LAVA Therapeutics NV Form 10-Q Quarterly Report Filed 2025-08-13

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UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, D.C. 20549

FORM 10-Q

(Mark One)

☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the quarterly period ended June 30, 2025

☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the Transition period from to

Commission file number: 001-40241

LAVA Therapeutics N.V.

(Exact Name of Registrant as Specified in Its Charter)

The Netherlands

(State or Other Jurisdiction of

Incorporation or Organization)

84-2745484

(I.R.S. Employer

Identification No.)

Yalelaan 62

Utrecht, The Netherlands

(Address of Principal Executive Offices)

3584 CM

(Zip Code)

+31 85 016 3100

(Registrant's telephone number, including area code)

Securities registered pursuant to Section 12(b) of the Act:

Title of each class

Trading Symbol(s)

Name of each exchange on which registered

Common shares, par value €0.12 per share

LVTX

The Nasdaq Stock Market LLC

(NASDAQ Global Select Market)

Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days.

Yes ☒ No ☐

Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S-T (§232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit such files). Yes ☒ No ☐

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging growth company” in Rule 12b 2 of the Exchange Act.

Large accelerated filer	☐	Accelerated filer	☐
Non-accelerated filer	☒	Smaller reporting company	☒
		Emerging growth company	☒

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act). Yes ☐ No ☒

The number of the registrant’s Common Shares outstanding as of August 8, 2025 was 26,305,295.

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		Page
	Special Note Regarding Forward-Looking Statements	2

PART I.	FINANCIAL INFORMATION	4

Item 1.	Financial Statements	4
	Condensed Consolidated Balance Sheets (Unaudited)	4
	Condensed Consolidated Statements of Operations and Comprehensive Loss (Unaudited)	5
	Condensed Consolidated Statements of Stockholders’ Equity (Unaudited)	6
	Condensed Consolidated Statements of Cash Flows (Unaudited)	7
	Notes to the Condensed Consolidated Financial Statements (Unaudited)	8
Item 2.	Management’s Discussion and Analysis of Financial Condition and Results of Operations	17
Item 3.	Quantitative and Qualitative Disclosures About Market Risk	28
Item 4.	Controls and Procedures	28

PART II.	OTHER INFORMATION	29

Item 1.	Legal Proceedings	29
Item 1A.	Risk Factors	29
Item 2.	Unregistered Sales of Equity Securities and Use of Proceeds	34
Item 3.	Defaults Upon Senior Securities	34
Item 4.	Mine Safety Disclosures	34
Item 5.	Other Information	34
Item 6.	Exhibits	35

Signatures		37

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Special Note Regarding Forward-Looking Statements

This Quarterly Report on Form 10-Q (Quarterly Report) contains statements that constitute forward-looking statements. Many of the forward-looking statements contained in this Quarterly Report can be identified by the use of forward-looking words such as “anticipate,” “believe,” “could,” “expect,” “should,” “plan,” “intend,” “estimate,” “potential,” “may,” “will,” and “would,” among others. Forward-looking statements are based on our management’s beliefs and assumptions and on information currently available to our management. Forward-looking statements appear in a number of places in this Quarterly Report and include, but are not limited to, statements regarding our intent, belief or current expectations, such as statements about:

●	our assessment of strategic alternatives;

●

our ability to identify and execute a strategic transaction, while preserving our cash balance to the extent practicable, including proposed transactions contemplated by the Share Purchase Agreement, dated as of August 3, 2025 (the “Purchase Agreement”), between us and XOMA Royalty Corporation, a Delaware corporation (“XOMA”), including our expectations regarding the ability of the parties to complete the transactions contemplated by the Purchase Agreement, the ability of the parties to satisfy the conditions to the consummation of the tender offer contemplated by the Purchase Agreement (the “Offer”), including our ability to achieve the closing net cash amount, and the other conditions set forth in the Purchase Agreement, the possibility of any termination of the Purchase Agreement, our ability to retain key personnel, the expected timetable for completing the transactions contemplated by the Purchase Agreement, our and XOMA’s beliefs and expectations and statements about the benefits sought to be achieved by XOMA’s proposed acquisition of us, the potential effects of the acquisition on both us and XOMA and whether or not the conditions for payment in respect of contingent value rights (the “CVRs”) pursuant to the Contingent Value Rights Agreement that we expect to enter into with a rights agent and a representative, agent and attorney-in-fact of the holders of the CVRs at or prior to the completion of the Offer will be met;

●	the risk of unanticipated costs, liabilities or delays relating to the Purchase Agreement and related transactions, including the outcome of any legal proceedings or shareholder litigation;

●	our ability to maintain our partnered programs including JNJ-89853413, targeting CD33 and hematologic cancers (NCT06618001), partnered with Johnson & Johnson, and PF-08046052, targeting EGFR-positive tumors (NCT05983133), partnered with Pfizer, Inc.;

●	anticipated costs and efforts associated with the discontinuation of clinical programs including the LAVA-1207 program and the LAVA-1266 program;

●	anticipated cost savings in connection with the discontinuation of the LAVA-1207 program and the LAVA-1266 program;

●	our intellectual property position and the duration of our patent rights;

●	our ability to dispose of our intellectual property and assets relating to the LAVA-1266 program;

●	our ability to control and correctly estimate our operating expenses and our expenses associated with the Purchase Agreement and transactions related thereto;

●	our ability to engage and retain the employees required to operate our business and conclude or wind-up our clinical and pre-clinical work;

●	compensation or severance expected to be paid to employees;

●	our expectations regarding market risk, including inflation, interest rate changes and foreign currency fluctuations; and

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●	our estimates regarding our financial condition, expenses, capital requirements and our needs for additional financing.

You should not rely on forward-looking statements as predictions of future events. We have based the forward-looking statements contained in this Quarterly Report primarily on our current expectations and projections about future events and trends that we believe may affect our business, financial condition, and results of operations. The outcome of the events described in these forward-looking statements is subject to risks and uncertainties, including the factors described in “Part I, Item 1A. Risk Factors” of our Annual Report on Form 10-K, or the Annual Report, filed with the Securities and Exchange Commission, or the SEC, on March 28, 2025, “Part II, Item 1A. Risk Factors” of our Quarterly Report on Form 10-Q filed with the SEC on May 14, 2025, and “Part II, Item 1A. Risk Factors” and elsewhere in this Quarterly Report. Moreover, we operate in a very competitive and rapidly changing environment. New risks and uncertainties emerge from time to time, and it is not possible for us to predict all risks and uncertainties that could have an impact on the forward-looking statements contained in this Quarterly Report. The results, events, and circumstances reflected in the forward-looking statements may not be achieved or occur, and actual results, events, or circumstances could differ materially from those described in the forward-looking statements.

In addition, statements that “we believe” and similar statements reflect our beliefs and opinions on the relevant subject. These statements are based on information available to us as of the date of this Quarterly Report. While we believe that such information provides a reasonable basis for these statements, that information may be limited or incomplete. Our statements should not be read to indicate that we have conducted an exhaustive inquiry into, or review of, all relevant information. These statements are inherently uncertain, and investors are cautioned not to unduly rely on these statements.

The forward-looking statements contained in this Quarterly Report relate only to events as of the date on which the statements are made. We undertake no obligation to update any forward-looking statements made in this Quarterly Report or to reflect new information or the occurrence of unanticipated events, except as required by law. We may not actually achieve the plans, intentions or expectations disclosed in or expressed by, and you should not place undue reliance on, our forward-looking statements. Our forward-looking statements do not reflect the potential impact of any future acquisitions, mergers, dispositions, joint ventures, or investments.

Unless the context otherwise requires, all references in this Quarterly Report to “we,” “us,” “our,” “our Company,” and “LAVA” refer to LAVA Therapeutics N.V. and its subsidiaries.

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PART I. FINANCIAL INFORMATION

Item 1. Financial Statements

LAVA Therapeutics N.V.

Condensed Consolidated Balance Sheets (Unaudited)

(In thousands, except par value and share data)


	June 30,		December 31,
	2025		2024
Assets
Current assets:
Cash and cash equivalents	$	26,380	$	35,015
Short-term investments		29,789		41,561
Prepaid expenses		1,922		1,072
Other current assets		2,404		1,649
Total current assets		60,495		79,297
Property and equipment, net		43		1,002
Operating lease right-of-use assets		—		441
Other non-current assets		9		91
Total assets	$	60,547	$	80,831
Liabilities and shareholders' equity
Current liabilities:
Accounts payable	$	1,428	$	2,722
Accrued expenses and other current liabilities		4,184		10,083
Borrowings		—		4,886
Current portion of operating lease liabilities		—		315
Total current liabilities		5,612		18,006
Non-current portion of deferred revenue		35,000		35,000
Non-current portion of operating lease liabilities		—		80
Total liabilities		40,612		53,086
Commitments and contingencies (Note 8)
Shareholders' equity:
Common shares, $0.14 par value; 90,000,000 shares authorized as of June 30, 2025, and December 31, 2024; 26,305,295 shares issued and outstanding as of June 30, 2025, and December 31, 2024		3,717		3,717
Additional paid-in capital		212,637		211,656
Accumulated deficit		(187,091)		(174,973)
Accumulated other comprehensive loss		(9,328)		(12,655)
Total shareholders' equity		19,935		27,745
Total liabilities and shareholders' equity	$	60,547	$	80,831

The accompanying notes are an integral part of these condensed consolidated financial statements.

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LAVA Therapeutics N.V.

Condensed Consolidated Statements of Operations and Comprehensive Loss (Unaudited)

(In thousands, except share and per share amounts)


	Three Months Ended				Six Months Ended
	June 30,				June 30,
	2025		2024		2025		2024
Revenue:
Revenue from contracts with customers	$	—	$	—	$	—	$	6,992
Total revenue		—		—		—		6,992
Cost and expenses:
Research and development		(4,739)		(5,958)		(8,895)		(11,606)
General and administrative		(2,550)		(3,435)		(5,982)		(6,816)
Total cost and expenses		(7,289)		(9,393)		(14,877)		(18,422)
Operating loss		(7,289)		(9,393)		(14,877)		(11,430)
Other (expense) income, net
Interest income		607		968		1,320		1,938
Interest expense		—		(129)		(129)		(259)
Foreign currency exchange (loss) gain, net		(1,885)		340		(3,338)		997
Gain on extinguishment of borrowings		—		—		5,203		—
Total other (expense) income, net		(1,278)		1,179		3,056		2,676
Net loss before taxes		(8,567)		(8,214)		(11,821)		(8,754)
Income tax expense		(72)		(86)		(297)		(154)
Net loss	$	(8,639)	$	(8,300)	$	(12,118)	$	(8,908)
Other comprehensive income (loss):
Foreign currency translation adjustment		2,349		(424)		3,327		(1,471)
Comprehensive loss	$	(6,290)	$	(8,724)	$	(8,791)	$	(10,379)

Net loss per share, basic and diluted	$	(0.32)	$	(0.31)	$	(0.45)	$	(0.33)
Weighted-average common shares outstanding, basic and diluted		26,899,122		26,822,139		26,894,666		26,807,760

The accompanying notes are an integral part of these condensed consolidated financial statements.

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LAVA Therapeutics N.V.

Condensed Consolidated Statements of Shareholders’ Equity (Unaudited)

(In thousands, except for share amounts)


								Accumulated
								other
	Common Shares			Additional		Accumulated		comprehensive
	Shares	Amount		paid-in capital		deficit		loss		Total
Balance as of January 1, 2025	26,305,295	$	3,717	$	211,656	$	(174,973)	$	(12,655)	$	27,745
Share-based compensation expense	—		—		540		—		—		540
Foreign currency translation adjustment	—		—		—		—		978		978
Net loss	—		—		—		(3,479)		—		(3,479)
Balance as of March 31, 2025	26,305,295		3,717		212,196		(178,452)		(11,677)		25,784
Share-based compensation expense	—		—		441		—		—		441
Foreign currency translation adjustment	—		—		—		—		2,349		2,349
Net loss	—		—		—		(8,639)		—		(8,639)
Balance as of June 30, 2025	26,305,295	$	3,717	$	212,637	$	(187,091)	$	(9,328)	$	19,935


								Accumulated
								other
	Common Shares			Additional		Accumulated		comprehensive
	Shares	Amount		paid-in capital		deficit		loss		Total
Balance as of January 1, 2024	26,289,087	$	3,715	$	208,405	$	(149,859)	$	(10,897)	$	51,364
Exercise of share options	3,100		—		8		—		—		8
Share-based compensation expense	—		—		1,095		—		—		1,095
Foreign currency translation adjustment	—		—		—		—		(1,047)		(1,047)
Net loss	—		—		—		(608)		—		(608)
Balance as of March 31, 2024	26,292,187		3,715		209,508		(150,467)		(11,944)		50,812
Exercise of share options	5,135		1		15		—		—		16
Share-based compensation expense	—		—		820		—		—		820
Foreign currency translation adjustment	—		—		—		—		(424)		(424)
Net loss	—		—		—		(8,300)		—		(8,300)
Balance as of June 30, 2024	26,297,322	$	3,716	$	210,343	$	(158,767)	$	(12,368)	$	42,924

The accompanying notes are an integral part of these condensed consolidated financial statements.

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LAVA Therapeutics N.V.

Condensed Consolidated Statements of Cash Flows (Unaudited)

(In thousands, except for share amounts)


	Six Months Ended
	June 30,
Cash flows from operating activities:	2025		2024
Net loss	$	(12,118)	$	(8,908)
Adjustments to reconcile net loss to net cash used in operating activities
Depreciation and amortization		115		264
Non-cash operating lease expense		139		179
Foreign currency exchange loss, net		(395)		(401)
Share-based compensation expense		981		1,915
Accrued interest on borrowings		129		259
Amortization of premium on short-term investments		(1,107)		(1,342)
Gain on extinguishment of borrowings		(5,203)		—
Impairment of property, plant, and equipment and ROU asset		323		—
Loss on the sale of property, plant, and equipment		358		—
Changes in operating assets and liabilities:
Prepaid expenses and other current assets		(631)		(214)
Other non-current assets		85		136
Accounts payable		(1,465)		(262)
Accrued expenses and other current liabilities		(6,467)		(471)
Operating lease liabilities		(138)		(212)
Net cash used in operating activities		(25,394)		(9,057)
Cash flows from investing activities:
Proceeds from sale of property and equipment		283		92
Purchases of investments		(34,621)		(56,035)
Maturities of investments		47,000		57,000
Net cash provided by investing activities		12,662		1,057
Cash flows from financing activities:
Proceeds from option exercises		—		24
Net cash provided by financing activities		—		24
Net decrease in cash and cash equivalents		(12,732)		(7,976)
Effects of exchange rate changes		4,097		(1,168)
Cash and cash equivalents at beginning of period		35,015		44,231
Cash and cash equivalents at end of period	$	26,380	$	35,087

The accompanying notes are an integral part of these condensed consolidated financial statements.

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Notes to the Condensed Consolidated Financial Statements (Unaudited)

1. Organization and Description of Business

Description of the Business

LAVA Therapeutics N.V. (the “Company”) was founded in 2016 and is incorporated and domiciled in the Netherlands. The Company is a clinical-stage immuno-oncology company that has historically focused on its proprietary Gammabody® bispecific gamma delta (gd) T cell engagers to transform the treatment of cancer. Using its Gammabody platform, the Company developed a portfolio of novel bispecific antibodies designed to engage and leverage the potency and precision of gd T cells to orchestrate a robust, natural anti-tumor immune response and improve outcomes for cancer patients. With the collaboration of its partners, Pfizer Inc. (“Pfizer”) and Johnson & Johnson (“J&J”), the Company is advancing its Gammabody pipeline for the development of potential therapeutics in both hematologic malignancies and solid tumors.

Liquidity and Going Concern

In accordance with Accounting Standards Codification (“ASC”) 205-40, Going concern, the Company has evaluated whether there are conditions and events, considered in the aggregate, that raise substantial doubt about the Company’s ability to continue as a going concern within one year after the date the condensed consolidated financial statements are issued. The Company has incurred net losses since inception, and the Company expects to continue to generate operating losses in the foreseeable future. As of June 30, 2025, the Company had an accumulated deficit of $187.1 million. Management expects to incur additional losses in the foreseeable future.

In February 2025, the board of directors of the Company (the “Board”) adopted a restructuring plan (the “Restructuring Plan”) to extend the Company’s capital resources in connection with initiating a process to evaluate potential strategic alternatives such as a reverse merger, other business combination, dissolution and wind-down, or cash sale transaction. As a result of this strategic review process, the Company recently entered into the Purchase Agreement (as described in Note 11).

Through June 30, 2025, the Company has funded its operations with proceeds from equity financings, collaboration and licensing agreements, government grants, and borrowings under various agreements. The Company would need to raise additional capital to support the completion of its research and development activities, which have recently been halted, or any other strategic alternatives. As noted in Note 11, as of August 2025, the Company has announced its intent to discontinued the LAVA-1266 program. The Company has not incurred any new material financial obligations with respect to the termination of this program.

As of the issuance date of the condensed consolidated financial statements, the Company believes that its cash and cash equivalents and short-term investments will be sufficient to fund its operations for at least the next twelve months from the issuance date of these condensed consolidated financial statements.

2. Summary of Significant Accounting Policies

The significant accounting policies and estimates used in the preparation of the accompanying unaudited condensed consolidated financial statements are described in the Company’s audited consolidated financial statements for the year ended December 31, 2024 included in the Company’s Annual Report on Form 10-K filed with the SEC on March 28, 2025. There have been no material changes in the Company’s significant accounting policies during the three and six months ended June 30, 2025.

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Unaudited Interim Financial Information

The accompanying unaudited condensed consolidated financial statements have been prepared in conformity with accounting principles generally accepted in the United States of America (“U.S. GAAP”) as issued by the Financial Accounting Standards Board (the “FASB”) and include the operations of LAVA Therapeutics N.V. and its wholly-owned subsidiaries. All intercompany accounts, transactions and balances have been eliminated in consolidation.

In the opinion of the Company, the accompanying unaudited condensed consolidated financial statements contain all adjustments, consisting of only normal recurring adjustments, necessary for a fair statement of its financial position as of June 30, 2025, its results of operations for the three and six months ended June 30, 2025 and 2024, and its cash flows for the six months ended June 30, 2025 and 2024. The condensed balance sheet at December 31, 2024, was derived from audited annual financial statements but does not contain all of the footnote disclosures from the annual financial statements.

The results for the three and six months ended June 30, 2025 are not necessarily indicative of results to be expected for the full year or for any other subsequent interim period.

Basis of Presentation

The Company had historically been classified as a foreign private issuer (“FPI”). However, as of June 30, 2024, the Company determined that, pursuant to the definition provided in Rule 405 of the Securities Act of 1933, it no longer satisfied the criteria to be considered an FPI. As such, beginning on January 1, 2025, the Company was required to begin reporting with the U.S. Securities and Exchange Commission on domestic forms and comply with domestic company rules in the United States. The Company retrospectively made the transition from International Financial Reporting Standards (“IFRS”) to U.S. GAAP for all periods from the Company’s inception.

Cash and Cash Equivalents

The Company’s cash equivalents consist of highly liquid investments with remaining maturities at the date of purchase of three months or less.

The Company makes short-term deposits for varying periods of between one day and three months, depending on the Company’s immediate cash requirements. The deposits earn interest at the respective short-term deposit rates. The Company’s cash and cash equivalents balances as of June 30, 2025 and December 31, 2024, included $26.4 million and $35.0 million, respectively, of short-term bank deposits.

The Company did not have any restricted cash as of June 30, 2025 or December 31, 2024.

Short-term Investments

The Company’s investments consist only of holdings in U.S. Treasury debt securities with maturities ranging from three months to one year. Accordingly, the Company classifies these investments as current assets in its consolidated balance sheets. Because the Company has the intent and ability to hold these investments until maturity, the Company classifies its short-term investments in U.S. Treasury debt securities as held to maturity (“HTM”) and thus measures the investments at amortized cost. These assets are classified as Level 1 within the fair value hierarchy as there are quoted prices for identical assets in active markets.

The Company estimates the allowance for credit losses on its HTM debt securities using a current expected credit loss methodology. The Company deducts any expected credit loss on its HTM debt securities from the amortized cost basis of the securities so that the condensed consolidated balance sheets reflect the net amount the Company expects to collect. All of the Company's HTM debt securities are issued by the U.S. Treasury, a department of the U.S. government. U.S. Treasury debt securities are either explicitly or implicitly guaranteed by the U.S. government, are highly rated by major rating

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agencies, and have a long history of no credit losses. Accordingly, the Company has a zero-credit loss expectation on these securities. Therefore, as of June 30, 2025, and December 31, 2024, the Company did not record an allowance for credit losses on its short-term investments. The amortized cost basis of the Company’s HTM debt securities is $29.8 million and $41.6 million as of June 30, 2025 and December 31, 2024, respectively. As of June 30, 2025 and December 31, 2024, the difference between the amortized cost basis and fair value is less than $0.1 million.

The Company records the amortization of premiums or discounts in the condensed consolidated statements of operations and comprehensive loss within interest income and interest expense, respectively.

New Accounting Pronouncements – Not Yet Adopted

In December 2023, the FASB issued ASU No. 2023-09, Income Taxes (ASC Topic 740): Improvements to Income Tax Disclosures (“ASU 2023-09”), which establishes incremental disaggregation of income tax disclosures pertaining to the effective tax rate reconciliation and income taxes paid. The amendments in this update apply to all entities that are subject to ASC Topic 740, Income Taxes. For public business entities, the amendments in this update are effective for annual periods beginning after December 15, 2024, and early adoption is permitted. The Company has evaluated the impact of the provision and amendments that will change the annual tax footnote disclosures and is considering whether it will adopt prospectively or retrospectively.

In November 2024, the FASB issued ASU 2024-03, Disaggregation of Income Statement Expenses (DISE) (“ASU 2024-03”), requiring additional disclosure of the nature of expenses included in the income statement. The new standard requires disclosures about specific types of expenses included in the expense captions presented on the face of the condensed consolidated statements of operations and comprehensive loss as well as disclosures about selling expenses. The amendment in this update applies to all public business entities and is effective for annual reporting periods beginning after December 15, 2026 and interim reporting periods beginning after December 15, 2027. The Company is currently evaluating the provisions of the amendments and the impact on its disclosures.

3. Revenue

The Company does not currently have any commercial sales. The Company has entered into collaboration and licensing arrangements for research and development, manufacturing, and commercialization activities with counterparties for the development and commercialization of its product candidates. These arrangements contain multiple promised goods and services, such as licenses, research and development activities, and the manufacturing of certain materials. Payments pursuant to these arrangements include non-refundable payments upon the achievement of significant regulatory, development and commercial milestones, sales of product at certain agreed-upon amounts, and royalties on product sales.

The following table presents the components of the Company’s revenue:


	Six Months Ended
	June 30,
(in thousands)	2025		2024
Pfizer Inc. - Pfizer Agreement - Agreed-to reimbursement activities	$	—	$	24
Pfizer Inc. - Pfizer Agreement - Development milestones		—		6,960
Pfizer Inc. - Additional services		—		8
Total revenue from contracts with customers	$	—	$	6,992

Pfizer Agreement

In September 2022, the Company entered into a license agreement with Pfizer (formally Seagen Inc.) (“Pfizer”) to develop, manufacture, and commercialize PF-08046052 (formerly LAVA-1223), an advanced

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preclinical asset that utilizes the Company’s proprietary Gammabody technology to target EGFR-positive tumors (the “Pfizer Agreement”). Under the terms of the Pfizer Agreement, the Company received a $50.0 million nonrefundable upfront payment in October 2022 and could receive up to approximately $650.0 million in potential development, regulatory, and commercial milestones, and royalties ranging from high single-digit to mid-teen percentages on future sales. The Pfizer Agreement also provided Pfizer with the opportunity to exclusively negotiate rights to apply the Company's proprietary Gammabody platform on up to two additional tumor targets, although these rights expired during the year ended December 31, 2024. In March 2024, Pfizer achieved a clinical development milestone for PF-08046052, resulting in the first milestone payment of $7.0 million to the Company under the Pfizer Agreement, which was recognized in revenue during the six months ended June 30, 2024.

Under the Pfizer Agreement, the Company was also entitled to receive reimbursement of up to $6.5 million for certain agreed-to research, manufacturing, and supply activities, as well as the transfer of all manufacturing-related know-how and materials, including all CMC documentation, data, and processes, to enable the manufacture of licensed compounds and products by Pfizer. As of December 31, 2024, the Company has recognized an aggregate of $6.4 million for additional agreed-to services requested by Pfizer. The Company did not recognize any revenue related to the reimbursement of additional agreed-to services requested by Pfizer during the three months ended June 30, 2025 or 2024. For the six months ended June 30, 2024, the Company recognized less than $0.1 million related to the reimbursement of additional agreed-to services requested by Pfizer. The Company did not recognize any revenue related to the reimbursement of additional agreed-to services requested by Pfizer during the six months ended June 30, 2025. The Company does not anticipate receiving reimbursement for any additional agreed-to services at this time.

Deferred Revenue

The Company determined that the one-time buy-up fee of $35.0 million represents a variable consideration and not a performance obligation, for which it has deferred revenue recognition until such time the option expires or the Company exercises the option. The Company allocated the variable consideration from the buy-up fee to the license performance obligation as it aligns with the economic substance of the Pfizer Agreement. The Company received the non-refundable upfront payment of $50.0 million in October 2022, and recorded the variable consideration of $35.0 million as a deferred revenue liability. The balance as of June 30, 2025 and December 31, 2024 was $35.0 million. If the Company does not exercise the buy-up option and the option expires, the Company will recognize the revenue related to the license performance obligation as there are no remaining performance obligations. If the Company does exercise the buy-up option, the Company will account for this amount as a refund of the transaction price to the customer. The Company will make a decision on whether or not to exercise the buy-up option once clinical data is received from Pfizer, and the Company expects this decision could occur as early as 2026.

J&J Agreement

In May 2020, the Company entered into a research collaboration and license agreement (the “J&J Agreement”) with Johnson & Johnson (formerly Janssen Biotech, Inc.). As part of the J&J Agreement, the Company received a non-refundable upfront payment of $8.0 million. As of January 1, 2023, the Company had recognized the entirety of the $8.0 million upfront payment as revenue, which was recognized on a straight-line basis over the two-year term of the research activities under the J&J Agreement.

The Company did not recognize any revenue related to development milestones under the J&J Agreement during the three and six months ended June 30, 2025 or 2024.

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4. Accrued Expenses and Other Current Liabilities

The following table presents the components of the Company’s accrued expenses and other current liabilities:


	June 30,		December 31,
(in thousands)	2025		2024
Research and development external project costs	$	1,298	$	7,138
Personnel-related expenses		1,210		1,398
Income taxes		300		335
Professional fees		397		598
Employee termination benefits		564		—
Other		415		614
	$	4,184	$	10,083

5. Restructuring

In February 2025, the Company adopted a restructuring plan to extend its capital resources in connection with initiating a process to evaluate strategic alternatives (the “Restructuring Plan”). As part of the Restructuring Plan, the Company approved a reduction of approximately 30% of the global workforce to better align the Company’s resources with its then-focus on the LAVA-1266 program. During the three months ended June 30, 2025, the Company executed further initiatives in relation to the initial Restructuring Plan. On April 18, 2025, the Company entered into an agreement to terminate the operating lease arrangement effective May 1, 2025 for laboratory and office space in Utrecht, the Netherlands and sell a portion of the remaining fixed assets to the landlord and new tenant. Further, on May 12, 2025, the Board approved the reduction of all of the workforce remaining in the Netherlands by July 31, 2025 and the termination of its lease arrangement in Den Bosch, the Netherlands effective August 1, 2025.

The Company incurred the following restructuring and impairment charges for the three months ended June 30, 2025, of which $2.2 million and $0.4 million are recorded in research and development and general and administrative expenses, respectively, in the consolidated statement of operations and comprehensive loss (in thousands):


		Three Months Ended
		June 30, 2025
Employee termination benefits	$	1,514
Costs for terminated contracts		461
Loss on sale of fixed assets		358
Impairment charges		279
Total restructuring and impairment charges	$	2,612

The Company incurred the following restructuring and impairment charges for the six months ended June 30, 2025, of which $2.6 million and $0.6 million are recorded in research and development and general and administrative expenses, respectively, in the consolidated statement of operations and comprehensive loss (in thousands):


		Six Months Ended
		June 30, 2025
Employee termination benefits	$	1,967
Costs for terminated contracts		579
Loss on sale of fixed assets		358
Impairment charges		323
Total restructuring and impairment charges	$	3,227

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The actions associated with the Restructuring Plan commenced in February 2025 and are expected to be completed by the end of 2025.

Employee Termination Benefits

Employees affected by the Restructuring Plan received involuntary termination benefits pursuant to a one-time benefit for a set period of time. Employees who were notified of their termination in 2025 had no requirements to provide future services beyond the minimum retention period. As such, the Company recognized the liability for the termination benefits in full at fair value at the date of communication to the employee.

The following table shows the liability related to employee termination benefits as of June 30, 2025 (in thousands):


	June 30,
	2025
Accrued employee termination benefits as of January 1, 2025	$	—
Employee termination benefits charges incurred during the period		1,967
Amounts paid or otherwise settled during the period		(1,403)
Accrued employee termination benefits as of June 30, 2025	$	564

The Company does not anticipate incurring any additional costs as part of the workforce reduction.

Costs for Terminated Contracts

The Restructuring Plan resulted in contract termination costs from vendor contracts before the end of their term. In accordance with ASC 420, Exit or Disposal Cost Obligations, the Company recognized these unavoidable contract costs when incurred.

The following table shows the liability related to costs for contract termination costs as of June 30, 2025 (in thousands):


	June 30,
	2025
Accrued contract costs as of January 1, 2025	$	—
Contract costs incurred during the period		579
Amounts paid or otherwise settled during the period		(528)
Accrued contract costs as of June 30, 2025	$	51

These costs are subject to significant estimation based on the Company’s expectation of the costs that will continue to be incurred on the contracts, as well as negotiation of contract changes and terminations with its vendors. The Company does not anticipate incurring significant additional contract costs.

Loss on Sale of Fixed Assets and Impairment Charges

In conjunction with the Restructuring Plan and the agreements to terminate the operating lease arrangement for laboratory and office space in Utrecht, the Netherlands, effective May 1, 2025 and to terminate the lease arrangement in Den Bosch, the Netherlands effective August 1, 2025, the Company disposed of fixed assets through sale and abandonment. The Company recorded a loss of $0.4 million, net of proceeds of $0.3 million from the sale of fixed assets, which was recorded in research and

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development expenses in the condensed consolidated statements of operations and comprehensive loss for the three and six months ended June 30, 2025.

Additionally, the Company evaluated certain other fixed assets, leasehold improvements, and right of use assets and concluded that it would abandon the fixed assets, leasehold improvements, and right of use assets in the three months ended June 30, 2025, and as a result, the Company incurred $0.3 million in impairment charges, of which $0.2 million and less than $0.1 million were recorded in research and development and general and administrative expenses, respectively, in the condensed consolidated statements of operations and comprehensive loss for the three and six months ended June 30, 2025.

6. Discontinuation of Clinical Trials

In December 2024, the Company announced that the clinical trial of LAVA-1207 targeting prostate specific membrane antigen(“PSMA”)-expressing cancers for patients with metastatic castration resistant prostate cancer (“mCRPC”) was no longer recruiting and would be discontinued after no patients remain on treatment. The Company was evaluating LAVA-1207 in an open-label, multi-center Phase 1 clinical trial to evaluate safety, tolerability, pharmacokinetics, pharmacodynamics, immunogenicity and preliminary anti-tumor activity of LAVA-1207 and to determine recommended dose(s) for optimization in a Phase 2a clinical trial. The Company made the decision to discontinue the LAVA-1207 development program, as the Phase 1 trial did not reach the Company’s internal benchmarks. The decision was not due to safety concerns. As a result of the discontinuation, the Company had accrued $3.9 million as of December 31, 2024 and $0.7 million as of June 30, 2025 for costs associated with clinical trial, contract manufacturing, and bioanalytical activities for LAVA-1207. During the six months ended June 30, 2025 the Company paid $2.9 million and negotiated a reduction in a contract resulting in an update to the estimate for remaining costs of $0.3 million. The Company expects to pay or settle the remaining amount during the year ending December 31, 2025. The Company reviewed the relevant items of its condensed consolidated balance sheets and did not identify any asset that would require impairment as a result of the discontinuation of the clinical trial of LAVA-1207.

7. Borrowings

In 2019, the Company applied for and received a $5.5 million Innovation Credit (the “Credit”) from Rijksdienst voor Ondernemend Nederland (“RVO”). The Credit contributed to the development of LAVA-051, and the Company pledged certain assets of that project as a guarantee.

Borrowings under the Credit bore interest at 10.0% and were received in quarterly installments, based on the level of the underlying cost base of the project in each period.

In March 2025, the Company received notice from the RVO that repayment of the remaining loan balance of $5.2 million had been permanently waived. The Company recognized a gain on extinguishment within other income (expense), net in the condensed consolidated statements of operations and comprehensive loss during the three months ended March 31, 2025 and six months ended June 30, 2025.

The Company recognized interest expense related to the Credit of $0.0 million and $0.1 million for the three months ended June 30, 2025 and 2024, and $0.1 million and $0.3 million for the six months ended June 30, 2025 and 2024.

8. Commitments and Contingencies

The Company accrues for contingency liabilities, including those involving general liability, workers’ compensation, and other matters, when it is probable that the Company will incur and can reasonably estimate future costs (including legal fees and expenses). The Company bases the accruals on developments to date, management's estimates of the outcomes of these matters, and the Company's experience in contesting, litigating, and settling similar matters. The Company reviews its legal contingencies at each reporting period and adjusts the liabilities to reflect the current best estimate. The Company was not party to any pending legal proceedings or claims as of June 30, 2025 or December 31,

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2024. Other than the Amsterdam UMC Agreement described below, the Company has not made any material commitments.

Amsterdam UMC Agreement

In January 2017, the Company entered into an agreement with the Amsterdam UMC (the “Amsterdam UMC Agreement”) under which Amsterdam UMC granted the Company an exclusive (although non-exclusive with respect to certain intangible know-how), worldwide, sublicensable license for certain patent rights and know-how owned by Amsterdam UMC, effectively including research and other services provided in collaboration by Amsterdam UMC to develop, make, and sell licensed products related to such patent rights and know-how. Amsterdam UMC retains the right to use the patent rights and know-how for solely non-commercial research and educational purposes, but it may not conduct such work with respect to any product that is directed to a specified target for a specified time period.

The Company is obligated to pay Amsterdam UMC low single-digit tiered royalties on net sales of products covered by claims included in the assigned patent rights. The Company has not incurred or paid royalties to Amsterdam UMC at this time, as there have been no net sales of the products covered by the claims. Royalties are payable on a country-by-country basis for a royalty term that expires upon the expiration of the last valid claim in the assigned patent rights in such country that would be infringed by the use, manufacture, or sale of a product in such country in the absence of the Company having rights to such patent right.

9. Earnings Per Share (EPS)

The Company calculates basic EPS by dividing the loss for the period attributable to common equity holders of the parent by the weighted average number of common shares outstanding during the period. The Company accounts for vested share-based awards that are issued for little to no consideration, as issuable common shares. As the share options under the 2018 Stock Option Plan have an exercise price of little to no consideration, the Company considers these share options to be issuable common shares and therefore included these options in the common shares outstanding.

The Company calculates diluted EPS by dividing the loss attributable to common equity holders of the parent (after adjusting for the effect of dilution) by the weighted average number of common shares outstanding, adjusted for the effects of potentially dilutive share-based awards.

As of June 30, 2025 and 2024, the Company had potentially dilutive share-based options of 7,248,459 and 6,047,423, respectively. The Company excluded these awards from the calculation of the diluted weighted average number of common shares outstanding because their effect on the loss per share would have been anti-dilutive as the Company was in a net loss position in both periods.

10. Segment Information

The Company identifies operating segments based on whether the Company’s Chief Executive Officer, who is the Chief Operating Decision Maker (“CODM”), regularly reviews the allocation of resources and/or the assessment of performance of a particular component of the Company’s activities. The Company has one reportable segment – the development of the Gammabody platform of bispecific gd T cell engagers for the treatment of cancer.

The CODM assesses performance for the segment and decides how to allocate resources based on net loss that also is reported on the condensed consolidated statements of operations and comprehensive loss. Significant expenses within the condensed consolidated statements of operations and comprehensive loss, as well as within net loss, include research and development, and general and administrative expenses, which are each separately presented on the Company’s condensed consolidated statements of operations and comprehensive loss. Other segment items within net loss include other income (expense), net, and income tax expense, net. In the context of considerations

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around significant segment expenses, as the expense information that is regularly provided to the CODM is aligned with the consolidated expenses as presented on the statements of operations and comprehensive loss, such expense disclosures are not replicated here.

Net loss is used to monitor budget versus actual results. The monitoring of budgeted versus actual results are used in assessing performance of the segment and in part determining management’s compensation. The CODM also analyzes forecasted general and administrative and research and development expenses when assessing the performance of the segment.

All assets, liabilities, cash flows, revenue and expenses are reported on the Company’s one reportable segment.

11. Subsequent Events

Entry into Share Purchase Agreement with XOMA

On August 3, 2025, the Company entered into a share purchase agreement with XOMA Royalty Corporation, a Nevada corporation (“XOMA”). The purchase agreement (the “Purchase Agreement”) provides for, among other things, the acquisition of all of the Company’s issued and outstanding common shares, par value €0.12 per share, by XOMA through a tender offer, for a price per share of $1.16 plus an additional amount of cash of up to $0.08 per share plus one contingent value right per share, which represents the right to receive potential payments, in cash, described in, and subject to and in accordance with the terms and conditions of, a contingent value rights agreement.

If the Purchase Agreement is terminated by the Company under certain circumstances specified in the Purchase Agreement, including in connection wih the Company’s entry into an agreement with respect to a Superior Proposal (as such term is defined in the Purchase Agreement), the Company would be required to pay XOMA a termination fee of $0.75 million.

Decision to Discontinue Phase 1 Trial of LAVA-1266

On August 4, 2025, the Company announced its decision to discontinue its Phase 1 clinical trial of LAVA-1266 for acute myeloid leukemia and myelodysplastic syndrome and initiate the wind-down of the LAVA-1266 program. An estimate of costs related to the discontinuance of the LAVA-1266 clinical trial cannot be made at this time.

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Item 2. Management’s Discussion and Analysis of Financial Condition and Results of Operations

You should read the following discussion and analysis of our financial condition and results of operations together with our unaudited condensed consolidated financial statements and related notes and other financial information included elsewhere in this Quarterly Report, and the audited consolidated financial statements and notes thereto as of and for the year ended December 31, 2024 and the related Management’s Discussion and Analysis of Financial Condition and Results of Operations included in our Annual Report on Form 10-K filed with the SEC on March 28, 2025. Some of the information contained in this discussion and analysis or set forth elsewhere in this Quarterly Report, including information with respect to our plans and strategy for our business and related financing, includes forward-looking statements that involve risks and uncertainties. As a result of many factors, including those factors set forth in the “Special Note Regarding Forward-Looking Statements” and “Risk Factors” sections of this Quarterly Report and in our most recent Annual Report on Form 10-K, our actual results could differ materially from the results described in or implied by the forward-looking statements contained in the following discussion and analysis. Unless the context requires otherwise, references in this Quarterly Report to the “Company,” “we,” “us,” and “our” refer to LAVA Therapeutics N.V. and its subsidiaries.

Overview

We are a clinical-stage immuno-oncology company that has historically focused on our proprietary Gammabody® bispecific gamma delta (gd) T cell engagers to transform the treatment of cancer. We are currently advancing our Gammabody pipeline for the development of potential therapeutics in both hematologic malignancies and solid tumors through two partnered programs:

●

JNJ-89853413, targeting CD33 and hematologic cancers (NCT06618001), partnered with Johnson & Johnson, and

●

PF-08046052, targeting EGFR-positive tumors (NCT05983133), partnered with Pfizer, Inc.

In February 2025, our board of directors (the “Board”) adopted a restructuring plan (the “Restructuring Plan”) to extend our capital resources in connection with initiating a process to evaluate potential strategic alternatives such as a reverse merger, other business combination, dissolution and wind-down, or cash sale transaction. As a result of this strategic review process, we recently entered into the Purchase Agreement (as described below).

Our current pipeline consists of two partnered assets: JNJ-89853413, targeting CD33 and hematologic cancers (NCT06618001), partnered with Johnson & Johnson, and PF-08046052, targeting EGFR-positive tumors (NCT05983133), partnered with Pfizer, Inc. Through these partnered programs, we continue to investigate the utility of gamma delta bispecific antibodies to treat solid tumors and hematologic malignancies. We are exploring business development-related activities for these programs as well as other strategic alternatives, including for the recently halted LAVA-1266 program, to maximize shareholder value for our remaining assets.

Decision to Discontinue Phase 1 Trial of LAVA-1266

Purchase Agreement; Tender Offer

On August 3, 2025, we entered into a share purchase agreement (the “Purchase Agreement”) with XOMA Royalty Corporation, a Nevada corporation (“XOMA”). The Purchase Agreement provides for, among other things, the acquisition of all of our issued and outstanding common shares, par value €0.12 per

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share, by XOMA through a tender offer (the “Offer”), for a price per Share of $1.16 plus an additional amount of cash of up to $0.08 per Share plus one contingent value right (“CVR”) per share, which represents the right to receive potential payments, in cash, described in, and subject to and in accordance with the terms and conditions of, a contingent value rights agreement (the “CVR Agreement”).

XOMA’s obligation to purchase the shares pursuant to the Offer is subject to the satisfaction or waiver of various usual and customary conditions as described further in our Current Report on Form 8-K filed with the Securities and Exchange Commission on August 4, 2025 (the “Transaction 8-K”) and the documents filed as exhibits thereto. The terms of the CVR Agreement are also set forth in more detail in the Transaction 8-K. See also Item 1 of Part I, “Notes to Condensed Consolidated Financial Statements — Note 11 — Subsequent Events” of this Quarterly Report for further details.

Restructuring Plan

On February 20, 2025, our Board adopted a Restructuring Plan to extend our capital resources in connection with initiating a process to evaluate strategic alternatives. As part of the Restructuring Plan, we approved a workforce reduction of approximately 30% of the global workforce to better align our resources with our then-focus on our LAVA-1266 program. During the six months ended June 30, 2025, we recognized $0.5 million of expenses associated with the workforce reduction, of which $0.4 million was recorded within research and development expense and less than $0.1 million was recorded within general and administrative expense in our condensed consolidated statements of operations and comprehensive loss.

On April 18, 2025, we entered into an agreement to terminate our operating lease arrangement for laboratory and office space in Utrecht, the Netherlands and sell a portion of the remaining fixed assets to the landlord and new tenant. We incurred $1.0 million of expenses associated with the lease termination during the three months ending June 30, 2025, net of $0.3 million of proceeds received from the sale of the assets, of which $0.8 million was recorded within research and development expense and $0.2 million was recorded within general and administrative expense in our condensed consolidated statements of operations and comprehensive loss.

On May 13, 2025, the Board extended the Restructuring Plan in connection with the ongoing process to evaluate strategic alternatives and better align our resources with our then-focus on our LAVA-1266 program. As part of the Restructuring Plan, the Board approved the elimination of the positions of our remaining Netherlands employees by July 31, 2025 and the termination of our lease arrangement in Den Bosch, the Netherlands effective August 1, 2025. We incurred $1.7 million of expenses related to this additional restructuring during the three months ended June 30, 2025, of which $1.3 million was recorded within research and development expense and $0.4 million was recorded within general and administrative expense in our condensed consolidated statements of operations and comprehensive losses.

Key Components of Our Results of Operations

Revenue

To date, we have not generated any revenues from product sales, and we do not expect to generate any revenue from the sale of products in the near future. Our success depends primarily on the successful development and regulatory approval of our product candidates, development candidates and collaborator candidates and our ability to finance operations. If our development efforts result in clinical success and regulatory approval for our product candidates, development candidates or collaborator candidates, or we enter into collaboration agreements with third parties for additional product candidates, we may generate revenue from those product candidates.

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Collaboration Agreement with Pfizer

In September 2022, we entered into an exclusive license agreement with Pfizer (formerly Seagen Inc.) (the “Pfizer Agreement”) to develop, manufacture and commercialize PF-8046052 (formerly LAVA-1223), an advanced preclinical asset that utilizes our proprietary Gammabody technology to target EGFR-positive tumors. Under the Pfizer Agreement, we received a $50.0 million nonrefundable upfront payment in October 2022 and are eligible to receive up to approximately $650.0 million upon the achievement of development, regulatory and commercial milestones, as well as royalties ranging from the low teens to high mid-teens on future sales. The Pfizer Agreement also provided Pfizer with the opportunity to exclusively negotiate rights to apply our proprietary Gammabody platform on up to two additional tumor targets, which Pfizer did not exercise. In March 2024, Pfizer paid us $7.0 million for achieving a clinical milestone. Under the Pfizer Agreement, we were also entitled to receive reimbursement of up to $6.5 million for certain agreed-to research, manufacturing, and supply activities, as well as the transfer of all manufacturing-related know-how and materials, including all CMC documentation, data, and processes, to enable the manufacture of licensed compounds and products by Pfizer. We do not anticipate receiving reimbursement for any additional agreed-to services at this time.

Pfizer has also granted us a one-time option to obtain increased royalties if we exercise a buy up option within a certain amount of time from certain key early clinical data becoming available for the first licensed product. Following notice, we have a specified period to exercise the buy-up option to pay Pfizer a one-time $35.0 million fee (the “buy-up fee”). In the event we exercise the buy-up option and pay the buy-up fee, we are entitled to receive tiered royalties based on commercial sales levels from low teen to high teen percentages of net sales of licensed products.

Royalties are payable on a licensed product-by-licensed product and country-by-country basis beginning with the first commercial sale of such licensed product in such country of sale and expiring ten years after such sale, subject to specified and capped reductions for the market entry of biosimilar products, loss of patent coverage of licensed products, and for payments owed to third parties for additional rights necessary to commercialize licensed products in the territory.

Collaboration Agreement with J&J

In May 2020, we entered into a research collaboration and license agreement (the “J&J Agreement”) with Johnson & Johnson (“J&J”) (formerly Janssen Biotech, Inc.). As part of the J&J Agreement, we received a non-refundable upfront payment of $8.0 million, which we recognized on a straight-line basis over the two-year term of the research activities under the J&J Agreement. The straight-line method of recognition materially approximates the cost-to-cost method of revenue recognition. As of January 1, 2023, we had recorded the entirety of the $8.0 million upfront payment as revenue.

In December 2020, we achieved the first Research Milestone, as defined in the J&J Agreement, triggering a milestone payment of $1.0 million. In 2021, we achieved the second Research Milestone, triggering a milestone payment of $1.0 million. In May 2023, within the framework of the J&J Agreement, J&J selected a lead bispecific antibody utilizing the Gammabody platform for an undisclosed tumor associated antigen to progress into development, and we received a $2.5 million milestone payment. In October 2024, a milestone payment of $5.0 million from J&J was triggered under the terms of the J&J Agreement following filing with health authorities to start a Phase 1 clinical trial for JNJ-89853413. Each milestone payment was recorded as revenue when achieved, due to the variable consideration of the milestone payments no longer being constrained.

We are entitled to receive tiered royalties based on commercial sales levels from low to mid-single digit percentages of net sales of licensed products. Royalties are payable on a licensed product-by-licensed product and country-by-country basis beginning with the first commercial sale of such licensed product in such country of sale and expiring ten years after such sale, subject to specified and capped reductions for the market entry of biosimilar products, loss of patent coverage of licensed products, and for payments owed to third parties for additional rights necessary to commercialize licensed products in the territory.

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Operating Expenses

Our primary categories of operating expenses are research and development expenses and general and administrative expenses.

Research and Development Expenses

Research and development expenses consist primarily of the costs incurred in performing research and development activities and conducting preclinical studies and clinical trial activities. Our research and development expenses consist of:

●

personnel-related expenses such as compensation and employee benefits for employees engaged in research and development;

●

expenses incurred under agreements with contract manufacturing organizations (“CMOs”), contract research organizations (“CROs”), and consultants that conduct and support preclinical studies and clinical trial activities;

●

expenses incurred in connection with internal research and development and research services agreements with third-parties;

●

expenses including laboratory supplies and research materials, facility expenses, and depreciation of research and development fixed assets; and

●

share-based compensation for employees engaged in research and development.

We expense research and development costs as incurred. We do not allocate employee-related costs, costs associated with our discovery efforts, laboratory supplies, depreciation, facility expenses or other indirect costs to specific product development programs because these costs are deployed across multiple programs, and as such, are not separately classified.

General and Administrative Expenses

General and administrative expenses consist of costs incurred for operational expenses such as accounting, legal and insurance, and related activities. Our general and administrative expenses consist of:

●	personnel-related expenses, such as compensation and employee benefits for employees engaged in general and administrative activities;

●	professional and consultant fees for third-party consultants supporting audit, accounting, and finance compliance and financial consulting activities;

●	expenses including facilities, insurance and related costs such as depreciation expenses and other corporate and operating expenses not included in research and development;

●	share-based compensation for employees engaged in general and administrative activities; and

●	expenses and legal costs related to the protection of our intellectual property.

General and administrative expenses are expensed as incurred.

Gain on Extinguishment of Borrowings

In 2019, we applied for and received a $5.5 million Innovation Credit (the “Credit”) from Rijksdienst voor Ondernemend Nederland (“RVO”). The Credit contributed to the development of LAVA-051, and we

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pledged certain assets of that project as a guarantee. In March 2025, we received notice from the RVO that the remaining loan balance of $5.2 million had been permanently waived. We recognized this non-cash gain on extinguishment within other income (expense), net in the condensed consolidated statements of operations and comprehensive loss during the six months ended June 30, 2025.

Income Tax

We are subject to income taxes in the Netherlands, the United States, and Australia. Income tax expense of $0.3 million and $0.2 million was recognized during the six months ended June 30, 2025 and 2024, respectively, due to the profitable positions in the U.S. and Australia as a result of the cost plus intercompany renumeration in both jurisdictions.

We continue to be in a taxable loss position in the Netherlands and as such continue to maintain a full valuation allowance against all of our deferred tax assets in the jurisdiction. We have evaluated the positive and negative evidence involving our ability to realize the deferred tax assets and have concluded that it is more likely than not that we will not realize the benefits of our deferred tax assets. We reevaluate the positive and negative evidence at each reporting period.

On July 4, 2025, President Trump signed H.R. 1, the “One Big Beautiful Bill Act”, into law which contains a broad range of tax reform provisions affecting businesses. In accordance with U.S. GAAP, we will account for the tax effects of changes in tax law in the period of enactment, which is in the third quarter of calendar year 2025. We are currently in the process of analyzing the tax impacts of the law change; however, we do not expect a material impact on the financial statements.

Results of Operations

Comparison of the Three Months Ended June 30, 2025 and 2024

The following table summarizes our results of operations for the three months ended June 30, 2025 and 2024:


	Three Months Ended
	June 30,
(in thousands)	2025		2024		Change
Revenue:
Revenue from contracts with customers	$	—	$	—	$	-
Total revenue		—		—		-
Cost and expenses:
Research and development		(4,739)		(5,958)		(1,219)
General and administrative		(2,550)		(3,435)		(885)
Total cost and expenses		(7,289)		(9,393)		(2,104)
Operating loss		(7,289)		(9,393)		(2,104)
Other (expense) income, net
Interest income		607		968		(361)
Interest expense		—		(129)		129
Foreign currency exchange (loss) gain, net		(1,885)		340		(2,225)
Total other (expense) income, net		(1,278)		1,179		(2,457)
Net loss before taxes		(8,567)		(8,214)		353
Income tax expense		(72)		(86)		(14)
Net loss	$	(8,639)	$	(8,300)	$	339

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Research and Development Expenses

Below are our research and development expenses for the three months ended June 30, 2025 and 2024:


	Three Months Ended
	June 30,
(in thousands)	2025		2024		Change
Pre-clinical and clinical trial expenses	$	2,921	$	3,704	$	(783)
Personnel-related expenses		892		1,366		(474)
Facilities and other research and development expenses		640		340		300
Research and development activities expenses		164		274		(110)
Share-based compensation expense		122		274		(152)
	$	4,739	$	5,958	$	(1,219)

Research and development expenses were $4.7 million for the three months ended June 30, 2025, compared to $6.0 million for the three months ended June 30, 2024. Pre-clinical and clinical trial expenses decreased by $0.8 million, primarily due to the discontinuation of the LAVA-1207 clinical trial in December 2024, offset by clinical trial expenses for LAVA-1266. Personnel-related expenses decreased by $0.5 million primarily due to a reduction in headcount in 2024 offset by the accrual of severance payments related to the May 2025 restructuring activities. Facilities and other research and development expenses increased by $0.3 million due to the loss on the sale of fixed assets and impairment costs associated with the termination of our lease arrangements in Utrecht, Netherlands. Research and development activities expenses decreased by $0.1 million primarily due to decreased third-party research project expenses in the three months ended June 30, 2025 as compared to the same period in 2024. Share-based compensation expense decreased by $0.2 million due to fewer options being issued in 2025 as compared to 2024 and a reduction in our overall share price.

General and Administrative Expenses

Below are our general and administrative expenses for the three months ended June 30, 2025 and 2024:


	Three Months Ended
	June 30,
(in thousands)	2025		2024		Change
Personnel-related expenses	$	1,076	$	1,003	$	73
Professional and consultant fees		751		889		(138)
Insurance, facilities, fees and other related costs		404		625		(221)
Share-based compensation expense		318		547		(229)
Patent-related costs		1		371		(370)
	$	2,550	$	3,435	$	(885)

General and administrative expenses were $2.6 million for the three months ended June 30, 2025, compared to $3.4 million for the three months ended June 30, 2024. Personnel-related expenses increased by $0.1 million primarily due to the accrual of severance payments related to the May 2025 restructuring activities offset by a corresponding reduction in headcount. Professional and consultant fees decreased by $0.1 million primarily due to consultant costs associated with the transition to United States generally accepted accounting principles (“U.S. GAAP”) incurred during the three months ended June 30, 2024. Insurance, facilities, fees and other related costs decreased by $0.2 million primarily due to a reduction in directors and officers insurance premiums as well as reduced office lease costs. Share-based compensation expense decreased by $0.2 million due to fewer options being issued in 2025 as compared to 2024 and a reduction in our overall share price. Patent-related costs decreased by $0.4 million due to a reduction in the number of patent filings we made.

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Other (expense) income, net

Other (expense) income, net was $(1.3) million for the three months ended June 30, 2025, compared to $1.2 million for the three months ended June 30, 2024. The decrease of $2.5 million is primarily due a period over period change of $2.2 million in foreign exchange loss, net due to the impact of the fluctuation of the USD currency rate compared to the Euro. Interest income decreased by $0.4 million and interest expense decreased by $0.1 million, respectively, for the three months ended June 30, 2025 compared to the three months ended June 30, 2024. The decrease in interest income was due to lower interest rates for cash held in money market accounts, while the decrease in interest expense was due to the forgiveness of the RVO credit balance and related interest being waived in March 2025.

Comparison of the Six Months Ended June 30, 2025 and 2024

The following table summarizes our results of operations for the six months ended June 30, 2025 and 2024:


	Six Months Ended
	June 30,
(in thousands)	2025		2024		Change
Revenue:
Revenue from contracts with customers	$	—	$	6,992	$	(6,992)
Total revenue		—		6,992		(6,992)
Cost and expenses:
Research and development		(8,895)		(11,606)		(2,711)
General and administrative		(5,982)		(6,816)		(834)
Total cost and expenses		(14,877)		(18,422)		(3,545)
Operating loss		(14,877)		(11,430)		3,447
Other income (expense), net
Interest income		1,320		1,938		(618)
Interest expense		(129)		(259)		130
Foreign currency exchange (loss) gain, net		(3,338)		997		(4,335)
Gain on extinguishment of borrowings		5,203		—		5,203
Total other income, net		3,056		2,676		380
Net loss before taxes		(11,821)		(8,754)		3,067
Income tax expense		(297)		(154)		143
Net loss	$	(12,118)	$	(8,908)	$	3,210

Revenue from Contracts with Customers

Our revenue from contracts with customers was $0.0 million and $7.0 million for the six months ended June 30, 2025 and 2024, respectively.

In connection with the Pfizer Agreement, we recognized $7.0 million in revenue in the six months ended June 30, 2024 related to the achievement by Pfizer of a clinical development milestone for PF-08046052, less than $0.1 million for agreed-to reimbursement activities, and less than $0.1 million for other services in connection with the Pfizer Agreement. We did not recognize any revenue under the Pfizer Agreement in the six months ended June 30, 2025.

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Research and Development Expenses

Below are our research and development expenses for the six months ended June 30, 2025 and 2024:


	Six Months Ended
	June 30,
(in thousands)	2025		2024		Change
Pre-clinical and clinical trial expenses	$	4,035	$	7,098	$	(3,063)
Personnel-related expenses		2,645		2,525		120
Facilities and other research and development expenses		1,086		642		444
Research and development activities expenses		734		624		110
Share-based compensation expense		395		717		(322)
	$	8,895	$	11,606	$	(2,711)

Research and development expenses were $8.9 million for the six months ended June 30, 2025, compared to $11.6 million for the six months ended June 30, 2024. Pre-clinical and clinical trial expenses decreased by $3.1 million, primarily due to the discontinuation of the LAVA-1207 clinical trial in December 2024, offset by clinical trial expenses for our LAVA-1266 program. Personnel-related expenses increased by $0.1 million primarily due to the accrual of severance payments related to restructuring activities initiated in February and May 2025 and expenses related to the hiring of a new chief scientific officer in January 2025. Facilities and other research and development expenses increased by $0.4 million due to the loss on the sale of fixed assets and impairment costs associated with the termination of our lease arrangements in Utrecht and Den Bosch. Research and development activities expenses increased by $0.1 million primarily due to an increase in third-party research project expenses in the six months ended June 30, 2025 as compared to the same period in 2024. Share-based compensation expense decreased by $0.3 million due to fewer options issued in the six months ended June 30, 2025 as compared to the same period in 2024 and a reduction in our overall share price.

General and Administrative Expenses

Below are our general and administrative expenses for the six months ended June 30, 2025 and 2024:


	Six Months Ended
	June 30,
(in thousands)	2025		2024		Change
Personnel-related expenses	$	2,242	$	1,960	$	282
Professional and consultant fees		1,883		1,580		303
Insurance, facilities, fees and other related costs		1,119		1,354		(235)
Share-based compensation expense		585		1,199		(614)
Patent-related costs		153		723		(570)
	$	5,982	$	6,816	$	(834)

General and administrative expenses were $6.0 million for the six months ended June 30, 2025, compared to $6.8 million for the six months ended June 30, 2024. Personnel-related expenses increased $0.3 million primarily due to salary increases for employees and the accrual of severance payments related to restructuring activities initiated in February and May 2025 offset by a corresponding reduction in headcount. Professional and consultant fees increased by $0.3 million due to a transition of staffing from internal employees to external consultants and ongoing financial consulting services associated with the transition to U.S. GAAP and preparation and filing of our first Annual Report on Form 10-K since our transition to a domestic filer. Insurance, facilities, fees and other related costs decreased by $0.2 million primarily due to a reduction in directors and officers insurance premiums as well as reduced office lease costs. Share-based compensation expense decreased by $0.6 million due to fewer options issued in the six months ended June 30, 2025 as compared to the same period in 2024 and a reduction in our overall

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share price. Patent-related costs decreased by $0.6 million due to a reduction in the number of patent filings we made in 2025 as compared to the same period in the prior year.

Other income (expense), net

Other income (expense), net was $3.1 million for the six months ended June 30, 2025, compared to $2.7 million for the six months ended June 30, 2024. The increase of $0.4 million is primarily due a $5.2 million gain on extinguishment of borrowings due to the RVO credit balance being waived in March 2025, offset by a period over period change of $4.3 million in foreign exchange loss, net due to the impact of the fluctuation of the USD currency rate compared to the Euro and an interest income decrease by $0.6 million for the six months ended June 30, 2025 compared to the six months ended June 30, 2024.

Liquidity and Capital Resources

Sources of Liquidity

We have historically funded our operations primarily through issuance of preference shares prior to our initial public offering (“IPO”), from the sale of common shares in our IPO, and more recently, through research and licensing revenue and receipt of milestone payments under our collaboration agreements. Our expenditures are primarily related to research and development activities and general administrative activities to support business operations.

In 2019, we received a $5.5 million Innovation Credit from Rijksdienst voor Ondernemend Nederland (RVO) for the LAVA-051 program. Borrowings under the Innovation Credit, which bore interest at 10.0%, were received in quarterly installments. In March 2025, we received notice from the RVO that the remaining loan balance of $5.2 million had been permanently waived. We recognized this non-cash gain on extinguishment within other income (expense), net in the condensed consolidated statements of operations and comprehensive loss during the six months ended June 30, 2025.

Under the Pfizer Agreement, we received a nonrefundable up-front payment of $50.0 million in October 2022 and a clinical milestone payment of $7.0 million in March 2024. Additionally, we were entitled to reimbursement of up to $6.5 million for certain agreed-to research, manufacturing, and supply activities under the Pfizer Agreement, and received an aggregate amount of $6.4 million. We do not anticipate receiving reimbursement for any additional agreed-to services at this time. Under the J&J Agreement, we have recognized an aggregate amount of $17.5 million of revenue to date, including a nonrefundable up-front payment of $8.0 million in May 2020 and aggregate clinical milestone payments of $9.5 million to date.

Cash and cash equivalents and short-term investments are financial instruments that potentially subject us to concentrations of credit risk. As of June 30, 2025 and December 31, 2024, cash consists of cash deposited with four financial institutions and account balances in excess of the federally insured limits. Management believes that we are not exposed to significant credit risk due to the financial strength of these financial institutions.

Contractual Obligations and Commitments

During the three and six months ended June 30, 2025, there were no material changes to our contractual obligations and commitments from those described in our Annual Report on Form 10-K for the year ended December 31, 2024, which was filed with the SEC on March 28, 2025.

Funding Requirements

Based on our current operating plan, we believe that our cash, cash equivalents and short-term investments of $56.2 million as of June 30, 2025 are sufficient to meet our projected cash requirements for at least 12 months from the date of this Quarterly Report. However, our operating plan may change as

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a result of many factors currently unknown to us, including as a result of our ongoing strategic alternatives analysis and the outcome of the proposed transactions with XOMA described above. In light of the proposed transactions with XOMA, we expect our expenses and capital requirements will decrease in connection with our ongoing activities as we pursue these transactions and explore strategic alternatives for our clinical and research programs. However, our expenses and capital requirements could increase if we:

●

resume development of our product candidates, including LAVA-1266 and other early-stage development candidates;

●

initiate, conduct and complete any future preclinical studies and clinical trials for our current and future product candidates;

●

resume development of processes and scale manufacturing production for our current and future product candidates in accordance with cGMP;

●

seek regulatory and marketing approvals for LAVA-1266 and any of our other development candidates that successfully complete clinical trials;

●

maintain, protect and expand our intellectual property portfolio, including costs associated with opposing and invalidating competitor patents and licensing other technologies for our product candidates;

●

add clinical, scientific, operational, financial and management information systems and personnel, including personnel to support our product development and planned future commercialization efforts;

●

complete our strategic review of our business and acquire or in-license additional product candidates and technologies, pursue a sale, merger or acquisition of the business, or other strategic alternatives;

●

incur additional legal, accounting and other expenses associated with operating as a public company;

●

address any events outside of our control, including, but not limited to, outbreaks of infectious diseases; and

●

face general economic and market conditions and overall fluctuations in the United States and international equity markets, such as the Russian invasion of Ukraine, the conflict in the Middle East and other geopolitical conditions.

In the event that we do not consummate the transactions with XOMA, we will require substantial additional funding to develop our product candidates and support our continuing operations. Until such time as we can generate significant revenue from sales of our product candidates, if ever, we expect to finance our operations through equity offerings, debt financings or other capital sources, which may include strategic collaborations or other arrangements with third parties. Additional funds may not be available to us on acceptable terms or at all. If we raise additional funds by issuing equity or convertible debt securities, our shareholders will suffer dilution and the terms of these securities may include liquidation or other preferences that adversely affect the rights of our common shareholders. Debt financing, if available, may involve restrictive covenants limiting our flexibility in conducting future business activities, and, in the event of insolvency, debt holders would be repaid before holders of our equity securities receive any distribution of our corporate assets. If we raise funds through collaborations or other similar arrangements with third parties, we may have to relinquish valuable rights to technologies, future revenue streams, product candidates or research programs or grant licenses on terms that may not be favorable to us and/or may reduce the value of our common shares. Our ability to raise additional funds or complete a strategic transaction may be adversely impacted by potential worsening global economic conditions and the recent disruptions to, and volatility in, the credit and financial markets in the United States and worldwide.

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Additional funds may not be available when we need them on terms that are acceptable to us, or at all. If adequate funds are not available to us on a timely basis, we may be required to delay, limit, scale back or cease our research and development activities, preclinical studies and clinical trials for our product candidates.

Cash Flows

Comparison of the Six Months Ended June 30, 2025 and 2024

The following table summarizes our cash flows for each of the periods presented:


	Six Months Ended
	June 30,
(in thousands)	2025		2024		Change
Net cash used in operating activities	$	(25,394)	$	(9,057)	$	(16,337)
Net cash provided by investing activities		12,662		1,057		11,605
Net cash provided by financing activities		—		24		(24)
Net decrease in cash and cash equivalents	$	(12,732)	$	(7,976)	$	(4,756)

Operating Activities

During the six months ended June 30, 2025, $25.4 million of cash was used in operating activities, primarily resulting from our net loss of $12.1 million, net non-cash add-backs of $4.7 million, which included a gain on extinguishment of borrowings of $5.2 million, and net cash used by changes in our operating assets and liabilities of $8.6 million. Net cash used by changes in our operating assets and liabilities for the six months ended June 30, 2025 consisted primarily of an increase in prepaid expenses and other current assets of $0.6 million, a decrease in accrued expenses and other current liabilities of $6.5 million, and a decrease in accounts payable of $1.5 million.

During the six months ended June 30, 2024, $9.1 million of cash was used in operating activities, primarily resulting from our net loss of $8.9 million, net non-cash add-backs of $0.9 million, and net cash used by changes in our operating assets and liabilities of $1.0 million. Net cash used by changes in our operating assets and liabilities for the six months ended June 30, 2024 consisted primarily of an increase in prepaid expenses and other current assets of $0.2 million, a decrease in accounts payable of $0.3 million, and a decrease in accrued expenses and other current liabilities of $0.5 million.

Investing Activities

Net cash provided by investing activities for the six months ended June 30, 2025 was $12.7 million compared to net cash provided by investing activities of $1.1 million for the six months ended June 30, 2024. During the six months ended June 30, 2025, we received $47.0 million from the maturities of investments, offset by investment purchases of $34.6 million. During the six months ended June 30, 2024, we received $57.0 million from the maturities of investments and proceeds from the sale of property and equipment, respectively, offset by purchases of investments of $56.0 million.

Financing Activities

Net cash provided by financing activities for the six months ended June 30, 2025 and 2024 was $0.0 million and less than $0.1 million, respectively. The net cash provided by financing activities for the six months ended June 30, 2024 was due to proceeds from option exercises.

Critical Accounting Policies and Estimates

Our financial statements are prepared in accordance with generally accepted accounting principles in the United States. The preparation of our financial statements and related disclosures requires us to make estimates, assumptions and judgments that affect the reported amount of assets, liabilities, revenue,

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costs and expenses, and related disclosures. Our critical accounting policies are described under the heading “Management’s Discussion and Analysis of Financial Condition and Results of Operations—Critical Accounting Policies and Estimates” in our Annual Report on Form 10-K. If actual results or events differ materially from the estimates, judgments and assumptions used by us in applying these policies, our reported financial condition and results of operations could be materially affected. There have been no significant changes to our critical accounting policies from those described in our Annual Report on Form 10-K.

Recently Adopted Accounting Pronouncements

A description of recently adopted accounting pronouncements that may potentially impact our financial position, results of operations and cash flows is disclosed in Note 2 to our unaudited condensed consolidated financial statements appearing elsewhere in this Quarterly Report.

Item 3. Quantitative and Qualitative Disclosures About Market Risk

We are a smaller reporting company as defined by Item 10 of Regulation S-K and are not required to provide the information otherwise required under this item.

Item 4. Controls and Procedures

Evaluation of Disclosure Controls and Procedures

Our management, with the participation of our Chief Executive Officer and our Chief Financial Officer, have evaluated the effectiveness of our disclosure controls and procedures (as defined in Rule 13a-15(e) and 15d-15(e) of the Exchange Act of 1934, as amended) as of the end of the period covered by this Quarterly Report. Based on that evaluation, management, including our Chief Executive Officer and Chief Financial Officer, have concluded that as of June 30, 2025, our disclosure controls and procedures were effective at a reasonable assurance level.

Our disclosure controls and procedures are designed to provide reasonable assurance that information required to be disclosed by us in reports that we file or submit under the Exchange Act is (i) recorded, processed, summarized and reported within the time periods specified in the SEC’s rules and forms and (ii) accumulated and communicated to management, including our Chief Executive Officer and Chief Financial Officer, as appropriate, to allow timely discussions regarding required disclosure. We believe that a control system, no matter how well designed and operated, cannot provide absolute assurance that the objectives of the control system are met, and no evaluation of controls can provide absolute assurance that all control issues and instances of fraud, if any, within a company have been detected. As such, management necessarily applies its judgment in evaluating the cost-benefit relationship of possible controls and procedures.

Changes in Internal Control Over Financial Reporting

There were no changes in our internal control over financial reporting (as defined in Rules 13a-15(f) and 15d-15(f) under the Exchange Act) during the quarter ended June 30, 2025 that have materially affected, or are reasonably likely to materially affect, our internal control over financial reporting.

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PART II. OTHER INFORMATION

Item 1. Legal Proceedings

From time to time, we may become involved in legal proceedings arising in the ordinary course of our business. We are not currently subject to any material legal proceedings.

Item 1A. Risk Factors

Investing in our common shares involves a high degree of risk. In addition to the other information set forth in this Quarterly Report on Form 10-Q, you should carefully consider the risks described in the Annual Report, including the disclosure therein under Part I, Item 1A, “Risk Factors,” before deciding whether to invest in our common shares. These are not the only risks facing our business. Other risks and uncertainties that we are not currently aware of or that we currently consider immaterial also may materially adversely affect our business, financial condition and future results. Risks we have identified but currently consider immaterial could still also materially adversely affect our business, financial condition and future results of operations if our assumptions about those risks are incorrect or if circumstances change.

There were no material changes during the period covered in this Quarterly Report to the risk factors previously disclosed in Part I, Item 1A of the Annual Report, except as follows:

Risks Related to the Proposed Transactions with XOMA

The proposed transactions with XOMA are subject to a number of conditions beyond our control. Failure to complete proposed transactions within the expected time frame, or at all, could have a material adverse effect on our business, operating results, financial condition and our share price.

On August 3, 2025, we entered into the Purchase Agreement with XOMA, pursuant to which, and upon the terms and subject to the conditions of, XOMA will commence a tender offer to purchase all of our outstanding common shares. XOMA’s obligation to accept our common shares tendered in the Offer is subject to conditions, including: (i) that the number of common shares validly tendered and not validly withdrawn, represents at least 80% (which may be lowered to 75% in certain cases) of our issued and outstanding share capital immediately prior to the expiration of the Offer (such condition, the “Minimum Condition”); (ii) our Closing Net Cash (as defined in and determined in accordance with the Purchase Agreement) will be at least $31.5 million as of the expiration of the Offer (the “Closing Net Cash Condition”); (iii) the accuracy of our representations and warranties contained in the Purchase Agreement, including that, since the date of the Purchase Agreement, there shall not have occurred any Company Material Adverse Effect (as defined in the Purchase Agreement), (iv) our performance in all material respects of its obligations under the Purchase Agreement, (v) the adoption of certain resolutions by our shareholders at an extraordinary general meeting and (vi) the other conditions set forth in the Purchase Agreement. The obligations of XOMA to consummate the proposed transactions under the Purchase Agreement are not subject to a financing condition.

We cannot predict whether or when these conditions will be satisfied. If one or more of these conditions are not satisfied, and as a result, we do not complete the proposed transactions, we would remain liable for significant transaction costs, and the focus of our management would have been diverted from seeking other potential strategic opportunities, in each case without realizing any benefits of the proposed transactions. Certain costs associated with the proposed transactions have already been incurred or may be payable even if the proposed transactions are not consummated. Finally, any disruptions to our business resulting from the announcement and pendency of the proposed transactions, including any adverse changes in our relationships with our partners, suppliers and employees, could continue or accelerate in the event that we fail to consummate the proposed transactions.

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Our share price may also fluctuate significantly based on announcements by XOMA, other third parties, or us regarding the proposed transactions or based on market perceptions of the likelihood of the satisfaction of the Minimum Condition or other conditions to the consummation of the proposed transactions. Such announcements may lead to perceptions in the market that the proposed transactions may not be completed, which could cause our share price to fluctuate or decline. Other factors outside of our control, such as a governmental entity enacting a legal restraint or prohibition that prevents or prohibits the proposed transactions, could cause us not to satisfy the closing condition relating to the absence of legal restraints and thus the proposed transactions would not be consummated. Further, unforeseen and unexpected expenses could cause our net cash to be below the applicable threshold thus causing us to fail to satisfy the Closing Net Cash Condition.

If we do not consummate the proposed transactions, the price of our common shares may decline significantly from the current market price, which may reflect a market assumption that the proposed transactions will be consummated. Any of these events could have a material adverse effect on our business, operating results and financial condition and could cause a decline in the price of our common shares.

The consideration payable to holders of our common shares and in-the-money options pursuant to the Purchase Agreement will be adjusted if our net cash amount exceeds a certain threshold but will not otherwise be adjusted for changes in our business, assets, liabilities, prospects, outlook, financial condition or results of operations, or in the event of any change in our share price.

The consideration payable to holders of our common shares and in the money Company Options will be adjusted based on our Closing Net Cash but will not be otherwise adjusted for changes in our business, assets, liabilities, prospects, outlook, financial condition or results of operations, or changes in the market price of, analyst estimates of, or projections relating to, our common shares.

Our shareholders may not receive any payment on the CVR and the CVR may expire valueless.

If the proposed transactions are completed, the holders of our common shares and in the money Company Options will be entitled to receive one CVR per share (or underlying share, as the case may be), representing the right to receive, subject to the terms and conditions of the CVR Agreement, contingent cash payments calculated as follows: (i) 100% of the amount by which our Closing Net Cash as adjusted for any Permitted Deductions (as defined in the CVR Agreement) made within ninety (90) days following the date on which the closing occurs (the "Closing Date”), exceeds Closing Net Cash as finally determined pursuant to the Purchase Agreement; (ii) (A) 100% of the Net Proceeds (as defined in the CVR Agreement), if any, from any disposition by us, of all or any part of the rights, intellectual property and other assets related to our LAVA-1266 program entered into prior to the Closing or (B) 75% of the Net Proceeds, if any, of such dispositions by XOMA and its affiliates (including us after the Closing) from the Closing until 10 years after the Closing (the “Expiration Date”); and (iii) 75% of the Net Proceeds, if any, due to or received by XOMA or any of its affiliates, including us (after the Closing) and New Topco, in respect of our collaborations with Pfizer and J&J after the Closing until the Expiration Date. In the event that no CVR Proceeds (as defined in and determined in accordance with the CVR Agreement) become payable prior to the Expiration Date, holders of the CVRs will not receive any payment pursuant to the CVR Agreement. The CVRs will not be transferable, except in the limited circumstances specified in the CVR Agreement, will not have any voting or dividend rights, and will not represent any equity or ownership interest in us or any of our affiliates, and interest will not accrue on any amounts potentially payable on the CVRs. Accordingly, the right of any of our shareholders to receive any future payment on or derive any value from the CVRs will be contingent solely upon the occurrence of a disposition or the receipt of payments under our Pfizer and J&J collaborations, as outlined above, and if no such dispositions or payments are achieved for any reason within the time periods specified in the CVR Agreement, no payments will be made under the CVRs, and the CVRs will expire valueless.

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The Purchase Agreement contains provisions that could discourage a potential competing acquirer.

The Purchase Agreement provides that, upon the terms and subject to the conditions thereof, we and our representatives cannot directly or indirectly solicit, initiate, encourage or knowingly facilitate discussions with third parties regarding other proposals to acquire or combine with us and we are subject to restrictions on our ability to respond to any such proposal. In the event that we receive an acquisition proposal from a third party, we must notify XOMA of such proposal and negotiate in good faith with XOMA prior to terminating the Purchase Agreement or effecting a change in the recommendation of our board of directors to our shareholders with respect to the proposed transactions. The Purchase Agreement also contains certain termination rights for XOMA and us and further provides that, upon termination of the Purchase Agreement under specified circumstances, including certain terminations in connection with an alternative business combination transaction as permitted by the terms of the Purchase Agreement, we will be required to pay XOMA a termination fee of $750,000. These provisions could discourage a potential third-party acquirer that might have an interest in acquiring all or a significant portion of us from considering or proposing that acquisition, even if it were prepared to pay consideration with a higher per share cash or market value than the market value proposed to be received or realized in the transaction. These provisions also might result in a potential third-party acquirer proposing to pay a lower price to our shareholders than it might otherwise have proposed to pay due to the added expense of the termination fee that may become payable in certain circumstances. If the Purchase Agreement is terminated and we decide to seek another business combination, we may not be able to negotiate a transaction with another party on terms comparable to, or better than, the terms of the proposed transactions with XOMA.

Shareholder or other litigation could prevent or delay the consummation of the proposed transactions with XOMA or otherwise negatively impact our business, operating results and financial condition.

Complaints or lawsuits may in the future be filed against us, our board of directors, XOMA, any of XOMA’s boards of directors and/or others in connection with the transactions contemplated by the Purchase Agreement. The outcome of litigation is uncertain, including the amount of costs associated with defending these claims or any other liabilities that may be incurred in connection with the litigation of these claims, and we may not be successful in defending against any such future claims.

We may incur additional costs in connection with the defense or settlement of any future shareholder or other litigation (including creditor opposition filed under Dutch law) in connection with the proposed transactions. Further, any such future litigation (including creditor opposition) could cause a delay in completion of the proposed transactions or may adversely affect our ability to complete the proposed transactions and may impact our ability to meet the Closing Net Cash Condition. We could incur significant costs in connection with any such litigation (including creditor opposition), including costs associated with the indemnification of our directors and executive officers, and lawsuits may, and divert the attention of our management and employees from our day-to-day business which could affect our operations and otherwise adversely affect us financially.

The announcement and pendency of the transaction with XOMA could adversely affect our business, financial results and/or operations.

Employee retention may be particularly challenging while the transaction is pending because employees may experience uncertainty about their roles following the transaction. A substantial amount of our management’s and employees’ attention is being directed toward the completion of the transactions and thus is being diverted from our day-to-day operations. The adverse effects of the pendency of the transaction could be exacerbated by any delays in the completion of the transaction or termination of the Purchase Agreement. In addition, our executive officers and directors may have interests in the Merger that are different from, or are in addition to, those of our shareholders generally. These interests include without limitation the following: the receipt of transaction bonuses payable to executive officers under

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certain transaction bonus letters; and the potential receipt of severance payments and benefits by executive officers under their respective employment letters.

While the proposed transactions with XOMA are pending, we are subject to business uncertainties and contractual restrictions that could disrupt our business, and the proposed transactions may impair our ability to attract and retain qualified employees or retain and maintain relationships with our suppliers and other business partners.

Whether or not the proposed transactions are consummated, the proposed transactions may disrupt our current plans and operations, which could have an adverse effect on our business and financial results. The pendency of the proposed transactions may also divert management’s attention and our resources from ongoing business and operations and our employees. Other key personnel may have uncertainties about the effect of the proposed transactions, and the uncertainties may impact our ability to retain key personnel while the proposed transactions are pending or in the event that we are unable to consummate the proposed transactions within the expected time frames or at all. If key personnel depart because of such uncertainties, our business and results of operations may be adversely affected.

In addition, pending consummation of the proposed transactions, the Purchase Agreement generally requires us to operate in the ordinary course of business consistent with past practice and our intent to wind down our activities, and restricts us from taking certain actions with respect to our business and financial affairs without XOMA’s consent. Such restrictions will be in place until either the proposed transactions are consummated or the Purchase Agreement is terminated. These restrictions could restrict our ability to, or prevent us from, pursuing attractive business opportunities (if any) that arise prior to the consummation of the proposed transactions. For these and other reasons, the pendency of the proposed transactions could adversely affect our business, operating results and financial condition.

We have incurred, and will continue to incur, direct and indirect costs as a result of the proposed transactions with XOMA.

We have incurred, and will continue to incur, significant costs and expenses, including fees for professional services and other transaction costs, in connection with the proposed transactions, including costs that we may not currently expect. We must pay substantially all of these costs and expenses whether or not the transaction is completed. If the Purchase Agreement is terminated under certain circumstances specified in the Purchase Agreement, including in connection with the Company’s entry into an agreement with respect to a Superior Proposal, we will be required to pay XOMA a termination fee of approximately $750,000. There are a number of factors beyond our control that could affect the total amount or the timing of these costs and expenses.

If we are not able to complete the proposed transactions with XOMA, we will likely pursue other strategic alternatives. We may not be successful in identifying and implementing any strategic business combination or other transaction and any strategic transaction that we may consummate in the future could have negative consequences. There can be no assurance that the terms of any such other transaction will be favorable.

As part of our Restructuring Plan, we have undertaken a comprehensive assessment of strategic alternatives to maximize shareholder value. Our board of directors (i) unanimously determined that the terms of the proposed transactions under the Purchase Agreement are in the best interests of the Company and the sustainable success of our business, having considered the interests of our shareholders, employees and other relevant stakeholders, (ii) duly authorized and approved the terms and conditions of the Purchase Agreement and the execution, delivery and performance of our obligations under the Purchase Agreement, and, (iii) resolved, on the terms and subject to the conditions set forth in the Purchase Agreement, to support the Offer and other transaction, to recommend acceptance of the Offer by our shareholders and to recommend that our shareholders vote in favor of approval and adoption of the resolutions set forth in the Purchase Agreement.

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If we are not able to consummate the proposed transactions and decide to evaluate other strategic alternatives, there can be no assurance that this review process will result in us pursuing a transaction or that any transaction, if pursued, will be completed on attractive terms or at all. The process of evaluating other strategic alternatives may be time-consuming and complex, and we may incur significant costs related to this evaluation, such as for financial advisors, as well as legal and accounting fees and expenses and other related charges, in addition to those we have already incurred in connection with the proposed transactions. We may also incur additional unanticipated expenses in connection with this process. A considerable portion of these costs will be incurred regardless of whether any alternative strategic transaction is pursued or completed. Any such expenses will decrease the remaining cash available for use in our business and may diminish or delay any future distributions to our shareholders.

In addition, if we are not able to complete the proposed transactions and are required to pursue another strategic alternative, such alternative transaction may yield unexpected results that adversely affect our business and decrease the remaining cash available for use in our business or the execution of our Restructuring Plan. There can be no assurances that any particular course of action, business arrangement or transaction, or series of transactions, will be pursued, successfully consummated, lead to increased shareholder value, value for stakeholders, or achieve its anticipated results. Any failure of such potential transaction to achieve its anticipated results could significantly impair our ability to enter into any future strategic transactions and may significantly diminish or delay any future distributions to our shareholders.

We may not realize any additional value in a strategic transaction.

XOMA has placed no value on our assets and intellectual property and may spend only limited resources as provided in the CVR Agreement to potentially monetize our assets. Other potential counterparties in a strategic transaction involving us may likewise place minimal or no value on our assets. Further, the development and any potential commercialization of our product candidates will require substantial additional cash to fund the costs associated with conducting the necessary preclinical and clinical testing and obtaining regulatory approval. Consequently, any potential counterparty in a strategic transaction involving us may choose not to spend additional resources and continue development of our product candidates and may likewise attribute little or no value, in such a transaction, to those assets.

If a strategic transaction is not consummated, our board of directors may decide to pursue a dissolution and liquidation. In such an event, the amount of cash available for distribution to our shareholders will depend heavily on the timing of such liquidation as well as the amount of cash that will need to be reserved for commitments and contingent liabilities.

There can be no assurance that the proposed transactions with XOMA or any other strategic transaction will be consummated. If the proposed transactions with XOMA or a strategic transaction is not consummated, the board of directors may decide to pursue a dissolution and liquidation of the Company. In such an event, the amount of cash available for distribution to our shareholders will depend heavily on the timing of such decision, as the amount of cash available for distribution will decline over time as we continue to fund our operations. In addition, if our board of directors were to approve and recommend, and our shareholders were to approve, a dissolution and liquidation, we would be required under Dutch corporate law to pay our outstanding obligations, as well as to make reasonable provision for contingent and unknown obligations, prior to making any distributions in liquidation to our shareholders, which distributions may also be subject to applicable taxes. As a result of this requirement, a portion of our assets may need to be reserved pending the resolution of such obligations and the timing of any such resolution would be uncertain.

In addition, we may be subject to litigation (including creditor opposition), or other claims related to a dissolution and liquidation. If a dissolution and liquidation were pursued, our board of directors, in consultation with our advisors, would need to evaluate these matters and make a determination about a reasonable amount to reserve. Accordingly, holders of our common shares could lose all or a significant portion of their investment in the event of a liquidation, dissolution or winding up.

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Our ability to consummate the proposed transactions with XOMA or complete another strategic transaction or our dissolution and liquidation depends on our ability to retain our employees and engage other advisors and consultants required to consummate such transactions.

As part of our Restructuring Plan, we reduced our workforce by approximately 68% to a total of 11 full-time employees. Our cash conservation activities may yield unintended consequences, such as attrition beyond our planned reduction in workforce, decline in employee productivity and reduced employee morale, which may cause remaining employees to seek alternative employment. Our ability to successfully consummate the proposed transactions or complete another strategic transaction or our dissolution and liquidation depends in large part on our ability to retain certain of our remaining personnel, the loss of whose services may adversely impact our ability to consummate such transaction, and engage other advisors and consultants. Due to our limited employee resources, we may not be able to effectively manage our operations or recruit and retain qualified personnel, which may result in weaknesses in our operations, risks that we may not be able to comply with legal and regulatory requirements.

Item 2. Unregistered Sales of Equity Securities and Use of Proceeds

Recent Sales of Unregistered Equity Securities

None.

Use of Proceeds from our Public Offering of Common Stock

The offer and sale of shares in our IPO was registered under the Securities Act pursuant to a Registration Statement on Form F-1 (File No. 333-253795), which was declared effective by the SEC on March 24, 2021. As a result of the IPO, we received net proceeds of approximately $94.2 million, after deducting underwriting discounts, commissions and estimated offering expenses borne by us. We have invested the net proceeds from the offering in money market funds, short-term investments, and long-term investments. There has been no material change in the planned use of proceeds from our IPO as described in our final prospectus filed with the SEC pursuant to Rule 424(b)(4) under the Securities Act on March 26, 2021.

Item 3. Defaults Upon Senior Securities

None.

Item 4. Mine Safety Disclosures

Not applicable.

Item 5. Other Information

Adoption, Modification and Termination of Rule 10b5-1 Plans and Certain Other Trading Arrangements

During the fiscal quarter ended June 30, 2025, none of our directors or officers (as defined in Rule 16a-1(f) under the Exchange Act) adopted, modified or terminated a “Rule 10b5-1 trading arrangement” or a “non-Rule 10b5-1 trading arrangement” (as each term is defined in Item 408 of Regulation S-K).

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Item 6. Exhibits


		Incorporation by Reference
Exhibit Number	Description	Schedule/ Form	File Number	Exhibit	Filling Date

2.1+	Share Purchase Agreement, dated August 3, 2025, by and among XOMA Royalty Corporation and LAVA Therapeutics N.V.	8-K	000-40241	2.1	August 4, 2025
3.1	Amended and Restated English translation of Articles of Association of LAVA Therapeutics N.V.	10-K	000-40241	3.1	March 28, 2025


31.1*	Certification of Principal Executive Officer Pursuant to Rule 13a-14(a) and 15d-14(a) under the Securities Exchange Act of 1934, as Adopted Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002

31.2*	Certification of Principal Financial Officer Pursuant to Rule 13a-14(a) and 15d-14(a) under the Securities Exchange Act of 1934, as Adopted Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002.

32.1*†	Certification of Principal Executive Officer Pursuant to 18 U.S.C. Section1350, as Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.

32.2*†	Certification of Principal Financial Officer Pursuant to 18 U.S.C. Section1350, as Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.


101.INS*	Inline XBRL Instance Document.

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101.SCH*		Inline XBRL Taxonomy Extension Schema Document.

101.CAL*		Inline XBRL Taxonomy Calculation Linkbase Document.

101.DEF*		Inline XBRL Taxonomy Extension Definition Linkbase Document.

101.LAB*		Inline XBRL Taxonomy Label Linkbase Document.

101.PRE*		Inline XBRL Taxonomy Presentation Linkbase Document.

104		Cover Page Interactive Data File (the cover page iXBRL tags are embedded within the Inline XBRL document)

* Filed or furnished herewith

+ Certain schedules and annexes have been omitted pursuant to Item 601(a)(5) of Regulation S-K. The Company hereby undertakes to furnish supplementally copies of any of the omitted schedules and annexes upon request by the SEC; provided, however, that the Company may request confidential treatment pursuant to Rule 24b-2 of the Exchange Act for any annexes or schedules so furnished.

† These certifications are being furnished solely to accompany this Quarterly Report pursuant to 18 U.S.C. Section 1350, and are not being filed for purposes of Section 18 of the Securities Exchange Act of 1934, as amended, and are not to be incorporated by reference into any filing of the Registrant, whether made before or after the date hereof, regardless of any general incorporation language in such filing.

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SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.

LAVA Therapeutics N.V.
	LAVA Therapeutics N.V.
Date: August 13, 2025	By:	/s/ Stephen Hurly
		Stephen Hurly
		President and Chief Executive Officer (Principal Executive Officer)
Date: August 13, 2025	By:	/s/ Fred Powell
		Fred Powell
		Chief Financial Officer (Principal Financial Officer and Principal Accounting Officer)

Exhibit 31.1

CERTIFICATION OF THE PRINCIPAL EXECUTIVE OFFICER

PURSUANT TO EXCHANGE ACT RULE 13A-14(A) OR 15D-14(A) AS ADOPTED

PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002

I, Stephen Hurly, certify that:

1.	I have reviewed this quarterly report on Form 10-Q of LAVA Therapeutics N.V.;

2.	Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;

3.	Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the company as of, and for, the periods presented in this report;

The company’s other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the company and have:

(a)

Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the company, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;

(b)

Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;

(c)

Evaluated the effectiveness of the company’s disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and

(d)

Disclosed in this report any change in the company’s internal control over financial reporting that occurred during the company’s most recent fiscal quarter (the company’s fourth quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the company’s internal control over financial reporting; and

5.	The company’s other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the company’s auditors and the audit committee of the company’s board of directors (or persons performing the equivalent functions):

(a)

All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the company’s ability to record, process, summarize and report financial information; and

(b)

Any fraud, whether or not material, that involves management or other employees who have a significant role in the company’s internal control over financial reporting.

Date: August 13, 2025

By:	/s/ Stephen Hurly
Name:	Stephen Hurly
Title:	Chief Executive Officer (Principal Executive Officer)

EXHIBIT 31.2

CERTIFICATION OF THE PRINCIPAL FINANCIAL OFFICER

PURSUANT TO EXCHANGE ACT RULE 13A-14(A) OR 15D-14(A) AS ADOPTED

PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002

I, Fred Powell, certify that:

1.	I have reviewed this quarterly report on Form 10-Q of LAVA Therapeutics N.V.;

2.	Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;

3.	Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the company as of, and for, the periods presented in this report;

(a)

(b)

(c)

(d)

Disclosed in this report any change in the company’s internal control over financial reporting that occurred during the company’s most recent fiscal quarter (the company’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the company’s internal control over financial reporting; and

5.	The company’s other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the company’s auditors and the audit committee of the company’s board of directors (or persons performing the equivalent functions):

(a)

(b)

Any fraud, whether or not material, that involves management or other employees who have a significant role in the company’s internal control over financial reporting.

Date: August 13, 2025

By:	/s/ Fred Powell
Name:	Fred Powell
Title:	Chief Financial Officer (Principal Financial Officer)

EXHIBIT 32.1

Certification by the Principal Executive Officer

Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002

In connection with the quarterly report of LAVA Therapeutics N.V. (the “Company”) on Form 10-Q for the period ended June 30, 2025 as filed with the Securities and Exchange Commission on the date hereof (the “Quarterly Report”), I, Stephen Hurly, Chief Executive Officer of the Company, certify, pursuant to Rule 13a-14(b) of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), and 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that to my knowledge:

(1)

The Quarterly Report fully complies with the requirements of Section 13(a) or Section 15(d) of the Exchange Act; and

(2)

The information contained in the Quarterly Report fairly presents, in all material respects, the financial condition and results of operations of the Company.

Date: August 13, 2025


By:	/s/ Stephen Hurly
Name:	Stephen Hurly
Title:	Chief Executive Officer (Principal Executive Officer)

	This certification accompanies the Form 10-Q to which it relates, is not deemed filed with the Securities and Exchange Commission and is not to be incorporated by reference into any filing of the Company under the Securities Act of 1933, as amended, or the Securities Exchange Act or 1934, as amended (whether made before or after the date of the Form 10-Q), irrespective of any general incorporation language contained in such filing.

EXHIBIT 32.2

Certification by the Principal Financial Officer

Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002

In connection with the quarterly report of LAVA Therapeutics N.V. (the “Company”) on Form 10-Q for the period ended June 30, 2025 as filed with the Securities and Exchange Commission on the date hereof (the “Quarterly Report”), I, Fred Powell, Chief Financial Officer of the Company, certify, pursuant to Rule 13a-14(b) of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), and 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that to my knowledge:

(1)

The Quarterly Report fully complies with the requirements of Section 13(a) or Section 15(d) of the Exchange Act; and

(2)

The information contained in the Quarterly Report fairly presents, in all material respects, the financial condition and results of operations of the Company.

Date: August 13, 2025

By:	/s/ Fred Powell
Name:	Fred Powell
Title:	Chief Financial Officer (Principal Financial Officer)

	This certification accompanies the Form 10-Q to which it relates, is not deemed filed with the Securities and Exchange Commission and is not to be incorporated by reference into any filing of the Company under the Securities Act of 1933, as amended, or the Securities Exchange Act or 1934, as amended (whether made before or after the date of the Form 10-Q), irrespective of any general incorporation language contained in such filing.

v3.25.2

Document and Entity Information - shares
6 Months Ended

Jun. 30, 2025

Aug. 08, 2025

Document and Entity Information [Abstract]

Document Type 10-Q

Document Quarterly Report true

Document Period End Date Jun. 30, 2025

Document Transition Report false

Entity File Number 001-40241

Entity Registrant Name LAVA Therapeutics NV

Entity Incorporation, State or Country Code P7

Entity Tax Identification Number 84-2745484

Entity Address, Address Line One Yalelaan 62

Entity Address, City or Town Utrecht

Entity Address State Or Province NL

Entity Address, Postal Zip Code 3584

City Area Code 31

Local Phone Number 85 016 3100

Title of 12(b) Security Common shares, par value €0.12 per share

Trading Symbol LVTX

Security Exchange Name NASDAQ

Entity Current Reporting Status Yes

Entity Interactive Data Current Yes

Entity Filer Category Non-accelerated Filer

Entity Small Business true

Entity Emerging Growth Company true

Entity Ex Transition Period false

Entity Shell Company false

Entity Common Stock, Shares Outstanding 26,305,295

Entity Central Index Key 0001840748

Current Fiscal Year End Date --12-31

Document Fiscal Year Focus 2025

Document Fiscal Period Focus Q2

Amendment Flag false

v3.25.2

Condensed Consolidated Balance Sheets (Unaudited) - USD ($)

Jun. 30, 2025

Dec. 31, 2024

Current assets:

Cash and cash equivalents $ 26,380,000 $ 35,015,000

Short-term investments 29,789,000 41,561,000

Prepaid expenses 1,922,000 1,072,000

Other current assets 2,404,000 1,649,000

Total current assets 60,495,000 79,297,000

Property and equipment, net 43,000 1,002,000

Operating lease right-of-use assets 441,000

Other non-current assets 9,000 91,000

Total assets 60,547,000 80,831,000

Current liabilities:

Accounts payable 1,428,000 2,722,000

Accrued expenses and other current liabilities 4,184,000 10,083,000

Borrowings 4,886,000

Current portion of operating lease liabilities 315,000

Total current liabilities 5,612,000 18,006,000

Non-current portion of deferred revenue 35,000,000 35,000,000

Non-current portion of operating lease liabilities 80,000

Total liabilities 40,612,000 53,086,000

Commitments and contingencies (Note 8)

Shareholders' equity:

Common shares, $0.14 par value; 90,000,000 shares authorized as of June 30, 2025, and December 31, 2024; 26,305,295 shares issued and outstanding as of June 30, 2025, and December 31, 2024 3,717,000 3,717,000

Additional paid-in capital 212,637,000 211,656,000

Accumulated deficit (187,091,000) (174,973,000)

Accumulated other comprehensive loss (9,328,000) (12,655,000)

Total shareholders' equity 19,935,000 27,745,000

Total liabilities and shareholders' equity $ 60,547,000 $ 80,831,000

v3.25.2

Condensed Consolidated Balance Sheets (Unaudited) (Parenthetical) - $ / shares

Jun. 30, 2025

Dec. 31, 2024

Condensed Consolidated Balance Sheets (Unaudited)

Common stock, par value (in dollars per share) $ 0.14 $ 0.14

Common stock, shares authorized 90,000,000 90,000,000

Common stock, shares issued 26,305,295 26,305,295

Common stock, shares outstanding 26,305,295 26,305,295

v3.25.2

Condensed Consolidated Statements of Operations and Comprehensive Loss (Unaudited) - USD ($)
3 Months Ended 6 Months Ended

Jun. 30, 2025

Jun. 30, 2024

Jun. 30, 2025

Jun. 30, 2024

Revenue:

Total revenue $ 6,992,000

Cost and expenses:

Research and development $ (4,739,000) $ (5,958,000) $ (8,895,000) (11,606,000)

General and administrative (2,550,000) (3,435,000) (5,982,000) (6,816,000)

Total cost and expenses (7,289,000) (9,393,000) (14,877,000) (18,422,000)

Operating loss (7,289,000) (9,393,000) (14,877,000) (11,430,000)

Other income (expense), net

Interest income 607,000 968,000 1,320,000 1,938,000

Interest expense (129,000) (129,000) (259,000)

Foreign currency exchange (loss) gain, net (1,885,000) 340,000 (3,338,000) 997,000

Gain on extinguishment of borrowings 5,203,000

Total other income (expense), net (1,278,000) 1,179,000 3,056,000 2,676,000

Net loss before taxes (8,567,000) (8,214,000) (11,821,000) (8,754,000)

Income tax expense, net (72,000) (86,000) (297,000) (154,000)

Net loss (8,639,000) (8,300,000) (12,118,000) (8,908,000)

Other comprehensive income (loss):

Foreign currency translation adjustment 2,349,000 (424,000) 3,327,000 (1,471,000)

Comprehensive loss $ (6,290,000) $ (8,724,000) $ (8,791,000) $ (10,379,000)

Net loss per share, basic $ (0.32) $ (0.31) $ (0.45) $ (0.33)

Net loss per share, diluted $ (0.32) $ (0.31) $ (0.45) $ (0.33)

Weighted-average common shares outstanding, basic 26,899,122 26,822,139 26,894,666 26,807,760

Weighted-average common shares outstanding, diluted 26,899,122 26,822,139 26,894,666 26,807,760

v3.25.2

Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($)
$ in Thousands
6 Months Ended

Jun. 30, 2025

Jun. 30, 2024

Cash flows from operating activities:

Net loss $ (12,118) $ (8,908)

Adjustments to reconcile net loss to net cash used in operating activities

Depreciation and amortization 115 264

Non-cash operating lease expense 139 179

Foreign currency exchange loss (gain), net (395) (401)

Share-based compensation expense 981 1,915

Accrued interest on borrowings 129 259

Amortization of premium on short-term investments (1,107) (1,342)

Gain on extinguishment of borrowings (5,203)

Impairment of property, plant, and equipment and ROU asset 323

Loss on the sale of property, plant, and equipment 358

Changes in operating assets and liabilities:

Prepaid expenses and other current assets (631) (214)

Other non-current assets 85 136

Accounts payable (1,465) (262)

Accrued expenses and other current liabilities (6,467) (471)

Operating lease liabilities (138) (212)

Net cash used in operating activities (25,394) (9,057)

Cash flows from investing activities:

Proceeds from sale of property and equipment 283 92

Purchases of investments (34,621) (56,035)

Maturities of investments 47,000 57,000

Net cash provided by investing activities 12,662 1,057

Cash flows from financing activities:

Proceeds from option exercises 24

Net cash provided by financing activities 24

Net increase (decrease) in cash and cash equivalents (12,732) (7,976)

Cash and cash equivalents at beginning of period 35,015 44,231

Effects of exchange rate changes 4,097 (1,168)

Cash and cash equivalents at end of period $ 26,380 $ 35,087

v3.25.2

Organization and Description of Business
6 Months Ended

Jun. 30, 2025

Organization and Description of Business

Organization and Description of Business
1. Organization and Description of Business
Description of the Business
LAVA Therapeutics N.V. (the “Company”) was founded in 2016 and is incorporated and domiciled in the Netherlands. The Company is a clinical-stage immuno-oncology company that has historically focused on its proprietary Gammabody® bispecific gamma delta (gd) T cell engagers to transform the treatment of cancer. Using its Gammabody platform, the Company developed a portfolio of novel bispecific antibodies designed to engage and leverage the potency and precision of gd T cells to orchestrate a robust, natural anti-tumor immune response and improve outcomes for cancer patients. With the collaboration of its partners, Pfizer Inc. (“Pfizer”) and Johnson & Johnson (“J&J”), the Company is advancing its Gammabody pipeline for the development of potential therapeutics in both hematologic malignancies and solid tumors.
Liquidity and Going Concern
In accordance with Accounting Standards Codification (“ASC”) 205-40, Going concern, the Company has evaluated whether there are conditions and events, considered in the aggregate, that raise substantial doubt about the Company’s ability to continue as a going concern within one year after the date the condensed consolidated financial statements are issued. The Company has incurred net losses since inception, and the Company expects to continue to generate operating losses in the foreseeable future. As of June 30, 2025, the Company had an accumulated deficit of $187.1 million. Management expects to incur additional losses in the foreseeable future.
In February 2025, the board of directors of the Company (the “Board”) adopted a restructuring plan (the “Restructuring Plan”) to extend the Company’s capital resources in connection with initiating a process to evaluate potential strategic alternatives such as a reverse merger, other business combination, dissolution and wind-down, or cash sale transaction. As a result of this strategic review process, the Company recently entered into the Purchase Agreement (as described in Note 11).
Through June 30, 2025, the Company has funded its operations with proceeds from equity financings, collaboration and licensing agreements, government grants, and borrowings under various agreements. The Company would need to raise additional capital to support the completion of its research and development activities, which have recently been halted, or any other strategic alternatives. As noted in Note 11, as of August 2025, the Company has announced its intent to discontinued the LAVA-1266 program. The Company has not incurred any new material financial obligations with respect to the termination of this program.

As of the issuance date of the condensed consolidated financial statements, the Company believes that its cash and cash equivalents and short-term investments will be sufficient to fund its operations for at least the next twelve months from the issuance date of these condensed consolidated financial statements.

v3.25.2

Summary of Significant Accounting Policies
6 Months Ended

Jun. 30, 2025

Summary of Significant Accounting Policies

Summary of Significant Accounting Policies
2. Summary of Significant Accounting Policies
The significant accounting policies and estimates used in the preparation of the accompanying unaudited condensed consolidated financial statements are described in the Company’s audited consolidated financial statements for the year ended December 31, 2024 included in the Company’s Annual Report on Form 10-K filed with the SEC on March 28, 2025. There have been no material changes in the Company’s significant accounting policies during the three and six months ended June 30, 2025.
Unaudited Interim Financial Information
The accompanying unaudited condensed consolidated financial statements have been prepared in conformity with accounting principles generally accepted in the United States of America (“U.S. GAAP”) as issued by the Financial Accounting Standards Board (the “FASB”) and include the operations of LAVA Therapeutics N.V. and its wholly-owned subsidiaries. All intercompany accounts, transactions and balances have been eliminated in consolidation.
In the opinion of the Company, the accompanying unaudited condensed consolidated financial statements contain all adjustments, consisting of only normal recurring adjustments, necessary for a fair statement of its financial position as of June 30, 2025, its results of operations for the three and six months ended June 30, 2025 and 2024, and its cash flows for the six months ended June 30, 2025 and 2024. The condensed balance sheet at December 31, 2024, was derived from audited annual financial statements but does not contain all of the footnote disclosures from the annual financial statements.
The results for the three and six months ended June 30, 2025 are not necessarily indicative of results to be expected for the full year or for any other subsequent interim period.
Basis of Presentation
The Company had historically been classified as a foreign private issuer (“FPI”). However, as of June 30, 2024, the Company determined that, pursuant to the definition provided in Rule 405 of the Securities Act of 1933, it no longer satisfied the criteria to be considered an FPI. As such, beginning on January 1, 2025, the Company was required to begin reporting with the U.S. Securities and Exchange Commission on domestic forms and comply with domestic company rules in the United States. The Company retrospectively made the transition from International Financial Reporting Standards (“IFRS”) to U.S. GAAP for all periods from the Company’s inception.
Cash and Cash Equivalents
The Company’s cash equivalents consist of highly liquid investments with remaining maturities at the date of purchase of three months or less.
The Company makes short-term deposits for varying periods of between one day and three months, depending on the Company’s immediate cash requirements. The deposits earn interest at the respective short-term deposit rates. The Company’s cash and cash equivalents balances as of June 30, 2025 and December 31, 2024, included $26.4 million and $35.0 million, respectively, of short-term bank deposits.
The Company did not have any restricted cash as of June 30, 2025 or December 31, 2024.
Short-term Investments
The Company’s investments consist only of holdings in U.S. Treasury debt securities with maturities ranging from three months to one year. Accordingly, the Company classifies these investments as current assets in its consolidated balance sheets. Because the Company has the intent and ability to hold these investments until maturity, the Company classifies its short-term investments in U.S. Treasury debt securities as held to maturity (“HTM”) and thus measures the investments at amortized cost. These assets are classified as Level 1 within the fair value hierarchy as there are quoted prices for identical assets in active markets.
The Company estimates the allowance for credit losses on its HTM debt securities using a current expected credit loss methodology. The Company deducts any expected credit loss on its HTM debt securities from the amortized cost basis of the securities so that the condensed consolidated balance sheets reflect the net amount the Company expects to collect. All of the Company's HTM debt securities are issued by the U.S. Treasury, a department of the U.S. government. U.S. Treasury debt securities are either explicitly or implicitly guaranteed by the U.S. government, are highly rated by major rating
agencies, and have a long history of no credit losses. Accordingly, the Company has a zero-credit loss expectation on these securities. Therefore, as of June 30, 2025, and December 31, 2024, the Company did not record an allowance for credit losses on its short-term investments. The amortized cost basis of the Company’s HTM debt securities is $29.8 million and $41.6 million as of June 30, 2025 and December 31, 2024, respectively. As of June 30, 2025 and December 31, 2024, the difference between the amortized cost basis and fair value is less than $0.1 million.
The Company records the amortization of premiums or discounts in the condensed consolidated statements of operations and comprehensive loss within interest income and interest expense, respectively.
New Accounting Pronouncements – Not Yet Adopted
In December 2023, the FASB issued ASU No. 2023-09, Income Taxes (ASC Topic 740): Improvements to Income Tax Disclosures (“ASU 2023-09”), which establishes incremental disaggregation of income tax disclosures pertaining to the effective tax rate reconciliation and income taxes paid. The amendments in this update apply to all entities that are subject to ASC Topic 740, Income Taxes. For public business entities, the amendments in this update are effective for annual periods beginning after December 15, 2024, and early adoption is permitted. The Company has evaluated the impact of the provision and amendments that will change the annual tax footnote disclosures and is considering whether it will adopt prospectively or retrospectively.

In November 2024, the FASB issued ASU 2024-03, Disaggregation of Income Statement Expenses (DISE) (“ASU 2024-03”), requiring additional disclosure of the nature of expenses included in the income statement. The new standard requires disclosures about specific types of expenses included in the expense captions presented on the face of the condensed consolidated statements of operations and comprehensive loss as well as disclosures about selling expenses. The amendment in this update applies to all public business entities and is effective for annual reporting periods beginning after December 15, 2026 and interim reporting periods beginning after December 15, 2027. The Company is currently evaluating the provisions of the amendments and the impact on its disclosures.

v3.25.2

Revenue
6 Months Ended

Jun. 30, 2025

Revenue

Revenue
3. Revenue
The Company does not currently have any commercial sales. The Company has entered into collaboration and licensing arrangements for research and development, manufacturing, and commercialization activities with counterparties for the development and commercialization of its product candidates. These arrangements contain multiple promised goods and services, such as licenses, research and development activities, and the manufacturing of certain materials. Payments pursuant to these arrangements include non-refundable payments upon the achievement of significant regulatory, development and commercial milestones, sales of product at certain agreed-upon amounts, and royalties on product sales.
The following table presents the components of the Company’s revenue:

Six Months Ended

June 30,
(in thousands)

2025

2024
Pfizer Inc. - Pfizer Agreement - Agreed-to reimbursement activities

$
—

$
24
Pfizer Inc. - Pfizer Agreement - Development milestones

—

6,960
Pfizer Inc. - Additional services

—

8
Total revenue from contracts with customers

$
—

$
6,992

Pfizer Agreement
In September 2022, the Company entered into a license agreement with Pfizer (formally Seagen Inc.) (“Pfizer”) to develop, manufacture, and commercialize PF-08046052 (formerly LAVA-1223), an advanced
preclinical asset that utilizes the Company’s proprietary Gammabody technology to target EGFR-positive tumors (the “Pfizer Agreement”). Under the terms of the Pfizer Agreement, the Company received a $50.0 million nonrefundable upfront payment in October 2022 and could receive up to approximately $650.0 million in potential development, regulatory, and commercial milestones, and royalties ranging from high single-digit to mid-teen percentages on future sales. The Pfizer Agreement also provided Pfizer with the opportunity to exclusively negotiate rights to apply the Company's proprietary Gammabody platform on up to two additional tumor targets, although these rights expired during the year ended December 31, 2024. In March 2024, Pfizer achieved a clinical development milestone for PF-08046052, resulting in the first milestone payment of $7.0 million to the Company under the Pfizer Agreement, which was recognized in revenue during the six months ended June 30, 2024.

Under the Pfizer Agreement, the Company was also entitled to receive reimbursement of up to $6.5 million for certain agreed-to research, manufacturing, and supply activities, as well as the transfer of all manufacturing-related know-how and materials, including all CMC documentation, data, and processes, to enable the manufacture of licensed compounds and products by Pfizer. As of December 31, 2024, the Company has recognized an aggregate of $6.4 million for additional agreed-to services requested by Pfizer. The Company did not recognize any revenue related to the reimbursement of additional agreed-to services requested by Pfizer during the three months ended June 30, 2025 or 2024. For the six months ended June 30, 2024, the Company recognized less than $0.1 million related to the reimbursement of additional agreed-to services requested by Pfizer. The Company did not recognize any revenue related to the reimbursement of additional agreed-to services requested by Pfizer during the six months ended June 30, 2025. The Company does not anticipate receiving reimbursement for any additional agreed-to services at this time.

Deferred Revenue
The Company determined that the one-time buy-up fee of $35.0 million represents a variable consideration and not a performance obligation, for which it has deferred revenue recognition until such time the option expires or the Company exercises the option. The Company allocated the variable consideration from the buy-up fee to the license performance obligation as it aligns with the economic substance of the Pfizer Agreement. The Company received the non-refundable upfront payment of $50.0 million in October 2022, and recorded the variable consideration of $35.0 million as a deferred revenue liability. The balance as of June 30, 2025 and December 31, 2024 was $35.0 million. If the Company does not exercise the buy-up option and the option expires, the Company will recognize the revenue related to the license performance obligation as there are no remaining performance obligations. If the Company does exercise the buy-up option, the Company will account for this amount as a refund of the transaction price to the customer. The Company will make a decision on whether or not to exercise the buy-up option once clinical data is received from Pfizer, and the Company expects this decision could occur as early as 2026.
J&J Agreement
In May 2020, the Company entered into a research collaboration and license agreement (the “J&J Agreement”) with Johnson & Johnson (formerly Janssen Biotech, Inc.). As part of the J&J Agreement, the Company received a non-refundable upfront payment of $8.0 million. As of January 1, 2023, the Company had recognized the entirety of the $8.0 million upfront payment as revenue, which was recognized on a straight-line basis over the two-year term of the research activities under the J&J Agreement.
The Company did not recognize any revenue related to development milestones under the J&J Agreement during the three and six months ended June 30, 2025 or 2024.

v3.25.2

Accrued Expenses and Other Current Liabilities
6 Months Ended

Jun. 30, 2025

Accrued Expenses and Other Current Liabilities

Accrued Expenses and Other Current Liabilities
4. Accrued Expenses and Other Current Liabilities
The following table presents the components of the Company’s accrued expenses and other current liabilities:

June 30,

December 31,
(in thousands)

2025

2024
Research and development external project costs

$
1,298

$
7,138
Personnel-related expenses

1,210

1,398
Income taxes

300

335
Professional fees

397

598
Employee termination benefits

564

—
Other

415

614

$
4,184

$
10,083

v3.25.2

Restructuring
6 Months Ended

Jun. 30, 2025

Restructuring

Restructuring
5. Restructuring
In February 2025, the Company adopted a restructuring plan to extend its capital resources in connection with initiating a process to evaluate strategic alternatives (the “Restructuring Plan”). As part of the Restructuring Plan, the Company approved a reduction of approximately 30% of the global workforce to better align the Company’s resources with its then-focus on the LAVA-1266 program. During the three months ended June 30, 2025, the Company executed further initiatives in relation to the initial Restructuring Plan. On April 18, 2025, the Company entered into an agreement to terminate the operating lease arrangement effective May 1, 2025 for laboratory and office space in Utrecht, the Netherlands and sell a portion of the remaining fixed assets to the landlord and new tenant. Further, on May 12, 2025, the Board approved the reduction of all of the workforce remaining in the Netherlands by July 31, 2025 and the termination of its lease arrangement in Den Bosch, the Netherlands effective August 1, 2025.
The Company incurred the following restructuring and impairment charges for the three months ended June 30, 2025, of which $2.2 million and $0.4 million are recorded in research and development and general and administrative expenses, respectively, in the consolidated statement of operations and comprehensive loss (in thousands):

Three Months Ended

June 30, 2025
Employee termination benefits

$
1,514
Costs for terminated contracts

461
Loss on sale of fixed assets

358
Impairment charges

279
Total restructuring and impairment charges

$
2,612

The Company incurred the following restructuring and impairment charges for the six months ended June 30, 2025, of which $2.6 million and $0.6 million are recorded in research and development and general and administrative expenses, respectively, in the consolidated statement of operations and comprehensive loss (in thousands):

Six Months Ended

June 30, 2025
Employee termination benefits

$
1,967
Costs for terminated contracts

579
Loss on sale of fixed assets

358
Impairment charges

323
Total restructuring and impairment charges

$
3,227

The actions associated with the Restructuring Plan commenced in February 2025 and are expected to be completed by the end of 2025.

Employee Termination Benefits

Employees affected by the Restructuring Plan received involuntary termination benefits pursuant to a one-time benefit for a set period of time. Employees who were notified of their termination in 2025 had no requirements to provide future services beyond the minimum retention period. As such, the Company recognized the liability for the termination benefits in full at fair value at the date of communication to the employee.

The following table shows the liability related to employee termination benefits as of June 30, 2025 (in thousands):

June 30,

2025
Accrued employee termination benefits as of January 1, 2025

$
—
Employee termination benefits charges incurred during the period

1,967
Amounts paid or otherwise settled during the period

(1,403)
Accrued employee termination benefits as of June 30, 2025

$
564

The Company does not anticipate incurring any additional costs as part of the workforce reduction.

Costs for Terminated Contracts

The Restructuring Plan resulted in contract termination costs from vendor contracts before the end of their term. In accordance with ASC 420, Exit or Disposal Cost Obligations, the Company recognized these unavoidable contract costs when incurred.

The following table shows the liability related to costs for contract termination costs as of June 30, 2025 (in thousands):

June 30,

2025
Accrued contract costs as of January 1, 2025

$
—
Contract costs incurred during the period

579
Amounts paid or otherwise settled during the period

(528)
Accrued contract costs as of June 30, 2025

$
51

These costs are subject to significant estimation based on the Company’s expectation of the costs that will continue to be incurred on the contracts, as well as negotiation of contract changes and terminations with its vendors. The Company does not anticipate incurring significant additional contract costs.

Loss on Sale of Fixed Assets and Impairment Charges

In conjunction with the Restructuring Plan and the agreements to terminate the operating lease arrangement for laboratory and office space in Utrecht, the Netherlands, effective May 1, 2025 and to terminate the lease arrangement in Den Bosch, the Netherlands effective August 1, 2025, the Company disposed of fixed assets through sale and abandonment. The Company recorded a loss of $0.4 million, net of proceeds of $0.3 million from the sale of fixed assets, which was recorded in research and
development expenses in the condensed consolidated statements of operations and comprehensive loss for the three and six months ended June 30, 2025.

Additionally, the Company evaluated certain other fixed assets, leasehold improvements, and right of use assets and concluded that it would abandon the fixed assets, leasehold improvements, and right of use assets in the three months ended June 30, 2025, and as a result, the Company incurred $0.3 million in impairment charges, of which $0.2 million and less than $0.1 million were recorded in research and development and general and administrative expenses, respectively, in the condensed consolidated statements of operations and comprehensive loss for the three and six months ended June 30, 2025.

v3.25.2

Discontinuation of Clinical Trials
6 Months Ended

Jun. 30, 2025

Discontinuation of Clinical Trials

Discontinuation of Clinical Trials
6. Discontinuation of Clinical Trials
In December 2024, the Company announced that the clinical trial of LAVA-1207 targeting prostate specific membrane antigen(“PSMA”)-expressing cancers for patients with metastatic castration resistant prostate cancer (“mCRPC”) was no longer recruiting and would be discontinued after no patients remain on treatment. The Company was evaluating LAVA-1207 in an open-label, multi-center Phase 1 clinical trial to evaluate safety, tolerability, pharmacokinetics, pharmacodynamics, immunogenicity and preliminary anti-tumor activity of LAVA-1207 and to determine recommended dose(s) for optimization in a Phase 2a clinical trial. The Company made the decision to discontinue the LAVA-1207 development program, as the Phase 1 trial did not reach the Company’s internal benchmarks. The decision was not due to safety concerns. As a result of the discontinuation, the Company had accrued $3.9 million as of December 31, 2024 and $0.7 million as of June 30, 2025 for costs associated with clinical trial, contract manufacturing, and bioanalytical activities for LAVA-1207. During the six months ended June 30, 2025 the Company paid $2.9 million and negotiated a reduction in a contract resulting in an update to the estimate for remaining costs of $0.3 million. The Company expects to pay or settle the remaining amount during the year ending December 31, 2025. The Company reviewed the relevant items of its condensed consolidated balance sheets and did not identify any asset that would require impairment as a result of the discontinuation of the clinical trial of LAVA-1207.

v3.25.2

Borrowings
6 Months Ended

Jun. 30, 2025

Borrowings

Borrowings
7. Borrowings
In 2019, the Company applied for and received a $5.5 million Innovation Credit (the “Credit”) from Rijksdienst voor Ondernemend Nederland (“RVO”). The Credit contributed to the development of LAVA-051, and the Company pledged certain assets of that project as a guarantee.
Borrowings under the Credit bore interest at 10.0% and were received in quarterly installments, based on the level of the underlying cost base of the project in each period.
In March 2025, the Company received notice from the RVO that repayment of the remaining loan balance of $5.2 million had been permanently waived. The Company recognized a gain on extinguishment within other income (expense), net in the condensed consolidated statements of operations and comprehensive loss during the three months ended March 31, 2025 and six months ended June 30, 2025.
The Company recognized interest expense related to the Credit of $0.0 million and $0.1 million for the three months ended June 30, 2025 and 2024, and $0.1 million and $0.3 million for the six months ended June 30, 2025 and 2024.

v3.25.2

Commitments and Contingencies
6 Months Ended

Jun. 30, 2025

Commitments and Contingencies

Commitments and Contingencies
8. Commitments and Contingencies
The Company accrues for contingency liabilities, including those involving general liability, workers’ compensation, and other matters, when it is probable that the Company will incur and can reasonably estimate future costs (including legal fees and expenses). The Company bases the accruals on developments to date, management's estimates of the outcomes of these matters, and the Company's experience in contesting, litigating, and settling similar matters. The Company reviews its legal contingencies at each reporting period and adjusts the liabilities to reflect the current best estimate. The Company was not party to any pending legal proceedings or claims as of June 30, 2025 or December 31,
2024. Other than the Amsterdam UMC Agreement described below, the Company has not made any material commitments.
Amsterdam UMC Agreement
In January 2017, the Company entered into an agreement with the Amsterdam UMC (the “Amsterdam UMC Agreement”) under which Amsterdam UMC granted the Company an exclusive (although non-exclusive with respect to certain intangible know-how), worldwide, sublicensable license for certain patent rights and know-how owned by Amsterdam UMC, effectively including research and other services provided in collaboration by Amsterdam UMC to develop, make, and sell licensed products related to such patent rights and know-how. Amsterdam UMC retains the right to use the patent rights and know-how for solely non-commercial research and educational purposes, but it may not conduct such work with respect to any product that is directed to a specified target for a specified time period.
The Company is obligated to pay Amsterdam UMC low single-digit tiered royalties on net sales of products covered by claims included in the assigned patent rights. The Company has not incurred or paid royalties to Amsterdam UMC at this time, as there have been no net sales of the products covered by the claims. Royalties are payable on a country-by-country basis for a royalty term that expires upon the expiration of the last valid claim in the assigned patent rights in such country that would be infringed by the use, manufacture, or sale of a product in such country in the absence of the Company having rights to such patent right.

v3.25.2

Earnings Per Share (EPS)
6 Months Ended

Jun. 30, 2025

Earnings Per Share (EPS)

Earnings Per Share (EPS)
9. Earnings Per Share (EPS)
The Company calculates basic EPS by dividing the loss for the period attributable to common equity holders of the parent by the weighted average number of common shares outstanding during the period. The Company accounts for vested share-based awards that are issued for little to no consideration, as issuable common shares. As the share options under the 2018 Stock Option Plan have an exercise price of little to no consideration, the Company considers these share options to be issuable common shares and therefore included these options in the common shares outstanding.
The Company calculates diluted EPS by dividing the loss attributable to common equity holders of the parent (after adjusting for the effect of dilution) by the weighted average number of common shares outstanding, adjusted for the effects of potentially dilutive share-based awards.
As of June 30, 2025 and 2024, the Company had potentially dilutive share-based options of 7,248,459 and 6,047,423, respectively. The Company excluded these awards from the calculation of the diluted weighted average number of common shares outstanding because their effect on the loss per share would have been anti-dilutive as the Company was in a net loss position in both periods.

v3.25.2

Segment Information
6 Months Ended

Jun. 30, 2025

Segment Information

Segment Information
10. Segment Information
The Company identifies operating segments based on whether the Company’s Chief Executive Officer, who is the Chief Operating Decision Maker (“CODM”), regularly reviews the allocation of resources and/or the assessment of performance of a particular component of the Company’s activities. The Company has one reportable segment – the development of the Gammabody platform of bispecific gd T cell engagers for the treatment of cancer.
The CODM assesses performance for the segment and decides how to allocate resources based on net loss that also is reported on the condensed consolidated statements of operations and comprehensive loss. Significant expenses within the condensed consolidated statements of operations and comprehensive loss, as well as within net loss, include research and development, and general and administrative expenses, which are each separately presented on the Company’s condensed consolidated statements of operations and comprehensive loss. Other segment items within net loss include other income (expense), net, and income tax expense, net. In the context of considerations
around significant segment expenses, as the expense information that is regularly provided to the CODM is aligned with the consolidated expenses as presented on the statements of operations and comprehensive loss, such expense disclosures are not replicated here.
Net loss is used to monitor budget versus actual results. The monitoring of budgeted versus actual results are used in assessing performance of the segment and in part determining management’s compensation. The CODM also analyzes forecasted general and administrative and research and development expenses when assessing the performance of the segment.
All assets, liabilities, cash flows, revenue and expenses are reported on the Company’s one reportable segment.

v3.25.2

Subsequent Events
6 Months Ended

Jun. 30, 2025

Subsequent Events

Subsequent Events
11. Subsequent Events
Entry into Share Purchase Agreement with XOMA
On August 3, 2025, the Company entered into a share purchase agreement with XOMA Royalty Corporation, a Nevada corporation (“XOMA”). The purchase agreement (the “Purchase Agreement”) provides for, among other things, the acquisition of all of the Company’s issued and outstanding common shares, par value €0.12 per share, by XOMA through a tender offer, for a price per share of $1.16 plus an additional amount of cash of up to $0.08 per share plus one contingent value right per share, which represents the right to receive potential payments, in cash, described in, and subject to and in accordance with the terms and conditions of, a contingent value rights agreement.
If the Purchase Agreement is terminated by the Company under certain circumstances specified in the Purchase Agreement, including in connection wih the Company’s entry into an agreement with respect to a Superior Proposal (as such term is defined in the Purchase Agreement), the Company would be required to pay XOMA a termination fee of $0.75 million.
Decision to Discontinue Phase 1 Trial of LAVA-1266
On August 4, 2025, the Company announced its decision to discontinue its Phase 1 clinical trial of LAVA-1266 for acute myeloid leukemia and myelodysplastic syndrome and initiate the wind-down of the LAVA-1266 program. An estimate of costs related to the discontinuance of the LAVA-1266 clinical trial cannot be made at this time.

v3.25.2

Pay vs Performance Disclosure - USD ($)
3 Months Ended 6 Months Ended

Jun. 30, 2025

Mar. 31, 2025

Jun. 30, 2024

Mar. 31, 2024

Jun. 30, 2025

Jun. 30, 2024

Pay vs Performance Disclosure

Net Income (Loss) $ (8,639,000) $ (3,479,000) $ (8,300,000) $ (608,000) $ (12,118,000) $ (8,908,000)

v3.25.2

Insider Trading Arrangements
3 Months Ended

Jun. 30, 2025

Trading Arrangements, by Individual

Rule 10b5-1 Arrangement Adopted false

Non-Rule 10b5-1 Arrangement Adopted false

Rule 10b5-1 Arrangement Terminated false

Non-Rule 10b5-1 Arrangement Terminated false

Rule 10b5-1 Arrangement Modified [Flag] false

Non-Rule 10b5-1 Arrangement Modified [Flag] false

v3.25.2

Summary of Significant Accounting Policies (Policies)
6 Months Ended

Jun. 30, 2025

Summary of Significant Accounting Policies

Unaudited Interim Financial Information
Unaudited Interim Financial Information
The accompanying unaudited condensed consolidated financial statements have been prepared in conformity with accounting principles generally accepted in the United States of America (“U.S. GAAP”) as issued by the Financial Accounting Standards Board (the “FASB”) and include the operations of LAVA Therapeutics N.V. and its wholly-owned subsidiaries. All intercompany accounts, transactions and balances have been eliminated in consolidation.
In the opinion of the Company, the accompanying unaudited condensed consolidated financial statements contain all adjustments, consisting of only normal recurring adjustments, necessary for a fair statement of its financial position as of June 30, 2025, its results of operations for the three and six months ended June 30, 2025 and 2024, and its cash flows for the six months ended June 30, 2025 and 2024. The condensed balance sheet at December 31, 2024, was derived from audited annual financial statements but does not contain all of the footnote disclosures from the annual financial statements.
The results for the three and six months ended June 30, 2025 are not necessarily indicative of results to be expected for the full year or for any other subsequent interim period.

Basis of Presentation
Basis of Presentation
The Company had historically been classified as a foreign private issuer (“FPI”). However, as of June 30, 2024, the Company determined that, pursuant to the definition provided in Rule 405 of the Securities Act of 1933, it no longer satisfied the criteria to be considered an FPI. As such, beginning on January 1, 2025, the Company was required to begin reporting with the U.S. Securities and Exchange Commission on domestic forms and comply with domestic company rules in the United States. The Company retrospectively made the transition from International Financial Reporting Standards (“IFRS”) to U.S. GAAP for all periods from the Company’s inception.

Cash and Cash Equivalents
Cash and Cash Equivalents
The Company’s cash equivalents consist of highly liquid investments with remaining maturities at the date of purchase of three months or less.
The Company makes short-term deposits for varying periods of between one day and three months, depending on the Company’s immediate cash requirements. The deposits earn interest at the respective short-term deposit rates. The Company’s cash and cash equivalents balances as of June 30, 2025 and December 31, 2024, included $26.4 million and $35.0 million, respectively, of short-term bank deposits.
The Company did not have any restricted cash as of June 30, 2025 or December 31, 2024.

Short-term Investments
Short-term Investments
The Company’s investments consist only of holdings in U.S. Treasury debt securities with maturities ranging from three months to one year. Accordingly, the Company classifies these investments as current assets in its consolidated balance sheets. Because the Company has the intent and ability to hold these investments until maturity, the Company classifies its short-term investments in U.S. Treasury debt securities as held to maturity (“HTM”) and thus measures the investments at amortized cost. These assets are classified as Level 1 within the fair value hierarchy as there are quoted prices for identical assets in active markets.
The Company estimates the allowance for credit losses on its HTM debt securities using a current expected credit loss methodology. The Company deducts any expected credit loss on its HTM debt securities from the amortized cost basis of the securities so that the condensed consolidated balance sheets reflect the net amount the Company expects to collect. All of the Company's HTM debt securities are issued by the U.S. Treasury, a department of the U.S. government. U.S. Treasury debt securities are either explicitly or implicitly guaranteed by the U.S. government, are highly rated by major rating
agencies, and have a long history of no credit losses. Accordingly, the Company has a zero-credit loss expectation on these securities. Therefore, as of June 30, 2025, and December 31, 2024, the Company did not record an allowance for credit losses on its short-term investments. The amortized cost basis of the Company’s HTM debt securities is $29.8 million and $41.6 million as of June 30, 2025 and December 31, 2024, respectively. As of June 30, 2025 and December 31, 2024, the difference between the amortized cost basis and fair value is less than $0.1 million.
The Company records the amortization of premiums or discounts in the condensed consolidated statements of operations and comprehensive loss within interest income and interest expense, respectively.

New Accounting Pronouncements - Not Yet Adopted
New Accounting Pronouncements – Not Yet Adopted
In December 2023, the FASB issued ASU No. 2023-09, Income Taxes (ASC Topic 740): Improvements to Income Tax Disclosures (“ASU 2023-09”), which establishes incremental disaggregation of income tax disclosures pertaining to the effective tax rate reconciliation and income taxes paid. The amendments in this update apply to all entities that are subject to ASC Topic 740, Income Taxes. For public business entities, the amendments in this update are effective for annual periods beginning after December 15, 2024, and early adoption is permitted. The Company has evaluated the impact of the provision and amendments that will change the annual tax footnote disclosures and is considering whether it will adopt prospectively or retrospectively.

In November 2024, the FASB issued ASU 2024-03, Disaggregation of Income Statement Expenses (DISE) (“ASU 2024-03”), requiring additional disclosure of the nature of expenses included in the income statement. The new standard requires disclosures about specific types of expenses included in the expense captions presented on the face of the condensed consolidated statements of operations and comprehensive loss as well as disclosures about selling expenses. The amendment in this update applies to all public business entities and is effective for annual reporting periods beginning after December 15, 2026 and interim reporting periods beginning after December 15, 2027. The Company is currently evaluating the provisions of the amendments and the impact on its disclosures.

v3.25.2

Revenue (Tables)
6 Months Ended

Jun. 30, 2025

Revenue

Schedule of components of Company's revenue

Six Months Ended

June 30,
(in thousands)

2025

2024
Pfizer Inc. - Pfizer Agreement - Agreed-to reimbursement activities

$
—

$
24
Pfizer Inc. - Pfizer Agreement - Development milestones

—

6,960
Pfizer Inc. - Additional services

—

8
Total revenue from contracts with customers

$
—

$
6,992

v3.25.2

Accrued Expenses and Other Current Liabilities (Tables)
6 Months Ended

Jun. 30, 2025

Accrued Expenses and Other Current Liabilities

Schedule of components of the Company's accrued expenses and other current liabilities

June 30,

December 31,
(in thousands)

2025

2024
Research and development external project costs

$
1,298

$
7,138
Personnel-related expenses

1,210

1,398
Income taxes

300

335
Professional fees

397

598
Employee termination benefits

564

—
Other

415

614

$
4,184

$
10,083

v3.25.2

Restructuring (Tables)
6 Months Ended

Jun. 30, 2025

Restructuring

Schedule of restructuring and impairment charges
The Company incurred the following restructuring and impairment charges for the three months ended June 30, 2025, of which $2.2 million and $0.4 million are recorded in research and development and general and administrative expenses, respectively, in the consolidated statement of operations and comprehensive loss (in thousands):

Three Months Ended

June 30, 2025
Employee termination benefits

$
1,514
Costs for terminated contracts

461
Loss on sale of fixed assets

358
Impairment charges

279
Total restructuring and impairment charges

$
2,612

The Company incurred the following restructuring and impairment charges for the six months ended June 30, 2025, of which $2.6 million and $0.6 million are recorded in research and development and general and administrative expenses, respectively, in the consolidated statement of operations and comprehensive loss (in thousands):

Six Months Ended

June 30, 2025
Employee termination benefits

$
1,967
Costs for terminated contracts

579
Loss on sale of fixed assets

358
Impairment charges

323
Total restructuring and impairment charges

$
3,227

Reduction of global workforce

Restructuring

Schedule of liability related to employee termination benefits
The following table shows the liability related to employee termination benefits as of June 30, 2025 (in thousands):

June 30,

2025
Accrued employee termination benefits as of January 1, 2025

$
—
Employee termination benefits charges incurred during the period

1,967
Amounts paid or otherwise settled during the period

(1,403)
Accrued employee termination benefits as of June 30, 2025

$
564

Ongoing contracts and contract termination costs

Restructuring

Schedule of liability related to employee termination benefits
The following table shows the liability related to costs for contract termination costs as of June 30, 2025 (in thousands):

June 30,

2025
Accrued contract costs as of January 1, 2025

$
—
Contract costs incurred during the period

579
Amounts paid or otherwise settled during the period

(528)
Accrued contract costs as of June 30, 2025

$
51

v3.25.2

Organization and Description of Business (Details) - USD ($)
$ in Thousands

Jun. 30, 2025

Dec. 31, 2024

Organization and Description of Business

Accumulated deficit $ 187,091 $ 174,973

v3.25.2

Summary of Significant Accounting Policies (Details)
$ in Millions
6 Months Ended

Jun. 30, 2025

USD ($)

segment

Dec. 31, 2024

USD ($)

Summary of Significant Accounting Policies

Number of reportable segments | segment 1

Short-term bank deposits $ 26.4 $ 35.0

Restricted cash 0.0 0.0

Allowance for credit losses on short term investments 0.0 0.0

Amortized cost basis of the Company's HTM debt securities 29.8 41.6

Difference between amortized cost basis and fair value $ 0.1 $ 0.1

v3.25.2

Revenue - Components of Company's revenue (Details) - USD ($)
$ in Thousands
3 Months Ended 6 Months Ended

Jun. 30, 2025

Jun. 30, 2024

Jun. 30, 2024

Revenue

Total revenue $ 6,992

Pfizer Inc. - Pfizer Agreement - Agreed-to reimbursement activities | Pfizer Inc

Revenue

Total revenue 24

Pfizer Inc. - Pfizer Agreement - Development milestones | Pfizer Inc

Revenue

Total revenue 6,960

Pfizer Inc. - Additional services | Pfizer Inc

Revenue

Total revenue $ 0 $ 0 $ 8

v3.25.2

Revenue - Pfizer Agreement (Details)
1 Months Ended 3 Months Ended 6 Months Ended 12 Months Ended

Mar. 31, 2024

USD ($)

Oct. 31, 2022

USD ($)

Sep. 30, 2022

USD ($)

item

Jun. 30, 2025

USD ($)

Jun. 30, 2024

USD ($)

Jun. 30, 2024

USD ($)

Dec. 31, 2024

USD ($)

Revenue

Revenue recognized $ 6,992,000

Pfizer Inc. - Pfizer Agreement - Agreed-to reimbursement activities | Pfizer Inc

Revenue

Non refundable upfront payment received $ 50,000,000

Maximum amount of nonrefundable upfront payment receivable $ 650,000,000

Number of additional tumor targets | item 2

Milestone payment $ 7,000,000

Reimbursement entitled to receive by the Company $ 6,500,000

Revenue recognized 24,000

Pfizer Inc. - Additional services | Pfizer Inc

Revenue

Revenue recognized $ 0 $ 0 8,000

Pfizer Inc. - Additional services | Pfizer Inc | Maximum

Revenue

Revenue recognized $ 100,000 $ 6,400,000

v3.25.2

Revenue - Deferred revenue (Details) - USD ($)
1 Months Ended 6 Months Ended

Oct. 31, 2022

Jun. 30, 2025

Up-front Payment Arrangement [Member]

Revenue

Variable consideration $ 35,000,000 $ 35,000,000

Non-refundable upfront payment received. $ 50,000,000

Pfizer Inc. - Pfizer Agreement - Agreed-to reimbursement activities

Revenue

Deferred Revenue $ 35,000,000

v3.25.2

Revenue - J&J Agreement (Details) - USD ($)
1 Months Ended 3 Months Ended 6 Months Ended

Jan. 31, 2023

May 31, 2020

Jun. 30, 2025

Jun. 30, 2024

Jun. 30, 2025

Jun. 30, 2024

Revenue

Revenue recognized $ 6,992,000

Johnson & Johnson Inc. - J&J Agreement | Johnson & Johnson Inc.

Revenue

Non refundable upfront payment received $ 8,000,000

Term of agreement 2 years

Revenue recognized $ 8,000,000 $ 0 $ 0 $ 0 $ 0

v3.25.2

Accrued Expenses and Other Current Liabilities (Details) - USD ($)
$ in Thousands

Jun. 30, 2025

Dec. 31, 2024

Accrued Expenses and Other Current Liabilities

Research and development external project costs $ 1,298 $ 7,138

Personnel-related expenses 1,210 1,398

Income taxes 300 335

Professional fees 397 598

Severance expenses 564

Other 415 614

Total $ 4,184 $ 10,083

v3.25.2

Restructuring (Details) - USD ($)
1 Months Ended 3 Months Ended 6 Months Ended

Feb. 28, 2025

Jun. 30, 2025

Jun. 30, 2025

Jun. 30, 2024

Restructuring

Restructuring and impairment charges $ 2,612,000 $ 3,227,000

Loss on sale of fixed assets 358,000 358,000

Net proceeds from the sale of fixed assets 300,000 283,000 $ 92,000

Impairment charges 279,000 323,000

Research and development expenses

Restructuring

Restructuring and impairment charges 2,200,000 2,600,000

Research and development expenses | Maximum

Restructuring

Impairment charges 200,000

General and administrative expenses

Restructuring

Restructuring and impairment charges 400,000 $ 600,000

General and administrative expenses | Maximum

Restructuring

Impairment charges $ 100,000

Reduction of global workforce

Restructuring

Percentage of reduction in workforce (as a percent) 30.00%

v3.25.2

Restructuring - Restructuring and impairment charges (Details) - USD ($)
$ in Thousands
3 Months Ended 6 Months Ended

Jun. 30, 2025

Jun. 30, 2025

Restructuring

Employee termination benefits $ 1,514 $ 1,967

Costs for ongoing contracts and terminated contracts 461 579

Loss on sale of fixed assets 358 358

Impairment charges 279 323

Total restructuring and impairment charges $ 2,612 $ 3,227

v3.25.2

Restructuring - Liabilities (Details)
$ in Thousands
6 Months Ended

Jun. 30, 2025

USD ($)

Reduction of global workforce

Restructuring

Charges incurred during the period $ 1,967

Amounts paid or otherwise settled during the period (1,403)

Accrued liability as of June 30, 2025 564

Ongoing contracts and contract termination costs

Restructuring

Charges incurred during the period 579

Amounts paid or otherwise settled during the period (528)

Accrued liability as of June 30, 2025 $ 51

v3.25.2

Discontinuation of Clinical Trials (Details) - Discontinuation of clinical trial of LAVA-1207 - USD ($)
6 Months Ended

Jun. 30, 2025

Dec. 31, 2024

Discontinuation of Clinical Trials

Accrued restructuring costs $ 700,000 $ 3,900,000

Payment of restructuring costs 2,900,000

Restructuring charges $ 300,000

v3.25.2

Borrowings (Details) - USD ($)
1 Months Ended 3 Months Ended 6 Months Ended

Mar. 31, 2025

Jun. 30, 2025

Jun. 30, 2024

Jun. 30, 2025

Jun. 30, 2024

Dec. 31, 2019

Borrowings

Innovation Credit received $ 5,500,000

Stated interest rate 10.00% 10.00% 10.00%

Payment for debt instrument $ 5,200,000

Interest expense $ 0 $ 100,000 $ 100,000 $ 300,000

Gain on extinguishment of borrowings $ 5,200,000 $ 5,203,000

v3.25.2

Earnings Per Share (EPS) - Potentially Dilutive Share Based Options (Details) - shares
6 Months Ended

Jun. 30, 2025

Jun. 30, 2024

Earnings Per Share (EPS)

Potentially dilutive share-based options excluded from calculation of diluted weighted average shares 7,248,459 6,047,423

v3.25.2

Segment Information (Details)
6 Months Ended

Jun. 30, 2025

segment

Segment Information

Number of reportable segments 1

v3.25.2

Subsequent Events (Details) - Subsequent Event - Share Purchase Agreement With Xoma Royalty Corporation [member] - USD ($)

Aug. 03, 2025

Aug. 23, 2025

Subsequent Events

Common Stock, No Par Value $ 0.12

Business Combination, Price Per Share $ 1.16

Maximum Additional Cash Per Share $ 0.08

Termination fee $ 750,000

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Document and Entity Information - shares	6 Months Ended
Document and Entity Information - shares	Jun. 30, 2025	Aug. 08, 2025
Document and Entity Information [Abstract]
Document Type	10-Q
Document Quarterly Report	true
Document Period End Date	Jun. 30, 2025
Document Transition Report	false
Entity File Number	001-40241
Entity Registrant Name	LAVA Therapeutics NV
Entity Incorporation, State or Country Code	P7
Entity Tax Identification Number	84-2745484
Entity Address, Address Line One	Yalelaan 62
Entity Address, City or Town	Utrecht
Entity Address State Or Province	NL
Entity Address, Postal Zip Code	3584
City Area Code	31
Local Phone Number	85 016 3100
Title of 12(b) Security	Common shares, par value €0.12 per share
Trading Symbol	LVTX
Security Exchange Name	NASDAQ
Entity Current Reporting Status	Yes
Entity Interactive Data Current	Yes
Entity Filer Category	Non-accelerated Filer
Entity Small Business	true
Entity Emerging Growth Company	true
Entity Ex Transition Period	false
Entity Shell Company	false
Entity Common Stock, Shares Outstanding		26,305,295
Entity Central Index Key	0001840748
Current Fiscal Year End Date	--12-31
Document Fiscal Year Focus	2025
Document Fiscal Period Focus	Q2
Amendment Flag	false

Condensed Consolidated Balance Sheets (Unaudited) - USD ($)	Jun. 30, 2025	Dec. 31, 2024
Current assets:
Cash and cash equivalents	$ 26,380,000	$ 35,015,000
Short-term investments	29,789,000	41,561,000
Prepaid expenses	1,922,000	1,072,000
Other current assets	2,404,000	1,649,000
Total current assets	60,495,000	79,297,000
Property and equipment, net	43,000	1,002,000
Operating lease right-of-use assets		441,000
Other non-current assets	9,000	91,000
Total assets	60,547,000	80,831,000
Current liabilities:
Accounts payable	1,428,000	2,722,000
Accrued expenses and other current liabilities	4,184,000	10,083,000
Borrowings		4,886,000
Current portion of operating lease liabilities		315,000
Total current liabilities	5,612,000	18,006,000
Non-current portion of deferred revenue	35,000,000	35,000,000
Non-current portion of operating lease liabilities		80,000
Total liabilities	40,612,000	53,086,000
Commitments and contingencies (Note 8)
Shareholders' equity:
Common shares, $0.14 par value; 90,000,000 shares authorized as of June 30, 2025, and December 31, 2024; 26,305,295 shares issued and outstanding as of June 30, 2025, and December 31, 2024	3,717,000	3,717,000
Additional paid-in capital	212,637,000	211,656,000
Accumulated deficit	(187,091,000)	(174,973,000)
Accumulated other comprehensive loss	(9,328,000)	(12,655,000)
Total shareholders' equity	19,935,000	27,745,000
Total liabilities and shareholders' equity	$ 60,547,000	$ 80,831,000

Condensed Consolidated Balance Sheets (Unaudited) (Parenthetical) - $ / shares	Jun. 30, 2025	Dec. 31, 2024
Condensed Consolidated Balance Sheets (Unaudited)
Common stock, par value (in dollars per share)	$ 0.14	$ 0.14
Common stock, shares authorized	90,000,000	90,000,000
Common stock, shares issued	26,305,295	26,305,295
Common stock, shares outstanding	26,305,295	26,305,295

Condensed Consolidated Statements of Operations and Comprehensive Loss (Unaudited) - USD ($)	3 Months Ended		6 Months Ended
	Jun. 30, 2025	Jun. 30, 2024	Jun. 30, 2025	Jun. 30, 2024
Revenue:
Total revenue				$ 6,992,000
Cost and expenses:
Research and development	$ (4,739,000)	$ (5,958,000)	$ (8,895,000)	(11,606,000)
General and administrative	(2,550,000)	(3,435,000)	(5,982,000)	(6,816,000)
Total cost and expenses	(7,289,000)	(9,393,000)	(14,877,000)	(18,422,000)
Operating loss	(7,289,000)	(9,393,000)	(14,877,000)	(11,430,000)
Other income (expense), net
Interest income	607,000	968,000	1,320,000	1,938,000
Interest expense		(129,000)	(129,000)	(259,000)
Foreign currency exchange (loss) gain, net	(1,885,000)	340,000	(3,338,000)	997,000
Gain on extinguishment of borrowings			5,203,000
Total other income (expense), net	(1,278,000)	1,179,000	3,056,000	2,676,000
Net loss before taxes	(8,567,000)	(8,214,000)	(11,821,000)	(8,754,000)
Income tax expense, net	(72,000)	(86,000)	(297,000)	(154,000)
Net loss	(8,639,000)	(8,300,000)	(12,118,000)	(8,908,000)
Other comprehensive income (loss):
Foreign currency translation adjustment	2,349,000	(424,000)	3,327,000	(1,471,000)
Comprehensive loss	$ (6,290,000)	$ (8,724,000)	$ (8,791,000)	$ (10,379,000)
Net loss per share, basic	$ (0.32)	$ (0.31)	$ (0.45)	$ (0.33)
Net loss per share, diluted	$ (0.32)	$ (0.31)	$ (0.45)	$ (0.33)
Weighted-average common shares outstanding, basic	26,899,122	26,822,139	26,894,666	26,807,760
Weighted-average common shares outstanding, diluted	26,899,122	26,822,139	26,894,666	26,807,760

Condensed Consolidated Statements of Shareholders' Equity (Unaudited) - USD ($)	Common Shares	Additional paid-in capital	Accumulated deficit	Accumulated other comprehensive loss	Total
Balance as of beginning at Dec. 31, 2023	$ 3,715,000	$ 208,405,000	$ (149,859,000)	$ (10,897,000)	$ 51,364,000
Balance as of beginning (in shares) at Dec. 31, 2023	26,289,087
Exercise of share options		8,000			8,000
Exercise of share options (in shares)	3,100
Share-based compensation expense		1,095,000			1,095,000
Foreign currency translation adjustment				(1,047,000)	(1,047,000)
Net Income (Loss)			(608,000)		(608,000)
Balance as of ending at Mar. 31, 2024	$ 3,715,000	209,508,000	(150,467,000)	(11,944,000)	50,812,000
Balance as of ending (in shares) at Mar. 31, 2024	26,292,187
Balance as of beginning at Dec. 31, 2023	$ 3,715,000	208,405,000	(149,859,000)	(10,897,000)	51,364,000
Balance as of beginning (in shares) at Dec. 31, 2023	26,289,087
Foreign currency translation adjustment					(1,471,000)
Net Income (Loss)					(8,908,000)
Balance as of ending at Jun. 30, 2024	$ 3,716,000	210,343,000	(158,767,000)	(12,368,000)	42,924,000
Balance as of ending (in shares) at Jun. 30, 2024	26,297,322
Balance as of beginning at Mar. 31, 2024	$ 3,715,000	209,508,000	(150,467,000)	(11,944,000)	50,812,000
Balance as of beginning (in shares) at Mar. 31, 2024	26,292,187
Exercise of share options	$ 1,000	15,000			16,000
Exercise of share options (in shares)	5,135
Share-based compensation expense		820,000			820,000
Foreign currency translation adjustment				(424,000)	(424,000)
Net Income (Loss)			(8,300,000)		(8,300,000)
Balance as of ending at Jun. 30, 2024	$ 3,716,000	210,343,000	(158,767,000)	(12,368,000)	42,924,000
Balance as of ending (in shares) at Jun. 30, 2024	26,297,322
Balance as of beginning at Dec. 31, 2024	$ 3,717,000	211,656,000	(174,973,000)	(12,655,000)	$ 27,745,000
Balance as of beginning (in shares) at Dec. 31, 2024	26,305,295				26,305,295
Share-based compensation expense		540,000			$ 540,000
Foreign currency translation adjustment				978,000	978,000
Net Income (Loss)			(3,479,000)		(3,479,000)
Balance as of ending at Mar. 31, 2025	$ 3,717,000	212,196,000	(178,452,000)	(11,677,000)	25,784,000
Balance as of ending (in shares) at Mar. 31, 2025	26,305,295
Balance as of beginning at Dec. 31, 2024	$ 3,717,000	211,656,000	(174,973,000)	(12,655,000)	$ 27,745,000
Balance as of beginning (in shares) at Dec. 31, 2024	26,305,295				26,305,295
Foreign currency translation adjustment					$ 3,327,000
Net Income (Loss)					(12,118,000)
Balance as of ending at Jun. 30, 2025	$ 3,717,000	212,637,000	(187,091,000)	(9,328,000)	$ 19,935,000
Balance as of ending (in shares) at Jun. 30, 2025	26,305,295				26,305,295
Balance as of beginning at Mar. 31, 2025	$ 3,717,000	212,196,000	(178,452,000)	(11,677,000)	$ 25,784,000
Balance as of beginning (in shares) at Mar. 31, 2025	26,305,295
Share-based compensation expense		441,000			441,000
Foreign currency translation adjustment				2,349,000	2,349,000
Net Income (Loss)			(8,639,000)		(8,639,000)
Balance as of ending at Jun. 30, 2025	$ 3,717,000	$ 212,637,000	$ (187,091,000)	$ (9,328,000)	$ 19,935,000
Balance as of ending (in shares) at Jun. 30, 2025	26,305,295				26,305,295

Pay vs Performance Disclosure - USD ($)	3 Months Ended				6 Months Ended
Pay vs Performance Disclosure - USD ($)	Jun. 30, 2025	Mar. 31, 2025	Jun. 30, 2024	Mar. 31, 2024	Jun. 30, 2025	Jun. 30, 2024
Pay vs Performance Disclosure
Net Income (Loss)	$ (8,639,000)	$ (3,479,000)	$ (8,300,000)	$ (608,000)	$ (12,118,000)	$ (8,908,000)

Insider Trading Arrangements	3 Months Ended
Insider Trading Arrangements	Jun. 30, 2025
Trading Arrangements, by Individual
Rule 10b5-1 Arrangement Adopted	false
Non-Rule 10b5-1 Arrangement Adopted	false
Rule 10b5-1 Arrangement Terminated	false
Non-Rule 10b5-1 Arrangement Terminated	false
Rule 10b5-1 Arrangement Modified [Flag]	false
Non-Rule 10b5-1 Arrangement Modified [Flag]	false

Summary of Significant Accounting Policies (Policies)	6 Months Ended
Summary of Significant Accounting Policies (Policies)	Jun. 30, 2025
Summary of Significant Accounting Policies
Unaudited Interim Financial Information	Unaudited Interim Financial Information The accompanying unaudited condensed consolidated financial statements have been prepared in conformity with accounting principles generally accepted in the United States of America (“U.S. GAAP”) as issued by the Financial Accounting Standards Board (the “FASB”) and include the operations of LAVA Therapeutics N.V. and its wholly-owned subsidiaries. All intercompany accounts, transactions and balances have been eliminated in consolidation. In the opinion of the Company, the accompanying unaudited condensed consolidated financial statements contain all adjustments, consisting of only normal recurring adjustments, necessary for a fair statement of its financial position as of June 30, 2025, its results of operations for the three and six months ended June 30, 2025 and 2024, and its cash flows for the six months ended June 30, 2025 and 2024. The condensed balance sheet at December 31, 2024, was derived from audited annual financial statements but does not contain all of the footnote disclosures from the annual financial statements. The results for the three and six months ended June 30, 2025 are not necessarily indicative of results to be expected for the full year or for any other subsequent interim period.
Basis of Presentation	Basis of Presentation The Company had historically been classified as a foreign private issuer (“FPI”). However, as of June 30, 2024, the Company determined that, pursuant to the definition provided in Rule 405 of the Securities Act of 1933, it no longer satisfied the criteria to be considered an FPI. As such, beginning on January 1, 2025, the Company was required to begin reporting with the U.S. Securities and Exchange Commission on domestic forms and comply with domestic company rules in the United States. The Company retrospectively made the transition from International Financial Reporting Standards (“IFRS”) to U.S. GAAP for all periods from the Company’s inception.
Cash and Cash Equivalents	Cash and Cash Equivalents The Company’s cash equivalents consist of highly liquid investments with remaining maturities at the date of purchase of three months or less. The Company makes short-term deposits for varying periods of between one day and three months, depending on the Company’s immediate cash requirements. The deposits earn interest at the respective short-term deposit rates. The Company’s cash and cash equivalents balances as of June 30, 2025 and December 31, 2024, included $26.4 million and $35.0 million, respectively, of short-term bank deposits. The Company did not have any restricted cash as of June 30, 2025 or December 31, 2024.
Short-term Investments	Short-term Investments The Company’s investments consist only of holdings in U.S. Treasury debt securities with maturities ranging from three months to one year. Accordingly, the Company classifies these investments as current assets in its consolidated balance sheets. Because the Company has the intent and ability to hold these investments until maturity, the Company classifies its short-term investments in U.S. Treasury debt securities as held to maturity (“HTM”) and thus measures the investments at amortized cost. These assets are classified as Level 1 within the fair value hierarchy as there are quoted prices for identical assets in active markets. The Company estimates the allowance for credit losses on its HTM debt securities using a current expected credit loss methodology. The Company deducts any expected credit loss on its HTM debt securities from the amortized cost basis of the securities so that the condensed consolidated balance sheets reflect the net amount the Company expects to collect. All of the Company's HTM debt securities are issued by the U.S. Treasury, a department of the U.S. government. U.S. Treasury debt securities are either explicitly or implicitly guaranteed by the U.S. government, are highly rated by major rating agencies, and have a long history of no credit losses. Accordingly, the Company has a zero-credit loss expectation on these securities. Therefore, as of June 30, 2025, and December 31, 2024, the Company did not record an allowance for credit losses on its short-term investments. The amortized cost basis of the Company’s HTM debt securities is $29.8 million and $41.6 million as of June 30, 2025 and December 31, 2024, respectively. As of June 30, 2025 and December 31, 2024, the difference between the amortized cost basis and fair value is less than $0.1 million. The Company records the amortization of premiums or discounts in the condensed consolidated statements of operations and comprehensive loss within interest income and interest expense, respectively.
New Accounting Pronouncements - Not Yet Adopted	New Accounting Pronouncements – Not Yet Adopted In December 2023, the FASB issued ASU No. 2023-09, Income Taxes (ASC Topic 740): Improvements to Income Tax Disclosures (“ASU 2023-09”), which establishes incremental disaggregation of income tax disclosures pertaining to the effective tax rate reconciliation and income taxes paid. The amendments in this update apply to all entities that are subject to ASC Topic 740, Income Taxes. For public business entities, the amendments in this update are effective for annual periods beginning after December 15, 2024, and early adoption is permitted. The Company has evaluated the impact of the provision and amendments that will change the annual tax footnote disclosures and is considering whether it will adopt prospectively or retrospectively. In November 2024, the FASB issued ASU 2024-03, Disaggregation of Income Statement Expenses (DISE) (“ASU 2024-03”), requiring additional disclosure of the nature of expenses included in the income statement. The new standard requires disclosures about specific types of expenses included in the expense captions presented on the face of the condensed consolidated statements of operations and comprehensive loss as well as disclosures about selling expenses. The amendment in this update applies to all public business entities and is effective for annual reporting periods beginning after December 15, 2026 and interim reporting periods beginning after December 15, 2027. The Company is currently evaluating the provisions of the amendments and the impact on its disclosures.

Organization and Description of Business (Details) - USD ($) $ in Thousands	Jun. 30, 2025	Dec. 31, 2024
Organization and Description of Business
Accumulated deficit	$ 187,091	$ 174,973

Summary of Significant Accounting Policies (Details) $ in Millions	6 Months Ended
	Jun. 30, 2025 USD ($) segment	Dec. 31, 2024 USD ($)
Summary of Significant Accounting Policies
Number of reportable segments \| segment	1
Short-term bank deposits	$ 26.4	$ 35.0
Restricted cash	0.0	0.0
Allowance for credit losses on short term investments	0.0	0.0
Amortized cost basis of the Company's HTM debt securities	29.8	41.6
Difference between amortized cost basis and fair value	$ 0.1	$ 0.1

Revenue - Pfizer Agreement (Details)	1 Months Ended			3 Months Ended		6 Months Ended	12 Months Ended
Revenue - Pfizer Agreement (Details)	Mar. 31, 2024 USD ($)	Oct. 31, 2022 USD ($)	Sep. 30, 2022 USD ($) item	Jun. 30, 2025 USD ($)	Jun. 30, 2024 USD ($)	Jun. 30, 2024 USD ($)	Dec. 31, 2024 USD ($)
Revenue
Revenue recognized						$ 6,992,000
Pfizer Inc. - Pfizer Agreement - Agreed-to reimbursement activities \| Pfizer Inc
Revenue
Non refundable upfront payment received		$ 50,000,000
Maximum amount of nonrefundable upfront payment receivable			$ 650,000,000
Number of additional tumor targets \| item			2
Milestone payment	$ 7,000,000
Reimbursement entitled to receive by the Company			$ 6,500,000
Revenue recognized						24,000
Pfizer Inc. - Additional services \| Pfizer Inc
Revenue
Revenue recognized				$ 0	$ 0	8,000
Pfizer Inc. - Additional services \| Pfizer Inc \| Maximum
Revenue
Revenue recognized						$ 100,000	$ 6,400,000

Revenue - Deferred revenue (Details) - USD ($)	1 Months Ended	6 Months Ended
Revenue - Deferred revenue (Details) - USD ($)	Oct. 31, 2022	Jun. 30, 2025
Up-front Payment Arrangement [Member]
Revenue
Variable consideration	$ 35,000,000	$ 35,000,000
Non-refundable upfront payment received.	$ 50,000,000
Pfizer Inc. - Pfizer Agreement - Agreed-to reimbursement activities
Revenue
Deferred Revenue		$ 35,000,000

Revenue - J&J Agreement (Details) - USD ($)	1 Months Ended		3 Months Ended		6 Months Ended
Revenue - J&J Agreement (Details) - USD ($)	Jan. 31, 2023	May 31, 2020	Jun. 30, 2025	Jun. 30, 2024	Jun. 30, 2025	Jun. 30, 2024
Revenue
Revenue recognized						$ 6,992,000
Johnson & Johnson Inc. - J&J Agreement \| Johnson & Johnson Inc.
Revenue
Non refundable upfront payment received		$ 8,000,000
Term of agreement		2 years
Revenue recognized	$ 8,000,000		$ 0	$ 0	$ 0	$ 0

Accrued Expenses and Other Current Liabilities (Details) - USD ($) $ in Thousands	Jun. 30, 2025	Dec. 31, 2024
Accrued Expenses and Other Current Liabilities
Research and development external project costs	$ 1,298	$ 7,138
Personnel-related expenses	1,210	1,398
Income taxes	300	335
Professional fees	397	598
Severance expenses	564
Other	415	614
Total	$ 4,184	$ 10,083

Restructuring (Details) - USD ($)	1 Months Ended	3 Months Ended	6 Months Ended
Restructuring (Details) - USD ($)	Feb. 28, 2025	Jun. 30, 2025	Jun. 30, 2025	Jun. 30, 2024
Restructuring
Restructuring and impairment charges		$ 2,612,000	$ 3,227,000
Loss on sale of fixed assets		358,000	358,000
Net proceeds from the sale of fixed assets		300,000	283,000	$ 92,000
Impairment charges		279,000	323,000
Research and development expenses
Restructuring
Restructuring and impairment charges		2,200,000	2,600,000
Research and development expenses \| Maximum
Restructuring
Impairment charges		200,000
General and administrative expenses
Restructuring
Restructuring and impairment charges		400,000	$ 600,000
General and administrative expenses \| Maximum
Restructuring
Impairment charges		$ 100,000
Reduction of global workforce
Restructuring
Percentage of reduction in workforce (as a percent)	30.00%

Restructuring - Liabilities (Details) $ in Thousands	6 Months Ended
Restructuring - Liabilities (Details) $ in Thousands	Jun. 30, 2025 USD ($)
Reduction of global workforce
Restructuring
Charges incurred during the period	$ 1,967
Amounts paid or otherwise settled during the period	(1,403)
Accrued liability as of June 30, 2025	564
Ongoing contracts and contract termination costs
Restructuring
Charges incurred during the period	579
Amounts paid or otherwise settled during the period	(528)
Accrued liability as of June 30, 2025	$ 51

Discontinuation of Clinical Trials (Details) - Discontinuation of clinical trial of LAVA-1207 - USD ($)	6 Months Ended
	Jun. 30, 2025	Dec. 31, 2024
Discontinuation of Clinical Trials
Accrued restructuring costs	$ 700,000	$ 3,900,000
Payment of restructuring costs	2,900,000
Restructuring charges	$ 300,000

Borrowings (Details) - USD ($)	1 Months Ended	3 Months Ended		6 Months Ended
Borrowings (Details) - USD ($)	Mar. 31, 2025	Jun. 30, 2025	Jun. 30, 2024	Jun. 30, 2025	Jun. 30, 2024	Dec. 31, 2019
Borrowings
Innovation Credit received						$ 5,500,000
Stated interest rate		10.00%		10.00%		10.00%
Payment for debt instrument	$ 5,200,000
Interest expense		$ 0	$ 100,000	$ 100,000	$ 300,000
Gain on extinguishment of borrowings	$ 5,200,000			$ 5,203,000

Earnings Per Share (EPS) - Potentially Dilutive Share Based Options (Details) - shares	6 Months Ended
	Jun. 30, 2025	Jun. 30, 2024
Earnings Per Share (EPS)
Potentially dilutive share-based options excluded from calculation of diluted weighted average shares	7,248,459	6,047,423

Segment Information (Details)	6 Months Ended
Segment Information (Details)	Jun. 30, 2025 segment
Segment Information
Number of reportable segments	1

Subsequent Events (Details) - Subsequent Event - Share Purchase Agreement With Xoma Royalty Corporation [member] - USD ($)	Aug. 03, 2025	Aug. 23, 2025
Subsequent Events
Common Stock, No Par Value		$ 0.12
Business Combination, Price Per Share	$ 1.16
Maximum Additional Cash Per Share	$ 0.08
Termination fee	$ 750,000