UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F COVER PAGE
OMB APPROVAL
OMB Number:3235-0006
Expires:July 31, 2015
Estimated average burden
hours per response:23.8
Report for the Calendar Year or Quarter Ended:
03-31-2025
Check here if Amendment: ☐ Amendment Number:
This Amendment (Check only one.):☐ is a restatement.
☐ adds new holdings entries.

Institutional Investment Manager Filing this Report:

Name:
RTW INVESTMENTS, LP
Address:
40 10TH AVENUE
7TH FLOOR
NEW YORK, NY 10014
Form 13F File Number:
028-16670

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.


Person Signing this Report on Behalf of Reporting Manager:
Name:
Roderick Wong
Title:
Managing Partner
Phone:
646-597-6980


Signature, Place, and Date of Signing:

/s/ Roderick Wong
                         [Signature]
NEW YORK, NEW YORK
                 [City, State]
05-15-2025
                           [Date]
                          

Report Type (Check only one.):

☒ 13F HOLDINGS REPORT. (Check here if all holdings of this reporting manager are reported in this report.) 

☐ 13F NOTICE. (Check here if no holdings reported are in this report, and all holdings are reported by other reporting manager(s).) 

☐ 13F COMBINATION REPORT. (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)


Form 13F Summary Page

Report Summary:

Number of Other Included Managers:
0
Form 13F Information table Entry Total:
68
Form 13F Information table Value Total:
6538371722
          (thousands)

List of Other Included Managers:

Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report.
[If there are no entries in this list, state "NONE" and omit the column headings and list entries.]

  
NONE


UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number:3235-0006
Expires:July 31, 2015
Estimated average burden
hours per response:23.8
COLUMN 1COLUMN 2COLUMN 3COLUMN 4COLUMN 5COLUMN 6COLUMN 7COLUMN 8
VALUESHRS ORSH/PUT/INVESTMENTOTHERVOTING AUTHORITY
NAME OF ISSUERTITLE OF CLASSCUSIP(x$1000)PRN AMTPRNCALLDISCRETIONMANAGERSOLESHAREDNONE
89BIO INCCOM28255910314,303,9211,967,527SHSOLE1,967,527 0 0
ACADIA PHARMACEUTICALS INCCOM004225108141,851,3438,540,117SHSOLE8,540,117 0 0
ADAGIO MED HLDGS INCCOM00534B100168,515209,361SHSOLE209,361 0 0
AKERO THERAPEUTICS INCCOM00973Y108300,334,8837,419,340SHSOLE7,419,340 0 0
ALKERMES PLCSHSG01767105227,332,7286,884,698SHSOLE6,884,698 0 0
ALLURION TECHNOLOGIES INCCOMMON STOCK02008G2013,370,7021,050,063SHSOLE1,050,063 0 0
APOGEE THERAPEUTICS INCCOM03770N101101,323,9442,712,097SHSOLE2,712,097 0 0
ARGENX SESPONSORED ADR04016X101398,619,302673,497SHSOLE673,497 0 0
ARVINAS INCCOM04335A10523,406,8423,334,308SHSOLE3,334,308 0 0
AVIDITY BIOSCIENCES INCCOM05370A108258,209,2568,746,926SHSOLE8,746,926 0 0
AXSOME THERAPEUTICS INCCOM05464T104340,877,8832,922,729SHSOLE2,922,729 0 0
BEAM THERAPEUTICS INCCOM07373V1058,567,010438,659SHSOLE438,659 0 0
BETA BIONICS INCCOM08659B10240,390,4093,299,870SHSOLE3,299,870 0 0
BIOAGE LABS INCCOM09077V1002,956,687786,353SHSOLE786,353 0 0
CARGO THERAPEUTICS INCCOM14179K10116,788,1764,124,859SHSOLE4,124,859 0 0
CENTESSA PHARMACEUTICALS PLCSPONSORED ADS152309100719,00050,000SHSOLE50,000 0 0
CERIBELL INCCOM15678C1022,881,500150,000SHSOLE150,000 0 0
CG ONCOLOGY INCCOM15694410041,662,7801,701,216SHSOLE1,701,216 0 0
COMPASS PATHWAYS PLCSPONSORED ADS20451W10115,839,1605,538,168SHSOLE5,538,168 0 0
CORVUS PHARMACEUTICALS INCCOM2210151008,520,7432,679,479SHSOLE2,679,479 0 0
CULLINAN THERAPEUTICS INCCOM23003110612,914,1171,705,960SHSOLE1,705,960 0 0
CYTOKINETICS INCCOM NEW23282W605109,363,3402,721,158SHSOLE2,721,158 0 0
DYNE THERAPEUTICS INCCOM26818M10817,683,3311,690,567SHSOLE1,690,567 0 0
ESTABLISHMENT LABS HLDGS INCCOMG31249108105,435,5092,583,887SHSOLE2,583,887 0 0
EXAGEN INCCOM30068X1035,427,5991,511,866SHSOLE1,511,866 0 0
GE HEALTHCARE TECHNOLOGIES ICOMMON STOCK36266G10741,969,200520,000SHSOLE520,000 0 0
GH RESEARCH PLCORDINARY SHARESG3855L10660,662,4525,499,769SHSOLE5,499,769 0 0
GLAUKOS CORPCOM37732210218,699,800190,000SHSOLE190,000 0 0
GLOBUS MED INCCL A37957720882,350,0001,125,000SHSOLE1,125,000 0 0
IMMATICS N.VSHSN4444510931,161,8906,909,510SHSOLE6,909,510 0 0
IMMUNOCORE HLDGS PLCADS45258D105144,486,9074,869,798SHSOLE4,869,798 0 0
INSMED INCCOM PAR $.01457669307229,980,6303,014,558SHSOLE3,014,558 0 0
INTUITIVE SURGICAL INCCOM NEW46120E602100,270,383202,456SHSOLE202,456 0 0
KESTRA MED TECHNOLOGIES LTDSHSG524411054,984,000200,000SHSOLE200,000 0 0
LENZ THERAPEUTICS INCCOM52635N10322,197,731863,389SHSOLE863,389 0 0
MADRIGAL PHARMACEUTICALS INCCOM558868105660,368,9451,993,687SHSOLE1,993,687 0 0
MASIMO CORPCOM574795100113,836,780683,294SHSOLE683,294 0 0
MERUS N VCOMN5749R100175,489,7514,169,393SHSOLE4,169,393 0 0
MILESTONE PHARMACEUTICALS INCOM59935V1072,005,1322,506,102SHSOLE2,506,102 0 0
NATERA INCCOM632307104366,753,3402,593,546SHSOLE2,593,546 0 0
NEUROGENE INCCOM64135M10515,792,7621,348,656SHSOLE1,348,656 0 0
ORCHESTRA BIOMED HLDGS INCCOM68572M10635,122,3738,206,162SHSOLE8,206,162 0 0
ORUKA THERAPEUTICS INCCOM68760410819,962,3591,945,649SHSOLE1,945,649 0 0
PENUMBRA INCCOM70975L107230,713,326862,770SHSOLE862,770 0 0
PERCEPTIVE CAP SOLUTIONS CORCL A ORD SHSG700771057,647,750742,500SHSOLE742,500 0 0
PROTAGONIST THERAPEUTICS INCCOM74366E102276,590,9095,719,415SHSOLE5,719,415 0 0
PTC THERAPEUTICS INCCOM69366J200381,340,1527,483,127SHSOLE7,483,127 0 0
QUEST DIAGNOSTICS INCCOM74834L10016,750,29298,997SHSOLE98,997 0 0
RADNET INCCOM750491102115,230,1772,317,582SHSOLE2,317,582 0 0
RAPT THERAPEUTICS INCCOM75382E10914,352,08011,764,000SHSOLE11,764,000 0 0
REPLIMUNE GROUP INCCOM76029N10620,133,8482,065,010SHSOLE2,065,010 0 0
ROCKET PHARMACEUTICALS INC*W EXP 09/02/20277313F11416,450350,000SHSOLE350,000 0 0
ROCKET PHARMACEUTICALS INCCOM77313F106117,977,43917,687,772SHSOLE17,687,772 0 0
SPYRE THERAPEUTICS INCCOM NEW00773J20258,440,9053,621,996SHSOLE3,621,996 0 0
STOKE THERAPEUTICS INCCOM86150R10734,071,4415,123,525SHSOLE5,123,525 0 0
STRYKER CORPORATIONCOM863667101219,709,767590,221SHSOLE590,221 0 0
TARSUS PHARMACEUTICALS INCCOM87650L103170,344,5643,316,032SHSOLE3,316,032 0 0
TAYSHA GENE THERAPIES INCCOM SHS87761910626,115,13418,787,866SHSOLE18,787,866 0 0
TEMPUS AI INCCL A88023B10319,296,000400,000SHSOLE400,000 0 0
TENAX THERAPEUTICS INCCOM NEW88032L6052,478,166378,346SHSOLE378,346 0 0
ULTRAGENYX PHARMACEUTICAL INCOM90400D10861,825,0261,707,402SHSOLE1,707,402 0 0
UNIQURE NVSHSN9006410145,213,5374,265,428SHSOLE4,265,428 0 0
UROGEN PHARMA LTDCOMM9608810542,412,8223,834,794SHSOLE3,834,794 0 0
VERASTEM INCCOM NEW92337C20325,600,2204,245,476SHSOLE4,245,476 0 0
VERONA PHARMA PLCSPONSORED ADS925050106180,870,3122,848,800SHSOLE2,848,800 0 0
WAVE LIFE SCIENCES LTDSHSY953081057,272,000900,000SHSOLE900,000 0 0
XENCOR INCCOM98401F10525,566,6752,402,883SHSOLE2,402,883 0 0
ZAI LAB LTDADR98887Q104113,359,6153,136,680SHSOLE3,136,680 0 0