UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F COVER PAGE
OMB APPROVAL
OMB Number:3235-0006
Expires:July 31, 2015
Estimated average burden
hours per response:23.8
Report for the Calendar Year or Quarter Ended:
09-30-2021
Check here if Amendment: ☐ Amendment Number:
This Amendment (Check only one.):☐ is a restatement.
☐ adds new holdings entries.

Institutional Investment Manager Filing this Report:

Name:
GRANAHAN INVESTMENT MANAGEMENT INC/MA
Address:
404 WYMAN STREET
SUITE 460
WALTHAM, MA 02451
Form 13F File Number:
028-05876

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.


Person Signing this Report on Behalf of Reporting Manager:
Name:
Susan Rawley
Title:
VP/Operations and Account Administration
Phone:
781-902-1413


Signature, Place, and Date of Signing:

Susan Rawley
                         [Signature]
Waltham, MASSACHUSETTS
                 [City, State]
10-28-2021
                           [Date]
                          

Report Type (Check only one.):

☒ 13F HOLDINGS REPORT. (Check here if all holdings of this reporting manager are reported in this report.) 

☐ 13F NOTICE. (Check here if no holdings reported are in this report, and all holdings are reported by other reporting manager(s).) 

☐ 13F COMBINATION REPORT. (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)


Form 13F Summary Page

Report Summary:

Number of Other Included Managers:
1
Form 13F Information table Entry Total:
193
Form 13F Information table Value Total:
5270659
          (thousands)

List of Other Included Managers:

Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report.
[If there are no entries in this list, state "NONE" and omit the column headings and list entries.]

No.Form 13F File NumberNameCIK
1
028-15699
Destra Capital Advisors LLC
 


UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number:3235-0006
Expires:July 31, 2015
Estimated average burden
hours per response:23.8
COLUMN 1COLUMN 2COLUMN 3COLUMN 4COLUMN 5COLUMN 6COLUMN 7COLUMN 8
VALUESHRS ORSH/PUT/INVESTMENTOTHERVOTING AUTHORITY
NAME OF ISSUERTITLE OF CLASSCUSIP(x$1000)PRN AMTPRNCALLDISCRETIONMANAGERSOLESHAREDNONE
23ANDME HOLDING COCLASS A COM90138Q1082,776306,416SHSOLE272,260 0 34,156
2U INCCOM90214J10180,0432,384,361SHSOLE2,104,563 0 279,798
908 DEVICES INCCOM65443P10220,545631,752SHSOLE569,564 0 62,188
ACACIA RESH CORPACACIA TCH COM00388130715,9252,345,352SHSOLE2,302,845 0 42,507
ACCELERON PHARMA INCCOM00434H10811,68467,888SHSOLE58,020 0 9,868
AERIE PHARMACEUTICALS INCCOM00771V10815,8951,394,270SHSOLE1,250,455 0 143,815
AFFIMED N VCOMN0104510820,8683,376,700SHSOLE3,269,544 0 107,156
AIRGAIN INCCOM00938A1045,994475,371SHSOLE431,559 0 43,812
AKOUSTIS TECHNOLOGIES INCCOM00973N1028,740901,000SHSOLE834,490 0 66,510
ALDEL FINANCIAL INCCL A COM01407X10410,2341,014,242SHSOLE995,590 0 18,652
ALTA EQUIPMENT GROUP INCCOMMON STOCK02128L10621,1891,543,234SHSOLE1,405,754 0 137,480
AMBARELLA INCSHSG037AX1016,19039,748SHSOLE39,058 0 690
AMERESCO INCCL A02361E1088,346142,844SHSOLE140,024 0 2,820
AMERICAN WELL CORPCL A03044L1057,014769,871SHSOLE684,894 0 84,977
ARCTURUS THERAPEUTICS HLDGSCOM03969T1093,49673,177SHSOLE71,097 0 2,080
ARCUS BIOSCIENCES INCCOM03969F1093,656104,848SHSOLE94,338 0 10,510
ARRAY TECHNOLOGIES INCCOM SHS04271T10077,4084,179,692SHSOLE4,061,495 0 118,197
ATRICURE INCCOM04963C2098,268118,875SHSOLE101,901 0 16,974
AUTOLUS THERAPEUTICS PLCSPON ADS05280R1001,157176,683SHSOLE149,610 0 27,073
AVITA MEDICAL INCCOM05380C10228215,907SHSOLE15,907 0 0
AXON ENTERPRISE INCCOM05464C101190,2321,086,915SHSOLE951,831 0 135,084
AXT INCCOM00246W1036,337760,769SHSOLE694,984 0 65,785
BEAM THERAPEUTICS INCCOM07373V1057,90490,840SHSOLE81,597 0 9,243
BIOCRYST PHARMACEUTICALS INCCOM09058V10312,472867,920SHSOLE803,401 0 64,519
BIOLIFE SOLUTIONS INCCOM NEW09062W20412,842303,443SHSOLE273,854 0 29,589
BIOMERICA INCCOM NEW09061H3074,6411,031,358SHSOLE989,866 0 41,492
BLUEPRINT MEDICINES CORPCOM09627Y1095,42852,797SHSOLE45,202 0 7,595
BRIGHT HORIZONS FAM SOL IN DCOM10919410048,608348,644SHSOLE302,203 0 46,441
BROOKS AUTOMATION INC NEWCOM11434010280,070782,320SHSOLE680,818 0 101,502
BUMBLE INCCOM CL A12047B10528,780575,836SHSOLE499,333 0 76,503
CAI INTERNATIONAL INCCOM12477X1065409,665SHSOLE9,665 0 0
CALLAWAY GOLF COCOM1311931042,02073,107SHSOLE66,537 0 6,570
CANADIAN SOLAR INCCOM13663510917,064493,316SHSOLE484,321 0 8,995
CARDIOVASCULAR SYS INC DELCOM14161910611,895362,330SHSOLE324,425 0 37,905
CARIBOU BIOSCIENCES INCCOM1420381083,388141,951SHSOLE129,233 0 12,718
CASELLA WASTE SYS INCCL A14744810413,114172,689SHSOLE155,584 0 17,105
CASTLE BIOSCIENCES INCCOM14843C10529,990450,980SHSOLE411,429 0 39,551
CERUS CORPCOM15708510110,9211,793,255SHSOLE1,754,395 0 38,860
CEVA INCCOM15721010511,110260,367SHSOLE237,349 0 23,018
CHART INDS INCCOM16115Q308108,666568,602SHSOLE512,962 0 55,640
CHEFS WHSE INCCOM16308610120,954643,349SHSOLE604,359 0 38,990
CHEGG INCCOM16309210939,136575,356SHSOLE507,988 0 67,368
CHICKEN SOUP FOR THE SOUL ENCL A16842Q10022,492983,484SHSOLE964,454 0 19,030
CIENA CORPCOM NEW17177930910,363201,820SHSOLE181,507 0 20,313
CLEAN ENERGY FUELS CORPCOM1844991015,461670,093SHSOLE574,204 0 95,889
COLUMBUS MCKINNON CORP N YCOM19933310533,383690,440SHSOLE621,868 0 68,572
COMPUTER TASK GROUP INCCOM2054771024,308539,873SHSOLE539,873 0 0
CONMED CORPCOM20741010121,170161,810SHSOLE144,182 0 17,628
CORVEL CORPCOM2210061095,60930,122SHSOLE26,766 0 3,356
COSTAR GROUP INCCOM22160N109115,4111,341,053SHSOLE1,164,090 0 176,963
CRICUT INCCOM CL A22658D10056,4032,045,065SHSOLE1,815,593 0 229,472
CRISPR THERAPEUTICS AGNAMEN AKTH171821085,07445,330SHSOLE40,732 0 4,598
CRYOPORT INCCOM PAR $0.00122905030719,645295,376SHSOLE267,669 0 27,707
CYBERARK SOFTWARE LTDSHSM2682V1083,07619,492SHSOLE17,252 0 2,240
CYTOSORBENTS CORPCOM NEW23283X2069,3751,154,561SHSOLE1,101,625 0 52,936
DARLING INGREDIENTS INCCOM23726610120,410283,871SHSOLE281,592 0 2,279
DATTO HLDG CORPCOM23821D10040,1041,678,010SHSOLE1,437,324 0 240,686
DERMTECH INCCOM24984K1053,07795,824SHSOLE86,334 0 9,490
DICERNA PHARMACEUTICALS INCCOM25303110856027,775SHSOLE24,725 0 3,050
DIGITAL TURBINE INCCOM NEW25400W102149,1642,169,653SHSOLE2,105,604 0 64,049
DOMO INCCOM CL B25755410566,753790,533SHSOLE686,228 0 104,305
DOUGLAS DYNAMICS INCCOM25960R10514,060387,338SHSOLE349,432 0 37,906
EDITAS MEDICINE INCCOM28106W1035,080123,667SHSOLE111,047 0 12,620
ENANTA PHARMACEUTICALS INCCOM29251M10610,386182,816SHSOLE164,273 0 18,543
ENOVIX CORPORATIONCOM29359410718,885999,757SHSOLE869,123 0 130,634
ENPHASE ENERGY INCCOM29355A107121,677811,341SHSOLE745,174 0 66,167
ESPERION THERAPEUTICS INC NECOM29664W1053,540293,766SHSOLE260,776 0 32,990
ETSY INCCOM29786A106138,133664,230SHSOLE589,987 0 74,243
EURONET WORLDWIDE INCCOM29873610929,264229,918SHSOLE221,027 0 8,891
EVERQUOTE INCCOM CL A30041R10821,0851,131,777SHSOLE973,711 0 158,066
EVOLENT HEALTH INCCL A30050B101149,2204,813,553SHSOLE4,559,245 0 254,308
EXECUTIVE NETWORK PARTNERINGCL A30158L10016,7521,705,891SHSOLE1,499,257 0 206,634
EXECUTIVE NETWORK PARTNERING*W EXP 09/25/20230158L118344424,193SHSOLE372,536 0 51,657
FATE THERAPEUTICS INCCOM31189P1024,41574,492SHSOLE66,122 0 8,370
FLEX LTDORDY2573F10226,1581,479,545SHSOLE1,467,702 0 11,843
FLEXION THERAPEUTICS INCCOM33938J1067,5221,233,194SHSOLE1,111,589 0 121,605
FREQUENCY THERAPEUTICS INCCOM35803L10830443,030SHSOLE43,030 0 0
GENIUS SPORTS LIMITEDSHARES CL AG3934V10954,7662,934,919SHSOLE2,549,943 0 384,976
GENTHERM INCCOM37253A10320,051247,754SHSOLE243,416 0 4,338
GLOBANT S ACOML4438510943,805155,885SHSOLE135,546 0 20,339
GRAND CANYON ED INCCOM38526M10620,303230,822SHSOLE197,140 0 33,682
GRAY TELEVISION INCCOM38937510616,051703,387SHSOLE690,526 0 12,861
GREEN BRICK PARTNERS INCCOM39270910122,4361,093,372SHSOLE1,058,771 0 34,601
HARVARD BIOSCIENCE INCCOM41690610511,0261,579,655SHSOLE1,523,623 0 56,032
HEALTH CATALYST INCCOM42225T1079,073181,414SHSOLE161,683 0 19,731
HEALTHEQUITY INCCOM42226A10749,840769,606SHSOLE665,216 0 104,390
HESKA CORPCOM RESTRC NEW42805E3065,06919,605SHSOLE17,625 0 1,980
HUDSON TECHNOLOGIES INCCOM4441441096,9731,975,220SHSOLE1,942,676 0 32,544
ICAD INCCOM NEW44934S20624,1082,242,603SHSOLE2,198,183 0 44,420
IMMUNOGEN INCCOM45253H1013,842677,618SHSOLE602,087 0 75,531
INMODE LTDSHSM5425M10318,211114,214SHSOLE110,259 0 3,955
INNOVATIVE INDL PPTYS INCCOM45781V10117,10874,008SHSOLE66,883 0 7,125
INSMED INCCOM PAR $.014576693078,447306,730SHSOLE265,785 0 40,945
INTELLIA THERAPEUTICS INCCOM45826J10525,084186,985SHSOLE174,651 0 12,334
JAMES RIV GROUP LTDCOMG5005R10724,531650,184SHSOLE585,262 0 64,922
JOUNCE THERAPEUTICS INCCOM4811161011,294174,175SHSOLE147,491 0 26,684
KINIKSA PHARMACEUTICALS LTDCOM CL AG5269C1014,622405,834SHSOLE369,851 0 35,983
KINSALE CAP GROUP INCCOM49714P10817,316107,086SHSOLE97,796 0 9,290
KORNIT DIGITAL LTDSHSM6372Q113338,5002,338,674SHSOLE2,107,266 0 231,408
KULICKE & SOFFA INDS INCCOM50124210162,4651,071,802SHSOLE1,036,850 0 34,952
LAWSON PRODS INCCOM52077610512,903258,015SHSOLE235,165 0 22,850
LENDINGTREE INC NEWCOM52603B10719,388138,655SHSOLE135,933 0 2,722
LIFEMD INCCOM53216B1041,011162,775SHSOLE149,490 0 13,285
LIGAND PHARMACEUTICALS INCCOM NEW53220K50416,305117,033SHSOLE114,776 0 2,257
LIMELIGHT NETWORKS INCCOM53261M1044,6281,944,533SHSOLE1,737,103 0 207,430
LIQUIDITY SVCS INCCOM53635B10738,6551,788,742SHSOLE1,550,003 0 238,739
LITHIA MTRS INCCOM53679710333,392105,325SHSOLE102,419 0 2,906
LIVEPERSON INCCOM538146101122,6542,080,653SHSOLE1,805,248 0 275,405
LOVESAC COMPANYCOM54738L10946,970710,699SHSOLE620,130 0 90,569
LUXFER HOLDINGS PLCSHSG5698W11623,6781,206,230SHSOLE1,084,741 0 121,489
MACROGENICS INCCOM5560991094,838231,058SHSOLE207,692 0 23,366
MAGNITE INCCOM55955D100200,5547,162,652SHSOLE6,690,390 0 472,262
MATERION CORPCOM57669010115,933232,121SHSOLE208,531 0 23,590
MESA LABS INCCOM59064R1093,22710,672SHSOLE9,684 0 988
MITEK SYS INCCOM NEW60671020015,949862,124SHSOLE846,177 0 15,947
MONOLITHIC PWR SYS INCCOM6098391054,5289,343SHSOLE8,288 0 1,055
MOTORCAR PTS AMER INCCOM6200711007,604389,926SHSOLE379,007 0 10,919
NATERA INCCOM6323071049,66786,750SHSOLE81,427 0 5,323
NAUTILUS INCCOM63910B10214,8531,595,350SHSOLE1,496,971 0 98,379
NEOGENOMICS INCCOM NEW64049M20915,961330,872SHSOLE293,415 0 37,457
NEOLEUKIN THERAPEUTICS INCCOM64049K104906125,331SHSOLE106,125 0 19,206
NEOPHOTONICS CORPCOM64051T1009,2631,063,486SHSOLE999,114 0 64,372
NEURONETICS INCCOM64131A1055,774880,203SHSOLE819,068 0 61,135
NEW RELIC INCCOM64829B1004,19758,472SHSOLE51,802 0 6,670
NEWMARK GROUP INCCL A65158N10214,3201,000,677SHSOLE982,500 0 18,177
NUTANIX INCCL A67059N10810,123268,506SHSOLE241,611 0 26,895
OLINK HLDG ABSPONSORED ADS6807101004,506185,830SHSOLE169,316 0 16,514
ONESPAWORLD HOLDINGS LIMITEDCOMP7368411330,2053,029,575SHSOLE2,630,825 0 398,750
ONTO INNOVATION INCCOM6833441056,42888,970SHSOLE78,619 0 10,351
ORGANOGENESIS HLDGS INCCOM68621F10230,2172,122,005SHSOLE1,977,305 0 144,700
ORTHOPEDIATRICS CORPCOM68752L10011,731179,078SHSOLE164,317 0 14,761
OSI SYSTEMS INCCOM67104410560,570638,922SHSOLE555,281 0 83,641
OVERSTOCK COM INC DELCOM69037010156,996731,462SHSOLE636,090 0 95,372
PACIFIC BIOSCIENCES CALIF INCOM69404D10811,556452,302SHSOLE430,492 0 21,810
PARATEK PHARMACEUTICALS INCCOM6993743023,993821,654SHSOLE740,954 0 80,700
PAYCOM SOFTWARE INCCOM70432V102196,019395,399SHSOLE343,712 0 51,687
PERFICIENT INCCOM71375U10117,006146,981SHSOLE132,272 0 14,709
PORCH GROUP INCCOM73324510494,6615,354,138SHSOLE4,849,339 0 504,799
POWER INTEGRATIONS INCCOM73927610315,002151,555SHSOLE144,722 0 6,833
PROS HOLDINGS INCCOM74346Y10313,997394,506SHSOLE353,064 0 41,442
PROTHENA CORP PLCSHSG728001083,22745,304SHSOLE40,253 0 5,051
PROTO LABS INCCOM7437131093,10446,611SHSOLE41,231 0 5,380
PTC INCCOM69370C1005,42645,293SHSOLE40,083 0 5,210
PULSE BIOSCIENCES INCCOM74587B1017,901365,765SHSOLE327,988 0 37,777
PURE STORAGE INCCL A74624M10219,100759,141SHSOLE715,516 0 43,625
QUALYS INCCOM74758T3035,20546,772SHSOLE41,367 0 5,405
QUANTERIX CORPCOM74766Q10129,827599,059SHSOLE557,884 0 41,175
RADIUS HEALTH INCCOM NEW7504692074,404354,888SHSOLE319,768 0 35,120
RADWARE LTDORDM818731077,502222,488SHSOLE199,058 0 23,430
RAPID7 INCCOM75342210414,103124,779SHSOLE111,524 0 13,255
RBC BEARINGS INCCOM75524B10411,04952,070SHSOLE45,802 0 6,268
RENALYTIX PLCADS75973T1019,983497,930SHSOLE471,027 0 26,903
REVANCE THERAPEUTICS INCCOM7613301093,573128,239SHSOLE113,940 0 14,299
RISKIFIED LTDSHS CL AM8216R10925,7081,127,069SHSOLE977,262 0 149,807
RUSH ENTERPRISES INCCL A78184620912,953286,814SHSOLE257,149 0 29,665
SANGAMO THERAPEUTICS INCCOM8006771063,140348,473SHSOLE313,252 0 35,221
SHARPS COMPLIANCE CORPCOM8200171016,211751,054SHSOLE751,054 0 0
SHOTSPOTTER INCCOM82536T10723,496646,030SHSOLE565,629 0 80,401
SI-BONE INCCOM8257041098,408392,546SHSOLE360,796 0 31,750
SIERRA WIRELESS INCCOM8265161063,955255,176SHSOLE247,845 0 7,331
SILICON LABORATORIES INCCOM8269191024,74633,862SHSOLE29,962 0 3,900
SILICON MOTION TECHNOLOGY COSPONSORED ADR82706C10813,074189,526SHSOLE185,907 0 3,619
SILK RD MED INCCOM82710M10019,373352,036SHSOLE336,282 0 15,754
SPERO THERAPEUTICS INCCOM84833T10310,229555,614SHSOLE501,535 0 54,079
SPRINKLR INCCL A85208T10729,0691,661,084SHSOLE1,441,941 0 219,143
SPROUT SOCIAL INCCOM CL A85209W10960,513496,213SHSOLE433,801 0 62,412
SPS COMM INCCOM78463M107171,3981,062,535SHSOLE922,341 0 140,194
STRATEGIC ED INCCOM86272C10321,777308,893SHSOLE264,542 0 44,351
TECHTARGET INCCOM87874R1009,600116,480SHSOLE102,980 0 13,500
TEXAS CAP BANCSHARES INCCOM88224Q10719,627327,004SHSOLE297,914 0 29,090
THE BEAUTY HEALTH COMPANYCOM CL A88331L1084,675180,011SHSOLE154,054 0 25,957
THE TRADE DESK INCCOM CL A88339J1055,21074,110SHSOLE74,110 0 0
THREDUP INCCL A88556E10246,3062,134,881SHSOLE1,903,023 0 231,858
TITAN MACHY INCCOM88830R10113,187508,956SHSOLE460,362 0 48,594
TURNING POINT THERAPEUTICS ICOM90041T1082,95444,467SHSOLE38,080 0 6,387
VARONIS SYS INCCOM92228010231,007509,570SHSOLE497,613 0 11,957
VEECO INSTRS INC DELCOM9224171006,313284,237SHSOLE263,087 0 21,150
VERACYTE INCCOM92337F10780,5301,733,701SHSOLE1,651,297 0 82,404
VERICEL CORPCOM92346J10818,665382,479SHSOLE342,478 0 40,001
VERITONE INCCOM92347M1002,19791,950SHSOLE81,350 0 10,600
VICOR CORPCOM92581510216,457122,669SHSOLE117,874 0 4,795
VICTORY CAP HLDGS INCCOM CL A92645B10326,901768,391SHSOLE665,374 0 103,017
VIEW INCCOM CL A92671V10613,2452,443,804SHSOLE2,093,562 0 350,242
VONAGE HLDGS CORPCOM92886T2019,321578,235SHSOLE521,815 0 56,420
WESTERN DIGITAL CORP.COM9581021052,31340,977SHSOLE36,237 0 4,740
WILLSCOT MOBIL MINI HLDNG COCOM CL A97137810422,600712,497SHSOLE637,519 0 74,978
WIX COM LTDSHSM980681055,40727,591SHSOLE27,368 0 223
WNS HLDGS LTDSPON ADR92932M1018,234100,665SHSOLE90,945 0 9,720
WORKIVA INCCOM CL A98139A105176,1541,249,671SHSOLE1,080,619 0 169,052
XENCOR INCCOM98401F1054,172127,734SHSOLE109,401 0 18,333
XENON PHARMACEUTICALS INCCOM98420N1051,28183,854SHSOLE75,044 0 8,810
XERIS PHARMACEUTICALS INCCOM98422L1071,139465,049SHSOLE465,049 0 0
ZETA GLOBAL HOLDINGS CORPCL A98956A10535,1365,995,934SHSOLE5,241,619 0 754,315