufacture) and supply (or arrange for a third party to supply) the active pharmaceutical ingredient for the clinical supply of abaloparatide-SC in sufficient quantities to enable Teijin to conduct its clinical trials in Japan, and (vi) a right to request that the Company arrange for Teijin to directly enter into commercial supply agreements with the Company’s existing contract manufacturers on the same pricing terms and on substantially similar commercial terms to those set forth in the Company’s existing agreements with such contract manufacturers. In consideration for these rights, the Company received an upfront payment of $10.0 million, and may receive further payments upon the achievement of certain regulatory and sales milestones, as well as a fixed low double-digit royalty based on net sales of abaloparatide-SC in Japan during the royalty term, as defined below. In addition, the Company has an option to negotiate a co-promotion agreement with Teijin for abaloparatide-SC in Japan upon commercialization.

Pursuant to the Teijin Agreement, the parties may further collaborate on new indications for abaloparatide-SC. The Company also maintains full global rights to the abaloparatide-coated transdermal system product (“abaloparatide-TD”) that we are developing with Kindeva Drug Delivery (“Kindeva”), which is not currently part of the Teijin Agreement.

Unless earlier terminated, the Teijin Agreement expires on the later of the (i) date on which the use, sale or importation of abaloparatide-SC is no longer covered by a valid claim under the Company’s patent rights licensed to Teijin in Japan, (ii)

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expiration of marketing or data exclusivity for abaloparatide-SC in Japan, or (iii) 10th anniversary of the first commercial sale of abaloparatide-SC in Japan.

The Company assessed this arrangement in accordance with Topic 606 and concluded that the contract counterparty, Teijin, is a customer. The Company identified the following material promises under the contract: the commercialization and manufacturing licenses under certain intellectual property rights relating to abaloparatide-SC in Japan, as well as the right of reference to certain regulatory information. In addition, the Company identified the following customer option that would create an obligation for the Company if exercised by Teijin - the transfer of manufacturing know-how. The customer option for the transfer of manufacturing know-how represents a material right. Finally, the Company also identified the following customer option that would create a manufacturing obligation for the Company if exercised by Teijin - the supply of abaloparatide-SC for Teijin’s clinical trial needs. The customer option for clinical supply of abaloparatide-SC does not represent a material right. Based on these assessments, the Company identified the (i) commercialization and manufacturing licenses, as well as the right of reference to certain regulatory information, and (ii) transfer of manufacturing know-how as the only performance obligations at the inception of the arrangement, which were both deemed to be distinct.

The Company further determined that the up-front payment of $10.0 million constituted the entirety of the consideration to be included in the transaction price, which was allocated to the performance obligations based on the Company’s best estimate of their relative stand-alone selling prices. For the commercialization and manufacturing licenses, including the right of reference to certain regulatory information, the stand-alone selling price was calculated using the expected cost approach by leveraging the direct costs incurred by the Company in its ACTIVExtend Phase 3 clinical trial for abaloparatide-SC, plus an estimated inflation rate. The stand-alone selling price of the transfer of manufacturing know-how was computed using a cost plus margin approach reflecting the level of effort required, which can be reasonably estimated to be incurred over the performance period, multiplied by a fully-burdened internal labor rate plus an expected margin. Based on the estimates of the stand-alone selling prices for each of the performance obligations, as referenced above, the Company determined that substantially all of the $10.0 million transaction price should be allocated to the performance obligation for the commercialization and manufacturing licenses, including the right of reference to certain regulatory information. The consideration allocated to the performance obligation for the transfer of manufacturing know-how was immaterial. The Company believes that a change in the assumptions used to determine its best estimate of the selling price for the commercialization and manufacturing licenses, including the right of reference to certain regulatory information, would not have a significant effect on the allocation of the underlying consideration to the performance obligations.

Upon execution of the Teijin Agreement, the transaction price included only the $10.0 million up-front payment owed to the Company. As referenced above, the Company has received and may receive further payments upon the achievement of certain regulatory and sales milestones, totaling up to $40.0 million, as well as a fixed low double-digit royalty based on net sales of abaloparatide-SC in Japan during the royalty term. The regulatory milestone, which represents variable consideration that was evaluated under the most likely amount method, was not included in the transaction price, because the amount was fully constrained. As part of its evaluation of the constraint, the Company considered numerous factors, including that receipt of the milestone was outside the control of the Company. Any consideration related to sales-based milestones as well as royalties on net sales upon commercialization by Teijin, will be recognized when the related sales occur as they were determined to relate predominantly to the licenses granted to Teijin and, therefore, have also been excluded from the transaction price in accordance with the sales-based royalty exception. The Company will re-evaluate the transaction price in each reporting period, as uncertain events are resolved, or as other changes in circumstances occur.

In March 2021, Teijin received approval for Ostabaro® abaloparatide acetate for the treatment of osteoporosis and for promotion of bone formation in both female and male patients with high risk fracture. Upon achievement of this regulatory milestone the Company received a payment of $10.0 million from Teijin, which was recognized as license revenue during the three months ended June 30, 2021.

Berlin-Chemie

In July 2020, the Company entered into to a license agreement (“License Agreement”) with Berlin-Chemie under which the Company granted Berlin-Chemie an exclusive license to develop and commercialize products containing elacestrant (RAD1901) worldwide.

The Company and Berlin-Chemie simultaneously entered into a Transition Services Agreement (the “TSA”), pursuant to which the Company has agreed to perform certain services for Berlin-Chemie related to the EMERALD Phase 3 monotherapy study until the earlier of the completion of the contemplated services or the filing with the FDA of a NDA for elacestrant. Following submission of the NDA for elacestrant in patients with ER+/HER2- advanced or metastatic breast cancer, the Company no longer has any obligations to perform services for Berlin-Chemie. Pursuant to the TSA as amended in June 2022, Berlin-Chemie agreed to reimburse the Company for all out-of-pocket and full-time employee costs in performing the services, for total estimated reimbursements of $109.7 million of which $90.8 million has been reimbursed through June 30, 2022.

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Pursuant to the terms of the License Agreement, Berlin-Chemie made a nonrefundable initial license fee payment to the Company of $30.0 million in July 2020. The Company is also eligible to receive up to $20.0 million in development and regulatory milestone payments and up to $300.0 million in sales milestone payments, with such payments contingent on the achievement of specified milestones with respect to the licensed products. The Company is also eligible to receive tiered royalties on sales of licensed products at percentages ranging from low to mid-teens, subject to certain reductions. Royalties on net sales will be payable on a product-by-product and country-by-country basis until the latest of the expiration date of the last to expire of the relevant patent rights, the expiration of regulatory exclusivity, or ten years from such first commercial sale.

The License Agreement will continue on a licensed product-by-licensed product and country-by-country basis until the last to expire royalty term. Either party may terminate the License Agreement for an uncured material breach by the other party or upon the bankruptcy or insolvency of the other party. The Company may terminate the License Agreement for certain patent challenges or if no development, manufacture or commercialization activity occurs in any given 24-month period. Berlin-Chemie may terminate the License Agreement at its discretion for any reason by delivering 180 days’ prior written notice to the Company; provided that such termination will not be effective prior to the third anniversary of the effective date.

The Company determined that the License Agreement and TSA should be combined and evaluated as a single arrangement as they were executed on the same date and negotiated as a package. The arrangement with Berlin-Chemie provides for the transfer of the following goods or services: (i) license, (ii) know-how, (iii) regulatory filings, (iv) inventory, (v) transition services, including certain clinical, manufacturing, regulatory and other services associated with the Phase 3 EMERALD monotherapy study, and (vi) participation in various joint committees.

Management applied the guidance in ASC 606 to identify all distinct goods and services within the arrangement to assess whether there is a unit of account that should be accounted for under ASC 606. Management evaluated all of the promised goods or services within the contract and determined which of those were separate performance obligations. The Company determined that the license granted, at arrangement inception, should be combined with the know-how and regulatory filings as they are not capable of being distinct (the “License”). The Company also concluded that the license rights, know-how, and regulatory filings are capable of being distinct from the supply of inventory, as Berlin-Chemie would be able to benefit from the inventory on its own or with other resources that are readily available, and capable of being distinct from the transition services and participation in joint committees as these are research and development services that can typically be performed by other third parties.

The License and the initial transfer of inventory are elements of the arrangement that are subject to the revenue recognition accounting guidance, as the performance obligations are an output of the Company’s ordinary activities in exchange for consideration. Conversely, the transition services, and the participation on joint committees are elements of the arrangements that are outside the scope of the revenue recognition guidance, as the Company is providing goods and services that are not an output of the Company’s ordinary activities.

The transaction price at inception was comprised of fixed consideration of $30.0 million. The $30.0 million upfront fee, which represents the fixed consideration in the transaction price, was allocated to the License and the supply of inventory, on a relative standalone selling price basis. The Company estimated the standalone selling price for the License by applying a risk adjusted, net present value, estimate of future potential cash flows approach and determined the standalone selling price for the inventory using a cost approach. Accordingly, the Company has allocated $27.4 million to the License and $2.6 million to the inventory. The Company concluded that the reimbursements for the research and development transition services and participation in the joint steering committees was commensurate with the standalone selling prices of the services, and as such, will be attributed to those services. The reimbursements for these services are recorded as a reduction of the related research and development expenses as the expenses are incurred.

Under the Berlin-Chemie agreements, the Company is eligible to receive various development and regulatory, and sales milestones. In June 2022, Berlin-Chemie, with support from the Company, submitted an NDA to the FDA for elacestrant in patients with ER+/HER2- advanced or metastatic breast cancer, which submission triggered one of the three development and commercialization milestones. Accordingly, the Company recorded $5.0 million in License revenue during the three months ended June 30, 2022 that is payable within 60 days after achievement of the milestone. There is uncertainty that the remaining events to obtain the development and regulatory milestones will be achieved. The Company has thus determined that all such milestones will be constrained until it is deemed probable that a significant revenue reversal will not occur. Additional transaction price recognized in future periods related to milestone payments and royalties will be allocated solely to the License.

Sales milestones and sales-based royalties were also excluded from the transaction price as the License is deemed to be the predominant item to which the sales milestones and sales-based royalties relate. The Company will recognize such revenue at the later of (i) when the related sales occur, or (ii) when the performance obligation to which some or all of the royalty has been allocated has been satisfied (or partially satisfied).

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During the three and six months ended June 30, 2022 and 2021, the Company recorded $9.6 million and $18.7 million for the three and six months ended June 30, 2022, respectively, and $18.5 million and $32.8 million for the three and six months ended June 30, 2021, respectively, as reductions of research and development expenses for reimbursement of transition services performed under the TSA. As of June 30, 2022 and December 31, 2021, the Company had receivable balances of $12.2 million and $11.8 million, respectively, related to reimbursable research and development expenses under this agreement, which is presented in other current assets on the condensed consolidated balance sheet. The Company also had a license receivable of $5.0 million related to achievement of milestones under the License Agreement, which is presented in License receivables on the condensed consolidated balance sheet.

10. Commitments and Contingencies

Litigation

From time to time, the Company may become subject to legal proceedings and claims which arise in the ordinary course of its business. The Company records a liability in its condensed consolidated financial statements for these matters when a loss is known or considered probable and the amount can be reasonably estimated. The Company reviews these estimates each accounting period as additional information is known and adjusts the loss provision when appropriate. If a matter is both probable to result in a liability and the amounts of loss can be reasonably estimated, the Company estimates and discloses the possible loss or range of loss to the extent necessary to make the condensed consolidated financial statements not misleading. If the loss is not probable or cannot be reasonably estimated, a liability is not recorded in its consolidated financial statements.

As of June 30, 2022, the Company was not party to any significant litigation.

Kindeva

The Company was, until June 10, 2022, a party to a Scale-Up and Commercial Supply Agreement (the “Supply Agreement”) with Kindeva Drug Delivery (“Kindeva”) as successor to 3M Company and 3M Innovative Properties Company (collectively with 3M Company, “3M”), pursuant to which Kindeva agreed to exclusively manufacture Phase 3 and global commercial supplies of an abaloparatide-coated transdermal system (“abaloparatide-TD”). Under the Supply Agreement, Kindeva manufactured abaloparatide-TD for the Company according to agreed-upon specifications in sufficient quantities to meet the Company’s projected supply requirements. If abaloparatide-TD is commercialized, Kindeva would have manufactured commercial supplies of abaloparatide-TD at unit prices that decrease with an increase in the quantity the Company orders. The Company would have paid Kindeva a mid-to-low single-digit royalty on worldwide net sales of abaloparatide-TD and reimburse Kindeva for certain capital expenditures incurred to establish commercial supply of abaloparatide-TD. The Company was responsible for providing, at its expense, supplies of abaloparatide drug substance to be used in manufacturing abaloparatide-TD. During the term of the Supply Agreement, Kindeva and the Company agreed to work exclusively with each other with respect to the delivery of abaloparatide, parathyroid hormone (“PTH”), and/or PTH related proteins via active transdermal, intradermal, or microneedle technology.

In December 2021, the Company announced the results of its Phase 3 clinical trial for abaloparatide-TD whereby the wearABLe Trial did not meet its primary or secondary endpoints. Based upon both the Company’s internal analysis and regulatory feedback from the FDA on possible paths forward for abaloparatide-TD, in June 2022 the Company announced the decision to cease all work on abaloparatide-TD, and the Company terminated the Supply Agreement effective June 10, 2022 as permitted within the terms of the contract which allows for the Company to terminate the Supply Agreement upon the occurrence of certain events, including if the Company ceased development or commercialization of abaloparatide-TD. As a result, the Company recorded approximately $3.2 million in expenses related to the termination of the abaloparatide-TD program. The Company has paid 3M and Kindeva approximately $70.9 million, in the aggregate, through June 30, 2022 with respect to performance under the Supply Agreement.

Until June 2022, the Company was a party to the Development and Clinical Supplies Agreement with 3M, as amended (the “Development Agreement”), under which abaloparatide-TD development activities occurred and 3M manufactured phase 1 and 2 clinical trial supplies on an exclusive basis. The initial term of the Development Agreement remained in effect until June 2022 when the Supply Agreement was terminated. The Company has paid 3M and Kindeva approximately $31.8 million, in the aggregate, through June 30, 2022 with respect to performance under the Development Agreement.

Manufacturing Agreements

The Company is a party to a Supply Agreement with Ypsomed AG (“Ypsomed”), as amended, pursuant to which Ypsomed has agreed to supply commercial and clinical supplies of a disposable pen injection device customized for subcutaneous injection of abaloparatide, the active pharmaceutical ingredient (“API”) for TYMLOS. The Company has agreed to purchase a minimum number of devices at prices per device that decrease with an increase in quantity supplied. In addition, the Company has made milestone payments for Ypsomed’s capital developments in connection with the initiation of the commercial supply of the device and to pay a one-time capacity fee. All costs and payments under the agreement are delineated in Swiss Francs. The

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agreement had an initial term of three years, which began on June 1, 2017, after which it automatically renewed for a two-year term. Following its current term, the agreement automatically renews for additional two-year terms unless either party terminates the agreement upon 18 months’ notice prior to the end of the then-current term. During the two-year term beginning May 2020, the Company is required to purchase a minimum number of batches for CHF 1.9 million (approximately $2.0 million).

The Company is also a party to a Commercial Supply Agreement with Vetter Pharma International GmbH (“Vetter”), as amended, pursuant to which Vetter has agreed to formulate the finished abaloparatide-SC drug product containing abaloparatide, the API, to fill cartridges with the drug product, to assemble the pen delivery device, and to package the pen for commercial distribution. The Company has agreed to purchase the cartridges and pens in specified batch sizes at a price per unit. For labeling and packaging services, the Company has agreed to pay a per unit price dependent upon the number of pens loaded with cartridges that are labeled and packaged. These prices are subject to an annual price adjustment. The term of the agreement automatically renewed on January 1, 2021 for an additional two-year term and will automatically renew for additional two-year terms thereafter, unless either party notifies the other party two years before the end of the then-current term that it does not intend to renew.

The Company is also a party to a Manufacturing Services Agreement with Polypeptide Laboratories Holding AB (“PPL”), as amended, as successor-in-interest to Lonza Group Ltd., pursuant to which PPL has agreed to manufacture the commercial and clinical supplies of the API for abaloparatide. The Company has agreed to purchase the API in batches at a price per gram in euros, subject to an annual increase by PPL. The Company is also required to purchase a minimum number of batches annually, equal to €2.9 million (approximately $3.0 million) per year and $17.2 million in total through the year ended December 31, 2022. The agreement has an initial term of six years, which began on June 28, 2016, after which it automatically renews for three-year terms unless either party provides notice of non-renewal 24 months before the end of the then-current term.

Asset Purchase Agreement

In December 2020, the Company entered into an Asset Purchase Agreement with Fresh Cut Development, LLC and Benuvia Therapeutics Inc. for the acquisition of certain assets related to formulations of cannabidiol (“CBD”) related to the oral administration of a liquid formulation of CBD for therapeutic use in humans or animals (“RAD011”). Under the terms of the agreement, the Company may be obligated to make additional payments of up to $60.0 million in future periods, which would become due and payable only upon the achievement of certain development milestones. In addition, the Company may be obligated to pay up to $30.0 million in sales milestones contingent upon the realization of sales revenues and sublicense revenue. As of June 30, 2022, the Company has a liability of $2.5 million, related to certain development milestones that were deemed probable of achievement.

11. Income Taxes

The Company did not record a federal or state income tax provision or benefit for each of the six months ended June 30, 2022 and 2021 due to the expected loss before income taxes to be incurred for the years ended December 31, 2022 and 2021, as well as the Company’s continued maintenance of a full valuation allowance against its net deferred tax assets.

12. Subsequent Events

In July 2022, the Company and Teijin entered into the Amended License and Development Agreement (the “Amended Teijin Agreement”) and concurrently executed a Commercial Supply Agreement (the “Teijin Supply Agreement” and together with the Amended Teijin Agreement, the “Teijin Development and Supply Agreements”). The Amended Teijin Agreement amended the terms of the Teijin Agreement referenced in Note 9.

The Teijin Agreement has been amended to remove references to the joint commercialization opportunity and to waive the royalty on net sales of any abaloparatide-SC purchased by Teijin through the Teijin Supply Agreement. The Teijin Development and Supply Agreements does not have any impact on royalties owed on sales of abaloparatide-SC not purchased through the Teijin Supply Agreement, and accordingly, for any abaloparatide-SC sold by Teijin but not purchased through the Teijin Supply Agreement, royalty payments will be owed by Teijin to the Company under the Teijin Agreement referenced in Note 9 in consideration for the license granted by the Company to Teijin thereunder.

Under the Teijin Supply Agreement, the Company will supply to Teijin, and Teijin will purchase from the Company, a finished product comprising of a cartridge filled with abaloparatide-SC. Specifically, the Company will purchase, for Teijin, the abaloparatide-SC from a material supplier and then have a commercial supplier fill the cartridges with abaloparatide-SC and supply final abaloparatide-SC for commercialization and distribution by Teijin in Japan. As consideration, the Company will receive an annual fee and a per-unit supply price for all abaloparatide-SC purchased by Teijin through the Company under the Teijin Supply Agreement. Any other costs borne by the Company for the purchase of abaloparatide-SC or manufacture of the abaloparatide-SC will be reimbursed by Teijin. The Company has also agreed under the Teijin Supply Agreement, in the event

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of any breach of the supply agreement by the commercial supplier resulting in the Company’s breach of the Teijin Supply Agreement, to pursue any potential claims against commercial supplier on behalf of Teijin to the extent required under the Teijin Supply Agreement.

The Teijin Supply Agreement will remain in effect, unless terminated earlier for breach, until the earlier of the expiration or termination of the Teijin Agreement, the expiration or termination of the Company’s commercial supply agreement with the commercial supplier, or termination by either party in the event of the other party’s bankruptcy.

Item 2. Management’s Discussion and Analysis of Financial Condition and Results of Operations.

Cautionary Statement

This Quarterly Report on Form 10-Q, including in the sections titled “Risk Factors,” “Management’s Discussion and Analysis of Financial Condition and Results of Operations,” and including the information incorporated by reference herein, contains, in addition to historical information, forward-looking statements. We may, in some cases, use words such as “project,” “believe,” “anticipate,” “plan,” “expect,” “estimate,” “intend,” “continue,” “should,” “would,” “could,” “potentially,” “will,” “may” or similar words and expressions that convey uncertainty of future events or outcomes to identify these forward-looking statements. Forward-looking statements in this Quarterly Report on Form 10-Q may include, among other things, statements about:

•our expectations regarding commercialization of TYMLOS in the U.S., including our market access coverage expectations;

•the therapeutic benefits and effectiveness of TYMLOS and our investigational product candidates and the potential indications and market opportunities therefor;

•our ability to obtain U.S. and foreign regulatory approval for our product candidates, including supplemental regulatory approvals for TYMLOS, and the timing thereof;

•our ability to compete with other companies that are or may be developing or selling products that are competitive with TYMLOS or our investigational product candidates;

•the direct and indirect impact of the COVID-19 pandemic on the U.S. and global economies and our business and operations, including sales, expenses, supply chain, manufacturing, research and development costs, clinical trials and employees;

•our plans with respect to collaborations and licenses related to the development, manufacture or sale of TYMLOS and our investigational product candidates,

•our goals and expectations with respect to development and commercialization of RAD011, our cannabidiol oral asset (“CBD”);

•our expectations with respect to development and commercialization of elacestrant by Berlin-Chemie;

•our plans with respect to expanding our product portfolio;

•our plans and expectations with respect to our intellectual property profile;

•our expectations regarding the timing of our regulatory submissions;

•our expectations for our clinical trials, including projected costs, study designs or the timing for initiation, recruitment, completion, or reporting top-line data;

•the progress of, timing of and amount of expenses associated with our research, development and commercialization activities;

•the safety profile and related adverse events of TYMLOS and our investigational product candidates;

•our expectations regarding federal, state and foreign regulatory requirements;

•our expectations related to the Merger Agreement with affiliates of Gurnet Point Capital, LLC and Patient Square Capital, LP, including our ability to complete the pending transaction as contemplated by the Merger Agreement, the parties’ ability to satisfy the conditions to the consummation of the Offer and the other conditions set forth in the Merger Agreement, the expected timetable for completing the transaction, and the potential benefits of the transaction for the Company;

•our expectations as to future financial performance, expense levels, future payment obligations and liquidity sources;

•our ability to attract, motivate, and retain key personnel; and

•other factors discussed elsewhere in this Quarterly Report on Form 10-Q.

The outcome of the events described in these forward-looking statements is subject to known and unknown risks, uncertainties and other important factors that could cause actual results to differ materially from the results anticipated by these forward-looking statements. These important factors include our financial performance, the uncertainties inherent in commercializing pharmaceutical products or the initiation, execution and completion of clinical trials, uncertainties surrounding the timing of

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availability of data from our clinical trials, ongoing discussions with and actions by regulatory authorities, our ability to attract and retain customers, our development activities and those other factors we discuss in Part I, “Item 1A. Risk Factors” in our Annual Report on Form 10-K for the year ended December 31, 2021 and in Part II, “Item 1A. Risk Factors” in this Quarterly Report on Form 10-Q. You should read these factors and the other cautionary statements made in this Quarterly Report on Form 10-Q as being applicable to all related forward-looking statements wherever they appear in this Quarterly Report on Form 10-Q. These important factors are not exhaustive and other sections of this Quarterly Report on Form 10-Q may include additional factors which could adversely impact our business and financial performance.

You should read the following discussion of our financial condition and results of operations in conjunction with our financial statements and related notes set forth in this report. Unless the context otherwise requires, “we,” “our,” “us,” “Radius,” “Company,” and similar expressions used in this Management’s Discussion and Analysis of Financial Condition and Results of Operations section refer to Radius Health, Inc. and our consolidated entities.

Pending Transaction

On June 23, 2022, we entered into an Agreement and Plan of Merger (the “Merger Agreement”) with Ginger Acquisition, Inc., (“Parent”), a subsidiary jointly owned by affiliates of Gurnet Point Capital, LLC and Patient Square Capital, and Ginger Merger Sub, Inc., a wholly owned subsidiary of Parent (“Purchaser”).Pursuant to the Merger Agreement, and upon the terms and subject to the conditions thereof, Purchaser has commenced a tender offer (the “Offer”) to purchase each issued and outstanding share (the “Shares”) of common stock of the Company (the “Common Stock”)in exchange for an amount in cash equal to $10.00 and one contractual contingent value right (a “CVR”) that will represent the right to receive a contingent payment of $1.00 in cash, without interest but subject to applicable withholding, upon the achievement of the sum of (A) cumulative net sales of TYMLOS in the United States and (B) either (i) royalty payments based on sales of TYMLOS in Japan or (ii) if and at such time that no such royalty payments are owed, supply payments based on the supply of TYMLOS for sale in Japan that together exceed $300 million during any consecutive 12-month period prior beginning on the date of the CVR Agreement (defined below) and ending on or prior to December 31, 2025, pursuant to a Contingent Value Rights Agreement (the “CVR Agreement”) to be entered into between Parent and a rights agent. The Offer is currently scheduled to expire at one minute after 11:59 p.m. Eastern Time on August 10, 2022, the twentieth business day following the commencement of the Offer, but may be extended in accordance with the terms of the Merger Agreement. Subject to the terms and conditions of the Merger Agreement, if certain conditions are satisfied and the Offer closes, Parent, no later than the second day following the satisfaction of such conditions, would acquire any remaining shares by virtue of a merger of Purchaser with and into the Company (the “Merger”), with us being the surviving corporation and a wholly-owned subsidiary of Parent. If the Merger is consummated, the Company will cease to be a publicly traded company. The consummation of the transaction is subject to customary closing conditions, including our stockholders tendering a minimum number of Shares in the Offer and receipt of regulatory approvals.

Executive Overview

We are a global biopharmaceutical company focused on addressing unmet medical needs in the areas of bone health, neuroscience, and oncology.

In April 2017, our first commercial product, TYMLOS (abaloparatide) injection, was approved by the U.S. Food and Drug Administration (“FDA”) for the treatment of postmenopausal women with osteoporosis at high risk for fracture defined as history of osteoporotic fracture, multiple risk factors for fracture, or patients who have failed or are intolerant to other available osteoporosis therapy. In May 2017, we commenced U.S. commercial sales of TYMLOS and as of July 1, 2022 TYMLOS was available and covered for approximately 284 million U.S. insured lives, representing approximately 99% of U.S. commercial and 80% of Medicare Part D insured lives.

We are pursuing potential additional indications for TYMLOS. In October 2021, we announced positive top-line results from our Phase 3 clinical trial evaluating abaloparatide for subcutaneous injection (“abaloparatide-SC”) for use in males with osteoporosis (the “ATOM Trial”). The ATOM Trial met its primary and secondary endpoints and demonstrated a safety profile consistent with previous trials. We were developing an abaloparatide transdermal system (“abaloparatide-TD”) for potential use in the treatment of postmenopausal women with osteoporosis. In December 2021, we announced the results of our Phase 3 clinical trial for abaloparatide-TD, a different formulation of abaloparatide delivered using Kindeva Drug Delivery’s (“Kindeva”) patented microstructured transdermal system technology (the “wearABLe Trial”). The wearABLe Trial did not meet its primary or secondary endpoints. Based upon both our internal analysis and regulatory feedback from the FDA on possible paths forward for abaloparatide-TD, in June 2022, we announced the decision to cease all work on abaloparatide-TD.

We are also developing RAD011, a pharmaceutical-grade synthetic cannabidiol oral solution, manufactured utilizing traditional pharmaceutical manufacturing processes. In June 2021, we received feedback from the Type C meeting with the FDA, and in July 2022 we announced that the first patient had been randomized in the Phase 2/3 pivotal study, SCOUT-015, to evaluate

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RAD011 for the treatment of hyperphagia and related neuro-behavioral symptoms in Prader-Willi syndrome (“PWS”), a rare neuro-endocrine orphan disease which effects between approximately 20,000 and 30,000 patients in the U.S.. In the U.S., there are currently 9 sites that are activated for screening and patient recruitment will continue across the U.S. and globally as non-U.S. sites are activated. We also plan to initiate, on a gated basis, two additional clinical trials in Angelman syndrome (“AS”), with the goal of reducing seizures, and infantile spasms (“IS”), with the goal of spasm resolution. RAD011 has Orphan Drug Designation by the FDA for treatment of PWS, AS and IS and has been granted Fast Track by the FDA

Abaloparatide

Abaloparatide-SC

TYMLOS (abaloparatide-SC) is an FDA-approved treatment for postmenopausal women with osteoporosis at high risk for fracture defined as history of osteoporotic fracture, multiple risk factors for fracture, or patients who have failed or are intolerant to other available osteoporosis therapy.

We are commercializing TYMLOS in the United States through our internal commercial organization. We hold worldwide commercialization rights to abaloparatide-SC, except for Japan and Canada, where we are entitled to receive milestones and royalties based on the development and commercialization of abaloparatide-SC under our license and development agreements.

In July 2017, we entered into a license and development agreement with Teijin Pharma Limited (“Teijin”) for abaloparatide-SC in Japan. In May 2020, we announced that Teijin submitted an NDA for abaloparatide-SC in Japan for the treatment of osteoporosis in patients who are high risk of fracture and in March 2021, we announced the approval in Japan of Ostabaro® abaloparatide acetate for the treatment of osteoporosis and for promotion of bone formation in both female and male patients with high risk of fracture in Japan. Pursuant to the agreement with Teijin, we have received an upfront payment and a regulatory milestone payment upon the approval of Ostabaro. We may receive additional milestone payments upon the achievement of certain sales milestones, and a fixed low double-digit royalty based on net sales of abaloparatide-SC in Japan during the royalty term.

In October 2021, we announced positive top-line results of our ATOM Trial, evaluating TYMLOS for use in treatment of men with osteoporosis. This study met its primary endpoint of change in lumbar spine bone mineral density (“BMD”) at 12 months compared to placebo, demonstrating statistical significance after 12 months. It also met secondary endpoints of change in lumbar spine BMD at 6 months compared to placebo, change in total hip BMD at 12 months compared to placebo, and change in femoral neck BMD at 12 months compared to placebo. The ATOM Trial was a randomized, double-blind, placebo-controlled trial that enrolled 228 men with osteoporosis. The primary endpoint is change in lumbar spine BMD at 12 months compared with placebo. In previous clinical trials, TYMLOS has demonstrated increases in BMD in postmenopausal women. The ATOM Trial includes specialized high-resolution imaging to examine the effect of abaloparatide on bone structure, such as the hip, in a subset of the study participants. On February 25, 2022, the Company filed a Supplemental New Drug Application (“sNDA”) with the FDA for TYMLOS subcutaneous injection in men with osteoporosis at high risk for fracture. The sNDA filing will be a 10-month FDA review and is based on the data from the Phase 3 ATOM study that was announced on October 18, 2021.

Abaloparatide-TD

In December 2021, we announced Phase 3 top-line results from the wearABLe Trial, which evaluated the non-inferiority of abaloparatide-TD as compared to TYMLOS. The trial did not meet its primary endpoint, as patients treated with abaloparatide-TD demonstrated an increase of 7.1% in lumbar spine BMD versus an increase of 10.9% for those treated with TYMLOS. The wearABLe Trial similarly did not meet its secondary endpoint. The wearABLe study was a single, pivotal, randomized, open label, active controlled, BMD non-inferiority bridging study with an enrollment of approximately 500 patients with postmenopausal osteoporosis at high risk of fracture.

Based upon both our internal analysis and regulatory feedback from the FDA on possible paths forward for abaloparatide-TD., in June 2022 we announced the decision to cease all work on abaloparatide-TD.

RAD011

We are also developing RAD011, a pharmaceutical-grade synthetic cannabidiol oral solution, manufactured utilizing traditional pharmaceutical manufacturing processes. We acquired RAD011 from Fresh Cut Development, LLC and Benuvia Therapeutics Inc. in December 2020. Prior to the Company’s acquisition of RAD011, it was granted Fast Track Designation by the FDA in 2017 and Orphan Drug Designation in August 2020 for the treatment of hyperphagia behavior and weight loss in patients with PWS. In June 2021, we participated in a Type C meeting with the FDA to discuss initiation of a potentially pivotal Phase 2/3 study for treatment of PWS. In July 2022, we announced that the first patient had been randomized in the Phase 2/3 pivotal study, to evaluate RAD011 for the treatment of hyperphagia and related neuro-behavioral symptoms in PWS. This Synthetic Cannabidiol Oral Solution (“SCOUT”) 015 study is a randomized double-blind placebo-controlled seamless Phase 2/3 trial

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designed to support a 505(b)(2) NDA submission for RAD011 for the treatment of hyperphagia in patients with PWS. Currently, 9 U.S. sites are activated for screening and patient recruitment is expected to continue across the U.S. and globally as non-U.S. sites are activated. We intend to move forward with the development of RAD011 as not scheduled under the Controlled Substance Act (“CSA”) based on guidance from the U.S. Drug Enforcement Administration (“DEA”). The guidance states that if a product does not contain any quantity of synthetic tetrahydrocannabinol (“THC”) (or any other controlled substance), it is not controlled under the CSA. RAD011 is not scheduled as it does not contain traceable amounts of THC or any other controlled substance.

Elacestrant (RAD1901)

In October 2021, we and our licensee, Berlin-Chemie AG, a company of the Menarini Group (“Berlin-Chemie”), together announced positive top-line results from the EMERALD Phase 3 study of our investigational product candidate elacestrant, a selective estrogen receptor degrader (“SERD”). The EMERALD Phase 3 study was designed to evaluate elacestrant as a second or third-line monotherapy versus the standard of care for treatment of patients with estrogen receptor-positive (“ER+”) and human epidermal growth factor receptor 2-negative (“HER2-”) advanced or metastatic breast cancer. The study met both primary endpoints, demonstrating statistically significant progression-free survival in the overall population and in patients with tumors harboring estrogen receptor 1 (“ESR1”) mutations. Based on these results, in June 2022, Berlin-Chemie, with our support, submitted an NDA to the FDA for elacestrant in patients with ER+/HER2- advanced or metastatic breast cancer, which submission triggered one of the three development and commercialization milestones. Accordingly, we recorded $5.0 million in license revenue during the three months ended June 30, 2022 that is payable within 60 days after achievement of the milestone.

Berlin-Chemie holds an exclusive, worldwide license to develop and commercialize products containing elacestrant. For a more detailed discussion of the terms of our license agreement with Berlin-Chemie, please see Note 9 in the Notes to Condensed Consolidated Financial Statements included in Part I, Item 1 of this Quarterly Report on Form 10-Q.

Financial Overview

Product Revenue

Product revenue is derived from our sales of our commercial product, TYMLOS, in the United States.

License Revenue

License revenue is derived from payments received from contracts with customers, which includes upfront payments for licenses.

Cost of Product Revenue

Cost of product revenue consist primarily of costs associated with the manufacturing of TYMLOS, royalties owed to our licensor for such sales, and certain period costs.

Research and Development Expenses

Research and development expenses consist primarily of clinical trial costs made to contract research organizations (“CROs”), salaries and related personnel costs, fees paid to consultants and outside service providers for regulatory and quality assurance support, licensing of drug compounds and other expenses relating to the manufacture, development, testing and enhancement of our product candidates. We expense our research and development costs as they are incurred.

None of the research and development expenses, in relation to our investigational product candidates, are currently borne by third parties, with the exception of elacestrant (“RAD1901”). Abaloparatide represents the largest portion of our research and development expenses for our investigational product candidates since our inception. We began tracking program expenses for TYMLOS (abaloparatide-SC) in 2005, and program expenses from inception to June 30, 2022 were approximately $262.2 million. We began tracking program expenses for abaloparatide-TD in 2007, and program expenses from inception to June 30, 2022 were approximately $200.9 million. We began tracking program expenses for RAD1901 in 2006, and program expenses from inception to June 30, 2022 were approximately $131.9 million. We began tracking program expenses for RAD140 in 2008, and program expenses from inception to June 30, 2022 were approximately $18.0 million. We began tracking program expenses for RAD011 in 2020, and program expenses from inception to June 30, 2022 were approximately $36.3 million. These expenses relate primarily to external costs associated with manufacturing, preclinical studies and clinical trial costs.

Costs related to facilities, depreciation, share-based compensation, and research and development support services are not directly charged to programs as they benefit multiple research programs that share resources.

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The following table sets forth our research and development expenses that are directly attributable to the programs listed below for the three and six months ended June 30, 2022 and 2021 (in thousands):


	Three Months Ended June 30,				Six Months Ended June 30,
	2022		2021		2022		2021
Program-specific costs - external:
Abaloparatide-SC	$	913	$	3,116	$	3,026	$	10,725
Abaloparatide-TD	5,775		9,946		8,932		20,393
Elacestrant (RAD1901)	1,756		212		(762)		1,622
RAD140	—		216		1		309
RAD011	5,197		3,612		10,969		3,621
Total program-specific costs - external	$	13,641	$	17,102	$	22,166	$	36,670

Shared-services costs - external:
R&D support costs	4,751		3,041		9,358		8,167
Other operating costs	90		163		928		369
Total shared-services costs - external	$	4,841	$	3,204	$	10,286	$	8,536

Shared-services costs - internal
Personnel-related costs	6,087		4,997		13,163		9,887
Share-based compensation	1,433		1,607		2,675		3,208
Occupancy costs	268		9		636		18
Depreciation expense	42		31		83		72
Total shared-services costs - internal	$	7,830	$	6,644	$	16,557	$	13,185

Total research and development costs	$	26,312	$	26,950	$	49,009	$	58,391

Selling, General and Administrative Expenses

Selling, general and administrative expenses consist primarily of salaries and related expenses for commercial operations, executive, finance and other administrative personnel, professional fees, business insurance, rent, general legal activities, including the cost of maintaining our intellectual property portfolio, and other corporate expenses.

Our results also include share-based compensation expense as a result of the issuance of stock options, restricted stock units, and performance unit grants to our employees, directors and consultants. The share-based compensation expense is included in the respective categories of expense in our condensed consolidated statements of operations and comprehensive loss (i.e., research and development or selling, general and administrative expenses). We expect to record additional non-cash compensation expense in the future, which may be significant.

Interest Income

Interest income reflects interest earned on our cash, cash equivalents.

Interest Expense

Interest expense consists of interest expense related to the Convertible Notes the Company issued in a registered unwritten public offering on August 14, 2017 (“Convertible Notes”) and Amended and Restated Credit and Security Agreement with MidCap Funding IV Trust (“Term Loan”) the Company refinanced on March 3, 2021. A portion of the interest expense on the Convertible Notes is non-cash expense relating to accretion of the debt discount and amortization of issuance costs.

Critical Accounting Policies and Estimates

Our management’s discussion and analysis of financial condition and results of operations is based upon our consolidated financial statements, which have been prepared in accordance with the rules and regulations of the Securities and Exchange Commission (“SEC”), and generally accepted accounting principles in the United States (“U.S. GAAP”). The preparation of these financial statements requires us to make estimates and assumptions that affect the reported amounts of assets and

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liabilities and the disclosure of contingent assets and liabilities at the date of the financial statements, as well as reported revenues and expenses during the reporting periods. We evaluate our estimates and judgements on an ongoing basis, including those related to revenue recognition, accrued clinical expenses, research and development expenses, share-based compensation, and fair value measures, among others, which we discussed in our Annual Report on Form 10-K for the year ended December 31, 2021. We base our estimates on historical experience and various other assumptions that we believe are reasonable under the circumstances, the results of which form the basis for making judgments about the carrying value of assets and liabilities that are not readily apparent from other sources. Our actual results may differ from these estimates under different assumptions or conditions.

We have reviewed our policies and estimates to determine our critical accounting policies for the three and six months ended June 30, 2022. There were no changes to significant accounting policies during the three and six months ended June 30, 2022, except for the adoption of certain ASUs issued by the FASB, as disclosed above within Note 2, “Basis of Presentation and Significant Accounting Policies,” in the Notes to Condensed Consolidated Financial Statements included in Part I, Item 1 of this Quarterly Report on Form 10-Q.

Results of Operations

Three Months Ended June 30, 2022 and 2021 (in thousands, except percentages)


	Three Months Ended
	June 30,				Change
	2022		2021		$		%
Revenues:
Product revenue, net	$	52,535	$	51,797	$	738	1	%
License revenue	5,750		—		5,750		100	%

Total revenue	58,285		51,797		6,488		13	%
Operating expenses:
Cost of sales - product	5,377		4,394		983		22	%
Cost of sales - intangible amortization	199		200		(1)		(1)	%
Research and development, net of amounts reimbursable	26,312		26,950		(638)		(2)	%
Selling, general and administrative	34,248		32,143		2,105		7	%

Loss from operations	(7,851)		(11,890)		4,039		34	%
Other (expense) income:
Other expense, net	(109)		(79)		(30)		(38)	%
Interest expense	(4,861)		(4,847)		(14)		—	%
Interest income	88		6		82		1367	%

Net loss	$	(12,733)	$	(16,810)	$	4,077	24	%

Product revenue— We began U.S. commercial sales of TYMLOS in May 2017, following receipt of FDA marketing approval on April 28, 2017. For the three months ended June 30, 2022, we recorded approximately $52.5 million of net product revenue compared to $51.8 million for the three months ended June 30, 2021. The increase in product revenue was primarily driven by increases in both unit volume and net sales price.

License revenue— For the three months ended June 30, 2022, we recorded $5.8 million of license revenue. In June 2022, Berlin-Chemie submitted a NDA to the FDA for elacestrant, thus triggering one of the three development and commercialization milestones in the License Agreement with Berlin-Chemie. Accordingly, we recorded $5.0 million in License revenue during the three months ended June 30, 2022. In addition during the three months ended June 30, 2022, we executed two license and supply agreements and recorded $0.8 million in License revenue from these agreements. For the three months ended June 30, 2021, there was no license revenue recorded.

Cost of sales— Cost of sales was $5.6 million for the three months ended June 30, 2022 and $4.6 million the three months ended June 30, 2021. This increase was primarily driven by an increase in scrap offset by a decrease in foreign exchange losses.

Research and development expenses— For the three months ended June 30, 2022, research and development expense was $26.3 million compared to $27.0 million for the three months ended June 30, 2021, a decrease of $0.6 million, or 2%. This decrease was primarily driven by a decrease of $4.1 million in abaloparatide-TD program costs, a $2.2 million decrease in abaloparatide-

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SC program costs, and a $0.2 million decrease in RAD140 program expenses. These decreases were offset by a $1.6 million increase in RAD011 program costs, a $1.6 million increase in shared service costs largely driven by professional fees, a $1.5 million increase in elacestrant program costs, which is comprised of a $6.8 million decrease in gross program expenses offset by a $8.3 million change in billed reimbursable expenses, and a $0.9 million increase in compensation expense, which is comprised of a $1.1 million increase in compensation expense related to headcount and a $0.2 million increase related to stock compensation offset by a $0.3 million decrease in billed reimbursable expenses, and a $0.3 million increase in occupancy and depreciation costs.

Selling, general and administrative expenses— For the three months ended June 30, 2022, selling, general and administrative expenses were $34.2 million compared to $32.1 million for the three months ended June 30, 2021, an increase of $2.1 million, or 7%. This increase was primarily the result of a $6.1 million increase in professional support costs. This increase was offset by a $3.7 million decrease in wages and employee benefit costs due to a decrease in headcount and a $0.2 million decrease in occupancy and depreciation costs and other operating costs.

Other expense, net— For the three months ended June 30, 2022, other expense, net was $0.1 million, compared to $0.1 million during the three months ended June 30, 2021, an increase of $30.0 thousand, a nominal increase.

Interest expense— For the three months ended June 30, 2022, interest expense was approximately $4.9 million compared to $4.8 million for the three months ended June 30, 2021, an increase of $14.0 thousand, or 0.3%, a nominal increase.

Interest income— For the three months ended June 30, 2022, interest income was approximately $88.0 thousand compared to $6.0 thousand for the three months ended June 30, 2021, a decrease of $82.0 thousand, or 1,367%. This increase was primarily due to the increase in the interest rates of our cash equivalents.

Six Months Ended June 30, 2022 and 2021 (in thousands, except percentages)


	Six Months Ended
	June 30,				Change
	2022		2021		$		%
Revenues:
Product revenue, net	$	95,493	$	97,057	$	(1,564)	(2)	%
License revenue	5,950		11,000		(5,050)		(46)	%

Total revenue	101,443		108,057		(6,614)		(6)	%
Operating expenses:
Cost of sales - product	9,437		8,319		1,118		13	%
Cost of sales - intangible amortization	399		399		—		—	%
Research and development, net of amounts reimbursable	49,009		58,391		(9,382)		(16)	%
Selling, general and administrative	64,296		66,240		(1,944)		(3)	%

Loss from operations	(21,698)		(25,292)		3,594		14	%
Other (expense) income:
Other income (expense), net	269		(80)		349		(436)	%
Interest expense	(9,683)		(9,211)		(472)		(5)	%
Interest income	102		64		38		59	%
Gain on extinguishment of debt	—		1,960		(1,960)		(100)	%
Net loss	$	(31,010)	$	(32,559)	1,549		5	%

Product revenue— We began U.S. commercial sales of TYMLOS in May 2017, following receipt of FDA marketing approval on April 28, 2017. For the six months ended June 30, 2022, we recorded approximately $95.5 million of net product revenue compared to $97.1 million for the six months ended June 30, 2021. The decrease in product revenue was primarily driven by a decrease in units volume offset by the increase in net sales price.

License revenue— For the six months ended June 30, 2022, we recorded $6.0 million of license revenue. In June 2022, Berlin-Chemie submitted a NDA to the FDA for elacestrant, thus triggering one of the three development and commercialization milestones in the license agreement with Berlin-Chemie. Accordingly, we recorded $5.0 million in license revenue during the six months ended June 30, 2022. In addition during the six months ended June 30, 2022, we executed three license and supply agreements and recorded $1.0 million in License revenue from these agreements. For the six months ended June 30, 2021, we recorded $11.0 million of license revenue. In March 2021, Teijin received approval for Ostabaro® abaloparatide acetate for the

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treatment of osteoporosis and for promotion of bone formation in both female and male patients with high risk of fracture. Pursuant to our license and development agreement with Teijin, we recognized $10.0 million during the six months ended June 30, 2021 in connection with the completion of this regulatory milestone. In addition, we recognized $1.0 million in license revenue in connection with other license agreements for the six months ended June 30, 2021.

Cost of sales— Cost of sales was $9.8 million for the six months ended June 30, 2022 and $8.7 million the six months ended June 30, 2021. This increase was primarily driven by an increases in foreign currency gains, unit costs, and scrap, partially offset by a decrease in overhead.

Research and development expenses— For the six months ended June 30, 2022, research and development expense was $49.0 million compared to $58.4 million for the six months ended June 30, 2021, a decrease of $9.4 million, or 16%. This decrease was primarily driven by a decrease of $11.5 million in abaloparatide-TD program costs, a $7.7 million decrease in abaloparatide-SC program costs, a $2.4 million decrease in elacestrant program costs, which is comprised of a $14.9 million decrease in gross program expenses as well as a $12.5 million change in billed reimbursable expenses, and a $0.3 million decrease in RAD140 program expenses. These decreases were offset by a $7.4 million increase in RAD011 program costs, a $2.7 million increase in compensation expense, which is comprised of a $3.2 million increase in compensation expense related to headcount and a $0.5 million decrease in stock compensation, a $1.8 million increase in shared service costs largely driven by professional fees, a $0.6 million increase in occupancy and depreciation costs.

Selling, general and administrative expenses— For the six months ended June 30, 2022, selling, general and administrative expenses were $64.3 million compared to $66.2 million for the six months ended June 30, 2021, a decrease of $1.9 million, or 3%. This decrease was primarily the result of a $4.9 million decrease in wages and employee benefit costs due to a decrease in headcount. This decrease was offset by a $2.4 million increase in professional support costs and a $0.6 million increase in occupancy and depreciation costs and other operating costs.

Other income (expense), net— For the six months ended June 30, 2022, other income, net was $0.3 million, as compared to other expense, net of $0.1 million during the six months ended June 30, 2021. Other income, net of $0.3 million for the six months ended June 30, 2022 consisted primarily of other taxes and foreign currency revaluation gains.

Interest expense— For the six months ended June 30, 2022, interest expense was approximately $9.7 million compared to $9.2 million for the six months ended June 30, 2021, an increase of $0.5 million, or 5%. This increase was driven the issuance of the new term loan in March 2021 which resulted in higher interest expense for the six month period ending June 30, 2022 due to the debt being outstanding during the full period. This increase was offset by a decrease in the Convertible Notes interest due to the repurchase of $112.2 million face amount of Convertible Notes in March 2021.

Interest income— For the six months ended June 30, 2022, interest income was approximately $102.0 thousand compared to $64.0 thousand for the six months ended June 30, 2021, an increase of $38.0 thousand, or 59%. This increase was primarily due to the increase in the interest rates of our cash equivalents.

Gain on extinguishment of debt— For the six months ended June 30, 2022, there was no gain on extinguishment recognized. For the six months ended June 30, 2021, we recognized a gain on the extinguishment of debt of $2.0 million related to the repurchase of a portion of our Convertible Notes.

Liquidity and Capital Resources

From inception to June 30, 2022, we have incurred an accumulated deficit of $1,399.0 million, primarily as a result of expenses incurred through a combination of research and development activities related to our various product candidates and expenses supporting those activities. Our total cash and cash equivalents balance as of June 30, 2022 was $72.5 million. We have historically financed our operations since inception through public offerings of our common stock, issuance of convertible debt, private sales of preferred stock, and borrowings under credit facilities. Following our U.S. commercial launch of TYMLOS in May 2017, we have financed a portion of our operations through product revenue.

Based upon our cash and cash equivalents balance as of June 30, 2022 and funds available to us through our credit facilities, we believe that, prior to the consideration of potential proceeds from partnering and/or collaboration activities, we have sufficient capital to fund our development plans and our U.S. commercial and other operational activities for at least twelve months from the date of this filing. We expect to finance the future U.S. commercial activities and development costs of our product portfolio with our existing cash and cash equivalents, as well as through future product sales, or through strategic financing opportunities, that could include, but are not limited to partnering or other collaboration agreements, future offerings of equity, royalty-based financing arrangements, the incurrence of additional debt, or other alternative financing arrangements, which may involve a combination of the foregoing.

There is no guarantee that any strategic or financing opportunity will be executed or executed on favorable terms, and some could be dilutive to existing stockholders. Our future capital requirements will depend on many factors, including the scope of

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and progress in our research and development and commercialization activities, the results of our clinical trials, and the review and potential approval of our products by the FDA or other foreign regulatory authorities. The successful development of our product candidates is subject to numerous risks and uncertainties associated with commercializing and developing drugs, which could have a significant impact on the cost and timing associated with the commercialization and development of our products and product candidates. If we fail to obtain additional future capital, we may be unable to complete our planned commercialization activities or complete preclinical and clinical trials and obtain approval of any of our product candidates from the FDA or foreign regulatory authorities.

TYMLOS is our only approved product and our business currently depends heavily on its continued successful commercialization. Successful commercialization of an approved product is an expensive and uncertain process. See “Risk Factors - Risks Related to the Commercialization and Development of Our Product Candidates” set forth in Part I, “Item 1A. Risk Factors” in our Annual Report on Form 10-K for the year ended December 31, 2021.

The following table sets forth the major sources and uses of cash for each of the periods set forth below (in thousands):


	Six Months Ended
	June 30,				Change
	2022		2021		$		%
Net cash (used in) provided by:
Operating activities	$	(39,175)	$	(34,104)	$	(5,071)	(15)	%
Investing activities	(349)		23,240		(23,589)		(102)	%
Financing activities	482		18,601		(18,119)		(97)	%
Net increase in cash, cash equivalents, and restricted cash	$	(39,042)	$	7,737	$	(46,779)	(605)	%

Cash Flows from Operating Activities

Net cash used in operating activities during the six months ended June 30, 2022 was $39.2 million, which was primarily the result of a net loss of $31.0 million, partially offset by $11.0 million of net non-cash adjustments to reconcile net loss to net cash used in operations and net changes in working capital of $19.1 million. The $31.0 million net loss was primarily due to abaloparatide-SC program costs, abaloparatide-TD program costs, elacestrant and RAD011 program development expenses along with employee compensation incurred to support the commercialization of TYMLOS in the United States. The $11.0 million net non-cash adjustments to reconcile net loss to net cash used in operations primarily included share-based compensation expense of $9.4 million, depreciation of $0.8 million and amortization of debt discounts of $0.8 million.

Net cash used in operating activities during the six months ended June 30, 2021 was $34.1 million, which was primarily the result of a net loss of $32.6 million, partially offset by $9.5 million of net non-cash adjustments to reconcile net loss to net cash used in operations and net changes in working capital of $11.1 million. The $32.6 million net loss was primarily due to abaloparatide-SC program costs, abaloparatide-TD program costs, elacestrant and RAD011 program development expenses along with employee compensation incurred to support the commercialization of TYMLOS in the United States. The $9.5 million non-cash adjustments to reconcile net loss to net cash used in operations primarily included share-based compensation expense of $11.1 million, depreciation of $0.5 million and other non-cash adjustments offset by gain on extinguishment of debt of $2.0 million and gain on lease termination of $0.9 million.

Cash Flows from Investing Activities

Net cash used in investing activities during the six months ended June 30, 2022 was $0.3 million, which was the result of the purchase of property and equipment.

Net cash provided by investing activities during the six months ended June 30, 2021 was $23.2 million, which was the result of sales and maturities of marketable securities.

Cash Flows from Financing Activities

Net cash provided by financing activities during the six months ended June 30, 2022 was $0.5 million, which consisted of cash received upon issuance of common stock under the Radius Health, Inc. 2016 Employee Stock Purchase Plan (“ESPP”).

Net cash provided by financing activities during the six months ended June 30, 2021 was $18.6 million, which consisted of $122.7 million of proceeds received from issuance of the term loan, $3.8 million of proceeds received from exercises of stock options, and $0.7 million received upon issuance of common stock under the ESPP. These proceeds were partially offset by the use of $108.6 million to repurchase convertible notes.

Borrowings and Other Liabilities

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There were no material changes in borrowing arrangements and equity offerings since the filing of our most recent Annual Report.

Contractual Obligations and Commitments

Contractual obligations represent future cash commitments and liabilities under agreements with third parties and exclude contingent liabilities for which we cannot reasonably predict future payment. We enter into contracts in the normal course of business for marketing and promotion, commercial activities, preclinical and clinical research studies, research supplies, and other services and products for operating purposes. These contracts generally provide for termination on notice, and therefore are cancellable contracts and not included in the table of contractual obligations and commitments. We are also a party to certain material supply, manufacturing, license and other agreements entered into outside of the normal course of our business, as more fully described in our Annual Report on Form 10-K for the year ended December 31, 2021. In addition, we have certain obligations to make future payments to third parties that become due and payable on the achievement of certain development, regulatory and commercial milestones, such as the start of a clinical trial, filing of an NDA, approval by the FDA, or product launch. The disclosed balances exclude the potential payments we may be required to make under our agreements because the timing of payments and actual amounts paid under those agreements may be different depending on the timing of receipt of goods or services or changes to agreed-upon terms or amounts for some obligations, and those agreements are cancellable upon written notice by us and therefore, not long-term liabilities. Additionally, the expected timing of payment of the obligations presented below is estimated based on current information.

During the three months ended June 30, 2022, there were no material changes to our contractual obligations described under “Management’s Discussion and Analysis of Financial Condition and Results of Operations” included in our Annual Report on Form 10-K for the year ended December 31, 2021.

Net Operating Loss Carryforwards

As of December 31, 2021, we had federal and state net operating loss carryforwards of approximately $1,033.8 million and $710.5 million, respectively, subject to limitation, as described below. If not utilized, the net operating loss carryforwards will expire at various dates through 2036.

Under Section 382 of the Internal Revenue Code of 1986, or Section 382, substantial changes in our ownership may limit the amount of net operating loss carryforwards that could be used annually in the future to offset taxable income. We have completed studies through February 28, 2022, to determine whether any ownership change has occurred since our formation and have determined that transactions have resulted in two ownership changes, as defined under Section 382. There could be additional ownership changes and/or in the future that could further limit the amount of net operating loss and tax credit carryforwards that we can utilize. A full valuation allowance has been recorded against our net operating loss carryforwards and other deferred tax assets, as the realization of the deferred tax asset is uncertain.

As a result, we have not recorded any federal or state income tax benefit in our condensed consolidated statements of operations.

Off-Balance Sheet Arrangements

We do not have any off-balance sheet arrangements or any relationships with unconsolidated entities of financial partnerships, such as entities often referred to as structured finance or special purpose entities.

New Accounting Standards

See Note 2 - Basis of Presentation and Significant Accounting Policies - Accounting Standards Updates in the accompanying unaudited condensed consolidated financial statements in this Quarterly Report on Form 10-Q for a discussion of new accounting standards.

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Item 3. Quantitative and Qualitative Disclosures about Market Risk.

The Company’s quantitative and qualitative disclosures about market risk for changes in interest rates and foreign currency risk, which are incorporated by reference to Item 7A of the Company’s Annual Report on Form 10-K for the year ended December 31, 2021, have not materially changed since that report was filed.

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Item 4. Controls and Procedures.

Disclosure Controls and Procedures

Our management, with the participation of our principal executive officer and principal financial officer, evaluated the effectiveness of our disclosure controls and procedures as defined in Rules 13a-15(e) and 15d-15(e) under the Securities Exchange Act of 1934, as amended, as of the end of the period covered by this Quarterly Report on Form 10-Q. Based on this evaluation, our principal executive officer and principal financial officer concluded that our disclosure controls and procedures were effective as of June 30, 2022.

Changes in Internal Control over Financial Reporting

There was no change in our internal control over financial reporting during the three months ended June 30, 2022 that has materially affected, or is reasonably likely to materially affect, our internal control over financial reporting.

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PART II— OTHER INFORMATION

Item 1. Legal Proceedings.

From time to time, we are party to litigation arising in the ordinary course of our business. As of June 30, 2022, we were not party to any significant litigation.

Item 1A. Risk Factors.

Our business faces significant risks and uncertainties. Certain important factors may have a material adverse effect on our business prospects, financial condition and results of operations, and you should carefully consider them. Accordingly, in evaluating our business, we encourage you to carefully consider the discussion of risk factors in Part I, “Item 1A. Risk Factors” in our Annual Report on Form 10-K for the year ended December 31, 2021, and the additional risk factors set forth below, which could materially affect our business, financial condition or future results, in addition to other information contained in or incorporated by reference into this Quarterly Report on Form 10-Q and our other public filings with the SEC.

The Company reviewed its risk factors as of June 30, 2022 and determined that except for the additional risk set forth below, there were no material changes from the ones set forth in its Annual Report on Form 10-K for the year ended December 31, 2021.

Risks Related to the Offer and Merger

The Offer and Merger are subject to a number of conditions beyond our control. Failure to complete the Offer and the Merger within the expected time frame, or at all, could have a material adverse effect on our business, operating results, financial condition and our share price.

On June 23, 2022, we entered into the Merger Agreement, pursuant to which, and upon the terms and subject to the conditions thereof, Purchaser has commenced the Offer to purchase each issued and outstanding share of common stock of the Company. Subject to the terms and conditions of the Merger Agreement, if certain conditions are satisfied and the Offer closes, Parent would acquire any remaining shares in connection with a merger of Purchaser with and into the Company, with the Company being the surviving corporation and a wholly-owned subsidiary of Parent. Consummation of the Offer is subject to certain conditions, including, the Company’s stockholders tendering a minimum number of Shares in the Offer (the “Minimum Condition”) and receipt of regulatory approvals.

We cannot predict whether and when the conditions to the Offer will be satisfied. If one or more of these conditions are not satisfied, and as a result, we do not complete the Offer and Merger, we would remain liable for significant transaction costs, and the focus of our management would have been diverted from seeking other potential strategic opportunities, in each case without realizing any benefits of the Offer and the Merger. Certain costs associated with the Offer and Merger have already been incurred or may be payable even if the Offer and Merger are not consummated. Finally, any disruptions to our business resulting from the announcement and pendency of the Offer and Merger, including any adverse changes in our relationships with our customers, partners, suppliers and employees, could continue or accelerate in the event that we fail to consummate the Offer and Merger.

Our share price may also fluctuate significantly based on announcements by Gurnet Point Capital, LLC and Patient Square Capital LP, other third parties or us regarding the Offer and Merger or based on market perceptions of the likelihood of the satisfaction of the Minimum Condition or other conditions to the consummation of the Offer and Merger. Such announcements may lead to perceptions in the market that the Offer and Merger may not be completed, which could cause our share price to fluctuate or decline. If we do not consummate the Offer and Merger, the price of our common stock may decline significantly from the current market price, which may reflect a market assumption that the Offer and Merger will be consummated. Any of these events could have a material adverse effect on our business, operating results and financial condition and could cause a decline in the price of our common stock.

The Offer consideration payable to holders of our common stock will not be adjusted for changes in our business, assets liabilities, prospects, outlook, financial condition or results of operations, or in the event of any change in our share price.

The Offer consideration payable to holders of our common stock will not be adjusted for changes in our business, assets, liabilities, prospects, outlook, financial condition or results of operations, or changes in the market price of, analyst estimates of, or projections relating to, our ordinary shares. For example, if we experienced an improvement in our business, assets, liabilities, prospects, outlook, financial condition or results of operations prior to the consummation of the Offer and Merger, there would be no adjustment to the amount of the proposed Offer consideration.

Our stockholders may not receive any payment on the CVRs and the CVRs may otherwise expire valueless.

If the Merger is completed, the holders of our common stock will be entitled to receive $1.00 in cash per CVR, without interest, upon the achievement of the sum of (A) a cumulative net sales of TYMLOS in the United States and (B) either (i) royalty

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payments based on sales of TYMLOS in Japan or (ii) if and at such time that no such royalty payments are owed, supply payments based on the supply of TYMLOS for sale in Japan that together exceed $300 million during any consecutive 12-month period prior to December 31, 2025 (the “Milestone”). There is no guarantee, however, that the Milestone will be achieved, and such achievement is subject to the risks described in the risk factors in Part I, “Item 1A. Risk Factors” in our Annual Report on Form 10-K for the year ended December 31, 2021. The CVRs will not be transferable, will not have any voting or dividend rights, and interest will not accrue on any amounts potentially payable on the CVRs. Accordingly, the right of any of our stockholders to receive any future payment on or derive any value form the CVRs will be contingent solely upon the achievement of the Milestone within the time periods specified in the CVR Agreement and if these events are not achieved for any reason within the time periods specified in the CVR Agreement, no payments will be made under the CVRs, and the CVRs will expire valueless.

The Merger Agreement contains provisions that could discourage a potential competing acquirer.

Under the terms of the Merger Agreement, we have agreed not to solicit or initiate discussions with third parties regarding other proposals to acquire the Company and are subject to restrictions on our ability to respond to any such proposal, except as permitted under the terms of the Merger Agreement. In the event that we receive an acquisition proposal from a third party, we must notify Parent of such proposal and negotiate in good faith with Parent prior to terminating the Merger Agreement or effecting a change in the recommendation of our Board of Directors to our stockholders with respect to the Offer and Merger. The Merger Agreement also contains certain termination rights for Parent and us and further provides that, upon termination of the Merger Agreement under specified circumstances, including certain terminations in connection with an alternative business combination transaction as permitted by the terms of the Merger Agreement, we will be required to pay Parent a termination fee of $16.15 million.

These provisions could discourage a potential third-party acquirer that might have an interest in acquiring all or a significant portion of us from considering or proposing that acquisition, even if it were prepared to pay consideration with a higher per share cash or market value than the market value proposed to be received or realized in the transaction. These provisions also might result in a potential third-party acquirer proposing to pay a lower price to our stockholders than it might otherwise have proposed to pay due to the added expense of the $16.15 million termination fee that may become payable in certain circumstances.

If the Merger Agreement is terminated and we determine to seek another business combination, we may not be able to negotiate a transaction with another party on terms comparable to, or better than, the terms of the Offer and Merger.

Stockholder litigation could prevent or delay the consummation of the Offer and Merger or otherwise negatively impact our business, operating results and financial condition.

We may incur additional costs in connection with the defense or settlement of existing and any future stockholder litigation in connection with the Offer and Merger. These lawsuits or other future litigation may adversely affect our ability to complete the Offer and Merger. We could incur significant costs in connection with any such litigation, including costs associated with the indemnification of our directors and officers. Furthermore, one of the conditions to the consummation of the Offer and Merger is the absence of any governmental order or law preventing the consummation of the Offer and Merger or making the consummation of the Offer and Merger illegal. Consequently, if a plaintiff were to secure injunctive or other relief prohibiting, delaying or otherwise adversely affecting our ability to complete the consummation of the Offer and Merger, then such injunctive or other relief may prevent the Offer and Merger from becoming effective within the expected time frame or at all.

Our executive officers and directors may have interests in the Offer and the Merger that are different from, or in addition to, those of our stockholders generally.

Our executive officers and directors may have interests in the Offer and the Merger that are different from, or are in addition to, those of our stockholders generally. These interests include direct or indirect ownership of our common stock and equity awards, the acceleration of equity awards upon consummation of the transactions and other interests. Such interests of our directors and executive officers are set forth in further detail in the Schedule 14D-9 filed by the Company with the SEC on July 13, 2022.

We may be unable to obtain the regulatory approvals required to complete the consummation of the Offer and Merger.

One of the conditions to consummation of the Offer and Merger are receipt of certain regulatory approvals, including the expiration or termination of the applicable waiting periods (and any extension thereof) under the HSR Act. There can be no assurance that such regulatory approvals, or any other regulatory approvals that might be required to consummate the Offer and Merger, will be obtained. If such regulatory approvals are obtained, there can be no assurance as to the timing of such approvals, our ability to obtain the approvals on satisfactory terms or the absence of any litigation challenging such approvals.

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While the Offer and Merger is pending, we are subject to business uncertainties and contractual restrictions that could disrupt our business, and the Offer and Merger may impair our ability to attract and retain qualified employees or retain and maintain relationships with our customers, suppliers and other business partners.

Whether or not the Offer and Merger are consummated, the Offer and Merger may disrupt our current plans and operations, which could have an adverse effect on our business and financial results. The pendency of the Offer and Merger may also divert management’s attention and our resources from ongoing business and operations and our employees and other key personnel may have uncertainties about the effect of the Offer and Merger, and the uncertainties may impact our ability to retain, recruit and hire key personnel while the Offer and Merger are pending or if it fails to close. Furthermore, if key personnel depart because of such uncertainties, or because they do not wish to remain with the combined company after the consummation of the Offer and Merger, our business and results of operations may be adversely affected. In addition, we cannot predict how our suppliers, customers and other business partners will view or react to the Offer and Merger upon consummation. If we are unable to reassure our customers, suppliers and other business partners to continue transacting business with us, our sales, financial condition and results of operations may be adversely affected.

In addition, the Merger Agreement generally requires us to operate in the ordinary course of business consistent with past practice, pending consummation of the Offer and Merger, and restricts us from taking certain actions with respect to our business and financial affairs without Parent’s consent. Such restrictions will be in place until either the Offer and Merger are consummated or the Merger Agreement is terminated. These restrictions could restrict our ability to, or prevent us from, pursuing attractive business opportunities (if any) that arise prior to the consummation of the Offer and Merger. For these and other reasons, the pendency of the Offer and Merger could adversely affect our business, operating results and financial condition.

We have incurred, and will continue to incur, direct and indirect costs as a result of the Offer and Merger.

We have incurred, and will continue to incur, significant costs and expenses, including fees for professional services and other transaction costs, in connection with the Offer and Merger, including costs that we may not currently expect. We must pay substantially all of these costs and expenses whether or not the transaction is completed. If the Merger Agreement is terminated under specified circumstances, we would be required to pay to Parent a termination fee equal to $16.15 million. There are a number of factors beyond our control that could affect the total amount or the timing of these costs and expenses.

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Item 2. Unregistered Sales of Equity Securities and Use of Proceeds.

None.

Item 3. Defaults Upon Senior Securities.

None.

Item 4. Mine Safety Disclosures.

None.

Item 5. Other Information.

None.

Item 6. Exhibits.

A list of exhibits is set forth in the Exhibit Index below, which is incorporated herein by reference.

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EXHIBIT INDEX

Unless otherwise indicated, all references to previously filed Exhibits refer to the Company’s filings with the Securities and Exchange Commission, under File No. 001-35726.

Incorporated by Reference

Filed/

Exhibit

Filing

Furnished

Number

Exhibit Description

Form

File No.

Exhibit

Date

Herewith

2.1

Agreement and Plan of Merger, dated as of June 23, 2022, by and among the Company, Ginger Acquisition, Inc. and Ginger Merger Sub, Inc.

8-K

001-35726

2.1

6/23/2022

3.1

Restated Certificate of Incorporation

8-K

001-35726

3.1

6/13/2014

3.2

Amended and Restated By-Laws

8-K

001-35726

3.2

9/27/2021

31.1

Certification of Chief Executive Officer pursuant to Exchange Act Rule 13a-14(a)/15d-14(a)

31.2

Certification of Principal Financial Officer pursuant to Exchange Act Rule 13a-14(a)/15d-14(a)

32.1

Certification of Chief Executive Officer and Principal Financial Officer Pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002

101.SCH

Inline XBRL Taxonomy Extension Schema Document

101.CAL

Inline XBRL Taxonomy Extension Calculation Linkbase Document

101.LAB

Inline XBRL Taxonomy Extension Label Linkbase Document

101.PRE

Inline XBRL Taxonomy Extension Presentation Linkbase Document

101.DEF

Inline XBRL Taxonomy Extension Definition Linkbase Document

104

Cover Page Interactive Data File (formatted as inline XBRL with applicable taxonomy extension information contained in Exhibits 101.*)

* Filed herewith.

** Furnished herewith.

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.

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	RADIUS HEALTH, INC.

	By:	/s/ G. Kelly Martin
		G. Kelly Martin
		President and Chief Executive Officer
		(Principal Executive Officer)

Date: August 9, 2022


	By:	/s/ Mark W. Conley
		Mark W. Conley
		Vice President and Chief Financial Officer
		(Principal Accounting and Financial Officer)

Date: August 9, 2022

Exhibit 31.1

CERTIFICATIONS

I, G. Kelly Martin, certify that:

1. I have reviewed this Quarterly Report on Form 10-Q of Radius Health, Inc.;

2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;

3. Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;

4. The registrant’s other certifying officer(s) and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:

a. Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;

b. Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;

c. Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and

d. Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting.

5. The registrant’s other certifying officer(s) and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant’s auditors and the audit committee of the registrant’s Board of Directors (or persons performing the equivalent functions):

a. All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and

b. Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control over financial reporting.

Date: August 9, 2022


			/s/ G. Kelly Martin
			G. Kelly Martin
			President and Chief Executive Officer

Exhibit 31.2

CERTIFICATIONS

I, Mark W. Conley, certify that:

1. I have reviewed this Quarterly Report on Form 10-Q of Radius Health, Inc.;

b. Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control over financial reporting.

Date: August 9, 2022


			/s/ Mark W. Conley
			Mark W. Conley
			Vice President and Chief Financial Officer

Exhibit 32.1

CERTIFICATION OF CHIEF EXECUTIVE OFFICER AND

CHIEF FINANCIAL OFFICER PURSUANT TO

18 U.S.C. SECTION 1350, AS ADOPTED PURSUANT TO

SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

Each of G. Kelly Martin and Mark W. Conley hereby certifies, pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, in his capacity as President and Chief Executive Officer (principal executive officer) and Chief Financial Officer (principal financial officer), respectively, of Radius Health, Inc. (the “Company”), that, to his knowledge, the Quarterly Report of the Company on Form 10-Q for the period ended June 30, 2022 as filed with the Securities and Exchange Commission (the “Report”) fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934 and that the information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company.

Date:

August 9, 2022

By:

/s/ G. Kelly Martin

G. Kelly Martin

President and Chief Executive Officer

Date:

August 9, 2022

By:

/s/ Mark W. Conley

Mark W. Conley

Vice President and Chief Financial Officer

This written statement is being furnished to the Securities and Exchange Commission as an exhibit to the Report, and “accompanies” such Report to which it relates, is not deemed filed with the Securities and Exchange Commission and is not to be incorporated by reference into any filing of the Company under the Securities Act of 1933, as amended, or the Securities Exchange Act of 1934, as amended (whether made before or after the date of the Report to which it relates), notwithstanding any general incorporation language contained in such filing. A signed original of this statement has been provided to the Company and will be retained by the Company and furnished to the Securities and Exchange Commission or its staff upon request.

v3.22.2

Cover Page - shares
6 Months Ended

Jun. 30, 2022

Aug. 04, 2022

Cover [Abstract]

Document Type 10-Q

Document Quarterly Report true

Document Period End Date Jun. 30, 2022

Document Transition Report false

Entity File Number 001-35726

Entity Registrant Name Radius Health, Inc.

Entity Incorporation, State or Country Code DE

Entity Tax Identification Number 80-0145732

Entity Address, Address Line One 22 Boston Wharf Road, 7th Floor

Entity Address, City or Town Boston

Entity Address, State or Province MA

Entity Address, Postal Zip Code 02210

City Area Code 617

Local Phone Number 551-4000

Title of 12(b) Security Common Stock, $0.0001 par value per share

Trading Symbol RDUS

Security Exchange Name NASDAQ

Entity Current Reporting Status Yes

Entity Interactive Data Current Yes

Entity Filer Category Large Accelerated Filer

Entity Small Business false

Entity Emerging Growth Company false

Entity Shell Company false

Entity Common Stock, Shares Outstanding (in shares) 47,620,498

Entity Central Index Key 0001428522

Amendment Flag false

Current Fiscal Year End Date --12-31

Document Fiscal Year Focus 2022

Document Fiscal Period Focus Q2

Cover Page - shares	6 Months Ended
Jun. 30, 2022	Aug. 04, 2022
Cover [Abstract]
Document Type	10-Q
Document Quarterly Report	true
Document Period End Date	Jun. 30, 2022
Document Transition Report	false
Entity File Number	001-35726
Entity Registrant Name	Radius Health, Inc.
Entity Incorporation, State or Country Code	DE
Entity Tax Identification Number	80-0145732
Entity Address, Address Line One	22 Boston Wharf Road, 7th Floor
Entity Address, City or Town	Boston
Entity Address, State or Province	MA
Entity Address, Postal Zip Code	02210
City Area Code	617
Local Phone Number	551-4000
Title of 12(b) Security	Common Stock, $0.0001 par value per share
Trading Symbol	RDUS
Security Exchange Name	NASDAQ
Entity Current Reporting Status	Yes
Entity Interactive Data Current	Yes
Entity Filer Category	Large Accelerated Filer
Entity Small Business	false
Entity Emerging Growth Company	false
Entity Shell Company	false
Entity Common Stock, Shares Outstanding (in shares)		47,620,498
Entity Central Index Key	0001428522
Amendment Flag	false
Current Fiscal Year End Date	--12-31
Document Fiscal Year Focus	2022
Document Fiscal Period Focus	Q2

v3.22.2

Condensed Consolidated Balance Sheets - USD ($)
$ in Thousands

Jun. 30, 2022

Dec. 31, 2021

Current assets:

Cash and cash equivalents $ 72,491 $ 111,533

Restricted cash 567 567

Accounts receivable, net 26,260 23,355

Inventory 12,491 11,373

Prepaid expenses 16,674 10,050

License receivables 5,750 0

Other current assets 12,178 16,201

Total current assets 146,411 173,079

Property and equipment, net 912 647

Intangible assets 4,587 4,986

Right of use assets - operating leases 829 835

Other assets 1,701 1,995

Total assets 154,440 181,542

Current liabilities:

Accounts payable 14,485 17,625

Accrued expenses and other current liabilities 72,956 76,549

Operating lease liability, current 418 613

Total current liabilities 87,859 94,787

Convertible notes payable 190,892 190,479

Term loan 148,681 148,265

Operating lease liability, long term 411 315

Total liabilities 427,843 433,846

Stockholders’ deficit:

Common stock, 0.0001 par value; 200,000,000 shares authorized, 47,607,604 shares and 47,359,573 shares issued and outstanding at June 30, 2022 and December 31, 2021, respectively 5 5

Additional paid-in-capital 1,125,532 1,115,672

Accumulated other comprehensive income 50 0

Accumulated deficit (1,398,990) (1,367,981)

Total stockholders’ deficit (273,403) (252,304)

Total liabilities and stockholders’ deficit $ 154,440 $ 181,542

v3.22.2

Condensed Consolidated Balance Sheets (Parenthetical) - $ / shares

Jun. 30, 2022

Dec. 31, 2021

Statement of Financial Position [Abstract]

Common stock, par value (in dollars per share) $ 0.0001 $ 0.0001

Common stock, shares authorized (in shares) 200,000,000 200,000,000

Common stock, shares issued (in shares) 47,607,604 47,359,573

Common stock, shares outstanding (in shares) 47,607,604 47,359,573

v3.22.2

Condensed Consolidated Statements of Operations and Comprehensive Loss - USD ($)
$ in Thousands
3 Months Ended 6 Months Ended

Jun. 30, 2022

Jun. 30, 2021

Jun. 30, 2022

Jun. 30, 2021

REVENUES:

Total revenue $ 58,285 $ 51,797 $ 101,443 $ 108,057

OPERATING EXPENSES:

Cost of sales - product 5,377 4,394 9,437 8,319

Cost of sales - intangible amortization 199 200 399 399

Research and development, net of amounts reimbursable ^[1] 26,312 26,950 49,009 58,391

Selling, general and administrative 34,248 32,143 64,296 66,240

Loss from operations (7,851) (11,890) (21,698) (25,292)

OTHER INCOME (EXPENSE):

Other (expense) income (109) (79) 269 (80)

Interest expense (4,861) (4,847) (9,683) (9,211)

Interest income 88 6 102 64

Gain on extinguishment of debt 0 0 0 1,960

NET LOSS (12,733) (16,810) (31,010) (32,559)

OTHER COMPREHENSIVE LOSS:

Foreign currency 44 0 50 0

Unrealized loss from available-for-sale debt securities 0 0 0 (21)

COMPREHENSIVE LOSS (12,689) (16,810) (30,960) (32,580)

LOSS ATTRIBUTABLE TO COMMON STOCKHOLDERS - BASIC (12,733) (16,810) (31,010) (32,559)

LOSS ATTRIBUTABLE TO COMMON STOCKHOLDERS - DILUTED $ (12,733) $ (16,810) $ (31,010) $ (32,559)

LOSS PER SHARE:

Basic (in dollars per share) $ (0.27) $ (0.35) $ (0.65) $ (0.69)

Diluted (in dollars per share) $ (0.27) $ (0.35) $ (0.65) $ (0.69)

WEIGHTED AVERAGE SHARES:

Basic (in shares) 47,588,158 47,391,530 47,515,394 47,114,947

Diluted (in shares) 47,588,158 47,391,530 47,515,394 47,114,947

Product revenue, net

REVENUES:

Total revenue $ 52,535 $ 51,797 $ 95,493 $ 97,057

License revenue

REVENUES:

Total revenue $ 5,750 $ 0 $ 5,950 $ 11,000

[1] Amounts reimbursable for the three and six months ended June 30, 2022 were $9.6 million and $18.7 million, respectively, and $18.5 million and $32.8 million, respectively, for the three and six months ended June 30, 2021.

v3.22.2

Condensed Consolidated Statements of Operations and Comprehensive Loss (Parenthetical) - USD ($)
$ in Millions
3 Months Ended 6 Months Ended

Jun. 30, 2022

Jun. 30, 2021

Jun. 30, 2022

Jun. 30, 2021

Income Statement [Abstract]

Reimbursable expenses $ 9.6 $ 18.5 $ 18.7 $ 32.8

v3.22.2

Condensed Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
6 Months Ended

Jun. 30, 2022

Jun. 30, 2021

CASH FLOWS USED IN OPERATING ACTIVITIES:

Net loss $ (31,010) $ (32,559)

Adjustments to reconcile net loss to net cash used in operating activities:

Depreciation and amortization 777 494

Amortization of premium/discount on marketable securities, net 0 19

Amortization of debt discount and debt issuance costs 829 771

Share-based compensation 9,378 11,113

Gain on extinguishment of debt 0 (1,960)

Gain on the lease termination 0 (901)

Changes in operating assets and liabilities:

Inventory (1,118) (2,136)

Accounts receivable, net (2,905) (3,328)

Prepaid expenses (6,624) 1,877

License receivables (5,750) 0

Other current assets 4,023 (15,959)

Operating lease right of use assets 302 667

Other long-term assets 0 (967)

Accounts payable (3,090) 4,637

Deferred revenue 0 (1,000)

Accrued expenses and other current liabilities (3,592) 6,327

Lease liability, operating leases (395) (1,199)

Net cash used in operating activities (39,175) (34,104)

CASH FLOWS PROVIDED BY INVESTING ACTIVITIES:

Purchases of property and equipment (349) 0

Sales and maturities of marketable securities 0 23,240

Net cash (used in) provided by investing activities (349) 23,240

CASH FLOWS PROVIDED BY FINANCING ACTIVITIES:

Proceeds from exercise of stock options 0 3,804

Proceeds from issuance of term loan, net of issuance costs 0 122,687

Repurchase of convertible notes 0 (108,568)

Proceeds from issuance of shares under employee stock purchase plan 482 678

Net cash provided by financing activities 482 18,601

NET (DECREASE) INCREASE IN CASH, CASH EQUIVALENTS, AND RESTRICTED CASH (39,042) 7,737

CASH, CASH EQUIVALENTS, AND RESTRICTED CASH AT BEGINNING OF PERIOD 112,100 92,003

CASH, CASH EQUIVALENTS, AND RESTRICTED CASH AT END OF PERIOD 73,058 99,740

SUPPLEMENTAL DISCLOSURES:

Cash paid for interest 8,704 7,622

Cash paid for amounts included in the measurement of operating lease liabilities 412 1,340

Right of use assets obtained in exchange for operating lease liability $ 488 $ 332

v3.22.2

Organization
6 Months Ended

Jun. 30, 2022

Organization, Consolidation and Presentation of Financial Statements [Abstract]

Organization Organization
Radius Health, Inc. (“Radius,” the “Company,” “us,” “our” or “we”) is a global biopharmaceutical company focused on addressing unmet medical needs in the areas of bone health, neuroscience, and oncology. In April 2017, the Company’s first commercial product, TYMLOS (abaloparatide) injection, was approved by the U.S. Food and Drug Administration (“FDA”) for the treatment of postmenopausal women with osteoporosis at high risk for fracture defined as history of osteoporotic fracture, multiple risk factors for fracture, or patients who have failed or are intolerant to other available osteoporosis therapy. We are also developing certain assets we acquired related to formulations of cannabidiol related to the oral administration of a solution of CBD for therapeutic use in humans or animals (“RAD011”), for which the Company intends to seek FDA approval for a Phase 2/3 trial for treatment of hyperphagia behavior and weight loss in patients with Prader Willi syndrome (“PWS”). In June 2022, with support from the Company, our licensee, Berlin-Chemie AG, a company of the Menarini Group (“Berlin-Chemie”), submitted a New Drug Application (“NDA”) to the FDA for elacestrant in patients with ER+/HER2- advanced or metastatic breast cancer. The NDA submission was based on positive top-line results from the EMERALD Phase 3 study of our investigational product candidate elacestrant that was previously announced in October 2021. Berlin-Chemie holds an exclusive, worldwide license to develop and commercialize products containing elacestrant.
The Company is subject to risks common to companies in its industry including, but not limited to, the dependence on revenues from a single commercialized product, competition, uncertainty about clinical trial outcomes and regulatory approvals, uncertainties relating to pharmaceutical pricing reimbursement, uncertain protection of proprietary technology and potential product liability. As of June 30, 2022, the Company had an accumulated deficit of $1,399.0 million, and total cash and cash equivalents of $72.5 million.
Based upon its cash and cash equivalents balance and the $25.0 million secured revolving credit facility available to the Company under its Revolving Credit Agreement with MidCap Funding IV Trust as discussed in Note 6, “Term Loan and Credit Facilities” as of June 30, 2022, the Company believes that, prior to the consideration of revenue from the potential future sales of any of its investigational products that may receive regulatory approval or proceeds from partnering and/or collaboration activities, it has sufficient capital to fund its commercial operations, development plans, and other operational activities for at least one year from the date of this filing. The Company expects to finance its ongoing and future operations with its product revenue, existing cash and cash equivalents, or through strategic financing opportunities that could include, but are not limited to collaboration agreements or the incurrence of debt. However, there is no guarantee that any strategic or financing opportunities will be executed or executed on favorable terms, and some could be dilutive to existing stockholders.
Pending Transaction
On June 23, 2022, the Company entered into an Agreement and Plan of Merger (the “Merger Agreement”) with Ginger Acquisition, Inc., (“Parent”), a subsidiary jointly owned by affiliates of Gurnet Point Capital, LLC and Patient Square Capital, LP, and Ginger Merger Sub, Inc., a wholly owned subsidiary of Parent (“Purchaser”). Pursuant to the Merger Agreement, and upon the terms and subject to the conditions thereof, Purchaser has commenced a tender offer (the “Offer”) to purchase each issued and outstanding share (the “Shares”) of common stock of the Company (the “Common Stock”) in exchange for an amount in cash equal to $10.00 and one contractual contingent value right (a “CVR”) that will represent the right to receive a contingent payment of $1.00 in cash, without interest but subject to applicable withholding upon the achievement of the sum of (A) cumulative net sales of TYMLOS in the United States and (B) either (i) royalty payments based on sales of TYMLOS in Japan or (ii) if and at such time that no such royalty payments are owed, supply payments based on the supply of TYMLOS for sale in Japan that together exceed $300 million during any consecutive 12-month period beginning on the date of the CVR Agreement (defined below) and ending on or prior to December 31, 2025, pursuant to a Contingent Value Rights Agreement (the “CVR Agreement”) to be entered into between Parent and a rights agent. The Offer is currently scheduled to expire at one minute after 11:59 p.m. Eastern Time on August 10, 2022, the twentieth business day following the commencement of the Offer, but may be extended in accordance with the terms of the Merger Agreement. Subject to the terms and conditions of the Merger Agreement, if certain conditions are satisfied and the Offer closes, Parent, no later than the second day following the satisfaction of such conditions, would acquire any remaining shares by virtue of a merger of Purchaser with and into the Company (the “Merger”), with the Company being the surviving corporation and a wholly-owned subsidiary of Parent. If the Merger is consummated, the Company will cease to be a publicly-traded company. The consummation of the transaction is subject to customary closing conditions, including the Company’s stockholders tendering a minimum number of Shares in the Offer and receipt of regulatory approvals.

v3.22.2

Basis of Presentation and Significant Accounting Policies
6 Months Ended

Jun. 30, 2022

Accounting Policies [Abstract]

Basis of Presentation and Significant Accounting Policies Basis of Presentation and Significant Accounting Policies
Basis of Presentation
The accompanying unaudited condensed consolidated financial statements and the related disclosures of the Company have been prepared in accordance with accounting principles generally accepted in the United States (“U.S. GAAP”) for interim financial reporting and as required by Regulation S-X, Rule 10-01. Accordingly, they do not include all the information and footnotes required by U.S. GAAP for complete financial statements. In the opinion of management, all adjustments (including those which are normal and recurring) considered necessary for a fair presentation of the interim financial information have been included.
When preparing financial statements in conformity with U.S. GAAP, the Company must make estimates and assumptions that affect the reported amounts of assets, liabilities, revenue, expenses and related disclosures at the date of the financial statements. Actual results could differ from those estimates. Additionally, operating results for the three and six months ended June 30, 2022 are not necessarily indicative of the results that may be expected for any other interim period or for the fiscal year ending December 31, 2022.
Subsequent events have been evaluated up to the date of issuance of these financial statements. These interim condensed consolidated financial statements should be read in conjunction with the audited consolidated financial statements and notes, which are contained in the Company’s Annual Report on Form 10-K for the year ended December 31, 2021, filed with the Securities and Exchange Commission (“SEC”) on February 24, 2022.
Significant Accounting Policies
The significant accounting policies identified in the Company’s Annual Report on Form 10-K for the year ended December 31, 2021 that require the Company to make estimates and assumptions include: revenue recognition, inventory obsolescence, long-lived assets and intangible assets, accounting for share-based compensation, contingencies, tax valuation reserves, fair value measures, and accrued expenses. There were no changes to significant accounting policies during the six months ended June 30, 2022.
Recent Accounting Standards Not Yet Adopted
There are no applicable material accounting pronouncements recently issued that have not yet been adopted by the Company.

v3.22.2

Fair Value Measurements
6 Months Ended

Jun. 30, 2022

Fair Value Disclosures [Abstract]

Fair Value Measurements Fair Value Measurements
The Company determines the fair value of its financial instruments based upon the fair value hierarchy, which requires an entity to maximize the use of observable inputs and minimize the use of unobservable inputs when measuring fair value. Below are the three levels of inputs that may be used to measure fair value:
•Level 1—Quoted prices in active markets for identical assets or liabilities that the Company has the ability to access at the measurement date.
•Level 2—Observable inputs other than Level 1 prices, such as quoted prices for similar assets or liabilities; quoted prices in markets that are not active; or other inputs that are observable or can be corroborated by observable market data for substantially the full term of the assets or liabilities.
•Level 3—Unobservable inputs that are supported by little or no market activity and that are significant to the fair value of the assets or liabilities.
Transfers into or out of any hierarchy level are recognized at the end of the reporting period in which the transfers occurred. There were no material transfers between any levels during the six months ended June 30, 2022 or 2021.
The following table summarizes the financial instruments measured at fair value on a recurring basis as of June 30, 2022 and December 31, 2021 (in thousands):
As of June 30, 2022
Level 1 Level 2 Level 3 Total
Assets
Cash and cash equivalents:
Cash $ 22,156 $ — $ — $ 22,156
Money market funds (1) 50,335 — — 50,335
Total $ 72,491 $ — $ — $ 72,491

As of December 31, 2021
Level 1 Level 2 Level 3 Total
Assets
Cash and cash equivalents:
Cash $ 41,285 $ — $ — $ 41,285
Money market funds (1) 70,248 — — 70,248
Total $ 111,533 $ — $ — $ 111,533
(1) Fair value is based upon quoted market prices.
The Company considers only those investments that are highly liquid, readily convertible to cash, and that mature within three months from the date of purchase to be cash equivalents. From time to time, the Company may have balances in financial institutions in excess of insurance limits. The Company has not experienced any losses related to these balances.
The Company’s Convertible Notes are classified within Level 2 in the fair value hierarchy. The fair values of the Convertible Notes are based on data from readily available pricing sources which utilize market observable inputs and other characteristics for similar types of instruments. The fair value of the Convertible Notes, which differs from their carrying value, is influenced by interest rates, the Company’s stock price and stock price volatility. The estimated fair value of the Convertible Notes as of June 30, 2022 was approximately $189.1 million.
The Company’s Term Loan falls into the Level 2 category within the fair value level hierarchy and the fair value was determined using quoted prices for similar liabilities in active markets, as well as inputs that are observable for the liability (other than quoted prices), such as interest rates that are observable at commonly quoted intervals. The estimated fair value of the Term Facility as of June 30, 2022 was approximately $147.2 million.
As of June 30, 2022, the carrying amounts of the cash and cash equivalents, restricted cash, accounts receivable, prepaid expenses, license receivables, other current assets, accounts payable, accrued expenses, and operating lease liabilities approximated their estimated fair values.

v3.22.2

Inventory
6 Months Ended

Jun. 30, 2022

Inventory Disclosure [Abstract]

Inventory Inventory
Inventory consisted of the following as of June 30, 2022 and December 31, 2021 (in thousands):
June 30,
2022 December 31,
2021
Raw materials $ 7,716 $ 7,159
Work in process 1,377 1,335
Finished goods 3,398 2,879
Total inventories $ 12,491 $ 11,373
Finished goods manufactured by the Company have a 36-month shelf life from date of manufacture.

v3.22.2

Convertible Notes Payable
6 Months Ended

Jun. 30, 2022

Debt Disclosure [Abstract]

Convertible Notes Payable Convertible Notes Payable
On August 14, 2017, in a registered underwritten public offering, the Company issued $300.0 million aggregate principal amount of 3% Convertible Senior Notes due September 1, 2024 (the “Convertible Notes”). In addition, on September 12, 2017, the Company issued an additional $5.0 million principal amount of Convertible Notes pursuant to the exercise of an over-allotment option granted to the underwriters in the offering. In connection with the issuance of the Convertible Notes, the Company incurred approximately $9.4 million of debt issuance costs, which primarily consisted of underwriting, legal and other professional fees.
The Convertible Notes are senior unsecured obligations of the Company and bear interest at a rate of 3.00% per annum, payable semi-annually in arrears on March 1 and September 1. Upon conversion, the Convertible Notes will be convertible into cash, shares of the Company’s common stock or a combination of cash and shares of the Company’s common stock, at the Company’s election. The Convertible Notes may be redeemed at the Company’s option, in whole or in part, if the conditions described below are satisfied. The redemption of the Convertible Notes may also be subject to certain restrictions in the Credit Agreements. The Convertible Notes will mature on September 1, 2024, unless earlier converted, redeemed or repurchased in accordance with their terms. Subject to satisfaction of certain conditions and during the periods described below, the Convertible Notes may be converted at an initial conversion rate of 20.4891 shares of common stock per $1,000 principal amount of the Convertible Notes (equivalent to an initial conversion price of approximately $48.81 per share of common stock).
Holders of the Convertible Notes may convert all or any portion of their notes, in multiples of $1,000 principal amount, at their option at any time prior to the close of business on the business day immediately preceding June 1, 2024 only under the following circumstances:
(1)if the last reported sale price of the Company’s common stock for at least 20 trading days (whether consecutive or not) during a period of 30 consecutive trading days ending on the last trading day of the immediately preceding calendar quarter is greater than or equal to 130% of the conversion price on each applicable trading day;
(2)during the five-business day period after any five-consecutive trading day period (the “measurement period”) in which the “trading price” per $1,000 principal amount of the Convertible Notes for each trading day of the measurement period was less than 98% of the product of the last reported sale price of the Company’s common stock and the conversion rate on each such trading day;
(3)if the Company calls the Convertible Notes for redemption, until the close of business on the business day immediately preceding the redemption date; or
(4)upon the occurrence of specified corporate events.
As of June 30, 2022, none of the above circumstances had occurred and, as such, the Convertible Notes were not convertible.
The Company expects that a fundamental change, a make-whole fundamental change and a share exchange event will occur upon the consummation of the Offer and the Merger. Upon a fundamental change, holders of Convertible Notes are permitted to require the Company to repurchase for cash all or any portion of their Convertible Notes at a fundamental change repurchase price equal to 100% of the principal amount of the Convertible Notes to be repurchased, plus accrued and unpaid interest to, but excluding, the fundamental change repurchase date. Upon a make-whole fundamental change, under certain circumstances, the conversion rate for notes converted in connection with such make-whole fundamental change will increase. However, if the price per share of our common stock paid (or deemed paid) in the transaction is less than $36.835 per share, the conversion rate will not be increased. As a result, the Company does not expect the make-whole fundamental change will trigger an adjustment to the conversion rate. On or after the occurrence of a share exchange event, the right to convert the Convertible Notes will be substituted with the right to receive an amount in cash equal to the per share amount of cash received by holders of the Company’s common stock
The Company may redeem for cash all or part of the Convertible Notes if the last reported sale price of the Company’s common stock equals or exceeds 130% of the conversion price then in effect for at least 20 trading days (whether or not consecutive) during any 30-consecutive trading day period ending within five trading days prior to the date on which the Company provides notice of the redemption. The redemption price will be the principal amount of the Convertible Notes to be redeemed, plus accrued and unpaid interest to, but excluding, the redemption date. In addition, calling any Convertible Note for redemption will constitute a make-whole fundamental change with respect to that Convertible Note, in which case the conversion rate applicable to the conversion of that Convertible Note, if it is converted in connection with the redemption, will be increased in certain circumstances.
In March 2021, the Company entered into separate, privately negotiated transactions with certain holders of the Convertible Notes to repurchase $112.2 million face amount of the Convertible Notes for a cash purchase of $108.6 million. As the Company only extinguished a portion of the debt, the difference between the reacquisition price and the net carrying amount of the extinguished portion resulted in a gain on extinguishment of $2.0 million. Third party costs associated with the extinguishment of $0.3 million were included in selling, general and administrative expense for the six months ended June 30, 2021.
The outstanding balances of the Convertible Notes as of June 30, 2022 consisted of the following (in thousands):
2024 Convertible Notes
Liability
Principal $ 192,753
Less: debt discount and issuance costs (1,861)
Net carrying amount $ 190,892
The debt issuance costs on the Convertible Notes will be amortized over the remaining period.
The Company determined the expected life of the Convertible Notes was equal to their seven-year term. The effective interest rate on the Convertible Notes is 3.43%.
As of June 30, 2022, the “if-converted value” did not exceed the remaining principal amount of the Convertible Notes.
The following table sets forth total interest expense recognized related to the Convertible Notes during the three months and six ended June 30, 2022 and 2021 (in thousands):
Three Months Ended June 30, Six Months Ended June 30,
2022 2021 2022 2021
Contractual interest expense 1,446 1,446 2,892 3,602
Amortization of debt discount 195 196 391 489
Amortization of debt issuance costs 11 11 22 26
Total interest expense $ 1,652 $ 1,653 $ 3,305 $ 4,117
Future minimum payments on the Company’s Convertible Notes as of June 30, 2022 are as follows (in thousands):
Years ended December 31,
Future Minimum Payments
2022 (excluding the 6 months ended June 30, 2022)
2,891
2023 5,783
2024 198,535
Total minimum payments
$ 207,209
Less: interest
(14,456)
Less: unamortized discount
(1,861)
Convertible notes payable
$ 190,892
Term Loan and Credit Facilities
On March 3, 2021, the Company and two of its wholly-owned subsidiaries, Radius Pharmaceuticals, Inc. and Radius Health Ventures, Inc. (collectively with the Company, the “Borrowers”), entered into an (i) Amended and Restated Credit and Security Agreement (Term Loan) (the “Term Credit Agreement”), with MidCap Funding IV Trust, in its capacity as administrative agent, and the financial institutions or other entities from time to time parties thereto as lenders (the “Term Lenders”) and (ii) Amended and Restated Credit and Security Agreement (Revolving Loan) (the “Revolving Credit Agreement,” together with the Term Credit Agreement, the “Credit Agreements”), with MidCap Funding IV Trust, in its capacity as administrative agent, and the financial institutions or other entities from time to time parties thereto as lenders.
The Term Credit Agreement provides for a secured term loan facility (the “Term Facility”) in an aggregate principal amount of $150.0 million (the “Initial Term Loan”), an increase of $125.0 million from the arrangement entered into in January 2020.
The Revolving Credit Agreement provides for a secured revolving credit facility (the “Revolving Facility”, together with the Term Facility, the “Facilities”) under which the Borrowers may borrow up to $25.0 million, the availability of which is determined based on a borrowing base as follows: (i) up to 85% of the net collectable value of the Borrowers’ domestic accounts receivable due from eligible direct and third-party payors, plus (ii) up to 40% of the Borrowers’ domestic eligible inventory, minus certain reserves; provided that the availability from eligible inventory may not exceed 20% of the borrowing base at any time. As of June 30, 2022 and up to the date of issuance of these condensed consolidated financial statements, the Company was eligible to borrow $25.0 million of the Revolving Facility.
The Facilities have a maturity date of June 1, 2024. The obligations under the Credit Agreements are guaranteed by the Borrowers and are guaranteed by certain future subsidiaries of the Borrowers, subject to certain exceptions. The obligations under the Facilities are secured by substantially all of the assets of the Borrowers, and are secured by substantially all assets of the future subsidiaries of the Borrowers that become borrowers or guarantors under the Facilities, subject to certain exceptions.
Borrowings under the Term Facility bear interest through maturity at a variable rate based upon the LIBOR rate plus 5.75%, subject to a LIBOR floor of 2.00%. Borrowings under the Revolving Facility bear interest through maturity at a variable rate based upon the LIBOR rate plus 3.50%, subject to a LIBOR floor of 2.00%. The Borrowers are required to pay a monthly commitment fee on the unused commitments under the Revolving Facility of 0.50% per annum.
The Company’s obligations under the Credit Agreement are secured by substantially all of the assets of the Borrowers and their wholly-owned subsidiaries. The security interest granted over these assets could limit the Company’s ability to obtain additional debt financing. In addition, the Credit Agreements contain affirmative and negative covenants customarily applicable to senior secured credit facilities, including covenants that, among other things, will limit or restrict the Company’s ability,
subject to negotiated exceptions, to incur additional indebtedness and additional liens on its assets, engage in mergers or acquisitions or dispose of assets, pay dividends or make other distributions, voluntarily prepay other indebtedness, enter into transactions with affiliated persons, make investments, and change the nature of its businesses. In addition, the Company is required to maintain an amount of unrestricted cash of at least $50.0 million and to achieve net revenue for each preceding twelve-month period of at least certain specified amounts. Failure to comply with the covenants in the Credit Agreements, including the minimum cash and minimum net revenue covenants, could result in the acceleration of its obligations under the Credit Agreements. The Company expects the Credit Agreements to be repaid in full and terminated in connection with the consummation of the Offer and the Merger.
On March 11, 2021, the Company received proceeds of $122.6 million under the Term Loan, net of fees and expenses of $2.4 million. With the issuance of a new term loan, the Company performed an assessment comparing the discounted cash flows of the original debt and the new debt as of the modification date, and concluded that the change is considered a modification. As of the modification date, the Company established a new effective interest rate based on the carrying value of the debt and the revised cash flows. Fees paid to the lender of $2.4 million were capitalized as debt discount and will be amortized to interest expense using the effective interest method over the term of the loan. Third party costs associated with the modification of $2.8 million were included in selling, general and administrative expense for the six months ended June 30, 2021. The outstanding balance of the Term Loan as of June 30, 2022 consisted of the following (in thousands):
Term loan
Principal $ 150,000
Less: debt issuance costs (1,319)
Net carrying amount $ 148,681
The following table sets forth total interest expense recognized related to the Term Facility during the three and six months ended June 30, 2022 and 2021 (in thousands):
Three Months Ended June 30, Six Months Ended June 30,
2022 2021 2022 2021
Contractual interest expense $ 2,968 $ 2,939 $ 5,929 $ 3,976
Amortization of debt discount 208 208 416 256
Total interest expense $ 3,176 $ 3,147 $ 6,345 $ 4,232
Future minimum payments on the Term Facility as of June 30, 2022 are as follows (in thousands):
Years ended December 31,
Future Minimum Payments
2022 (excluding the 6 months ended June 30, 2022)
5,813
2023 61,302
2024 102,260
Total minimum payments
$ 169,375
Less: interest
(19,375)
Less: unamortized issuance costs
(1,319)
Term loan
$ 148,681

v3.22.2

Term Loan and Credit Facilities
6 Months Ended

Jun. 30, 2022

Debt Disclosure [Abstract]

Term Loan and Credit Facilities Convertible Notes Payable
On August 14, 2017, in a registered underwritten public offering, the Company issued $300.0 million aggregate principal amount of 3% Convertible Senior Notes due September 1, 2024 (the “Convertible Notes”). In addition, on September 12, 2017, the Company issued an additional $5.0 million principal amount of Convertible Notes pursuant to the exercise of an over-allotment option granted to the underwriters in the offering. In connection with the issuance of the Convertible Notes, the Company incurred approximately $9.4 million of debt issuance costs, which primarily consisted of underwriting, legal and other professional fees.
The Convertible Notes are senior unsecured obligations of the Company and bear interest at a rate of 3.00% per annum, payable semi-annually in arrears on March 1 and September 1. Upon conversion, the Convertible Notes will be convertible into cash, shares of the Company’s common stock or a combination of cash and shares of the Company’s common stock, at the Company’s election. The Convertible Notes may be redeemed at the Company’s option, in whole or in part, if the conditions described below are satisfied. The redemption of the Convertible Notes may also be subject to certain restrictions in the Credit Agreements. The Convertible Notes will mature on September 1, 2024, unless earlier converted, redeemed or repurchased in accordance with their terms. Subject to satisfaction of certain conditions and during the periods described below, the Convertible Notes may be converted at an initial conversion rate of 20.4891 shares of common stock per $1,000 principal amount of the Convertible Notes (equivalent to an initial conversion price of approximately $48.81 per share of common stock).
Holders of the Convertible Notes may convert all or any portion of their notes, in multiples of $1,000 principal amount, at their option at any time prior to the close of business on the business day immediately preceding June 1, 2024 only under the following circumstances:
(1)if the last reported sale price of the Company’s common stock for at least 20 trading days (whether consecutive or not) during a period of 30 consecutive trading days ending on the last trading day of the immediately preceding calendar quarter is greater than or equal to 130% of the conversion price on each applicable trading day;
(2)during the five-business day period after any five-consecutive trading day period (the “measurement period”) in which the “trading price” per $1,000 principal amount of the Convertible Notes for each trading day of the measurement period was less than 98% of the product of the last reported sale price of the Company’s common stock and the conversion rate on each such trading day;
(3)if the Company calls the Convertible Notes for redemption, until the close of business on the business day immediately preceding the redemption date; or
(4)upon the occurrence of specified corporate events.
As of June 30, 2022, none of the above circumstances had occurred and, as such, the Convertible Notes were not convertible.
The Company expects that a fundamental change, a make-whole fundamental change and a share exchange event will occur upon the consummation of the Offer and the Merger. Upon a fundamental change, holders of Convertible Notes are permitted to require the Company to repurchase for cash all or any portion of their Convertible Notes at a fundamental change repurchase price equal to 100% of the principal amount of the Convertible Notes to be repurchased, plus accrued and unpaid interest to, but excluding, the fundamental change repurchase date. Upon a make-whole fundamental change, under certain circumstances, the conversion rate for notes converted in connection with such make-whole fundamental change will increase. However, if the price per share of our common stock paid (or deemed paid) in the transaction is less than $36.835 per share, the conversion rate will not be increased. As a result, the Company does not expect the make-whole fundamental change will trigger an adjustment to the conversion rate. On or after the occurrence of a share exchange event, the right to convert the Convertible Notes will be substituted with the right to receive an amount in cash equal to the per share amount of cash received by holders of the Company’s common stock
The Company may redeem for cash all or part of the Convertible Notes if the last reported sale price of the Company’s common stock equals or exceeds 130% of the conversion price then in effect for at least 20 trading days (whether or not consecutive) during any 30-consecutive trading day period ending within five trading days prior to the date on which the Company provides notice of the redemption. The redemption price will be the principal amount of the Convertible Notes to be redeemed, plus accrued and unpaid interest to, but excluding, the redemption date. In addition, calling any Convertible Note for redemption will constitute a make-whole fundamental change with respect to that Convertible Note, in which case the conversion rate applicable to the conversion of that Convertible Note, if it is converted in connection with the redemption, will be increased in certain circumstances.
In March 2021, the Company entered into separate, privately negotiated transactions with certain holders of the Convertible Notes to repurchase $112.2 million face amount of the Convertible Notes for a cash purchase of $108.6 million. As the Company only extinguished a portion of the debt, the difference between the reacquisition price and the net carrying amount of the extinguished portion resulted in a gain on extinguishment of $2.0 million. Third party costs associated with the extinguishment of $0.3 million were included in selling, general and administrative expense for the six months ended June 30, 2021.
The outstanding balances of the Convertible Notes as of June 30, 2022 consisted of the following (in thousands):
2024 Convertible Notes
Liability
Principal $ 192,753
Less: debt discount and issuance costs (1,861)
Net carrying amount $ 190,892
The debt issuance costs on the Convertible Notes will be amortized over the remaining period.
The Company determined the expected life of the Convertible Notes was equal to their seven-year term. The effective interest rate on the Convertible Notes is 3.43%.
As of June 30, 2022, the “if-converted value” did not exceed the remaining principal amount of the Convertible Notes.
The following table sets forth total interest expense recognized related to the Convertible Notes during the three months and six ended June 30, 2022 and 2021 (in thousands):
Three Months Ended June 30, Six Months Ended June 30,
2022 2021 2022 2021
Contractual interest expense 1,446 1,446 2,892 3,602
Amortization of debt discount 195 196 391 489
Amortization of debt issuance costs 11 11 22 26
Total interest expense $ 1,652 $ 1,653 $ 3,305 $ 4,117
Future minimum payments on the Company’s Convertible Notes as of June 30, 2022 are as follows (in thousands):
Years ended December 31,
Future Minimum Payments
2022 (excluding the 6 months ended June 30, 2022)
2,891
2023 5,783
2024 198,535
Total minimum payments
$ 207,209
Less: interest
(14,456)
Less: unamortized discount
(1,861)
Convertible notes payable
$ 190,892
Term Loan and Credit Facilities
On March 3, 2021, the Company and two of its wholly-owned subsidiaries, Radius Pharmaceuticals, Inc. and Radius Health Ventures, Inc. (collectively with the Company, the “Borrowers”), entered into an (i) Amended and Restated Credit and Security Agreement (Term Loan) (the “Term Credit Agreement”), with MidCap Funding IV Trust, in its capacity as administrative agent, and the financial institutions or other entities from time to time parties thereto as lenders (the “Term Lenders”) and (ii) Amended and Restated Credit and Security Agreement (Revolving Loan) (the “Revolving Credit Agreement,” together with the Term Credit Agreement, the “Credit Agreements”), with MidCap Funding IV Trust, in its capacity as administrative agent, and the financial institutions or other entities from time to time parties thereto as lenders.
The Term Credit Agreement provides for a secured term loan facility (the “Term Facility”) in an aggregate principal amount of $150.0 million (the “Initial Term Loan”), an increase of $125.0 million from the arrangement entered into in January 2020.
The Revolving Credit Agreement provides for a secured revolving credit facility (the “Revolving Facility”, together with the Term Facility, the “Facilities”) under which the Borrowers may borrow up to $25.0 million, the availability of which is determined based on a borrowing base as follows: (i) up to 85% of the net collectable value of the Borrowers’ domestic accounts receivable due from eligible direct and third-party payors, plus (ii) up to 40% of the Borrowers’ domestic eligible inventory, minus certain reserves; provided that the availability from eligible inventory may not exceed 20% of the borrowing base at any time. As of June 30, 2022 and up to the date of issuance of these condensed consolidated financial statements, the Company was eligible to borrow $25.0 million of the Revolving Facility.
The Facilities have a maturity date of June 1, 2024. The obligations under the Credit Agreements are guaranteed by the Borrowers and are guaranteed by certain future subsidiaries of the Borrowers, subject to certain exceptions. The obligations under the Facilities are secured by substantially all of the assets of the Borrowers, and are secured by substantially all assets of the future subsidiaries of the Borrowers that become borrowers or guarantors under the Facilities, subject to certain exceptions.
Borrowings under the Term Facility bear interest through maturity at a variable rate based upon the LIBOR rate plus 5.75%, subject to a LIBOR floor of 2.00%. Borrowings under the Revolving Facility bear interest through maturity at a variable rate based upon the LIBOR rate plus 3.50%, subject to a LIBOR floor of 2.00%. The Borrowers are required to pay a monthly commitment fee on the unused commitments under the Revolving Facility of 0.50% per annum.
The Company’s obligations under the Credit Agreement are secured by substantially all of the assets of the Borrowers and their wholly-owned subsidiaries. The security interest granted over these assets could limit the Company’s ability to obtain additional debt financing. In addition, the Credit Agreements contain affirmative and negative covenants customarily applicable to senior secured credit facilities, including covenants that, among other things, will limit or restrict the Company’s ability,
subject to negotiated exceptions, to incur additional indebtedness and additional liens on its assets, engage in mergers or acquisitions or dispose of assets, pay dividends or make other distributions, voluntarily prepay other indebtedness, enter into transactions with affiliated persons, make investments, and change the nature of its businesses. In addition, the Company is required to maintain an amount of unrestricted cash of at least $50.0 million and to achieve net revenue for each preceding twelve-month period of at least certain specified amounts. Failure to comply with the covenants in the Credit Agreements, including the minimum cash and minimum net revenue covenants, could result in the acceleration of its obligations under the Credit Agreements. The Company expects the Credit Agreements to be repaid in full and terminated in connection with the consummation of the Offer and the Merger.
On March 11, 2021, the Company received proceeds of $122.6 million under the Term Loan, net of fees and expenses of $2.4 million. With the issuance of a new term loan, the Company performed an assessment comparing the discounted cash flows of the original debt and the new debt as of the modification date, and concluded that the change is considered a modification. As of the modification date, the Company established a new effective interest rate based on the carrying value of the debt and the revised cash flows. Fees paid to the lender of $2.4 million were capitalized as debt discount and will be amortized to interest expense using the effective interest method over the term of the loan. Third party costs associated with the modification of $2.8 million were included in selling, general and administrative expense for the six months ended June 30, 2021. The outstanding balance of the Term Loan as of June 30, 2022 consisted of the following (in thousands):
Term loan
Principal $ 150,000
Less: debt issuance costs (1,319)
Net carrying amount $ 148,681
The following table sets forth total interest expense recognized related to the Term Facility during the three and six months ended June 30, 2022 and 2021 (in thousands):
Three Months Ended June 30, Six Months Ended June 30,
2022 2021 2022 2021
Contractual interest expense $ 2,968 $ 2,939 $ 5,929 $ 3,976
Amortization of debt discount 208 208 416 256
Total interest expense $ 3,176 $ 3,147 $ 6,345 $ 4,232
Future minimum payments on the Term Facility as of June 30, 2022 are as follows (in thousands):
Years ended December 31,
Future Minimum Payments
2022 (excluding the 6 months ended June 30, 2022)
5,813
2023 61,302
2024 102,260
Total minimum payments
$ 169,375
Less: interest
(19,375)
Less: unamortized issuance costs
(1,319)
Term loan
$ 148,681

v3.22.2

Net Loss Per Share
6 Months Ended

Jun. 30, 2022

Earnings Per Share [Abstract]

Net Loss Per Share Net Loss Per Share
Basic and diluted net loss per share for the periods set forth below is calculated as follows (in thousands, except share and per share amounts):

Three Months Ended
June 30, Six Months Ended
June 30,
2022 2021 2022 2021
Numerator:
Net loss $ (12,733) $ (16,810) $ (31,010) $ (32,559)
Denominator:
Weighted-average number of common shares used in loss per share - basic and diluted 47,588,158 47,391,530 47,515,394 47,114,947
Loss per share - basic and diluted $ (0.27) $ (0.35) $ (0.65) $ (0.69)
The following potentially dilutive securities, prior to the use of the treasury stock method, have been excluded from the computation of diluted weighted-average shares outstanding, as they would be anti-dilutive. For the three and six months ended June 30, 2022 and 2021, respectively, all of the Company’s options to purchase common stock, restricted stock units outstanding, and performance options were assumed to be anti-dilutive as earnings attributable to common stockholders was in a loss position.
Three and Six Months Ended June 30,
2022 2021
Options to purchase common stock 5,757,747 6,287,436
Restricted stock units 1,686,052 438,134
Performance units 960,000 —
Performance options 1,035,000 1,035,000
The Company has the option to settle the conversion obligation for the Convertible Notes in cash, shares or any combination of the two. As the Convertible Notes are not convertible as of June 30, 2022, they are not participating securities and they will not have an impact on the calculation of basic earnings or loss per share. Based on the Company’s net loss position, there is no impact on the calculation of dilutive loss per share during the three and six month periods ended June 30, 2022 and 2021, respectively. The Company uses the if-converted method for the Convertible Notes.

v3.22.2

Product Revenue Reserves and Allowances
6 Months Ended

Jun. 30, 2022

Organization, Consolidation and Presentation of Financial Statements [Abstract]

Product Revenue Reserves and Allowances Product Revenue Reserves and Allowances
To date, the Company’s only source of product revenue has been from the U.S. sales of TYMLOS, which it began shipping to customers in May 2017. The following table summarizes activity in each of the product revenue allowance and reserve categories for the six months ended June 30, 2022 and 2021 (in thousands):
Chargebacks, Discounts, and Fees Government and other rebates Returns Total
Ending balance at December 31, 2021 $ 2,061 $ 24,604 $ 224 $ 26,889
Provision related to sales in the current year 10,447 63,772 262 74,481
Adjustments related to prior period sales — (435) — (435)
Credits and payments made (10,656) (58,624) (278) (69,558)
Ending balance at June 30, 2022 $ 1,852 $ 29,317 $ 208 $ 31,377
Ending balance at December 31, 2020 $ 1,891 $ 14,644 $ 2,572 $ 19,107
Provision related to sales in the current year 9,313 52,886 187 62,386
Adjustments related to prior period sales (54) (989) (2,249) (3,292)
Credits and payments made (9,677) (42,859) (189) (52,725)
Ending balance at June 30, 2021 $ 1,473 $ 23,682 $ 321 $ 25,476
Chargebacks, discounts, fees, and returns are recorded as reductions of accounts receivables, net on the condensed consolidated balance sheets. Government and other rebates are recorded as a component of accrued expenses and other current liabilities on the condensed consolidated balance sheets.

v3.22.2

License Revenue and Reimbursable Expenses
6 Months Ended

Jun. 30, 2022

Organization, Consolidation and Presentation of Financial Statements [Abstract]

License Revenue and Reimbursable Expenses License Revenue and Reimbursable Expenses
General
The Company has generated revenue from contracts with customers, which include upfront payments for licenses.
Teijin
In July 2017, the Company entered into a License and Development Agreement (the “Teijin Agreement”) with Teijin Limited (“Teijin”) for abaloparatide for subcutaneous injection (“abaloparatide-SC”) in Japan.
Pursuant to the Teijin Agreement, the Company granted Teijin: (i) an exclusive payment-bearing license under certain of the Company’s intellectual property to develop and commercialize abaloparatide-SC in Japan, (ii) a non-exclusive payment-bearing license under certain of the Company’s intellectual property to manufacture abaloparatide-SC for commercial supply in Japan, (iii) a right of reference to certain of the Company’s regulatory data related to abaloparatide-SC for purposes of developing, manufacturing and commercializing abaloparatide-SC in Japan, (iv) a manufacture transfer package, upon Teijin’s request, consisting of information and the Company’s know-how that is necessary for the manufacture of active pharmaceutical ingredient and abaloparatide-SC, (v) a right, at Teijin’s request, to have the Company manufacture (or arrange for a third party to manufacture) and supply (or arrange for a third party to supply) the active pharmaceutical ingredient for the clinical supply of abaloparatide-SC in sufficient quantities to enable Teijin to conduct its clinical trials in Japan, and (vi) a right to request that the Company arrange for Teijin to directly enter into commercial supply agreements with the Company’s existing contract manufacturers on the same pricing terms and on substantially similar commercial terms to those set forth in the Company’s existing agreements with such contract manufacturers. In consideration for these rights, the Company received an upfront payment of $10.0 million, and may receive further payments upon the achievement of certain regulatory and sales milestones, as well as a fixed low double-digit royalty based on net sales of abaloparatide-SC in Japan during the royalty term, as defined below. In addition, the Company has an option to negotiate a co-promotion agreement with Teijin for abaloparatide-SC in Japan upon commercialization.
Pursuant to the Teijin Agreement, the parties may further collaborate on new indications for abaloparatide-SC. The Company also maintains full global rights to the abaloparatide-coated transdermal system product (“abaloparatide-TD”) that we are developing with Kindeva Drug Delivery (“Kindeva”), which is not currently part of the Teijin Agreement.
Unless earlier terminated, the Teijin Agreement expires on the later of the (i) date on which the use, sale or importation of abaloparatide-SC is no longer covered by a valid claim under the Company’s patent rights licensed to Teijin in Japan, (ii)
expiration of marketing or data exclusivity for abaloparatide-SC in Japan, or (iii) 10th anniversary of the first commercial sale of abaloparatide-SC in Japan.
The Company assessed this arrangement in accordance with Topic 606 and concluded that the contract counterparty, Teijin, is a customer. The Company identified the following material promises under the contract: the commercialization and manufacturing licenses under certain intellectual property rights relating to abaloparatide-SC in Japan, as well as the right of reference to certain regulatory information. In addition, the Company identified the following customer option that would create an obligation for the Company if exercised by Teijin - the transfer of manufacturing know-how. The customer option for the transfer of manufacturing know-how represents a material right. Finally, the Company also identified the following customer option that would create a manufacturing obligation for the Company if exercised by Teijin - the supply of abaloparatide-SC for Teijin’s clinical trial needs. The customer option for clinical supply of abaloparatide-SC does not represent a material right. Based on these assessments, the Company identified the (i) commercialization and manufacturing licenses, as well as the right of reference to certain regulatory information, and (ii) transfer of manufacturing know-how as the only performance obligations at the inception of the arrangement, which were both deemed to be distinct.
The Company further determined that the up-front payment of $10.0 million constituted the entirety of the consideration to be included in the transaction price, which was allocated to the performance obligations based on the Company’s best estimate of their relative stand-alone selling prices. For the commercialization and manufacturing licenses, including the right of reference to certain regulatory information, the stand-alone selling price was calculated using the expected cost approach by leveraging the direct costs incurred by the Company in its ACTIVExtend Phase 3 clinical trial for abaloparatide-SC, plus an estimated inflation rate. The stand-alone selling price of the transfer of manufacturing know-how was computed using a cost plus margin approach reflecting the level of effort required, which can be reasonably estimated to be incurred over the performance period, multiplied by a fully-burdened internal labor rate plus an expected margin. Based on the estimates of the stand-alone selling prices for each of the performance obligations, as referenced above, the Company determined that substantially all of the $10.0 million transaction price should be allocated to the performance obligation for the commercialization and manufacturing licenses, including the right of reference to certain regulatory information. The consideration allocated to the performance obligation for the transfer of manufacturing know-how was immaterial. The Company believes that a change in the assumptions used to determine its best estimate of the selling price for the commercialization and manufacturing licenses, including the right of reference to certain regulatory information, would not have a significant effect on the allocation of the underlying consideration to the performance obligations.
Upon execution of the Teijin Agreement, the transaction price included only the $10.0 million up-front payment owed to the Company. As referenced above, the Company has received and may receive further payments upon the achievement of certain regulatory and sales milestones, totaling up to $40.0 million, as well as a fixed low double-digit royalty based on net sales of abaloparatide-SC in Japan during the royalty term. The regulatory milestone, which represents variable consideration that was evaluated under the most likely amount method, was not included in the transaction price, because the amount was fully constrained. As part of its evaluation of the constraint, the Company considered numerous factors, including that receipt of the milestone was outside the control of the Company. Any consideration related to sales-based milestones as well as royalties on net sales upon commercialization by Teijin, will be recognized when the related sales occur as they were determined to relate predominantly to the licenses granted to Teijin and, therefore, have also been excluded from the transaction price in accordance with the sales-based royalty exception. The Company will re-evaluate the transaction price in each reporting period, as uncertain events are resolved, or as other changes in circumstances occur.
In March 2021, Teijin received approval for Ostabaro® abaloparatide acetate for the treatment of osteoporosis and for promotion of bone formation in both female and male patients with high risk fracture. Upon achievement of this regulatory milestone the Company received a payment of $10.0 million from Teijin, which was recognized as license revenue during the three months ended June 30, 2021.
Berlin-Chemie
In July 2020, the Company entered into to a license agreement (“License Agreement”) with Berlin-Chemie under which the Company granted Berlin-Chemie an exclusive license to develop and commercialize products containing elacestrant (RAD1901) worldwide.
The Company and Berlin-Chemie simultaneously entered into a Transition Services Agreement (the “TSA”), pursuant to which the Company has agreed to perform certain services for Berlin-Chemie related to the EMERALD Phase 3 monotherapy study until the earlier of the completion of the contemplated services or the filing with the FDA of a NDA for elacestrant. Following submission of the NDA for elacestrant in patients with ER+/HER2- advanced or metastatic breast cancer, the Company no longer has any obligations to perform services for Berlin-Chemie. Pursuant to the TSA as amended in June 2022, Berlin-Chemie agreed to reimburse the Company for all out-of-pocket and full-time employee costs in performing the services, for total estimated reimbursements of $109.7 million of which $90.8 million has been reimbursed through June 30, 2022.
Pursuant to the terms of the License Agreement, Berlin-Chemie made a nonrefundable initial license fee payment to the Company of $30.0 million in July 2020. The Company is also eligible to receive up to $20.0 million in development and regulatory milestone payments and up to $300.0 million in sales milestone payments, with such payments contingent on the achievement of specified milestones with respect to the licensed products. The Company is also eligible to receive tiered royalties on sales of licensed products at percentages ranging from low to mid-teens, subject to certain reductions. Royalties on net sales will be payable on a product-by-product and country-by-country basis until the latest of the expiration date of the last to expire of the relevant patent rights, the expiration of regulatory exclusivity, or ten years from such first commercial sale.
The License Agreement will continue on a licensed product-by-licensed product and country-by-country basis until the last to expire royalty term. Either party may terminate the License Agreement for an uncured material breach by the other party or upon the bankruptcy or insolvency of the other party. The Company may terminate the License Agreement for certain patent challenges or if no development, manufacture or commercialization activity occurs in any given 24-month period. Berlin-Chemie may terminate the License Agreement at its discretion for any reason by delivering 180 days’ prior written notice to the Company; provided that such termination will not be effective prior to the third anniversary of the effective date.
The Company determined that the License Agreement and TSA should be combined and evaluated as a single arrangement as they were executed on the same date and negotiated as a package. The arrangement with Berlin-Chemie provides for the transfer of the following goods or services: (i) license, (ii) know-how, (iii) regulatory filings, (iv) inventory, (v) transition services, including certain clinical, manufacturing, regulatory and other services associated with the Phase 3 EMERALD monotherapy study, and (vi) participation in various joint committees.
Management applied the guidance in ASC 606 to identify all distinct goods and services within the arrangement to assess whether there is a unit of account that should be accounted for under ASC 606. Management evaluated all of the promised goods or services within the contract and determined which of those were separate performance obligations. The Company determined that the license granted, at arrangement inception, should be combined with the know-how and regulatory filings as they are not capable of being distinct (the “License”). The Company also concluded that the license rights, know-how, and regulatory filings are capable of being distinct from the supply of inventory, as Berlin-Chemie would be able to benefit from the inventory on its own or with other resources that are readily available, and capable of being distinct from the transition services and participation in joint committees as these are research and development services that can typically be performed by other third parties.
The License and the initial transfer of inventory are elements of the arrangement that are subject to the revenue recognition accounting guidance, as the performance obligations are an output of the Company’s ordinary activities in exchange for consideration. Conversely, the transition services, and the participation on joint committees are elements of the arrangements that are outside the scope of the revenue recognition guidance, as the Company is providing goods and services that are not an output of the Company’s ordinary activities.
The transaction price at inception was comprised of fixed consideration of $30.0 million. The $30.0 million upfront fee, which represents the fixed consideration in the transaction price, was allocated to the License and the supply of inventory, on a relative standalone selling price basis. The Company estimated the standalone selling price for the License by applying a risk adjusted, net present value, estimate of future potential cash flows approach and determined the standalone selling price for the inventory using a cost approach. Accordingly, the Company has allocated $27.4 million to the License and $2.6 million to the inventory. The Company concluded that the reimbursements for the research and development transition services and participation in the joint steering committees was commensurate with the standalone selling prices of the services, and as such, will be attributed to those services. The reimbursements for these services are recorded as a reduction of the related research and development expenses as the expenses are incurred.
Under the Berlin-Chemie agreements, the Company is eligible to receive various development and regulatory, and sales milestones. In June 2022, Berlin-Chemie, with support from the Company, submitted an NDA to the FDA for elacestrant in patients with ER+/HER2- advanced or metastatic breast cancer, which submission triggered one of the three development and commercialization milestones. Accordingly, the Company recorded $5.0 million in License revenue during the three months ended June 30, 2022 that is payable within 60 days after achievement of the milestone. There is uncertainty that the remaining events to obtain the development and regulatory milestones will be achieved. The Company has thus determined that all such milestones will be constrained until it is deemed probable that a significant revenue reversal will not occur. Additional transaction price recognized in future periods related to milestone payments and royalties will be allocated solely to the License.
Sales milestones and sales-based royalties were also excluded from the transaction price as the License is deemed to be the predominant item to which the sales milestones and sales-based royalties relate. The Company will recognize such revenue at the later of (i) when the related sales occur, or (ii) when the performance obligation to which some or all of the royalty has been allocated has been satisfied (or partially satisfied).
During the three and six months ended June 30, 2022 and 2021, the Company recorded $9.6 million and $18.7 million for the three and six months ended June 30, 2022, respectively, and $18.5 million and $32.8 million for the three and six months ended June 30, 2021, respectively, as reductions of research and development expenses for reimbursement of transition services performed under the TSA. As of June 30, 2022 and December 31, 2021, the Company had receivable balances of $12.2 million and $11.8 million, respectively, related to reimbursable research and development expenses under this agreement, which is presented in other current assets on the condensed consolidated balance sheet. The Company also had a license receivable of $5.0 million related to achievement of milestones under the License Agreement, which is presented in License receivables on the condensed consolidated balance sheet.

v3.22.2

Commitments and Contingencies
6 Months Ended

Jun. 30, 2022

Commitments and Contingencies Disclosure [Abstract]

Commitments and Contingencies Commitments and Contingencies
Litigation
From time to time, the Company may become subject to legal proceedings and claims which arise in the ordinary course of its business. The Company records a liability in its condensed consolidated financial statements for these matters when a loss is known or considered probable and the amount can be reasonably estimated. The Company reviews these estimates each accounting period as additional information is known and adjusts the loss provision when appropriate. If a matter is both probable to result in a liability and the amounts of loss can be reasonably estimated, the Company estimates and discloses the possible loss or range of loss to the extent necessary to make the condensed consolidated financial statements not misleading. If the loss is not probable or cannot be reasonably estimated, a liability is not recorded in its consolidated financial statements.
As of June 30, 2022, the Company was not party to any significant litigation.
Kindeva
The Company was, until June 10, 2022, a party to a Scale-Up and Commercial Supply Agreement (the “Supply Agreement”) with Kindeva Drug Delivery (“Kindeva”) as successor to 3M Company and 3M Innovative Properties Company (collectively with 3M Company, “3M”), pursuant to which Kindeva agreed to exclusively manufacture Phase 3 and global commercial supplies of an abaloparatide-coated transdermal system (“abaloparatide-TD”). Under the Supply Agreement, Kindeva manufactured abaloparatide-TD for the Company according to agreed-upon specifications in sufficient quantities to meet the Company’s projected supply requirements. If abaloparatide-TD is commercialized, Kindeva would have manufactured commercial supplies of abaloparatide-TD at unit prices that decrease with an increase in the quantity the Company orders. The Company would have paid Kindeva a mid-to-low single-digit royalty on worldwide net sales of abaloparatide-TD and reimburse Kindeva for certain capital expenditures incurred to establish commercial supply of abaloparatide-TD. The Company was responsible for providing, at its expense, supplies of abaloparatide drug substance to be used in manufacturing abaloparatide-TD. During the term of the Supply Agreement, Kindeva and the Company agreed to work exclusively with each other with respect to the delivery of abaloparatide, parathyroid hormone (“PTH”), and/or PTH related proteins via active transdermal, intradermal, or microneedle technology.
In December 2021, the Company announced the results of its Phase 3 clinical trial for abaloparatide-TD whereby the wearABLe Trial did not meet its primary or secondary endpoints. Based upon both the Company’s internal analysis and regulatory feedback from the FDA on possible paths forward for abaloparatide-TD, in June 2022 the Company announced the decision to cease all work on abaloparatide-TD, and the Company terminated the Supply Agreement effective June 10, 2022 as permitted within the terms of the contract which allows for the Company to terminate the Supply Agreement upon the occurrence of certain events, including if the Company ceased development or commercialization of abaloparatide-TD. As a result, the Company recorded approximately $3.2 million in expenses related to the termination of the abaloparatide-TD program. The Company has paid 3M and Kindeva approximately $70.9 million, in the aggregate, through June 30, 2022 with respect to performance under the Supply Agreement.
Until June 2022, the Company was a party to the Development and Clinical Supplies Agreement with 3M, as amended (the “Development Agreement”), under which abaloparatide-TD development activities occurred and 3M manufactured phase 1 and 2 clinical trial supplies on an exclusive basis. The initial term of the Development Agreement remained in effect until June 2022 when the Supply Agreement was terminated. The Company has paid 3M and Kindeva approximately $31.8 million, in the aggregate, through June 30, 2022 with respect to performance under the Development Agreement.
Manufacturing Agreements
The Company is a party to a Supply Agreement with Ypsomed AG (“Ypsomed”), as amended, pursuant to which Ypsomed has agreed to supply commercial and clinical supplies of a disposable pen injection device customized for subcutaneous injection of abaloparatide, the active pharmaceutical ingredient (“API”) for TYMLOS. The Company has agreed to purchase a minimum number of devices at prices per device that decrease with an increase in quantity supplied. In addition, the Company has made milestone payments for Ypsomed’s capital developments in connection with the initiation of the commercial supply of the device and to pay a one-time capacity fee. All costs and payments under the agreement are delineated in Swiss Francs. The
agreement had an initial term of three years, which began on June 1, 2017, after which it automatically renewed for a two-year term. Following its current term, the agreement automatically renews for additional two-year terms unless either party terminates the agreement upon 18 months’ notice prior to the end of the then-current term. During the two-year term beginning May 2020, the Company is required to purchase a minimum number of batches for CHF 1.9 million (approximately $2.0 million).
The Company is also a party to a Commercial Supply Agreement with Vetter Pharma International GmbH (“Vetter”), as amended, pursuant to which Vetter has agreed to formulate the finished abaloparatide-SC drug product containing abaloparatide, the API, to fill cartridges with the drug product, to assemble the pen delivery device, and to package the pen for commercial distribution. The Company has agreed to purchase the cartridges and pens in specified batch sizes at a price per unit. For labeling and packaging services, the Company has agreed to pay a per unit price dependent upon the number of pens loaded with cartridges that are labeled and packaged. These prices are subject to an annual price adjustment. The term of the agreement automatically renewed on January 1, 2021 for an additional two-year term and will automatically renew for additional two-year terms thereafter, unless either party notifies the other party two years before the end of the then-current term that it does not intend to renew.
The Company is also a party to a Manufacturing Services Agreement with Polypeptide Laboratories Holding AB (“PPL”), as amended, as successor-in-interest to Lonza Group Ltd., pursuant to which PPL has agreed to manufacture the commercial and clinical supplies of the API for abaloparatide. The Company has agreed to purchase the API in batches at a price per gram in euros, subject to an annual increase by PPL. The Company is also required to purchase a minimum number of batches annually, equal to €2.9 million (approximately $3.0 million) per year and $17.2 million in total through the year ended December 31, 2022. The agreement has an initial term of six years, which began on June 28, 2016, after which it automatically renews for three-year terms unless either party provides notice of non-renewal 24 months before the end of the then-current term.
Asset Purchase Agreement
In December 2020, the Company entered into an Asset Purchase Agreement with Fresh Cut Development, LLC and Benuvia Therapeutics Inc. for the acquisition of certain assets related to formulations of cannabidiol (“CBD”) related to the oral administration of a liquid formulation of CBD for therapeutic use in humans or animals (“RAD011”). Under the terms of the agreement, the Company may be obligated to make additional payments of up to $60.0 million in future periods, which would become due and payable only upon the achievement of certain development milestones. In addition, the Company may be obligated to pay up to $30.0 million in sales milestones contingent upon the realization of sales revenues and sublicense revenue. As of June 30, 2022, the Company has a liability of $2.5 million, related to certain development milestones that were deemed probable of achievement.

v3.22.2

Income Taxes
6 Months Ended

Jun. 30, 2022

Income Tax Disclosure [Abstract]

Income Taxes Income TaxesThe Company did not record a federal or state income tax provision or benefit for each of the six months ended June 30, 2022 and 2021 due to the expected loss before income taxes to be incurred for the years ended December 31, 2022 and 2021, as well as the Company’s continued maintenance of a full valuation allowance against its net deferred tax assets.

v3.22.2

Subsequent Events
6 Months Ended

Jun. 30, 2022

Subsequent Events [Abstract]

Subsequent Events Subsequent Events
In July 2022, the Company and Teijin entered into the Amended License and Development Agreement (the “Amended Teijin Agreement”) and concurrently executed a Commercial Supply Agreement (the “Teijin Supply Agreement” and together with the Amended Teijin Agreement, the “Teijin Development and Supply Agreements”). The Amended Teijin Agreement amended the terms of the Teijin Agreement referenced in Note 9.
The Teijin Agreement has been amended to remove references to the joint commercialization opportunity and to waive the royalty on net sales of any abaloparatide-SC purchased by Teijin through the Teijin Supply Agreement. The Teijin Development and Supply Agreements does not have any impact on royalties owed on sales of abaloparatide-SC not purchased through the Teijin Supply Agreement, and accordingly, for any abaloparatide-SC sold by Teijin but not purchased through the Teijin Supply Agreement, royalty payments will be owed by Teijin to the Company under the Teijin Agreement referenced in Note 9 in consideration for the license granted by the Company to Teijin thereunder.
Under the Teijin Supply Agreement, the Company will supply to Teijin, and Teijin will purchase from the Company, a finished product comprising of a cartridge filled with abaloparatide-SC. Specifically, the Company will purchase, for Teijin, the abaloparatide-SC from a material supplier and then have a commercial supplier fill the cartridges with abaloparatide-SC and supply final abaloparatide-SC for commercialization and distribution by Teijin in Japan. As consideration, the Company will receive an annual fee and a per-unit supply price for all abaloparatide-SC purchased by Teijin through the Company under the Teijin Supply Agreement. Any other costs borne by the Company for the purchase of abaloparatide-SC or manufacture of the abaloparatide-SC will be reimbursed by Teijin. The Company has also agreed under the Teijin Supply Agreement, in the event
of any breach of the supply agreement by the commercial supplier resulting in the Company’s breach of the Teijin Supply Agreement, to pursue any potential claims against commercial supplier on behalf of Teijin to the extent required under the Teijin Supply Agreement.The Teijin Supply Agreement will remain in effect, unless terminated earlier for breach, until the earlier of the expiration or termination of the Teijin Agreement, the expiration or termination of the Company’s commercial supply agreement with the commercial supplier, or termination by either party in the event of the other party’s bankruptcy.

v3.22.2

Basis of Presentation and Significant Accounting Policies (Policies)
6 Months Ended

Jun. 30, 2022

Accounting Policies [Abstract]

Basis of Presentation and Significant Accounting Policies
Basis of Presentation
The accompanying unaudited condensed consolidated financial statements and the related disclosures of the Company have been prepared in accordance with accounting principles generally accepted in the United States (“U.S. GAAP”) for interim financial reporting and as required by Regulation S-X, Rule 10-01. Accordingly, they do not include all the information and footnotes required by U.S. GAAP for complete financial statements. In the opinion of management, all adjustments (including those which are normal and recurring) considered necessary for a fair presentation of the interim financial information have been included.
When preparing financial statements in conformity with U.S. GAAP, the Company must make estimates and assumptions that affect the reported amounts of assets, liabilities, revenue, expenses and related disclosures at the date of the financial statements. Actual results could differ from those estimates. Additionally, operating results for the three and six months ended June 30, 2022 are not necessarily indicative of the results that may be expected for any other interim period or for the fiscal year ending December 31, 2022.
Subsequent events have been evaluated up to the date of issuance of these financial statements. These interim condensed consolidated financial statements should be read in conjunction with the audited consolidated financial statements and notes, which are contained in the Company’s Annual Report on Form 10-K for the year ended December 31, 2021, filed with the Securities and Exchange Commission (“SEC”) on February 24, 2022.
Significant Accounting Policies
The significant accounting policies identified in the Company’s Annual Report on Form 10-K for the year ended December 31, 2021 that require the Company to make estimates and assumptions include: revenue recognition, inventory obsolescence, long-lived assets and intangible assets, accounting for share-based compensation, contingencies, tax valuation reserves, fair value measures, and accrued expenses. There were no changes to significant accounting policies during the six months ended June 30, 2022.

Recent Accounting Standards Not Yet Adopted Recent Accounting Standards Not Yet AdoptedThere are no applicable material accounting pronouncements recently issued that have not yet been adopted by the Company.

v3.22.2

Fair Value Measurements (Tables)
6 Months Ended

Jun. 30, 2022

Fair Value Disclosures [Abstract]

Schedule of Financial Instruments Measured at Fair Value on a Recurring Basis
The following table summarizes the financial instruments measured at fair value on a recurring basis as of June 30, 2022 and December 31, 2021 (in thousands):
As of June 30, 2022
Level 1 Level 2 Level 3 Total
Assets
Cash and cash equivalents:
Cash $ 22,156 $ — $ — $ 22,156
Money market funds (1) 50,335 — — 50,335
Total $ 72,491 $ — $ — $ 72,491

As of December 31, 2021
Level 1 Level 2 Level 3 Total
Assets
Cash and cash equivalents:
Cash $ 41,285 $ — $ — $ 41,285
Money market funds (1) 70,248 — — 70,248
Total $ 111,533 $ — $ — $ 111,533
(1) Fair value is based upon quoted market prices.

v3.22.2

Inventory (Tables)
6 Months Ended

Jun. 30, 2022

Inventory Disclosure [Abstract]

Schedule of Inventory
Inventory consisted of the following as of June 30, 2022 and December 31, 2021 (in thousands):
June 30,
2022 December 31,
2021
Raw materials $ 7,716 $ 7,159
Work in process 1,377 1,335
Finished goods 3,398 2,879
Total inventories $ 12,491 $ 11,373

v3.22.2

Convertible Notes Payable (Tables)
6 Months Ended

Jun. 30, 2022

Debt Disclosure [Abstract]

Schedule of Outstanding Balances of Convertible Notes
The outstanding balances of the Convertible Notes as of June 30, 2022 consisted of the following (in thousands):
2024 Convertible Notes
Liability
Principal $ 192,753
Less: debt discount and issuance costs (1,861)
Net carrying amount $ 190,892

Schedule of Interest Expense Recognized Related to Debt
The following table sets forth total interest expense recognized related to the Convertible Notes during the three months and six ended June 30, 2022 and 2021 (in thousands):
Three Months Ended June 30, Six Months Ended June 30,
2022 2021 2022 2021
Contractual interest expense 1,446 1,446 2,892 3,602
Amortization of debt discount 195 196 391 489
Amortization of debt issuance costs 11 11 22 26
Total interest expense $ 1,652 $ 1,653 $ 3,305 $ 4,117
The following table sets forth total interest expense recognized related to the Term Facility during the three and six months ended June 30, 2022 and 2021 (in thousands):
Three Months Ended June 30, Six Months Ended June 30,
2022 2021 2022 2021
Contractual interest expense $ 2,968 $ 2,939 $ 5,929 $ 3,976
Amortization of debt discount 208 208 416 256
Total interest expense $ 3,176 $ 3,147 $ 6,345 $ 4,232

Schedule of Future Minimum Payments on Long-Term Debt
Future minimum payments on the Company’s Convertible Notes as of June 30, 2022 are as follows (in thousands):
Years ended December 31,
Future Minimum Payments
2022 (excluding the 6 months ended June 30, 2022)
2,891
2023 5,783
2024 198,535
Total minimum payments
$ 207,209
Less: interest
(14,456)
Less: unamortized discount
(1,861)
Convertible notes payable
$ 190,892
Future minimum payments on the Term Facility as of June 30, 2022 are as follows (in thousands):
Years ended December 31,
Future Minimum Payments
2022 (excluding the 6 months ended June 30, 2022)
5,813
2023 61,302
2024 102,260
Total minimum payments
$ 169,375
Less: interest
(19,375)
Less: unamortized issuance costs
(1,319)
Term loan
$ 148,681

v3.22.2

Term Loan and Credit Facilities (Tables)
6 Months Ended

Jun. 30, 2022

Debt Disclosure [Abstract]

Schedule of Carrying Values of Debt Instruments The outstanding balance of the Term Loan as of June 30, 2022 consisted of the following (in thousands):
Term loan
Principal $ 150,000
Less: debt issuance costs (1,319)
Net carrying amount $ 148,681

Schedule of Interest Expense Recognized Related to Debt
The following table sets forth total interest expense recognized related to the Convertible Notes during the three months and six ended June 30, 2022 and 2021 (in thousands):
Three Months Ended June 30, Six Months Ended June 30,
2022 2021 2022 2021
Contractual interest expense 1,446 1,446 2,892 3,602
Amortization of debt discount 195 196 391 489
Amortization of debt issuance costs 11 11 22 26
Total interest expense $ 1,652 $ 1,653 $ 3,305 $ 4,117
The following table sets forth total interest expense recognized related to the Term Facility during the three and six months ended June 30, 2022 and 2021 (in thousands):
Three Months Ended June 30, Six Months Ended June 30,
2022 2021 2022 2021
Contractual interest expense $ 2,968 $ 2,939 $ 5,929 $ 3,976
Amortization of debt discount 208 208 416 256
Total interest expense $ 3,176 $ 3,147 $ 6,345 $ 4,232

Schedule of Future Minimum Payments on Long-Term Debt
Future minimum payments on the Company’s Convertible Notes as of June 30, 2022 are as follows (in thousands):
Years ended December 31,
Future Minimum Payments
2022 (excluding the 6 months ended June 30, 2022)
2,891
2023 5,783
2024 198,535
Total minimum payments
$ 207,209
Less: interest
(14,456)
Less: unamortized discount
(1,861)
Convertible notes payable
$ 190,892
Future minimum payments on the Term Facility as of June 30, 2022 are as follows (in thousands):
Years ended December 31,
Future Minimum Payments
2022 (excluding the 6 months ended June 30, 2022)
5,813
2023 61,302
2024 102,260
Total minimum payments
$ 169,375
Less: interest
(19,375)
Less: unamortized issuance costs
(1,319)
Term loan
$ 148,681

v3.22.2

Net Loss Per Share (Tables)
6 Months Ended

Jun. 30, 2022

Earnings Per Share [Abstract]

Schedule of Basic and Diluted Net Loss Per Share
Basic and diluted net loss per share for the periods set forth below is calculated as follows (in thousands, except share and per share amounts):

Three Months Ended
June 30, Six Months Ended
June 30,
2022 2021 2022 2021
Numerator:
Net loss $ (12,733) $ (16,810) $ (31,010) $ (32,559)
Denominator:
Weighted-average number of common shares used in loss per share - basic and diluted 47,588,158 47,391,530 47,515,394 47,114,947
Loss per share - basic and diluted $ (0.27) $ (0.35) $ (0.65) $ (0.69)

Schedule of Potentially Dilutive Securities Excluded From the Computation of Diluted Weighted-Average Shares Outstanding
The following potentially dilutive securities, prior to the use of the treasury stock method, have been excluded from the computation of diluted weighted-average shares outstanding, as they would be anti-dilutive. For the three and six months ended June 30, 2022 and 2021, respectively, all of the Company’s options to purchase common stock, restricted stock units outstanding, and performance options were assumed to be anti-dilutive as earnings attributable to common stockholders was in a loss position.
Three and Six Months Ended June 30,
2022 2021
Options to purchase common stock 5,757,747 6,287,436
Restricted stock units 1,686,052 438,134
Performance units 960,000 —
Performance options 1,035,000 1,035,000

v3.22.2

Product Revenue Reserves and Allowances (Tables)
6 Months Ended

Jun. 30, 2022

Organization, Consolidation and Presentation of Financial Statements [Abstract]

Schedule of Product Revenue Allowance and Reserve Categories The following table summarizes activity in each of the product revenue allowance and reserve categories for the six months ended June 30, 2022 and 2021 (in thousands):
Chargebacks, Discounts, and Fees Government and other rebates Returns Total
Ending balance at December 31, 2021 $ 2,061 $ 24,604 $ 224 $ 26,889
Provision related to sales in the current year 10,447 63,772 262 74,481
Adjustments related to prior period sales — (435) — (435)
Credits and payments made (10,656) (58,624) (278) (69,558)
Ending balance at June 30, 2022 $ 1,852 $ 29,317 $ 208 $ 31,377
Ending balance at December 31, 2020 $ 1,891 $ 14,644 $ 2,572 $ 19,107
Provision related to sales in the current year 9,313 52,886 187 62,386
Adjustments related to prior period sales (54) (989) (2,249) (3,292)
Credits and payments made (9,677) (42,859) (189) (52,725)
Ending balance at June 30, 2021 $ 1,473 $ 23,682 $ 321 $ 25,476

v3.22.2

Organization (Details) - USD ($)
$ / shares in Units, $ in Thousands

Jun. 30, 2022

Dec. 31, 2021

Condensed Financial Statements, Captions [Line Items]

Accumulated deficit $ (1,398,990) $ (1,367,981)

Cash, cash equivalents, marketable securities, and investments $ 72,500

Common stock, par value (in dollars per share) $ 0.0001 $ 0.0001

Gurnet Point Capital | Radius Health, Inc.

Condensed Financial Statements, Captions [Line Items]

Acquisition price per share (in dollars per share) 10.00

Common stock, par value (in dollars per share) $ 1.00

Net sales $ 300,000

Revolving Credit Facility | Line of Credit

Condensed Financial Statements, Captions [Line Items]

Maximum borrowing capacity (up to) $ 25,000

v3.22.2

Inventory (Details) - USD ($)
$ in Thousands
6 Months Ended

Jun. 30, 2022

Dec. 31, 2021

Inventory Disclosure [Abstract]

Raw materials $ 7,716 $ 7,159

Work in process 1,377 1,335

Finished goods 3,398 2,879

Total inventories $ 12,491 $ 11,373

Finished goods shelf life (in months) 36 months

v3.22.2

Convertible Notes Payable - Narrative (Details)
1 Months Ended 3 Months Ended 6 Months Ended

Sep. 12, 2017

USD ($)

$ / shares

Mar. 31, 2021

USD ($)

Sep. 12, 2017

USD ($)

$ / shares

Jun. 30, 2022

USD ($)

Jun. 30, 2021

USD ($)

Jun. 30, 2022

USD ($)

day

business_day

$ / shares

Jun. 30, 2021

USD ($)

Aug. 14, 2017

USD ($)

Debt Instrument [Line Items]

Gain on extinguishment of debt $ 0 $ 0 $ 0 $ 1,960,000

3.00% Convertible notes | Convertible debt

Debt Instrument [Line Items]

Aggregate principal amount $ 5,000,000 $ 5,000,000 $ 300,000,000

Debt instrument stated rate (as a percent) 3.00% 3.00% 3.00%

Debt issuance costs $ 9,400,000 $ 9,400,000

Conversion ratio 0.0204801

Initial conversion price (in dollars per share) | $ / shares $ 48.81 $ 48.81

Repurchase price percentage (as a percent) 100.00% 100.00%

Conversion price (in dollars per share) | $ / shares $ 36.835

Repurchase aggregate principal amount $ 112,200,000

Repayments of debt 108,600,000

Gain on extinguishment of debt $ 2,000,000

Debt instrument term (in years) 7 years

Effective interest rate (as a percent) 3.43% 3.43%

3.00% Convertible notes | Convertible debt | Selling, General and Administrative Expenses

Debt Instrument [Line Items]

Third party costs $ 300,000

3.00% Convertible notes | Convertible debt | Stock price trigger at greater than or equal to 130%

Debt Instrument [Line Items]

Consecutive or non-consecutive trading days (in days) 20 days

Consecutive trading days (in days) | day 30

Percentage of stock price trigger (as a percent) 130.00%

3.00% Convertible notes | Convertible debt | Stock price trigger less than 98%

Debt Instrument [Line Items]

Consecutive trading days (in days) | day 5

Percentage of stock price trigger (as a percent) 98.00%

Trading days (in days) | business_day 5

3.00% Convertible notes | Convertible debt | Stock price trigger at greater than or equal to 130%, on or after September 1, 2021

Debt Instrument [Line Items]

Consecutive or non-consecutive trading days (in days) 20 days

Consecutive trading days (in days) | day 30

Percentage of stock price trigger (as a percent) 130.00%

Consecutive trading days, redemption notice period (in days) | day 5

v3.22.2

Convertible Notes Payable - Summary of Outstanding Balances of Convertible Notes (Details) - Convertible debt - 3.00% Convertible notes
$ in Thousands

Jun. 30, 2022

USD ($)

Debt Instrument [Line Items]

Principal $ 192,753

Less: debt discount and issuance costs (1,861)

Net carrying amount $ 190,892

v3.22.2

Convertible Notes Payable - Summary of Total Interest Expense Recognized Related to the Convertible Notes (Details) - Convertible debt - 3.00% Convertible notes - USD ($)
$ in Thousands
3 Months Ended 6 Months Ended

Jun. 30, 2022

Jun. 30, 2021

Jun. 30, 2022

Jun. 30, 2021

Debt Instrument [Line Items]

Contractual interest expense $ 1,446 $ 1,446 $ 2,892 $ 3,602

Amortization of debt discount 195 196 391 489

Amortization of debt issuance costs 11 11 22 26

Total interest expense $ 1,652 $ 1,653 $ 3,305 $ 4,117

v3.22.2

Convertible Notes Payable - Schedule of Future Minimum Payments on Long-Term Debt (Details) - Convertible debt - 3.00% Convertible notes
$ in Thousands

Jun. 30, 2022

USD ($)

Future Minimum Payments

2022 (excluding the 6 months ended June 30, 2022) $ 2,891

2023 5,783

2024 198,535

Total minimum payments 207,209

Less: interest (14,456)

Less: unamortized discount (1,861)

Net carrying amount $ 190,892

v3.22.2

Term Loan and Credit Facilities - Narrative (Details) - USD ($)
6 Months Ended

Mar. 11, 2021

Mar. 03, 2021

Jun. 30, 2022

Jun. 30, 2021

Line of Credit | Revolving Credit Facility

Debt Instrument [Line Items]

Maximum borrowing capacity (up to) $ 25,000,000

Debt instrument, covenant, percent net collectible value of accounts receivable (as a percent) 85.00%

Debt instrument, covenant, percent of eligible inventory (as a percent) 40.00%

Debt instrument, covenant, inventory percentage of availability (as a percent) 20.00%

Debt instrument, LIBOR floor (as a percent) 2.00%

Monthly commitment fee (as a percent) 0.50%

Debt instrument, covenant, required unrestricted cash balance $ 50,000,000

Debt instrument, covenant, minimum net revenue, period to achieve (in months) 12 months

Line of Credit | Revolving Credit Facility | London Interbank Offered Rate (LIBOR)

Debt Instrument [Line Items]

Basis spread (as a percent) 3.50%

Term Facility | Medium-term Notes

Debt Instrument [Line Items]

Aggregate principal amount $ 150,000,000

Increase in aggregate principal amount $ 125,000,000

Debt instrument, LIBOR floor (as a percent) 2.00%

Term Facility | Medium-term Notes | Selling, General and Administrative Expenses

Debt Instrument [Line Items]

Third party costs $ 2,800,000

Term Facility | Medium-term Notes | Debt Instrument, Tranche One

Debt Instrument [Line Items]

Aggregate principal amount $ 150,000,000

Proceeds from issuance of long-term debt $ 122,600,000

Debt issuance costs $ 2,400,000

Term Facility | Medium-term Notes | London Interbank Offered Rate (LIBOR)

Debt Instrument [Line Items]

Basis spread (as a percent) 5.75%

v3.22.2

Term Loan and Credit Facilities - Carrying Value (Details) - Medium-term Notes - Term Facility - USD ($)

Jun. 30, 2022

Mar. 03, 2021

Debt Instrument [Line Items]

Principal $ 150,000,000

Debt Instrument, Tranche One

Debt Instrument [Line Items]

Principal $ 150,000,000

Less: debt issuance costs (1,319,000)

Net carrying amount $ 148,681,000

v3.22.2

Term Loan and Credit Facilities - Interest Expense (Details) - Debt Instrument, Tranche One - Medium-term Notes - Term Facility - USD ($)
$ in Thousands
3 Months Ended 6 Months Ended

Jun. 30, 2022

Jun. 30, 2021

Jun. 30, 2022

Jun. 30, 2021

Debt Instrument [Line Items]

Contractual interest expense $ 2,968 $ 2,939 $ 5,929 $ 3,976

Amortization of debt discount 208 208 416 256

Total interest expense $ 3,176 $ 3,147 $ 6,345 $ 4,232

v3.22.2

Term Loan and Credit Facilities - Future Minimum Payments (Details) - Debt Instrument, Tranche One - Medium-term Notes - Term Facility
$ in Thousands

Jun. 30, 2022

USD ($)

Debt Instrument [Line Items]

2022 (excluding the 6 months ended June 30, 2022) $ 5,813

2023 61,302

2024 102,260

Total minimum payments 169,375

Less: interest (19,375)

Less: unamortized issuance costs (1,319)

Term loan $ 148,681

v3.22.2

Net Loss Per Share - Basic and Diluted (Details) - USD ($)
$ / shares in Units, $ in Thousands
3 Months Ended 6 Months Ended

Jun. 30, 2022

Mar. 31, 2022

Jun. 30, 2021

Mar. 31, 2021

Jun. 30, 2022

Jun. 30, 2021

Numerator:

Net loss $ (12,733) $ (18,276) $ (16,810) $ (15,749) $ (31,010) $ (32,559)

Denominator:

Weighted-average number of common shares used in loss per share - basic (in shares) 47,588,158 47,391,530 47,515,394 47,114,947

Weighted-average number of common shares used in loss per share - diluted (in shares) 47,588,158 47,391,530 47,515,394 47,114,947

Loss per share - basic (in dollars per share) $ (0.27) $ (0.35) $ (0.65) $ (0.69)

Loss per share - diluted (in dollars per share) $ (0.27) $ (0.35) $ (0.65) $ (0.69)

v3.22.2

Net Loss Per Share - Antidilutive Securities (Details) - shares
3 Months Ended 6 Months Ended

Jun. 30, 2022

Jun. 30, 2021

Jun. 30, 2022

Jun. 30, 2021

Options to purchase common stock

Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]

Potentially dilutive securities, prior to the use of the treasury stock method, excluded from the computation of diluted weighted-average shares outstanding, as they would be anti-dilutive (in shares) 5,757,747 6,287,436 5,757,747 6,287,436

Restricted stock units

Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]

Potentially dilutive securities, prior to the use of the treasury stock method, excluded from the computation of diluted weighted-average shares outstanding, as they would be anti-dilutive (in shares) 1,686,052 438,134 1,686,052 438,134

Performance units

Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]

Potentially dilutive securities, prior to the use of the treasury stock method, excluded from the computation of diluted weighted-average shares outstanding, as they would be anti-dilutive (in shares) 960,000 0 960,000 0

Performance options

Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]

Potentially dilutive securities, prior to the use of the treasury stock method, excluded from the computation of diluted weighted-average shares outstanding, as they would be anti-dilutive (in shares) 1,035,000 1,035,000 1,035,000 1,035,000

v3.22.2

Product Revenue Reserves and Allowances (Details) - USD ($)
$ in Thousands
6 Months Ended

Jun. 30, 2022

Jun. 30, 2021

Product Revenue Allowance and Reserves

Summary of Activity of Product Revenue Allowance and Reserves

Beginning balance $ 26,889 $ 19,107

Provision related to sales in the current year 74,481 62,386

Adjustments related to prior period sales (435) (3,292)

Credits and payments made (69,558) (52,725)

Ending balance 31,377 25,476

Chargebacks, Discounts, and Fees

Summary of Activity of Product Revenue Allowance and Reserves

Beginning balance 2,061 1,891

Provision related to sales in the current year 10,447 9,313

Adjustments related to prior period sales 0 (54)

Credits and payments made (10,656) (9,677)

Ending balance 1,852 1,473

Government and other rebates

Summary of Activity of Product Revenue Allowance and Reserves

Beginning balance 24,604 14,644

Provision related to sales in the current year 63,772 52,886

Adjustments related to prior period sales (435) (989)

Credits and payments made (58,624) (42,859)

Ending balance 29,317 23,682

Returns

Summary of Activity of Product Revenue Allowance and Reserves

Beginning balance 224 2,572

Provision related to sales in the current year 262 187

Adjustments related to prior period sales 0 (2,249)

Credits and payments made (278) (189)

Ending balance $ 208 $ 321

v3.22.2

License Revenue and Reimbursable Expenses (Details) - USD ($)
$ in Thousands
1 Months Ended 3 Months Ended 6 Months Ended

Mar. 31, 2021

Jul. 31, 2020

Jul. 31, 2017

Jun. 30, 2022

Jun. 30, 2021

Jun. 30, 2022

Jun. 30, 2021

Dec. 31, 2021

Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]

License agreements, upfront payment received $ 10,000

License agreements, first commercial sale anniversary 10 years

License revenue $ 58,285 $ 51,797 $ 101,443 $ 108,057

Reimbursable expenses 9,600 18,500 18,700 32,800

Receivable of reimbursable development expenses 12,200 12,200 $ 11,800

License receivables 5,750 5,750 $ 0

License revenue

Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]

License revenue $ 5,750 $ 0 5,950 $ 11,000

Berlin-Chemie

Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]

License agreements, upfront payment received $ 30,000

Reimbursement of cost 109,700

Reimbursement of cost, paid out $ 90,800

Collaborative agreement royalty period (in years) 10 years

Collaborative agreement, termination, period of no manufacture or commercialization activity (in months) 24 months

Collaborative agreement, termination, number of days of prior notice given by counterparty (in days) 180 days

Upfront payment received $ 30,000

Milestone payable (in days) 60 days

License 27,400

Inventory 2,600

License receivables $ 5,000 5,000

Berlin-Chemie | License revenue

Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]

License revenue $ 5,000

Berlin-Chemie | Maximum

Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]

Development and regulatory milestone payments receivable 20,000

Sales milestone payments receivable $ 300,000

Collaborative Arrangement | Teijin Agreement

Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]

License agreements, upfront payment received $ 10,000 $ 10,000

Additional payments to be made upon achievement of certain milestones (up to) $ 40,000

v3.22.2

Commitments and Contingencies - Manufacturing Agreements (Details)
€ in Millions, SFr in Millions, $ in Millions
1 Months Ended 38 Months Ended 52 Months Ended

Jun. 10, 2022

USD ($)

Jun. 01, 2017

Jun. 28, 2016

USD ($)

Jun. 28, 2016

EUR (€)

Dec. 31, 2020

USD ($)

May 31, 2020

USD ($)

May 31, 2020

CHF (SFr)

Jun. 30, 2016

Dec. 03, 2021

USD ($)

Jun. 30, 2022

USD ($)

3M Company | Collaborative Arrangement

Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]

Additional payments to be made upon achievement of certain sales milestones $ 30.0

3M And Kindeva | 3M Company | Collaborative Arrangement

Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]

Termination expenses $ 3.2

Nonrefundable, non-creditable payment $ 31.8 $ 70.9

Ypsomed Supply Agreement

Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]

Services agreement, term (in years) 3 years

Services agreement, renewal term (in years) 2 years 2 years 2 years 2 years

Services agreement, additional renewal term (in years) 2 years 2 years

Service agreement, period required for notice of non-renewal (in months) 18 months

Total minimum payments inclusive of milestone payments and one-time capacity fee $ 2.0 SFr 1.9

Services agreement, termination period (in years) 2 years

Lonza Agreement

Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]

Services agreement, term (in years) 6 years 6 years

Services agreement, renewal term (in years) 3 years 3 years

Service agreement, period required for notice of non-renewal (in months) 24 years 24 years

Collaborative arrangements, annual minimum batches $ 3.0 € 2.9

Collaborative arrangements, aggregate minimum payments $ 17.2

Fresh Cut Development L L C

Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]

Additional payments to be made upon achievement of certain clinical and regulatory milestones $ 60.0

Collaborative arrangement, expected milestone payments $ 2.5

v3.22.2

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 "version": "2.1"
}

Condensed Consolidated Balance Sheets - USD ($) $ in Thousands	Jun. 30, 2022	Dec. 31, 2021
Current assets:
Cash and cash equivalents	$ 72,491	$ 111,533
Restricted cash	567	567
Accounts receivable, net	26,260	23,355
Inventory	12,491	11,373
Prepaid expenses	16,674	10,050
License receivables	5,750	0
Other current assets	12,178	16,201
Total current assets	146,411	173,079
Property and equipment, net	912	647
Intangible assets	4,587	4,986
Right of use assets - operating leases	829	835
Other assets	1,701	1,995
Total assets	154,440	181,542
Current liabilities:
Accounts payable	14,485	17,625
Accrued expenses and other current liabilities	72,956	76,549
Operating lease liability, current	418	613
Total current liabilities	87,859	94,787
Convertible notes payable	190,892	190,479
Term loan	148,681	148,265
Operating lease liability, long term	411	315
Total liabilities	427,843	433,846
Stockholders’ deficit:
Common stock, 0.0001 par value; 200,000,000 shares authorized, 47,607,604 shares and 47,359,573 shares issued and outstanding at June 30, 2022 and December 31, 2021, respectively	5	5
Additional paid-in-capital	1,125,532	1,115,672
Accumulated other comprehensive income	50	0
Accumulated deficit	(1,398,990)	(1,367,981)
Total stockholders’ deficit	(273,403)	(252,304)
Total liabilities and stockholders’ deficit	$ 154,440	$ 181,542

Condensed Consolidated Balance Sheets (Parenthetical) - $ / shares	Jun. 30, 2022	Dec. 31, 2021
Statement of Financial Position [Abstract]
Common stock, par value (in dollars per share)	$ 0.0001	$ 0.0001
Common stock, shares authorized (in shares)	200,000,000	200,000,000
Common stock, shares issued (in shares)	47,607,604	47,359,573
Common stock, shares outstanding (in shares)	47,607,604	47,359,573

Condensed Consolidated Statements of Operations and Comprehensive Loss (Parenthetical) - USD ($) $ in Millions	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Income Statement [Abstract]
Reimbursable expenses	$ 9.6	$ 18.5	$ 18.7	$ 32.8

Condensed Consolidated Statements of Shareholders' Deficit - USD ($) $ in Thousands	Total	Cumulative Effect, Period of Adoption, Adjustment	Common Stock	Additional Paid-In Capital	Additional Paid-In Capital Cumulative Effect, Period of Adoption, Adjustment	Accumulated Other Comprehensive Income (Loss)	Accumulated Deficit	Accumulated Deficit Cumulative Effect, Period of Adoption, Adjustment
Beginning balance (in shares) at Dec. 31, 2020			46,779,479
Beginning balance at Dec. 31, 2020	$ (123,659)	$ (86,433)	$ 5	$ 1,222,137	$ (134,450)	$ 21	$ (1,345,822)	$ 48,017
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Net loss	(15,749)						(15,749)
Unrealized gain from available-for-sale securities	(21)					(21)
Vesting of restricted shares (in shares)			202,018
Exercise of options (in shares)			193,300
Exercise of options	$ 3,764			3,764
Issuance of common stock upon purchase by employee stock purchase plan (in shares)	66,301
Issuance of common stock upon purchase by employee stock purchase plan	$ 678			678
Share-based compensation expense	5,410
Ending balance (in shares) at Mar. 31, 2021			47,241,098
Ending balance at Mar. 31, 2021	(216,010)		$ 5	1,097,539		0	(1,313,554)
Beginning balance (in shares) at Dec. 31, 2020			46,779,479
Beginning balance at Dec. 31, 2020	(123,659)	$ (86,433)	$ 5	1,222,137	$ (134,450)	21	(1,345,822)	$ 48,017
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Net loss	(32,559)
Unrealized gain from available-for-sale securities	(21)
Foreign currency translation adjustment	0
Ending balance (in shares) at Jun. 30, 2021			47,255,094
Ending balance at Jun. 30, 2021	(227,077)		$ 5	1,103,282		0	(1,330,364)
Beginning balance (in shares) at Mar. 31, 2021			47,241,098
Beginning balance at Mar. 31, 2021	(216,010)		$ 5	1,097,539		0	(1,313,554)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Net loss	(16,810)						(16,810)
Unrealized gain from available-for-sale securities	0
Foreign currency translation adjustment	0
Vesting of restricted shares (in shares)			11,621
Exercise of options (in shares)			2,375
Exercise of options	40			40
Share-based compensation expense	5,703
Ending balance (in shares) at Jun. 30, 2021			47,255,094
Ending balance at Jun. 30, 2021	(227,077)		$ 5	1,103,282		0	(1,330,364)
Beginning balance (in shares) at Dec. 31, 2021			47,359,573
Beginning balance at Dec. 31, 2021	(252,304)		$ 5	1,115,672		0	(1,367,981)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Net loss	(18,276)						(18,276)
Foreign currency translation adjustment	6
Vesting of restricted shares (in shares)			139,056
Share-based compensation expense related to share-based awards for employee stock purchase plan	$ 113			113
Issuance of common stock upon purchase by employee stock purchase plan (in shares)	66,135
Issuance of common stock upon purchase by employee stock purchase plan	$ 482			482
Share-based compensation expense	4,032			4,032
Ending balance (in shares) at Mar. 31, 2022			47,564,764
Ending balance at Mar. 31, 2022	(265,947)		$ 5	1,120,299		6	(1,386,257)
Beginning balance (in shares) at Dec. 31, 2021			47,359,573
Beginning balance at Dec. 31, 2021	(252,304)		$ 5	1,115,672		0	(1,367,981)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Net loss	(31,010)
Unrealized gain from available-for-sale securities	0
Foreign currency translation adjustment	50
Ending balance (in shares) at Jun. 30, 2022			47,607,604
Ending balance at Jun. 30, 2022	(273,403)		$ 5	1,125,532		50	(1,398,990)
Beginning balance (in shares) at Mar. 31, 2022			47,564,764
Beginning balance at Mar. 31, 2022	(265,947)		$ 5	1,120,299		6	(1,386,257)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Net loss	(12,733)						(12,733)
Unrealized gain from available-for-sale securities	0
Foreign currency translation adjustment	44
Vesting of restricted shares (in shares)			40,901
Share-based compensation expense related to share-based awards for employee stock purchase plan	125			125
Issuance of common stock upon purchase by employee stock purchase plan (in shares)			1,939
Issuance of common stock upon purchase by employee stock purchase plan	0
Share-based compensation expense	5,108			5,108
Ending balance (in shares) at Jun. 30, 2022			47,607,604
Ending balance at Jun. 30, 2022	$ (273,403)		$ 5	$ 1,125,532		$ 50	$ (1,398,990)

Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021
CASH FLOWS USED IN OPERATING ACTIVITIES:
Net loss	$ (31,010)	$ (32,559)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	777	494
Amortization of premium/discount on marketable securities, net	0	19
Amortization of debt discount and debt issuance costs	829	771
Share-based compensation	9,378	11,113
Gain on extinguishment of debt	0	(1,960)
Gain on the lease termination	0	(901)
Changes in operating assets and liabilities:
Inventory	(1,118)	(2,136)
Accounts receivable, net	(2,905)	(3,328)
Prepaid expenses	(6,624)	1,877
License receivables	(5,750)	0
Other current assets	4,023	(15,959)
Operating lease right of use assets	302	667
Other long-term assets	0	(967)
Accounts payable	(3,090)	4,637
Deferred revenue	0	(1,000)
Accrued expenses and other current liabilities	(3,592)	6,327
Lease liability, operating leases	(395)	(1,199)
Net cash used in operating activities	(39,175)	(34,104)
CASH FLOWS PROVIDED BY INVESTING ACTIVITIES:
Purchases of property and equipment	(349)	0
Sales and maturities of marketable securities	0	23,240
Net cash (used in) provided by investing activities	(349)	23,240
CASH FLOWS PROVIDED BY FINANCING ACTIVITIES:
Proceeds from exercise of stock options	0	3,804
Proceeds from issuance of term loan, net of issuance costs	0	122,687
Repurchase of convertible notes	0	(108,568)
Proceeds from issuance of shares under employee stock purchase plan	482	678
Net cash provided by financing activities	482	18,601
NET (DECREASE) INCREASE IN CASH, CASH EQUIVALENTS, AND RESTRICTED CASH	(39,042)	7,737
CASH, CASH EQUIVALENTS, AND RESTRICTED CASH AT BEGINNING OF PERIOD	112,100	92,003
CASH, CASH EQUIVALENTS, AND RESTRICTED CASH AT END OF PERIOD	73,058	99,740
SUPPLEMENTAL DISCLOSURES:
Cash paid for interest	8,704	7,622
Cash paid for amounts included in the measurement of operating lease liabilities	412	1,340
Right of use assets obtained in exchange for operating lease liability	$ 488	$ 332

Organization	6 Months Ended
Organization	Jun. 30, 2022
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Organization	Organization Radius Health, Inc. (“Radius,” the “Company,” “us,” “our” or “we”) is a global biopharmaceutical company focused on addressing unmet medical needs in the areas of bone health, neuroscience, and oncology. In April 2017, the Company’s first commercial product, TYMLOS (abaloparatide) injection, was approved by the U.S. Food and Drug Administration (“FDA”) for the treatment of postmenopausal women with osteoporosis at high risk for fracture defined as history of osteoporotic fracture, multiple risk factors for fracture, or patients who have failed or are intolerant to other available osteoporosis therapy. We are also developing certain assets we acquired related to formulations of cannabidiol related to the oral administration of a solution of CBD for therapeutic use in humans or animals (“RAD011”), for which the Company intends to seek FDA approval for a Phase 2/3 trial for treatment of hyperphagia behavior and weight loss in patients with Prader Willi syndrome (“PWS”). In June 2022, with support from the Company, our licensee, Berlin-Chemie AG, a company of the Menarini Group (“Berlin-Chemie”), submitted a New Drug Application (“NDA”) to the FDA for elacestrant in patients with ER+/HER2- advanced or metastatic breast cancer. The NDA submission was based on positive top-line results from the EMERALD Phase 3 study of our investigational product candidate elacestrant that was previously announced in October 2021. Berlin-Chemie holds an exclusive, worldwide license to develop and commercialize products containing elacestrant. The Company is subject to risks common to companies in its industry including, but not limited to, the dependence on revenues from a single commercialized product, competition, uncertainty about clinical trial outcomes and regulatory approvals, uncertainties relating to pharmaceutical pricing reimbursement, uncertain protection of proprietary technology and potential product liability. As of June 30, 2022, the Company had an accumulated deficit of $1,399.0 million, and total cash and cash equivalents of $72.5 million. Based upon its cash and cash equivalents balance and the $25.0 million secured revolving credit facility available to the Company under its Revolving Credit Agreement with MidCap Funding IV Trust as discussed in Note 6, “Term Loan and Credit Facilities” as of June 30, 2022, the Company believes that, prior to the consideration of revenue from the potential future sales of any of its investigational products that may receive regulatory approval or proceeds from partnering and/or collaboration activities, it has sufficient capital to fund its commercial operations, development plans, and other operational activities for at least one year from the date of this filing. The Company expects to finance its ongoing and future operations with its product revenue, existing cash and cash equivalents, or through strategic financing opportunities that could include, but are not limited to collaboration agreements or the incurrence of debt. However, there is no guarantee that any strategic or financing opportunities will be executed or executed on favorable terms, and some could be dilutive to existing stockholders. Pending Transaction On June 23, 2022, the Company entered into an Agreement and Plan of Merger (the “Merger Agreement”) with Ginger Acquisition, Inc., (“Parent”), a subsidiary jointly owned by affiliates of Gurnet Point Capital, LLC and Patient Square Capital, LP, and Ginger Merger Sub, Inc., a wholly owned subsidiary of Parent (“Purchaser”). Pursuant to the Merger Agreement, and upon the terms and subject to the conditions thereof, Purchaser has commenced a tender offer (the “Offer”) to purchase each issued and outstanding share (the “Shares”) of common stock of the Company (the “Common Stock”) in exchange for an amount in cash equal to $10.00 and one contractual contingent value right (a “CVR”) that will represent the right to receive a contingent payment of $1.00 in cash, without interest but subject to applicable withholding upon the achievement of the sum of (A) cumulative net sales of TYMLOS in the United States and (B) either (i) royalty payments based on sales of TYMLOS in Japan or (ii) if and at such time that no such royalty payments are owed, supply payments based on the supply of TYMLOS for sale in Japan that together exceed $300 million during any consecutive 12-month period beginning on the date of the CVR Agreement (defined below) and ending on or prior to December 31, 2025, pursuant to a Contingent Value Rights Agreement (the “CVR Agreement”) to be entered into between Parent and a rights agent. The Offer is currently scheduled to expire at one minute after 11:59 p.m. Eastern Time on August 10, 2022, the twentieth business day following the commencement of the Offer, but may be extended in accordance with the terms of the Merger Agreement. Subject to the terms and conditions of the Merger Agreement, if certain conditions are satisfied and the Offer closes, Parent, no later than the second day following the satisfaction of such conditions, would acquire any remaining shares by virtue of a merger of Purchaser with and into the Company (the “Merger”), with the Company being the surviving corporation and a wholly-owned subsidiary of Parent. If the Merger is consummated, the Company will cease to be a publicly-traded company. The consummation of the transaction is subject to customary closing conditions, including the Company’s stockholders tendering a minimum number of Shares in the Offer and receipt of regulatory approvals.

Basis of Presentation and Significant Accounting Policies	6 Months Ended
	Jun. 30, 2022
Accounting Policies [Abstract]
Basis of Presentation and Significant Accounting Policies	Basis of Presentation and Significant Accounting Policies Basis of Presentation The accompanying unaudited condensed consolidated financial statements and the related disclosures of the Company have been prepared in accordance with accounting principles generally accepted in the United States (“U.S. GAAP”) for interim financial reporting and as required by Regulation S-X, Rule 10-01. Accordingly, they do not include all the information and footnotes required by U.S. GAAP for complete financial statements. In the opinion of management, all adjustments (including those which are normal and recurring) considered necessary for a fair presentation of the interim financial information have been included. When preparing financial statements in conformity with U.S. GAAP, the Company must make estimates and assumptions that affect the reported amounts of assets, liabilities, revenue, expenses and related disclosures at the date of the financial statements. Actual results could differ from those estimates. Additionally, operating results for the three and six months ended June 30, 2022 are not necessarily indicative of the results that may be expected for any other interim period or for the fiscal year ending December 31, 2022. Subsequent events have been evaluated up to the date of issuance of these financial statements. These interim condensed consolidated financial statements should be read in conjunction with the audited consolidated financial statements and notes, which are contained in the Company’s Annual Report on Form 10-K for the year ended December 31, 2021, filed with the Securities and Exchange Commission (“SEC”) on February 24, 2022. Significant Accounting Policies The significant accounting policies identified in the Company’s Annual Report on Form 10-K for the year ended December 31, 2021 that require the Company to make estimates and assumptions include: revenue recognition, inventory obsolescence, long-lived assets and intangible assets, accounting for share-based compensation, contingencies, tax valuation reserves, fair value measures, and accrued expenses. There were no changes to significant accounting policies during the six months ended June 30, 2022. Recent Accounting Standards Not Yet Adopted There are no applicable material accounting pronouncements recently issued that have not yet been adopted by the Company.

License Revenue and Reimbursable Expenses	6 Months Ended
License Revenue and Reimbursable Expenses	Jun. 30, 2022
Organization, Consolidation and Presentation of Financial Statements [Abstract]
License Revenue and Reimbursable Expenses	License Revenue and Reimbursable Expenses General The Company has generated revenue from contracts with customers, which include upfront payments for licenses. Teijin In July 2017, the Company entered into a License and Development Agreement (the “Teijin Agreement”) with Teijin Limited (“Teijin”) for abaloparatide for subcutaneous injection (“abaloparatide-SC”) in Japan. Pursuant to the Teijin Agreement, the Company granted Teijin: (i) an exclusive payment-bearing license under certain of the Company’s intellectual property to develop and commercialize abaloparatide-SC in Japan, (ii) a non-exclusive payment-bearing license under certain of the Company’s intellectual property to manufacture abaloparatide-SC for commercial supply in Japan, (iii) a right of reference to certain of the Company’s regulatory data related to abaloparatide-SC for purposes of developing, manufacturing and commercializing abaloparatide-SC in Japan, (iv) a manufacture transfer package, upon Teijin’s request, consisting of information and the Company’s know-how that is necessary for the manufacture of active pharmaceutical ingredient and abaloparatide-SC, (v) a right, at Teijin’s request, to have the Company manufacture (or arrange for a third party to manufacture) and supply (or arrange for a third party to supply) the active pharmaceutical ingredient for the clinical supply of abaloparatide-SC in sufficient quantities to enable Teijin to conduct its clinical trials in Japan, and (vi) a right to request that the Company arrange for Teijin to directly enter into commercial supply agreements with the Company’s existing contract manufacturers on the same pricing terms and on substantially similar commercial terms to those set forth in the Company’s existing agreements with such contract manufacturers. In consideration for these rights, the Company received an upfront payment of $10.0 million, and may receive further payments upon the achievement of certain regulatory and sales milestones, as well as a fixed low double-digit royalty based on net sales of abaloparatide-SC in Japan during the royalty term, as defined below. In addition, the Company has an option to negotiate a co-promotion agreement with Teijin for abaloparatide-SC in Japan upon commercialization. Pursuant to the Teijin Agreement, the parties may further collaborate on new indications for abaloparatide-SC. The Company also maintains full global rights to the abaloparatide-coated transdermal system product (“abaloparatide-TD”) that we are developing with Kindeva Drug Delivery (“Kindeva”), which is not currently part of the Teijin Agreement. Unless earlier terminated, the Teijin Agreement expires on the later of the (i) date on which the use, sale or importation of abaloparatide-SC is no longer covered by a valid claim under the Company’s patent rights licensed to Teijin in Japan, (ii) expiration of marketing or data exclusivity for abaloparatide-SC in Japan, or (iii) 10th anniversary of the first commercial sale of abaloparatide-SC in Japan. The Company assessed this arrangement in accordance with Topic 606 and concluded that the contract counterparty, Teijin, is a customer. The Company identified the following material promises under the contract: the commercialization and manufacturing licenses under certain intellectual property rights relating to abaloparatide-SC in Japan, as well as the right of reference to certain regulatory information. In addition, the Company identified the following customer option that would create an obligation for the Company if exercised by Teijin - the transfer of manufacturing know-how. The customer option for the transfer of manufacturing know-how represents a material right. Finally, the Company also identified the following customer option that would create a manufacturing obligation for the Company if exercised by Teijin - the supply of abaloparatide-SC for Teijin’s clinical trial needs. The customer option for clinical supply of abaloparatide-SC does not represent a material right. Based on these assessments, the Company identified the (i) commercialization and manufacturing licenses, as well as the right of reference to certain regulatory information, and (ii) transfer of manufacturing know-how as the only performance obligations at the inception of the arrangement, which were both deemed to be distinct. The Company further determined that the up-front payment of $10.0 million constituted the entirety of the consideration to be included in the transaction price, which was allocated to the performance obligations based on the Company’s best estimate of their relative stand-alone selling prices. For the commercialization and manufacturing licenses, including the right of reference to certain regulatory information, the stand-alone selling price was calculated using the expected cost approach by leveraging the direct costs incurred by the Company in its ACTIVExtend Phase 3 clinical trial for abaloparatide-SC, plus an estimated inflation rate. The stand-alone selling price of the transfer of manufacturing know-how was computed using a cost plus margin approach reflecting the level of effort required, which can be reasonably estimated to be incurred over the performance period, multiplied by a fully-burdened internal labor rate plus an expected margin. Based on the estimates of the stand-alone selling prices for each of the performance obligations, as referenced above, the Company determined that substantially all of the $10.0 million transaction price should be allocated to the performance obligation for the commercialization and manufacturing licenses, including the right of reference to certain regulatory information. The consideration allocated to the performance obligation for the transfer of manufacturing know-how was immaterial. The Company believes that a change in the assumptions used to determine its best estimate of the selling price for the commercialization and manufacturing licenses, including the right of reference to certain regulatory information, would not have a significant effect on the allocation of the underlying consideration to the performance obligations. Upon execution of the Teijin Agreement, the transaction price included only the $10.0 million up-front payment owed to the Company. As referenced above, the Company has received and may receive further payments upon the achievement of certain regulatory and sales milestones, totaling up to $40.0 million, as well as a fixed low double-digit royalty based on net sales of abaloparatide-SC in Japan during the royalty term. The regulatory milestone, which represents variable consideration that was evaluated under the most likely amount method, was not included in the transaction price, because the amount was fully constrained. As part of its evaluation of the constraint, the Company considered numerous factors, including that receipt of the milestone was outside the control of the Company. Any consideration related to sales-based milestones as well as royalties on net sales upon commercialization by Teijin, will be recognized when the related sales occur as they were determined to relate predominantly to the licenses granted to Teijin and, therefore, have also been excluded from the transaction price in accordance with the sales-based royalty exception. The Company will re-evaluate the transaction price in each reporting period, as uncertain events are resolved, or as other changes in circumstances occur. In March 2021, Teijin received approval for Ostabaro® abaloparatide acetate for the treatment of osteoporosis and for promotion of bone formation in both female and male patients with high risk fracture. Upon achievement of this regulatory milestone the Company received a payment of $10.0 million from Teijin, which was recognized as license revenue during the three months ended June 30, 2021. Berlin-Chemie In July 2020, the Company entered into to a license agreement (“License Agreement”) with Berlin-Chemie under which the Company granted Berlin-Chemie an exclusive license to develop and commercialize products containing elacestrant (RAD1901) worldwide. The Company and Berlin-Chemie simultaneously entered into a Transition Services Agreement (the “TSA”), pursuant to which the Company has agreed to perform certain services for Berlin-Chemie related to the EMERALD Phase 3 monotherapy study until the earlier of the completion of the contemplated services or the filing with the FDA of a NDA for elacestrant. Following submission of the NDA for elacestrant in patients with ER+/HER2- advanced or metastatic breast cancer, the Company no longer has any obligations to perform services for Berlin-Chemie. Pursuant to the TSA as amended in June 2022, Berlin-Chemie agreed to reimburse the Company for all out-of-pocket and full-time employee costs in performing the services, for total estimated reimbursements of $109.7 million of which $90.8 million has been reimbursed through June 30, 2022. Pursuant to the terms of the License Agreement, Berlin-Chemie made a nonrefundable initial license fee payment to the Company of $30.0 million in July 2020. The Company is also eligible to receive up to $20.0 million in development and regulatory milestone payments and up to $300.0 million in sales milestone payments, with such payments contingent on the achievement of specified milestones with respect to the licensed products. The Company is also eligible to receive tiered royalties on sales of licensed products at percentages ranging from low to mid-teens, subject to certain reductions. Royalties on net sales will be payable on a product-by-product and country-by-country basis until the latest of the expiration date of the last to expire of the relevant patent rights, the expiration of regulatory exclusivity, or ten years from such first commercial sale. The License Agreement will continue on a licensed product-by-licensed product and country-by-country basis until the last to expire royalty term. Either party may terminate the License Agreement for an uncured material breach by the other party or upon the bankruptcy or insolvency of the other party. The Company may terminate the License Agreement for certain patent challenges or if no development, manufacture or commercialization activity occurs in any given 24-month period. Berlin-Chemie may terminate the License Agreement at its discretion for any reason by delivering 180 days’ prior written notice to the Company; provided that such termination will not be effective prior to the third anniversary of the effective date. The Company determined that the License Agreement and TSA should be combined and evaluated as a single arrangement as they were executed on the same date and negotiated as a package. The arrangement with Berlin-Chemie provides for the transfer of the following goods or services: (i) license, (ii) know-how, (iii) regulatory filings, (iv) inventory, (v) transition services, including certain clinical, manufacturing, regulatory and other services associated with the Phase 3 EMERALD monotherapy study, and (vi) participation in various joint committees. Management applied the guidance in ASC 606 to identify all distinct goods and services within the arrangement to assess whether there is a unit of account that should be accounted for under ASC 606. Management evaluated all of the promised goods or services within the contract and determined which of those were separate performance obligations. The Company determined that the license granted, at arrangement inception, should be combined with the know-how and regulatory filings as they are not capable of being distinct (the “License”). The Company also concluded that the license rights, know-how, and regulatory filings are capable of being distinct from the supply of inventory, as Berlin-Chemie would be able to benefit from the inventory on its own or with other resources that are readily available, and capable of being distinct from the transition services and participation in joint committees as these are research and development services that can typically be performed by other third parties. The License and the initial transfer of inventory are elements of the arrangement that are subject to the revenue recognition accounting guidance, as the performance obligations are an output of the Company’s ordinary activities in exchange for consideration. Conversely, the transition services, and the participation on joint committees are elements of the arrangements that are outside the scope of the revenue recognition guidance, as the Company is providing goods and services that are not an output of the Company’s ordinary activities. The transaction price at inception was comprised of fixed consideration of $30.0 million. The $30.0 million upfront fee, which represents the fixed consideration in the transaction price, was allocated to the License and the supply of inventory, on a relative standalone selling price basis. The Company estimated the standalone selling price for the License by applying a risk adjusted, net present value, estimate of future potential cash flows approach and determined the standalone selling price for the inventory using a cost approach. Accordingly, the Company has allocated $27.4 million to the License and $2.6 million to the inventory. The Company concluded that the reimbursements for the research and development transition services and participation in the joint steering committees was commensurate with the standalone selling prices of the services, and as such, will be attributed to those services. The reimbursements for these services are recorded as a reduction of the related research and development expenses as the expenses are incurred. Under the Berlin-Chemie agreements, the Company is eligible to receive various development and regulatory, and sales milestones. In June 2022, Berlin-Chemie, with support from the Company, submitted an NDA to the FDA for elacestrant in patients with ER+/HER2- advanced or metastatic breast cancer, which submission triggered one of the three development and commercialization milestones. Accordingly, the Company recorded $5.0 million in License revenue during the three months ended June 30, 2022 that is payable within 60 days after achievement of the milestone. There is uncertainty that the remaining events to obtain the development and regulatory milestones will be achieved. The Company has thus determined that all such milestones will be constrained until it is deemed probable that a significant revenue reversal will not occur. Additional transaction price recognized in future periods related to milestone payments and royalties will be allocated solely to the License. Sales milestones and sales-based royalties were also excluded from the transaction price as the License is deemed to be the predominant item to which the sales milestones and sales-based royalties relate. The Company will recognize such revenue at the later of (i) when the related sales occur, or (ii) when the performance obligation to which some or all of the royalty has been allocated has been satisfied (or partially satisfied). During the three and six months ended June 30, 2022 and 2021, the Company recorded $9.6 million and $18.7 million for the three and six months ended June 30, 2022, respectively, and $18.5 million and $32.8 million for the three and six months ended June 30, 2021, respectively, as reductions of research and development expenses for reimbursement of transition services performed under the TSA. As of June 30, 2022 and December 31, 2021, the Company had receivable balances of $12.2 million and $11.8 million, respectively, related to reimbursable research and development expenses under this agreement, which is presented in other current assets on the condensed consolidated balance sheet. The Company also had a license receivable of $5.0 million related to achievement of milestones under the License Agreement, which is presented in License receivables on the condensed consolidated balance sheet.

Commitments and Contingencies	6 Months Ended
Commitments and Contingencies	Jun. 30, 2022
Commitments and Contingencies Disclosure [Abstract]
Commitments and Contingencies	Commitments and Contingencies Litigation From time to time, the Company may become subject to legal proceedings and claims which arise in the ordinary course of its business. The Company records a liability in its condensed consolidated financial statements for these matters when a loss is known or considered probable and the amount can be reasonably estimated. The Company reviews these estimates each accounting period as additional information is known and adjusts the loss provision when appropriate. If a matter is both probable to result in a liability and the amounts of loss can be reasonably estimated, the Company estimates and discloses the possible loss or range of loss to the extent necessary to make the condensed consolidated financial statements not misleading. If the loss is not probable or cannot be reasonably estimated, a liability is not recorded in its consolidated financial statements. As of June 30, 2022, the Company was not party to any significant litigation. Kindeva The Company was, until June 10, 2022, a party to a Scale-Up and Commercial Supply Agreement (the “Supply Agreement”) with Kindeva Drug Delivery (“Kindeva”) as successor to 3M Company and 3M Innovative Properties Company (collectively with 3M Company, “3M”), pursuant to which Kindeva agreed to exclusively manufacture Phase 3 and global commercial supplies of an abaloparatide-coated transdermal system (“abaloparatide-TD”). Under the Supply Agreement, Kindeva manufactured abaloparatide-TD for the Company according to agreed-upon specifications in sufficient quantities to meet the Company’s projected supply requirements. If abaloparatide-TD is commercialized, Kindeva would have manufactured commercial supplies of abaloparatide-TD at unit prices that decrease with an increase in the quantity the Company orders. The Company would have paid Kindeva a mid-to-low single-digit royalty on worldwide net sales of abaloparatide-TD and reimburse Kindeva for certain capital expenditures incurred to establish commercial supply of abaloparatide-TD. The Company was responsible for providing, at its expense, supplies of abaloparatide drug substance to be used in manufacturing abaloparatide-TD. During the term of the Supply Agreement, Kindeva and the Company agreed to work exclusively with each other with respect to the delivery of abaloparatide, parathyroid hormone (“PTH”), and/or PTH related proteins via active transdermal, intradermal, or microneedle technology. In December 2021, the Company announced the results of its Phase 3 clinical trial for abaloparatide-TD whereby the wearABLe Trial did not meet its primary or secondary endpoints. Based upon both the Company’s internal analysis and regulatory feedback from the FDA on possible paths forward for abaloparatide-TD, in June 2022 the Company announced the decision to cease all work on abaloparatide-TD, and the Company terminated the Supply Agreement effective June 10, 2022 as permitted within the terms of the contract which allows for the Company to terminate the Supply Agreement upon the occurrence of certain events, including if the Company ceased development or commercialization of abaloparatide-TD. As a result, the Company recorded approximately $3.2 million in expenses related to the termination of the abaloparatide-TD program. The Company has paid 3M and Kindeva approximately $70.9 million, in the aggregate, through June 30, 2022 with respect to performance under the Supply Agreement. Until June 2022, the Company was a party to the Development and Clinical Supplies Agreement with 3M, as amended (the “Development Agreement”), under which abaloparatide-TD development activities occurred and 3M manufactured phase 1 and 2 clinical trial supplies on an exclusive basis. The initial term of the Development Agreement remained in effect until June 2022 when the Supply Agreement was terminated. The Company has paid 3M and Kindeva approximately $31.8 million, in the aggregate, through June 30, 2022 with respect to performance under the Development Agreement. Manufacturing Agreements The Company is a party to a Supply Agreement with Ypsomed AG (“Ypsomed”), as amended, pursuant to which Ypsomed has agreed to supply commercial and clinical supplies of a disposable pen injection device customized for subcutaneous injection of abaloparatide, the active pharmaceutical ingredient (“API”) for TYMLOS. The Company has agreed to purchase a minimum number of devices at prices per device that decrease with an increase in quantity supplied. In addition, the Company has made milestone payments for Ypsomed’s capital developments in connection with the initiation of the commercial supply of the device and to pay a one-time capacity fee. All costs and payments under the agreement are delineated in Swiss Francs. The agreement had an initial term of three years, which began on June 1, 2017, after which it automatically renewed for a two-year term. Following its current term, the agreement automatically renews for additional two-year terms unless either party terminates the agreement upon 18 months’ notice prior to the end of the then-current term. During the two-year term beginning May 2020, the Company is required to purchase a minimum number of batches for CHF 1.9 million (approximately $2.0 million). The Company is also a party to a Commercial Supply Agreement with Vetter Pharma International GmbH (“Vetter”), as amended, pursuant to which Vetter has agreed to formulate the finished abaloparatide-SC drug product containing abaloparatide, the API, to fill cartridges with the drug product, to assemble the pen delivery device, and to package the pen for commercial distribution. The Company has agreed to purchase the cartridges and pens in specified batch sizes at a price per unit. For labeling and packaging services, the Company has agreed to pay a per unit price dependent upon the number of pens loaded with cartridges that are labeled and packaged. These prices are subject to an annual price adjustment. The term of the agreement automatically renewed on January 1, 2021 for an additional two-year term and will automatically renew for additional two-year terms thereafter, unless either party notifies the other party two years before the end of the then-current term that it does not intend to renew. The Company is also a party to a Manufacturing Services Agreement with Polypeptide Laboratories Holding AB (“PPL”), as amended, as successor-in-interest to Lonza Group Ltd., pursuant to which PPL has agreed to manufacture the commercial and clinical supplies of the API for abaloparatide. The Company has agreed to purchase the API in batches at a price per gram in euros, subject to an annual increase by PPL. The Company is also required to purchase a minimum number of batches annually, equal to €2.9 million (approximately $3.0 million) per year and $17.2 million in total through the year ended December 31, 2022. The agreement has an initial term of six years, which began on June 28, 2016, after which it automatically renews for three-year terms unless either party provides notice of non-renewal 24 months before the end of the then-current term. Asset Purchase Agreement In December 2020, the Company entered into an Asset Purchase Agreement with Fresh Cut Development, LLC and Benuvia Therapeutics Inc. for the acquisition of certain assets related to formulations of cannabidiol (“CBD”) related to the oral administration of a liquid formulation of CBD for therapeutic use in humans or animals (“RAD011”). Under the terms of the agreement, the Company may be obligated to make additional payments of up to $60.0 million in future periods, which would become due and payable only upon the achievement of certain development milestones. In addition, the Company may be obligated to pay up to $30.0 million in sales milestones contingent upon the realization of sales revenues and sublicense revenue. As of June 30, 2022, the Company has a liability of $2.5 million, related to certain development milestones that were deemed probable of achievement.

Income Taxes	6 Months Ended
Income Taxes	Jun. 30, 2022
Income Tax Disclosure [Abstract]
Income Taxes	Income TaxesThe Company did not record a federal or state income tax provision or benefit for each of the six months ended June 30, 2022 and 2021 due to the expected loss before income taxes to be incurred for the years ended December 31, 2022 and 2021, as well as the Company’s continued maintenance of a full valuation allowance against its net deferred tax assets.

Subsequent Events	6 Months Ended
Subsequent Events	Jun. 30, 2022
Subsequent Events [Abstract]
Subsequent Events	Subsequent Events In July 2022, the Company and Teijin entered into the Amended License and Development Agreement (the “Amended Teijin Agreement”) and concurrently executed a Commercial Supply Agreement (the “Teijin Supply Agreement” and together with the Amended Teijin Agreement, the “Teijin Development and Supply Agreements”). The Amended Teijin Agreement amended the terms of the Teijin Agreement referenced in Note 9. The Teijin Agreement has been amended to remove references to the joint commercialization opportunity and to waive the royalty on net sales of any abaloparatide-SC purchased by Teijin through the Teijin Supply Agreement. The Teijin Development and Supply Agreements does not have any impact on royalties owed on sales of abaloparatide-SC not purchased through the Teijin Supply Agreement, and accordingly, for any abaloparatide-SC sold by Teijin but not purchased through the Teijin Supply Agreement, royalty payments will be owed by Teijin to the Company under the Teijin Agreement referenced in Note 9 in consideration for the license granted by the Company to Teijin thereunder. Under the Teijin Supply Agreement, the Company will supply to Teijin, and Teijin will purchase from the Company, a finished product comprising of a cartridge filled with abaloparatide-SC. Specifically, the Company will purchase, for Teijin, the abaloparatide-SC from a material supplier and then have a commercial supplier fill the cartridges with abaloparatide-SC and supply final abaloparatide-SC for commercialization and distribution by Teijin in Japan. As consideration, the Company will receive an annual fee and a per-unit supply price for all abaloparatide-SC purchased by Teijin through the Company under the Teijin Supply Agreement. Any other costs borne by the Company for the purchase of abaloparatide-SC or manufacture of the abaloparatide-SC will be reimbursed by Teijin. The Company has also agreed under the Teijin Supply Agreement, in the event of any breach of the supply agreement by the commercial supplier resulting in the Company’s breach of the Teijin Supply Agreement, to pursue any potential claims against commercial supplier on behalf of Teijin to the extent required under the Teijin Supply Agreement.The Teijin Supply Agreement will remain in effect, unless terminated earlier for breach, until the earlier of the expiration or termination of the Teijin Agreement, the expiration or termination of the Company’s commercial supply agreement with the commercial supplier, or termination by either party in the event of the other party’s bankruptcy.

Organization (Details) - USD ($) $ / shares in Units, $ in Thousands	Jun. 30, 2022	Dec. 31, 2021
Condensed Financial Statements, Captions [Line Items]
Accumulated deficit	$ (1,398,990)	$ (1,367,981)
Cash, cash equivalents, marketable securities, and investments	$ 72,500
Common stock, par value (in dollars per share)	$ 0.0001	$ 0.0001
Gurnet Point Capital \| Radius Health, Inc.
Condensed Financial Statements, Captions [Line Items]
Acquisition price per share (in dollars per share)	10.00
Common stock, par value (in dollars per share)	$ 1.00
Net sales	$ 300,000
Revolving Credit Facility \| Line of Credit
Condensed Financial Statements, Captions [Line Items]
Maximum borrowing capacity (up to)	$ 25,000

Fair Value Measurements (Details) - USD ($) $ in Thousands	Jun. 30, 2022	Dec. 31, 2021
Level 2 \| 3.00% Convertible notes \| Convertible debt
Assets
Estimated fair value of debt	$ 189,100
Level 2 \| Term Facility \| Medium-term Notes
Assets
Estimated fair value of debt	147,200
Recurring basis
Assets
Cash and cash equivalents	72,491	$ 111,533
Recurring basis \| Cash
Assets
Cash and cash equivalents	22,156	41,285
Recurring basis \| Money market funds
Assets
Cash and cash equivalents	50,335	70,248
Recurring basis \| Level 1
Assets
Cash and cash equivalents	72,491	111,533
Recurring basis \| Level 1 \| Cash
Assets
Cash and cash equivalents	22,156	41,285
Recurring basis \| Level 1 \| Money market funds
Assets
Cash and cash equivalents	50,335	70,248
Recurring basis \| Level 2
Assets
Cash and cash equivalents	0	0
Recurring basis \| Level 2 \| Cash
Assets
Cash and cash equivalents	0	0
Recurring basis \| Level 2 \| Money market funds
Assets
Cash and cash equivalents	0	0
Recurring basis \| Level 3
Assets
Cash and cash equivalents	0	0
Recurring basis \| Level 3 \| Cash
Assets
Cash and cash equivalents	0	0
Recurring basis \| Level 3 \| Money market funds
Assets
Cash and cash equivalents	$ 0	$ 0

Inventory (Details) - USD ($) $ in Thousands	6 Months Ended
Inventory (Details) - USD ($) $ in Thousands	Jun. 30, 2022	Dec. 31, 2021
Inventory Disclosure [Abstract]
Raw materials	$ 7,716	$ 7,159
Work in process	1,377	1,335
Finished goods	3,398	2,879
Total inventories	$ 12,491	$ 11,373
Finished goods shelf life (in months)	36 months

Convertible Notes Payable - Narrative (Details)		1 Months Ended		3 Months Ended		6 Months Ended
Convertible Notes Payable - Narrative (Details)	Sep. 12, 2017 USD ($) $ / shares	Mar. 31, 2021 USD ($)	Sep. 12, 2017 USD ($) $ / shares	Jun. 30, 2022 USD ($)	Jun. 30, 2021 USD ($)	Jun. 30, 2022 USD ($) day business_day $ / shares	Jun. 30, 2021 USD ($)	Aug. 14, 2017 USD ($)
Debt Instrument [Line Items]
Gain on extinguishment of debt				$ 0	$ 0	$ 0	$ 1,960,000
3.00% Convertible notes \| Convertible debt
Debt Instrument [Line Items]
Aggregate principal amount	$ 5,000,000		$ 5,000,000					$ 300,000,000
Debt instrument stated rate (as a percent)	3.00%		3.00%					3.00%
Debt issuance costs	$ 9,400,000		$ 9,400,000
Conversion ratio	0.0204801
Initial conversion price (in dollars per share) \| $ / shares	$ 48.81		$ 48.81
Repurchase price percentage (as a percent)				100.00%		100.00%
Conversion price (in dollars per share) \| $ / shares						$ 36.835
Repurchase aggregate principal amount		$ 112,200,000
Repayments of debt		108,600,000
Gain on extinguishment of debt		$ 2,000,000
Debt instrument term (in years)			7 years
Effective interest rate (as a percent)				3.43%		3.43%
3.00% Convertible notes \| Convertible debt \| Selling, General and Administrative Expenses
Debt Instrument [Line Items]
Third party costs							$ 300,000
3.00% Convertible notes \| Convertible debt \| Stock price trigger at greater than or equal to 130%
Debt Instrument [Line Items]
Consecutive or non-consecutive trading days (in days)						20 days
Consecutive trading days (in days) \| day						30
Percentage of stock price trigger (as a percent)						130.00%
3.00% Convertible notes \| Convertible debt \| Stock price trigger less than 98%
Debt Instrument [Line Items]
Consecutive trading days (in days) \| day						5
Percentage of stock price trigger (as a percent)						98.00%
Trading days (in days) \| business_day						5
3.00% Convertible notes \| Convertible debt \| Stock price trigger at greater than or equal to 130%, on or after September 1, 2021
Debt Instrument [Line Items]
Consecutive or non-consecutive trading days (in days)						20 days
Consecutive trading days (in days) \| day						30
Percentage of stock price trigger (as a percent)						130.00%
Consecutive trading days, redemption notice period (in days) \| day						5

Convertible Notes Payable - Summary of Outstanding Balances of Convertible Notes (Details) - Convertible debt - 3.00% Convertible notes $ in Thousands	Jun. 30, 2022 USD ($)
Debt Instrument [Line Items]
Principal	$ 192,753
Less: debt discount and issuance costs	(1,861)
Net carrying amount	$ 190,892

Convertible Notes Payable - Schedule of Future Minimum Payments on Long-Term Debt (Details) - Convertible debt - 3.00% Convertible notes $ in Thousands	Jun. 30, 2022 USD ($)
Future Minimum Payments
2022 (excluding the 6 months ended June 30, 2022)	$ 2,891
2023	5,783
2024	198,535
Total minimum payments	207,209
Less: interest	(14,456)
Less: unamortized discount	(1,861)
Net carrying amount	$ 190,892

Term Loan and Credit Facilities - Narrative (Details) - USD ($)			6 Months Ended
	Mar. 11, 2021	Mar. 03, 2021	Jun. 30, 2022	Jun. 30, 2021
Line of Credit \| Revolving Credit Facility
Debt Instrument [Line Items]
Maximum borrowing capacity (up to)			$ 25,000,000
Debt instrument, covenant, percent net collectible value of accounts receivable (as a percent)			85.00%
Debt instrument, covenant, percent of eligible inventory (as a percent)			40.00%
Debt instrument, covenant, inventory percentage of availability (as a percent)			20.00%
Debt instrument, LIBOR floor (as a percent)		2.00%
Monthly commitment fee (as a percent)		0.50%
Debt instrument, covenant, required unrestricted cash balance			$ 50,000,000
Debt instrument, covenant, minimum net revenue, period to achieve (in months)			12 months
Line of Credit \| Revolving Credit Facility \| London Interbank Offered Rate (LIBOR)
Debt Instrument [Line Items]
Basis spread (as a percent)		3.50%
Term Facility \| Medium-term Notes
Debt Instrument [Line Items]
Aggregate principal amount		$ 150,000,000
Increase in aggregate principal amount		$ 125,000,000
Debt instrument, LIBOR floor (as a percent)		2.00%
Term Facility \| Medium-term Notes \| Selling, General and Administrative Expenses
Debt Instrument [Line Items]
Third party costs				$ 2,800,000
Term Facility \| Medium-term Notes \| Debt Instrument, Tranche One
Debt Instrument [Line Items]
Aggregate principal amount			$ 150,000,000
Proceeds from issuance of long-term debt	$ 122,600,000
Debt issuance costs	$ 2,400,000
Term Facility \| Medium-term Notes \| London Interbank Offered Rate (LIBOR)
Debt Instrument [Line Items]
Basis spread (as a percent)		5.75%

Term Loan and Credit Facilities - Future Minimum Payments (Details) - Debt Instrument, Tranche One - Medium-term Notes - Term Facility $ in Thousands	Jun. 30, 2022 USD ($)
Debt Instrument [Line Items]
2022 (excluding the 6 months ended June 30, 2022)	$ 5,813
2023	61,302
2024	102,260
Total minimum payments	169,375
Less: interest	(19,375)
Less: unamortized issuance costs	(1,319)
Term loan	$ 148,681

Net Loss Per Share - Basic and Diluted (Details) - USD ($) $ / shares in Units, $ in Thousands	3 Months Ended				6 Months Ended
	Jun. 30, 2022	Mar. 31, 2022	Jun. 30, 2021	Mar. 31, 2021	Jun. 30, 2022	Jun. 30, 2021
Numerator:
Net loss	$ (12,733)	$ (18,276)	$ (16,810)	$ (15,749)	$ (31,010)	$ (32,559)
Denominator:
Weighted-average number of common shares used in loss per share - basic (in shares)	47,588,158		47,391,530		47,515,394	47,114,947
Weighted-average number of common shares used in loss per share - diluted (in shares)	47,588,158		47,391,530		47,515,394	47,114,947
Loss per share - basic (in dollars per share)	$ (0.27)		$ (0.35)		$ (0.65)	$ (0.69)
Loss per share - diluted (in dollars per share)	$ (0.27)		$ (0.35)		$ (0.65)	$ (0.69)

Product Revenue Reserves and Allowances (Details) - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021
Product Revenue Allowance and Reserves
Summary of Activity of Product Revenue Allowance and Reserves
Beginning balance	$ 26,889	$ 19,107
Provision related to sales in the current year	74,481	62,386
Adjustments related to prior period sales	(435)	(3,292)
Credits and payments made	(69,558)	(52,725)
Ending balance	31,377	25,476
Chargebacks, Discounts, and Fees
Summary of Activity of Product Revenue Allowance and Reserves
Beginning balance	2,061	1,891
Provision related to sales in the current year	10,447	9,313
Adjustments related to prior period sales	0	(54)
Credits and payments made	(10,656)	(9,677)
Ending balance	1,852	1,473
Government and other rebates
Summary of Activity of Product Revenue Allowance and Reserves
Beginning balance	24,604	14,644
Provision related to sales in the current year	63,772	52,886
Adjustments related to prior period sales	(435)	(989)
Credits and payments made	(58,624)	(42,859)
Ending balance	29,317	23,682
Returns
Summary of Activity of Product Revenue Allowance and Reserves
Beginning balance	224	2,572
Provision related to sales in the current year	262	187
Adjustments related to prior period sales	0	(2,249)
Credits and payments made	(278)	(189)
Ending balance	$ 208	$ 321

License Revenue and Reimbursable Expenses (Details) - USD ($) $ in Thousands	1 Months Ended			3 Months Ended		6 Months Ended
	Mar. 31, 2021	Jul. 31, 2020	Jul. 31, 2017	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021	Dec. 31, 2021
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
License agreements, upfront payment received			$ 10,000
License agreements, first commercial sale anniversary			10 years
License revenue				$ 58,285	$ 51,797	$ 101,443	$ 108,057
Reimbursable expenses				9,600	18,500	18,700	32,800
Receivable of reimbursable development expenses				12,200		12,200		$ 11,800
License receivables				5,750		5,750		$ 0
License revenue
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
License revenue				$ 5,750	$ 0	5,950	$ 11,000
Berlin-Chemie
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
License agreements, upfront payment received		$ 30,000
Reimbursement of cost						109,700
Reimbursement of cost, paid out						$ 90,800
Collaborative agreement royalty period (in years)						10 years
Collaborative agreement, termination, period of no manufacture or commercialization activity (in months)						24 months
Collaborative agreement, termination, number of days of prior notice given by counterparty (in days)						180 days
Upfront payment received						$ 30,000
Milestone payable (in days)				60 days
License						27,400
Inventory						2,600
License receivables				$ 5,000		5,000
Berlin-Chemie \| License revenue
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
License revenue				$ 5,000
Berlin-Chemie \| Maximum
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Development and regulatory milestone payments receivable						20,000
Sales milestone payments receivable						$ 300,000
Collaborative Arrangement \| Teijin Agreement
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
License agreements, upfront payment received	$ 10,000		$ 10,000
Additional payments to be made upon achievement of certain milestones (up to)			$ 40,000

Commitments and Contingencies - Manufacturing Agreements (Details) € in Millions, SFr in Millions, $ in Millions					1 Months Ended				38 Months Ended	52 Months Ended
	Jun. 10, 2022 USD ($)	Jun. 01, 2017	Jun. 28, 2016 USD ($)	Jun. 28, 2016 EUR (€)	Dec. 31, 2020 USD ($)	May 31, 2020 USD ($)	May 31, 2020 CHF (SFr)	Jun. 30, 2016	Dec. 03, 2021 USD ($)	Jun. 30, 2022 USD ($)
3M Company \| Collaborative Arrangement
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Additional payments to be made upon achievement of certain sales milestones					$ 30.0
3M And Kindeva \| 3M Company \| Collaborative Arrangement
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Termination expenses	$ 3.2
Nonrefundable, non-creditable payment									$ 31.8	$ 70.9
Ypsomed Supply Agreement
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Services agreement, term (in years)		3 years
Services agreement, renewal term (in years)		2 years				2 years	2 years	2 years
Services agreement, additional renewal term (in years)		2 years						2 years
Service agreement, period required for notice of non-renewal (in months)		18 months
Total minimum payments inclusive of milestone payments and one-time capacity fee						$ 2.0	SFr 1.9
Services agreement, termination period (in years)								2 years
Lonza Agreement
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Services agreement, term (in years)			6 years	6 years
Services agreement, renewal term (in years)			3 years	3 years
Service agreement, period required for notice of non-renewal (in months)			24 years	24 years
Collaborative arrangements, annual minimum batches			$ 3.0	€ 2.9
Collaborative arrangements, aggregate minimum payments			$ 17.2
Fresh Cut Development L L C
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Additional payments to be made upon achievement of certain clinical and regulatory milestones					$ 60.0
Collaborative arrangement, expected milestone payments										$ 2.5