UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F COVER PAGE
OMB APPROVAL
OMB Number:3235-0006
Expires:July 31, 2015
Estimated average burden
hours per response:23.8
Report for the Calendar Year or Quarter Ended:
12-31-2024
Check here if Amendment: ☐ Amendment Number:
This Amendment (Check only one.):☐ is a restatement.
☐ adds new holdings entries.

Institutional Investment Manager Filing this Report:

Name:
Siren, L.L.C.
Address:
The Invus Group, Llc
750 Lexington Avenue, 30th Floor
New York, NY 10022
Form 13F File Number:
028-24464

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.


Person Signing this Report on Behalf of Reporting Manager:
Name:
Raymond Debbane
Title:
Managing Member
Phone:
212-371-1717


Signature, Place, and Date of Signing:

/s/ Raymond Debbane
                         [Signature]
New York, NEW YORK
                 [City, State]
02-14-2025
                           [Date]
                          

Report Type (Check only one.):

☒ 13F HOLDINGS REPORT. (Check here if all holdings of this reporting manager are reported in this report.) 

☐ 13F NOTICE. (Check here if no holdings reported are in this report, and all holdings are reported by other reporting manager(s).) 

☐ 13F COMBINATION REPORT. (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)


Form 13F Summary Page

Report Summary:

Number of Other Included Managers:
2
Form 13F Information table Entry Total:
119
Form 13F Information table Value Total:
2263488311
          (thousands)

List of Other Included Managers:

Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report.
[If there are no entries in this list, state "NONE" and omit the column headings and list entries.]

No.Form 13F File NumberNameCIK
1
028-19938
Invus Financial Advisors, LLC
0001802978
2
028-24462
Invus Group, LLC
0002044445


UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number:3235-0006
Expires:July 31, 2015
Estimated average burden
hours per response:23.8
COLUMN 1COLUMN 2COLUMN 3COLUMN 4COLUMN 5COLUMN 6COLUMN 7COLUMN 8
VALUESHRS ORSH/PUT/INVESTMENTOTHERVOTING AUTHORITY
NAME OF ISSUERTITLE OF CLASSCUSIP(x$1000)PRN AMTPRNCALLDISCRETIONMANAGERSOLESHAREDNONE
ACELYRIN IncCOM00445A1005,431,1481,729,665SHDFND21,729,665 0 0
Achilles Therapeutics PLCSPONSORED ADS00449L102861,128755,375SHDFND2755,375 0 0
Adobe IncCOM00724F1013,912,2958,798SHDFND28,798 0 0
Allovir IncCOM0198181032,770,8106,597,167SHDFND26,597,167 0 0
Alphabet IncCAP STK CL A02079K3051,325,1007,000SHDFND27,000 0 0
Amazon.com IncCOM0231351068,007,73536,500SHDFND236,500 0 0
Apellis Pharmaceuticals IncCOM03753U10689,866,7932,816,258SHDFND22,816,258 0 0
Apogee Therapeutics IncCOM03770N10133,853,823747,325SHDFND2747,325 0 0
Applied Therapeutics IncCOM03828A1011,398,8321,633,768SHDFND21,633,768 0 0
Arcus Biosciences IncCOM03969F10924,003,8271,612,077SHDFND11,612,077 0 0
argenx SESPONSORED ADR04016X10170,752,675115,045SHDFND2115,045 0 0
Arrowhead Pharmaceuticals IncCOM04280A10054,551,6032,901,681SHDFND22,901,681 0 0
Ascendis Pharma A/SSPONSORED ADR04351P10140,932,182297,321SHDFND2297,321 0 0
Avidity Biosciences IncCOM05370A10832,781,7391,127,295SHDFND21,127,295 0 0
Beigene LtdSPONSORED ADR07725L102120,748,806653,721SHDFND2653,721 0 0
Bicara Therapeutics IncCOM05547710357,012,6463,272,827SHDFND23,272,827 0 0
Bicycle Therapeutics PLCSPONSORED ADS08878610825,751,5721,839,398SHDFND21,839,398 0 0
BIOAGE Labs IncCOM09077V1002,246,520388,000SHDFND2388,000 0 0
Black Diamond Therapeutics IncCOM09203E1052,239,5461,046,517SHDFND21,046,517 0 0
Boeing CoCOM0970231054,425,00025,000SHDFND225,000 0 0
Caribou Biosciences IncCOM142038108167,502105,347SHDFND2105,347 0 0
Cartesian Therapeutics IncCOM NEW81621230210,248,747572,236SHDFND2572,236 0 0
Centessa Pharmaceuticals PLCSPONSORED ADS15230910050,328,3403,004,677SHDFND23,004,677 0 0
Couchbase IncCOM22207T101935,40060,000SHDFND260,000 0 0
Crinetics Pharmaceuticals IncCOM22663K10782,301,5071,609,652SHDFND21,609,652 0 0
CrowdStrike Holdings IncCL A22788C1058,211,84024,000SHDFND224,000 0 0
Cullinan Therapeutics IncCOM23003110614,754,3281,211,357SHDFND21,211,357 0 0
Cyclerion Therapeutics IncCOM23255M204374,019116,155SHDFND2116,155 0 0
Cytokinetics IncCOM NEW23282W60518,925,274402,323SHDFND2402,323 0 0
Datadog IncCL A COM23804L1034,347,42830,425SHDFND230,425 0 0
Denali Therapeutics IncCOM24823R10516,997,491834,028SHDFND2834,028 0 0
Dollar Tree IncCOM256746108749,40010,000SHDFND210,000 0 0
Dynatrace IncCOM NEW2681501094,496,32182,729SHDFND282,729 0 0
Dyne Therapeutics IncCOM26818M10831,746,0631,347,456SHDFND21,347,456 0 0
Edgewise Therapeutics IncCOM28036F10519,606,958734,343SHDFND2734,343 0 0
Elastic NVORD SHSN145061042,477,00025,000SHDFND225,000 0 0
Erasca IncCOM29479A10822,231,5198,857,179SHDFND28,857,179 0 0
Ferrari NVCOMN3167Y103854,4932,000SHDFND22,000 0 0
Foghorn Therapeutics Inc.COM3441741073,401,798720,720SHDFND2720,720 0 0
Freeport-McMoRan IncCL B35671D8572,856,00075,000SHDFND275,000 0 0
Generation Bio CoCOM37148K1003,161,6972,982,733SHDFND22,982,733 0 0
Gossamer Bio IncCOM38341P102187,252207,000SHCallDFND2207,000 0 0
Gossamer Bio IncCOM38341P1024,712,0325,208,968SHDFND25,208,968 0 0
HCA Healthcare IncCOM40412C1011,125,5633,750SHDFND23,750 0 0
HOOKIPA Pharma IncCOM NEW43906K2091,138,946566,640SHDFND2566,640 0 0
IGM Biosciences IncCOM44958510820,348,8783,330,422SHDFND23,330,422 0 0
IHS Holding LimitedORD SHSG4701H1096,883,9582,357,520SHDFND12,357,520 0 0
Instil Bio IncCOM NEW45783C2003,673,546192,433SHDFND2192,433 0 0
Intel CorpCOM458140100802,00040,000SHDFND240,000 0 0
Ionis Pharmaceuticals IncCOM4622221008,740,000250,000SHDFND2250,000 0 0
IONQ IncCOM46222L1087,100,900170,000SHDFND1170,000 0 0
Iovance Biotherapeutics IncCOM4622601008,184,6961,106,040SHDFND21,106,040 0 0
Ironwood Pharmaceuticals IncCOM CL A46333X108489,657110,532SHDFND2110,532 0 0
Janux Therapeutics IncCOM47103J1059,369,500175,000SHDFND2175,000 0 0
Jfrog LtdORD SHSM6191J1003,532,612120,116SHDFND2120,116 0 0
Kanzhun LtdSPONSORED ADS48553T106345,00025,000SHDFND225,000 0 0
Ke Holdings IncSPONSORED ADS4824971041,105,20060,000SHDFND260,000 0 0
Korro Bio IncCOM50094610815,944,972418,833SHDFND2418,833 0 0
Kronos Bio IncCOM50107A104800,806842,954SHDFND2842,954 0 0
Kura Oncology IncCOM50127T10911,670,8951,339,942SHDFND21,339,942 0 0
Kymera Therapeutics IncCOM501575104119,472,3592,969,733SHDFND22,969,733 0 0
Lexeo Therapeutics IncCOM52886X1073,970,602603,435SHDFND2603,435 0 0
Lexicon Pharmaceuticals IncCOM NEW52887230228,799,98838,918,903SHDFND238,918,903 0 0
Madrigal Pharmaceuticals IncCOM55886810538,861,923125,942SHDFND2125,942 0 0
Marvell Technology IncCOM573874104552,2505,000SHDFND25,000 0 0
Merus NVCOMN5749R10032,984,525784,412SHDFND2784,412 0 0
Meta Platforms IncCL A30303M102585,5101,000SHDFND21,000 0 0
Microsoft CorpCOM5949181049,694,50023,000SHDFND223,000 0 0
Monday.Com LtdSHSM7S64H106470,8802,000SHDFND22,000 0 0
Nebius Group NVSHS CLASS AN972841083,324,000120,000SHDFND2120,000 0 0
Neumora Therapeutics IncCOM64097910046,598,6604,396,100SHDFND24,396,100 0 0
New Oriental Education & Technology Group IncSPON ADR6475812064,396,33068,500SHDFND268,500 0 0
NewAmsterdam Pharma Company NVORDINARY SHARESN6250910953,857,8972,095,638SHDFND22,095,638 0 0
Nu Holdings LtdORD SHS CL AG6683N103518,00050,000SHDFND250,000 0 0
NVIDIA CorpCOM67066G1046,571,07848,932SHDFND248,932 0 0
Occidental Petroleum CorpCOM674599105741,15015,000SHDFND215,000 0 0
Omega Therapeutics IncCOMMON STOCK68217N105986,8241,323,530SHDFND21,323,530 0 0
Oric Pharmaceuticals IncCOM68622P1098,131,1301,007,575SHDFND11,007,575 0 0
Ovid Therapeutics IncCOM6904691012,661,0452,850,000SHDFND22,850,000 0 0
Palo Alto Networks IncCOM6974351051,091,7606,000SHDFND26,000 0 0
PayPal Holdings IncCOM70450Y1031,280,25015,000SHDFND215,000 0 0
PDD Holdings IncSPONSORED ADS7223041025,130,86852,901SHDFND252,901 0 0
Phathom Pharmaceuticals IncCOM71722W1073,741,314460,753SHDFND2460,753 0 0
Procore Technologies IncCOM74275K1081,498,60020,000SHDFND220,000 0 0
ProQR Therapeutics NVSHS EURON715421094,173,7501,575,000SHDFND21,575,000 0 0
Prothena Corporation PLCSHSG7280010815,232,7841,099,840SHDFND21,099,840 0 0
Qualcomm IncCOM7475251032,304,30015,000SHDFND215,000 0 0
Rapport Therapeutics IncCOM75383L1026,815,655384,197SHDFND2384,197 0 0
Regenxbio IncCOM75901B1072,195,320284,000SHDFND2284,000 0 0
Remitly Global IncCOM75960P10410,505,184465,449SHDFND1465,449 0 0
Remitly Global IncCOM75960P104564,25025,000SHDFND225,000 0 0
Revolution Medicines IncCOM76155X10024,999,510571,548SHDFND2571,548 0 0
Rocket Pharmaceuticals IncCOM77313F1067,542,000600,000SHDFND2600,000 0 0
Sagimet Biosciences IncCOM SER A7867001043,261,470724,771SHDFND2724,771 0 0
Scholar Rock Holding CorpCOM80706P103399,785,2169,250,005SHDFND29,250,005 0 0
Sea LtdSPONSORED ADS81141R1002,652,50025,000SHDFND225,000 0 0
Seer IncCOM CL A81578P1069,240,0004,000,000SHDFND24,000,000 0 0
SEMrush Holdings IncCL A COM81686C104415,80035,000SHDFND235,000 0 0
Septerna IncCOM81734D10450,437,5712,202,514SHDFND22,202,514 0 0
ServiceNow IncCOM81762P1025,941,9735,605SHDFND25,605 0 0
Silence Therapeutics PLCADS82686Q10119,482,5782,831,770SHDFND22,831,770 0 0
Soleno Therapeutics IncCOM83420330915,814,219351,818SHDFND2351,818 0 0
Solid Biosciences IncCOM NEW83422E20414,996,1643,749,041SHDFND23,749,041 0 0
SpringWorks Therapeutics IncCOM85205L10749,776,3371,377,701SHDFND21,377,701 0 0
Spyre Therapeutics IncCOM NEW00773J2028,706,720374,000SHDFND2374,000 0 0
Stoke Therapeutics IncCOM86150R10722,060,0002,000,000SHDFND22,000,000 0 0
Taboola.com LtdORD SHSM8744T10636,388,6579,969,495SHDFND19,969,495 0 0
Taiwan Semiconductor Manufacturing Co LtdSPONSORED ADS8740391002,962,35015,000SHDFND215,000 0 0
Tango Therapeutics IncCOM87583X1098,046,0422,603,897SHDFND22,603,897 0 0
Taysha Gene Therapies IncCOM SHS87761910611,422,2826,602,475SHDFND26,602,475 0 0
Tourmaline Bio IncCOM89157D1051,854,11991,426SHDFND291,426 0 0
Trevi Therapeutics IncCOM89532M10111,972,9672,906,060SHDFND22,906,060 0 0
Upstream Bio IncCOM91678A10713,152,000800,000SHDFND2800,000 0 0
Vaxcyte IncCOM92243G10824,557,263299,991SHDFND2299,991 0 0
Vera Therapeutics IncCL A92337R10132,075,485758,465SHDFND2758,465 0 0
Vigil Neuroscience IncCOM92673K1083,384,7651,991,038SHDFND21,991,038 0 0
WAVE Life Sciences LtdSHSY9530810546,393,5743,750,491SHDFND23,750,491 0 0
Workiva IncCOM CL A98139A1051,095,00010,000SHDFND210,000 0 0
Xenon Pharmaceuticals IncCOM98420N10529,155,745743,769SHDFND2743,769 0 0