UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F COVER PAGE
OMB APPROVAL
OMB Number:3235-0006
Expires:July 31, 2015
Estimated average burden
hours per response:23.8
Report for the Calendar Year or Quarter Ended:
12-31-2017
Check here if Amendment: ☐ Amendment Number:
This Amendment (Check only one.):☐ is a restatement.
☐ adds new holdings entries.

Institutional Investment Manager Filing this Report:

Name:
Asymmetry Capital Management, L.P.
Address:
101 CALIFORNIA STREET
SUITE 1725
SAN FRANCISCO, CA 94111
Form 13F File Number:
028-17016

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.


Person Signing this Report on Behalf of Reporting Manager:
Name:
Cynthia Goldsmith
Title:
CFO
Phone:
415-801-4600


Signature, Place, and Date of Signing:

Cynthia Goldsmith
                         [Signature]
San Francisco, CALIFORNIA
                 [City, State]
02-13-2018
                           [Date]
                          

Report Type (Check only one.):

☒ 13F HOLDINGS REPORT. (Check here if all holdings of this reporting manager are reported in this report.) 

☐ 13F NOTICE. (Check here if no holdings reported are in this report, and all holdings are reported by other reporting manager(s).) 

☐ 13F COMBINATION REPORT. (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)


Form 13F Summary Page

Report Summary:

Number of Other Included Managers:
0
Form 13F Information table Entry Total:
33
Form 13F Information table Value Total:
81478
          (thousands)

List of Other Included Managers:

Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report.
[If there are no entries in this list, state "NONE" and omit the column headings and list entries.]

  
NONE


UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number:3235-0006
Expires:July 31, 2015
Estimated average burden
hours per response:23.8
COLUMN 1COLUMN 2COLUMN 3COLUMN 4COLUMN 5COLUMN 6COLUMN 7COLUMN 8
VALUESHRS ORSH/PUT/INVESTMENTOTHERVOTING AUTHORITY
NAME OF ISSUERTITLE OF CLASSCUSIP(x$1000)PRN AMTPRNCALLDISCRETIONMANAGERSOLESHAREDNONE
ADAMAS PHARMACEUTICALS INCCOM00548A10685825,311SHSOLE25,311 0 0
AERIE PHARMACEUTICALS INCCOM00771V1082,41040,330SHSOLE40,330 0 0
ALDER BIOPHARMACEUTICALS INCCOM0143391051,05992,518SHSOLE92,518 0 0
AMICUS THERAPEUTICS INCCOM03152W1093,071213,413SHSOLE213,413 0 0
ARRAY BIOPHARMA INCCOM04269X10584666,095SHSOLE66,095 0 0
BIO-RAD LABRATORIESCOM0905722073,29213,794SHSOLE13,794 0 0
BIOMARIN PHARMACEUTICAL INCCOM09061G10195710,733SHSOLE10,733 0 0
CENTENE CORPCOM15135B1014,64246,011SHSOLE46,011 0 0
DURECT CORPORATIONCOM266605104810878,197SHSOLE878,197 0 0
ENDOCYTECOM29269A10234981,484SHSOLE81,484 0 0
HERON THERAPEUTICSCOM4277461021,79599,181SHSOLE99,181 0 0
INSMED INCCOM4576693074,935158,277SHSOLE158,277 0 0
INVITAE CORPCOM46185L1031,968216,687SHSOLE216,687 0 0
JAZZ PHARMACEUTICALSCOMG508711056,05644,976SHSOLE44,976 0 0
KALA PHARMACEUTICALSCOM48311910325013,504SHSOLE13,504 0 0
NATERA INCCOM6323071041,796199,777SHSOLE199,777 0 0
NEUROCRINE BIOSCIENCES INCCOM64125C1091,92424,795SHSOLE24,795 0 0
NEVRO CORPCOM64157F1031,64223,785SHSOLE23,785 0 0
OPTINOSE INCCOM68404V1005,682300,618SHSOLE300,618 0 0
PERRIGO CO PLCCOMG978221031,58018,129SHSOLE18,129 0 0
PROTEON THERAPEUTICS INCCOM74371L109189,400SHSOLE9,400 0 0
PTC THERAPEUTICSCOM69366J2009,200551,558SHSOLE551,558 0 0
PUMA BIOTECHNOLOGYINCCOM74587V1077297,371SHSOLE7,371 0 0
QUEST DIAGNOSTICSCOM74834L1006,26563,610SHSOLE63,610 0 0
SAREPTA THERAPEUTICS INCCOM8036071002,39943,125SHSOLE43,125 0 0
SIENNA BIOPHARMACEUTICALSCOM82622H10848426,692SHSOLE26,692 0 0
SYNERGY PHARMACEUTICALS INCCOM8716393081,065477,621SHSOLE477,621 0 0
SYNDAX PHARMACEUTICALS INCCOM87164F10553961,530SHSOLE61,530 0 0
TACTILE SYSTEMS TECHNOLOGY INCCOM87357P1001,24843,089SHSOLE43,089 0 0
TEVA PHARMACEUTICALADR8816242091,31069,124SHSOLE69,124 0 0
UNITEDHEALTH GROUP INCCOM91324P1024,49820,406SHSOLE20,406 0 0