UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F COVER PAGE
OMB APPROVAL
OMB Number:3235-0006
Expires:July 31, 2015
Estimated average burden
hours per response:23.8
Report for the Calendar Year or Quarter Ended:
12-31-2021
Check here if Amendment: ☐ Amendment Number:
This Amendment (Check only one.):☐ is a restatement.
☐ adds new holdings entries.

Institutional Investment Manager Filing this Report:

Name:
Asymmetry Capital Management, L.P.
Address:
1 SANSOME STREET
SUITE 1810
SAN FRANCISCO, CA 94104
Form 13F File Number:
028-17016

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.


Person Signing this Report on Behalf of Reporting Manager:
Name:
Cynthia Goldsmith
Title:
CFO
Phone:
5103040817


Signature, Place, and Date of Signing:

Cynthia Goldsmith
                         [Signature]
Alameda, CALIFORNIA
                 [City, State]
01-18-2022
                           [Date]
                          

Report Type (Check only one.):

☒ 13F HOLDINGS REPORT. (Check here if all holdings of this reporting manager are reported in this report.) 

☐ 13F NOTICE. (Check here if no holdings reported are in this report, and all holdings are reported by other reporting manager(s).) 

☐ 13F COMBINATION REPORT. (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)


Form 13F Summary Page

Report Summary:

Number of Other Included Managers:
0
Form 13F Information table Entry Total:
24
Form 13F Information table Value Total:
188376
          (thousands)

List of Other Included Managers:

Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report.
[If there are no entries in this list, state "NONE" and omit the column headings and list entries.]

  
NONE


UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number:3235-0006
Expires:July 31, 2015
Estimated average burden
hours per response:23.8
COLUMN 1COLUMN 2COLUMN 3COLUMN 4COLUMN 5COLUMN 6COLUMN 7COLUMN 8
VALUESHRS ORSH/PUT/INVESTMENTOTHERVOTING AUTHORITY
NAME OF ISSUERTITLE OF CLASSCUSIP(x$1000)PRN AMTPRNCALLDISCRETIONMANAGERSOLESHAREDNONE
ABBVIE INCCOM00287Y10912,78894,448SHSOLE94,448 0 0
ACLARIS THERAPEUTICS INCCOM00461U1052,886198,493SHSOLE198,493 0 0
AMICUS THERAPEUTICS INCCOM03152W1098,278716,709SHSOLE716,709 0 0
APELLIS PHARMACEUTICALS INCCOM03753U1066,593139,445SHSOLE139,445 0 0
ARGENX SE - ADRADR04016X1017,31220,881SHSOLE20,881 0 0
AVADEL PHARMACEUTICALS PLCADR05337M1042,983369,134SHSOLE369,134 0 0
BCLS ACQUISITION CORP- CL ACOMG0904B10569971,372SHSOLE71,372 0 0
BELLUS HEALTH INCCOM07987C20410,3101,280,757SHSOLE1,280,757 0 0
BIOMARIN PHARMACEUTICAL INCCOM09061G10115,703177,741SHSOLE177,741 0 0
CENTENE CORPCOM15135B10112,216148,254SHSOLE148,254 0 0
CYTOKINETICS INCCOM23282W60510,257225,032SHSOLE225,032 0 0
DICE MOLECULES HOLDINGS ORDCOM23345J1044,687185,201SHSOLE185,201 0 0
HORIZON THERAPEUTICS PLCCOMG4618810114,829137,610SHSOLE137,610 0 0
IQVIA HOLDINGS INCCOM46266C10512,50344,314SHSOLE44,314 0 0
ITEOS THERAPEUTICS INCCOM46565G1044,877104,755SHSOLE104,755 0 0
IVERIC BIO INCCOM46583P1026,287375,989SHSOLE375,989 0 0
JOHNSON & JOHNSONCOM4781601049,53855,755SHSOLE55,755 0 0
KURA ONCOLOGY INCCOM50127T1097,032502,275SHSOLE502,275 0 0
MIRATI THERAPEUTICS INCCOM60468T1056,43643,876SHSOLE43,876 0 0
NATERA INCCOM6323071049,495101,674SHSOLE101,674 0 0
PMV PHARMACEUTICALS INCCOM69353Y1032,25697,680SHSOLE97,680 0 0
QUANTERIX CORPCOM74766Q1016,072143,204SHSOLE143,204 0 0
REGULUS THERAPEUTICS INCCOM75915K2008602,731,044SHSOLE2,731,044 0 0
UNITEDHEALTH GROUP INCCOM91324P10213,47926,844SHSOLE26,844 0 0