UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F COVER PAGE
OMB APPROVAL
OMB Number:3235-0006
Expires:July 31, 2015
Estimated average burden
hours per response:23.8
Report for the Calendar Year or Quarter Ended:
03-31-2025
Check here if Amendment: ☐ Amendment Number:
This Amendment (Check only one.):☐ is a restatement.
☐ adds new holdings entries.

Institutional Investment Manager Filing this Report:

Name:
Novo Holdings A/S
Address:
TUBORG HAVNEVEJ 19
HELLERUP, G7 2900
Form 13F File Number:
028-16231

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.


Person Signing this Report on Behalf of Reporting Manager:
Name:
Barbara Fiorini
Title:
General Counsel
Phone:
45 3527 6500


Signature, Place, and Date of Signing:

/s/ Barbara Fiorini
                         [Signature]
Hellerup, DENMARK
                 [City, State]
05-15-2025
                           [Date]
                          

Report Type (Check only one.):

☒ 13F HOLDINGS REPORT. (Check here if all holdings of this reporting manager are reported in this report.) 

☐ 13F NOTICE. (Check here if no holdings reported are in this report, and all holdings are reported by other reporting manager(s).) 

☐ 13F COMBINATION REPORT. (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)


Form 13F Summary Page

Report Summary:

Number of Other Included Managers:
0
Form 13F Information table Entry Total:
31
Form 13F Information table Value Total:
1314623581
          (thousands)

List of Other Included Managers:

Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report.
[If there are no entries in this list, state "NONE" and omit the column headings and list entries.]

  
NONE


UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number:3235-0006
Expires:July 31, 2015
Estimated average burden
hours per response:23.8
COLUMN 1COLUMN 2COLUMN 3COLUMN 4COLUMN 5COLUMN 6COLUMN 7COLUMN 8
VALUESHRS ORSH/PUT/INVESTMENTOTHERVOTING AUTHORITY
NAME OF ISSUERTITLE OF CLASSCUSIP(x$1000)PRN AMTPRNCALLDISCRETIONMANAGERSOLESHAREDNONE
4D MOLECULAR THERAPEUTICS INCOM35104E1006,298,5001,950,000SHSOLE1,950,000 0 0
ABCELLERA BIOLOGICS INCCOM00288U1062,513,0201,126,915SHSOLE1,126,915 0 0
ALIBABA GROUP HLDG LTDSPONSORED ADS01609W10249,232,799372,327SHSOLE372,327 0 0
AMICUS THERAPEUTICS INCCOM03152W10922,440,0002,750,000SHSOLE2,750,000 0 0
ARRIVENT BIOPHARMA INCCOM04272N10234,615,9061,872,142SHSOLE1,872,142 0 0
ASML HOLDING N VN Y REGISTRY SHSN07059210109,887,909165,836SHSOLE165,836 0 0
BIOMARIN PHARMACEUTICAL INCCOM09061G10134,638,100490,000SHSOLE490,000 0 0
BLUEPRINT MEDICINES CORPCOM09627Y10920,251,442228,804SHSOLE228,804 0 0
BROOKFIELD CORPCL A LTD VT SH11271J107122,158,8002,330,830SHSOLE2,330,830 0 0
CELLDEX THERAPEUTICS INC NEWCOM NEW15117B20221,780,0001,200,000SHSOLE1,200,000 0 0
CERIBELL INCCOM15678C10216,904,800880,000SHSOLE880,000 0 0
CRINETICS PHARMACEUTICALS INCOM22663K10742,763,5001,275,000SHSOLE1,275,000 0 0
EDGEWISE THERAPEUTICS INCCOM28036F105117,700,0005,350,000SHSOLE5,350,000 0 0
GALECTO INCCOM NEW36322Q206309,73099,913SHSOLE99,913 0 0
INSMED INCCOM PAR $.0145766930755,284,769724,666SHSOLE724,666 0 0
IO BIOTECH INCCOM4497781093,656,3493,354,449SHSOLE3,354,449 0 0
KYVERNA THERAPEUTICS INCCOM5019761043,570,5001,850,000SHSOLE1,850,000 0 0
LANZATECH GLOBAL INCCOM51655R1013,828,77415,814,845SHSOLE15,814,845 0 0
LEXEO THERAPEUTICS INCCOM52886X1073,895,3561,122,581SHSOLE1,122,581 0 0
MARQETA INCCLASS A COM57142B1041,819,219441,558SHSOLE441,558 0 0
MERUS N V COMN5749R10033,214,440789,129SHSOLE789,129 0 0
MIRUM PHARMACEUTICALS INCCOM60474910167,575,0001,500,000SHSOLE1,500,000 0 0
PHARVARIS N VCOMN6960510827,082,5001,725,000SHSOLE1,725,000 0 0
RECURSION PHARMACEUTICALS INCL A 75629V10451,128,5279,665,128SHSOLE9,665,128 0 0
ROCKET PHARMACEUTICALS INCCOM77313F1067,337,0001,100,000SHSOLE1,100,000 0 0
SALESFORCE INCCOM 79466L30273,208,876272,801SHSOLE272,801 0 0
VANGUARD INDEX FDSTOTAL STK MKT922908769285,435,0821,038,550SHSOLE1,038,550 0 0
VAXCYTE INCCOM92243G10834,550,400915,000SHSOLE915,000 0 0
VERVE THERAPEUTICS INCCOM92539P10113,710,0003,000,000SHSOLE3,000,000 0 0
VIRIDIAN THERAPEUTICS INCCOM92790C10430,334,0442,250,300SHSOLE2,250,300 0 0
ZENAS BIOPHARMA INCCOM98937L10517,498,2392,214,967SHSOLE2,214,967 0 0